DE69504184T2 - Neue kationische phospholipide zur transfektion - Google Patents

Neue kationische phospholipide zur transfektion

Info

Publication number
DE69504184T2
DE69504184T2 DE69504184T DE69504184T DE69504184T2 DE 69504184 T2 DE69504184 T2 DE 69504184T2 DE 69504184 T DE69504184 T DE 69504184T DE 69504184 T DE69504184 T DE 69504184T DE 69504184 T2 DE69504184 T2 DE 69504184T2
Authority
DE
Germany
Prior art keywords
phospholipids
transfection
cationic phospholipids
novel
new cationic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69504184T
Other languages
English (en)
Other versions
DE69504184D1 (de
Inventor
Gary Ashley
Robert Macdonald
Miho Shida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Northwestern University
Original Assignee
Northwestern University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Northwestern University filed Critical Northwestern University
Publication of DE69504184D1 publication Critical patent/DE69504184D1/de
Application granted granted Critical
Publication of DE69504184T2 publication Critical patent/DE69504184T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/113—Esters of phosphoric acids with unsaturated acyclic alcohols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07F9/653—Five-membered rings
    • C07F9/65324—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
DE69504184T 1994-03-29 1995-03-28 Neue kationische phospholipide zur transfektion Expired - Fee Related DE69504184T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/220,376 US5651981A (en) 1994-03-29 1994-03-29 Cationic phospholipids for transfection
PCT/US1995/003635 WO1995026356A1 (en) 1994-03-29 1995-03-28 Novel cationic phospholipids for transfection

Publications (2)

Publication Number Publication Date
DE69504184D1 DE69504184D1 (de) 1998-09-24
DE69504184T2 true DE69504184T2 (de) 1999-04-01

Family

ID=22823310

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69504184T Expired - Fee Related DE69504184T2 (de) 1994-03-29 1995-03-28 Neue kationische phospholipide zur transfektion

Country Status (10)

Country Link
US (9) US5651981A (de)
EP (1) EP0752997B1 (de)
JP (1) JPH10500399A (de)
AT (1) ATE169923T1 (de)
AU (1) AU2192395A (de)
CA (1) CA2186588C (de)
DE (1) DE69504184T2 (de)
DK (1) DK0752997T3 (de)
ES (1) ES2121366T3 (de)
WO (1) WO1995026356A1 (de)

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US5688958A (en) 1997-11-18
CA2186588A1 (en) 1995-10-05
AU2192395A (en) 1995-10-17
US5855910A (en) 1999-01-05
DK0752997T3 (da) 1999-05-25
WO1995026356A1 (en) 1995-10-05
EP0752997B1 (de) 1998-08-19
US5695780A (en) 1997-12-09
US5651981A (en) 1997-07-29
US5780053A (en) 1998-07-14
DE69504184D1 (de) 1998-09-24
ES2121366T3 (es) 1998-11-16
ATE169923T1 (de) 1998-09-15
US5686620A (en) 1997-11-11
EP0752997A1 (de) 1997-01-15
JPH10500399A (ja) 1998-01-13
US5891714A (en) 1999-04-06
US6187760B1 (en) 2001-02-13
US5661018A (en) 1997-08-26

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