DE69504705T2 - Vorrichtung zur verabreichung von medikamenten durch elektrotransport - Google Patents

Vorrichtung zur verabreichung von medikamenten durch elektrotransport

Info

Publication number
DE69504705T2
DE69504705T2 DE69504705T DE69504705T DE69504705T2 DE 69504705 T2 DE69504705 T2 DE 69504705T2 DE 69504705 T DE69504705 T DE 69504705T DE 69504705 T DE69504705 T DE 69504705T DE 69504705 T2 DE69504705 T2 DE 69504705T2
Authority
DE
Germany
Prior art keywords
electrotransport
allowed
body surface
delivery
transition interval
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69504705T
Other languages
English (en)
Other versions
DE69504705D1 (de
Inventor
Larry Mcnichols
John Badzinski
Ronald Haak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alza Corp
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Application granted granted Critical
Publication of DE69504705D1 publication Critical patent/DE69504705D1/de
Publication of DE69504705T2 publication Critical patent/DE69504705T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0412—Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A61N1/303—Constructional details
DE69504705T 1994-12-08 1995-11-27 Vorrichtung zur verabreichung von medikamenten durch elektrotransport Expired - Lifetime DE69504705T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/353,036 US5697896A (en) 1994-12-08 1994-12-08 Electrotransport delivery device
PCT/US1995/015015 WO1996017651A1 (en) 1994-12-08 1995-11-27 Electrotransport delivery device

Publications (2)

Publication Number Publication Date
DE69504705D1 DE69504705D1 (de) 1998-10-15
DE69504705T2 true DE69504705T2 (de) 1999-02-25

Family

ID=23387488

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69504705T Expired - Lifetime DE69504705T2 (de) 1994-12-08 1995-11-27 Vorrichtung zur verabreichung von medikamenten durch elektrotransport

Country Status (15)

Country Link
US (2) US5697896A (de)
EP (1) EP0796127B1 (de)
JP (1) JP3848365B2 (de)
KR (1) KR100376723B1 (de)
AT (1) ATE170769T1 (de)
AU (1) AU688644B2 (de)
CA (1) CA2200602C (de)
DE (1) DE69504705T2 (de)
DK (1) DK0796127T3 (de)
ES (1) ES2122700T3 (de)
FI (1) FI116272B (de)
MX (1) MX9704049A (de)
NO (1) NO324646B1 (de)
NZ (1) NZ296913A (de)
WO (1) WO1996017651A1 (de)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3523334B2 (ja) * 1994-07-02 2004-04-26 久光製薬株式会社 イオントフォレ−シス用プラスター構造体
US5876368A (en) * 1994-09-30 1999-03-02 Becton Dickinson And Company Iontophoretic drug delivery device having improved controller
IE960312A1 (en) 1995-06-02 1996-12-11 Alza Corp An electrotransport delivery device with voltage boosting¹circuit
US6425892B2 (en) * 1995-06-05 2002-07-30 Alza Corporation Device for transdermal electrotransport delivery of fentanyl and sufentanil
KR100281171B1 (ko) * 1995-08-31 2001-03-02 나까도미 히로다카 이온토포레시스장치 및 그 전류제어방법
US6385487B1 (en) 1996-05-08 2002-05-07 Biophoretic Therapeutic Systems, Llc Methods for electrokinetic delivery of medicaments
US5676648A (en) 1996-05-08 1997-10-14 The Aps Organization, Llp Iontophoretic drug delivery apparatus and method for use
US5908401A (en) * 1996-05-08 1999-06-01 The Aps Organization, Llp Method for iontophoretic delivery of antiviral agents
US6246904B1 (en) * 1996-12-17 2001-06-12 Alza Corporation Electrotransport drug delivery reservoirs containing inert fillers
US6650934B2 (en) * 1996-12-17 2003-11-18 Alza Corp Polymeric foam reservoirs for an electrotransport delivery device
US6119036A (en) 1997-03-26 2000-09-12 The Board Of Regents Of The University Of Oklahoma Iontophoretic transdermal delivery device
US6029083A (en) * 1997-04-04 2000-02-22 Becton, Dickinson And Company Circuit and method for automatically turning off an iontophoresis system
US6208891B1 (en) * 1997-04-04 2001-03-27 Drug Delivery Technologies, Inc. Disabling circuit for an iontophoretic system
FR2766093B1 (fr) 1997-07-15 1999-09-03 Lhd Lab Hygiene Dietetique Procede de commande d'un dispositif d'administration transdermique de medicament sous champ electrique
WO1999018797A1 (en) 1997-10-09 1999-04-22 Emory University Method and devices for transdermal delivery of lithium
US6775569B2 (en) * 1997-11-05 2004-08-10 Hisamitsu Pharmaceutical Co., Inc. Electroporation device for in vivo delivery of therapeutic agents
USRE37796E1 (en) 1997-12-16 2002-07-23 Biophoretic Therapeutic Systems, Llc Methods for iontophoretic delivery of antiviral agents
FR2778108B1 (fr) * 1998-04-30 2000-07-21 Lhd Lab Hygiene Dietetique Dispositif d'administration transdermique de medicament par ionophorese
US6949081B1 (en) * 1998-08-26 2005-09-27 Non-Invasive Technology, Inc. Sensing and interactive drug delivery
US6148231A (en) * 1998-09-15 2000-11-14 Biophoretic Therapeutic Systems, Llc Iontophoretic drug delivery electrodes and method
US6708060B1 (en) 1998-11-09 2004-03-16 Transpharma Ltd. Handheld apparatus and method for transdermal drug delivery and analyte extraction
US6597946B2 (en) 1998-11-09 2003-07-22 Transpharma Ltd. Electronic card for transdermal drug delivery and analyte extraction
US6611706B2 (en) 1998-11-09 2003-08-26 Transpharma Ltd. Monopolar and bipolar current application for transdermal drug delivery and analyte extraction
US6148232A (en) 1998-11-09 2000-11-14 Elecsys Ltd. Transdermal drug delivery and analyte extraction
JP2000237330A (ja) * 1999-02-24 2000-09-05 Hisamitsu Pharmaceut Co Inc イオントフォレーシス用デバイス
US6553253B1 (en) 1999-03-12 2003-04-22 Biophoretic Therapeutic Systems, Llc Method and system for electrokinetic delivery of a substance
US6792306B2 (en) 2000-03-10 2004-09-14 Biophoretic Therapeutic Systems, Llc Finger-mounted electrokinetic delivery system for self-administration of medicaments and methods therefor
US6477410B1 (en) 2000-05-31 2002-11-05 Biophoretic Therapeutic Systems, Llc Electrokinetic delivery of medicaments
US6283938B1 (en) * 1999-05-04 2001-09-04 Mcconnell Daniel E. Medicating bandage and controllable permeable membrane
US6385488B1 (en) * 1999-05-20 2002-05-07 Vyteris, Inc. Circuits for increasing the reliability of an iontophoretic system
JP4162813B2 (ja) * 1999-10-28 2008-10-08 久光製薬株式会社 イオントフォレーシス装置
US20010041869A1 (en) * 2000-03-23 2001-11-15 Causey James D. Control tabs for infusion devices and methods of using the same
WO2003039620A2 (en) * 2001-05-17 2003-05-15 Transpharma Medical Ltd. Integrated transdermal drug delivery system
DE10141650C1 (de) 2001-08-24 2002-11-28 Lohmann Therapie Syst Lts Transdermales Therapeutisches System mit Fentanyl bzw. verwandten Substanzen
EP1499255B1 (de) * 2002-04-19 2015-07-22 Syneron Medical Ltd. In der hand gehaltene transdermale arzneimittelabgabe und analytenextraktion
US7933646B2 (en) 2002-10-15 2011-04-26 Medtronic, Inc. Clustering of recorded patient neurological activity to determine length of a neurological event
EP1562674A4 (de) * 2002-10-15 2008-10-08 Medtronic Inc Kontrolle der behandlung bei beginn und im betrieb einesmedizinischen vorrichtungssystems
US20040267240A1 (en) * 2003-01-29 2004-12-30 Yossi Gross Active drug delivery in the gastrointestinal tract
KR20050098277A (ko) * 2003-01-29 2005-10-11 이-필 파마 리미티드 위장관 내 약물의 능동 송달
US20050058701A1 (en) * 2003-01-29 2005-03-17 Yossi Gross Active drug delivery in the gastrointestinal tract
ES2370395T3 (es) 2003-05-21 2011-12-15 Alexza Pharmaceuticals, Inc. Utilización de una capa de combustible sólido, procedimiento para fabricarla y unidad de calefacción correspondiente.
US7706873B2 (en) * 2004-05-05 2010-04-27 Mario Ammirati System and method for controlled delivery of a therapeutic agent to a target location within an internal body tissue
US7402777B2 (en) 2004-05-20 2008-07-22 Alexza Pharmaceuticals, Inc. Stable initiator compositions and igniters
US8252321B2 (en) 2004-09-13 2012-08-28 Chrono Therapeutics, Inc. Biosynchronous transdermal drug delivery for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and the treatment of hyperglycemia, alzheimer's disease, sleep disorders, parkinson's disease, aids, epilepsy, attention deficit disorder, nicotine addiction, cancer, headache and pain control, asthma, angina, hypertension, depression, cold, flu and the like
CA2580329C (en) 2004-09-13 2015-01-06 Chrono Therapeutics Inc. Biosynchronous transdermal drug delivery
US10130801B1 (en) * 2005-02-07 2018-11-20 Ipventure, Inc. Electronic transdermal chemical delivery
US7856263B2 (en) * 2005-04-22 2010-12-21 Travanti Pharma Inc. Transdermal systems for the delivery of therapeutic agents including granisetron using iontophoresis
JP2008540023A (ja) * 2005-05-19 2008-11-20 イー−ピル ファーマ リミティド 組織における一酸化窒素生成のための摂取可能デバイス
US20070203534A1 (en) * 2006-02-13 2007-08-30 Robert Tapper Stimulating galvanic or slow AC current for therapeutic physiological effects
CN104138634B (zh) * 2006-04-13 2016-09-07 梯瓦制药国际有限责任公司 递送抗偏头痛化合物的透皮方法和系统
US20110054391A1 (en) * 2006-07-28 2011-03-03 Ward W Kenneth Analyte sensing and response system
US8095213B1 (en) * 2007-05-31 2012-01-10 Purdue Pharma L.P. Transdermal patch
US7853320B1 (en) 2007-05-31 2010-12-14 Purdue Pharma L.P. Transdermal device having mechanical assist for porator-to-skin contact
US8197844B2 (en) 2007-06-08 2012-06-12 Activatek, Inc. Active electrode for transdermal medicament administration
US8047399B1 (en) 2007-07-05 2011-11-01 Purdue Pharma L.P. Dispenser for transdermal devices
JP5466161B2 (ja) 2007-10-09 2014-04-09 トランスファーマ メディカル リミテッド 磁気的なパッチ連結物
WO2009050718A2 (en) 2007-10-17 2009-04-23 Transpharma Medical Ltd. Dissolution rate verification
MX2010006062A (es) 2007-12-05 2010-09-14 Syneron Medical Ltd Aplicador desechable de energia electromagnetica y metodo para su uso.
US8862223B2 (en) 2008-01-18 2014-10-14 Activatek, Inc. Active transdermal medicament patch and circuit board for same
US8155737B2 (en) 2008-06-19 2012-04-10 Nupathe, Inc. Pharmacokinetics of iontophoretic sumatriptan administration
US8366600B2 (en) * 2008-06-19 2013-02-05 Nupathe Inc. Polyamine enhanced formulations for triptan compound iontophoresis
ES2526118T3 (es) * 2008-12-30 2015-01-07 Nupathe Inc. Control electrónico de sistema de administración de fármacos
US8606366B2 (en) 2009-02-18 2013-12-10 Syneron Medical Ltd. Skin treatment apparatus for personal use and method for using same
US20110066175A1 (en) * 2009-05-07 2011-03-17 Rainbow Medical Ltd. Gastric anchor
US8414559B2 (en) 2009-05-07 2013-04-09 Rainbow Medical Ltd. Gastroretentive duodenal pill
US20100286587A1 (en) * 2009-05-07 2010-11-11 Yossi Gross Sublingual electrical drug delivery
CN105748401A (zh) 2009-08-10 2016-07-13 泰华制药国际有限公司 用离子电渗疗法治疗恶心和偏头痛的方法
WO2011046927A1 (en) * 2009-10-13 2011-04-21 Nupathe,Inc. Transdermal methods and systems for the delivery of rizatriptan
US9327105B2 (en) 2010-03-26 2016-05-03 Itrace Biomedical Inc. Active transdermal drug delivery system and the method thereof
CA2796575C (en) 2010-04-13 2018-05-15 Relmada Therapeutics, Inc. Dermal pharmaceutical compositions of 1-methyl-2',6'-pipecoloxylidide and method of use
CA2817824A1 (en) 2010-11-23 2012-05-31 Nupathe, Inc. User-activated self-contained co-packaged iontophoretic drug delivery system
US9731121B2 (en) 2011-03-31 2017-08-15 Incline Therapeutics, Inc. Switch validation circuit and method
US8781571B2 (en) * 2011-03-31 2014-07-15 Incline Therapeutics, Inc. Switch validation circuit and method
US8428709B1 (en) 2012-06-11 2013-04-23 Incline Therapeutics, Inc. Current control for electrotransport drug delivery
US8428708B1 (en) * 2012-05-21 2013-04-23 Incline Therapeutics, Inc. Self-test for analgesic product
WO2013006643A1 (en) 2011-07-06 2013-01-10 The Parkinson's Institute Compositions and methods for treatment of symptoms in parkinson's disease patients
US9700245B2 (en) 2011-09-23 2017-07-11 Itrace Biomedical Inc. Transdermal analyte extraction and detection system and the method thereof
US10179239B2 (en) 2013-01-15 2019-01-15 Itrace Biomedical Inc. Personalized pain management treatments
US9710607B2 (en) 2013-01-15 2017-07-18 Itrace Biomedical Inc. Portable electronic therapy device and the method thereof
US10105487B2 (en) 2013-01-24 2018-10-23 Chrono Therapeutics Inc. Optimized bio-synchronous bioactive agent delivery system
AU2016211330A1 (en) 2015-01-28 2017-08-03 Chrono Therapeutics Inc. Drug delivery methods and systems
JP2018511127A (ja) 2015-03-12 2018-04-19 クロノ セラピューティクス インコーポレイテッドＣｈｒｏｎｏ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． 渇望入力及び支援システム
JP2020503950A (ja) 2017-01-06 2020-02-06 クロノ セラピューティクス インコーポレイテッドＣｈｒｏｎｏ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． 経皮薬剤送達の装置及び方法
US11251635B2 (en) 2017-12-19 2022-02-15 Welch Allyn, Inc. Vital signs monitor with a removable and dischargable battery
AU2019279884A1 (en) 2018-05-29 2020-12-10 Morningside Venture Investments Limited Drug delivery methods and systems

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3991755A (en) * 1973-07-27 1976-11-16 Medicon, Inc. Iontophoresis apparatus for applying local anesthetics
US4141359A (en) * 1976-08-16 1979-02-27 University Of Utah Epidermal iontophoresis device
US4340047A (en) * 1978-10-18 1982-07-20 Robert Tapper Iontophoretic treatment apparatus
US4250878A (en) * 1978-11-22 1981-02-17 Motion Control, Inc. Non-invasive chemical species delivery apparatus and method
BR8008859A (pt) * 1979-10-10 1981-08-25 Cyclotech Med Ind Bandagem bloqueadora de dor
US4383529A (en) * 1980-11-03 1983-05-17 Wescor, Inc. Iontophoretic electrode device, method and gel insert
US4406658A (en) * 1981-03-06 1983-09-27 Medtronic, Inc. Iontophoretic device with reversible polarity
JPS5810066A (ja) * 1981-07-10 1983-01-20 株式会社アドバンス イオントフオレ−ゼ用プラスタ−構造体
US4456012A (en) * 1982-02-22 1984-06-26 Medtronic, Inc. Iontophoretic and electrical tissue stimulation device
EP0092015A1 (de) * 1982-04-16 1983-10-26 Roland Brodard Ionisierungsvorrichtung
US4931046A (en) * 1987-05-15 1990-06-05 Newman Martin H Iontophoresis drug delivery system
US5013293A (en) * 1987-05-28 1991-05-07 Drug Delivery Systems Inc. Pulsating transdermal drug delivery system
US4942883A (en) * 1987-09-29 1990-07-24 Newman Martin H Drug delivery device
US5006108A (en) * 1988-11-16 1991-04-09 Noven Pharmaceuticals, Inc. Apparatus for iontophoretic drug delivery
DE4028125A1 (de) * 1990-01-17 1991-07-18 Klimke Markus Applikationsvorrichtung fuer die geregelte dosierung verschiedener pharmakons mittels elektrischem strom zum perkutanen transport zur lokalen und systemischen therapie
US5207752A (en) * 1990-03-30 1993-05-04 Alza Corporation Iontophoretic drug delivery system with two-stage delivery profile
CA2084734C (en) * 1991-12-17 1998-12-01 John L. Haynes Iontophoresis system having features for reducing skin irritation

Also Published As

Publication number Publication date
FI972414A (fi) 1997-06-06
US5697896A (en) 1997-12-16
FI116272B (fi) 2005-10-31
NO324646B1 (no) 2007-11-26
MX9704049A (es) 1997-10-31
NO972498L (no) 1997-08-06
ES2122700T3 (es) 1998-12-16
EP0796127A1 (de) 1997-09-24
JPH10510179A (ja) 1998-10-06
NZ296913A (en) 1999-07-29
NO972498D0 (no) 1997-06-02
CA2200602A1 (en) 1996-06-13
JP3848365B2 (ja) 2006-11-22
US6090095A (en) 2000-07-18
AU688644B2 (en) 1998-03-12
WO1996017651A1 (en) 1996-06-13
DK0796127T3 (da) 1999-06-07
EP0796127B1 (de) 1998-09-09
CA2200602C (en) 2010-03-23
KR100376723B1 (ko) 2003-06-09
AU4165196A (en) 1996-06-26
FI972414A0 (fi) 1997-06-06
ATE170769T1 (de) 1998-09-15
DE69504705D1 (de) 1998-10-15

Similar Documents

Publication Publication Date Title
DE69504705T2 (de) Vorrichtung zur verabreichung von medikamenten durch elektrotransport
DE69220808T2 (de) Vorrichtung zur verabreichung von heilmitteln
DK0781152T3 (da) Elektrotransport-afgivelsesanordning med forbedret sikkerhed og reduceret misbrugspotentiale
EG18436A (en) Therapeutical application of phosponylmethoxy-alkyl adenines
SE9401406L (sv) Farmaceutiska produkter för att bota tumörsjukdomar samt förfarande för framställning av desamma
DE59009462D1 (de) Implantierbare Vorrichtung zur dosierten Abgabe von Medikamenten in den menschlichen Körper.
KR0125921B1 (en) Method and device for the diagnosis and treatment of nasal diseases
EP0378132A3 (de) Vorrichtung zum Eingeben von Medikamenten durch Iontophorese für örtliche oder regionale Behandlungen
ATE142116T1 (de) Durch körperliche aktivität gesteuerte vorrichtung zur iontophoretischen verabreichung von medikamenten
DE69925957D1 (de) Vorrichtung zur pulsartigen Verabreichung von Stickoxid mit genauer Dosis sowie Überwachunggerät und Alarmanlagen
ATE114118T1 (de) System zur verabreichung von medikamenten durch ein zweistufiges iontophoresenverfahren.
ATE179339T1 (de) Elektrische stimulierung zur behandlung von inkontinenz und anderen neuromuskularerkrankungen
EP0147261A3 (en) Medicine and medicinal composition for the treatment and the prevention of skin affections involving an inflammation process
MY100987A (en) Electrical dosimetry control system.
MX9708823A (es) Dispositivo de electrotransporte que tiene un controlador que se puede volver a usar.
MX168630B (es) Sistema y metodo para controlar la tasa de liberacion electrocinetica de un medicamento
WO1994017792A3 (en) Compositions and methods for transdermal drug delivery
ATE169832T1 (de) Ionophoretische vorrichtung zur transdermalen verabreichung von medikamenten undentsprechende wegwerfeinheit
DE68909750D1 (de) Vorrichtung zur therapeutischen behandlung von lumbago sowie lumbago/ischias.
DE69502025D1 (de) Iontophoretisches gerät zur transkutanen abgabe von medikamenten zu einem patienten, das eine genaue dosierungskontrolle ermöglicht

Legal Events

Date Code Title Description
8364 No opposition during term of opposition