DE69507339T2 - Polymer-mikrokugeln und verfahren zu deren herstellung - Google Patents

Polymer-mikrokugeln und verfahren zu deren herstellung

Info

Publication number
DE69507339T2
DE69507339T2 DE69507339T DE69507339T DE69507339T2 DE 69507339 T2 DE69507339 T2 DE 69507339T2 DE 69507339 T DE69507339 T DE 69507339T DE 69507339 T DE69507339 T DE 69507339T DE 69507339 T2 DE69507339 T2 DE 69507339T2
Authority
DE
Germany
Prior art keywords
water
soluble polymer
pct
polymer
microspheres
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69507339T
Other languages
English (en)
Other versions
DE69507339D1 (de
Inventor
Allan Coombes
Stanley Davis
Etienne Schacht
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universiteit Gent
University of Nottingham
Original Assignee
Universiteit Gent
University of Nottingham
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universiteit Gent, University of Nottingham filed Critical Universiteit Gent
Publication of DE69507339D1 publication Critical patent/DE69507339D1/de
Application granted granted Critical
Publication of DE69507339T2 publication Critical patent/DE69507339T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5161—Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/005—Processes for mixing polymers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/12—Powdering or granulating
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/12—Powdering or granulating
    • C08J3/126—Polymer particles coated by polymer, e.g. core shell structures
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]
    • Y10T428/2985—Solid-walled microcapsule from synthetic polymer
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2989—Microcapsule with solid core [includes liposome]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991—Coated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991—Coated
    • Y10T428/2998—Coated including synthetic resin or polymer
DE69507339T 1994-03-28 1995-03-27 Polymer-mikrokugeln und verfahren zu deren herstellung Expired - Fee Related DE69507339T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9406094A GB9406094D0 (en) 1994-03-28 1994-03-28 Polymer microspheres and a method of production thereof
PCT/GB1995/000686 WO1995026376A2 (en) 1994-03-28 1995-03-27 Polymer microspheres and a method of production thereof

Publications (2)

Publication Number Publication Date
DE69507339D1 DE69507339D1 (de) 1999-02-25
DE69507339T2 true DE69507339T2 (de) 1999-08-26

Family

ID=10752618

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69507339T Expired - Fee Related DE69507339T2 (de) 1994-03-28 1995-03-27 Polymer-mikrokugeln und verfahren zu deren herstellung

Country Status (7)

Country Link
US (1) US5922357A (de)
EP (1) EP0797615B1 (de)
JP (1) JPH09511002A (de)
AT (1) ATE175699T1 (de)
DE (1) DE69507339T2 (de)
GB (1) GB9406094D0 (de)
WO (1) WO1995026376A2 (de)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL110787A0 (en) 1993-08-27 1994-11-11 Sandoz Ag Biodegradable polymer, its preparation and pharmaceutical composition containing it
DE19545257A1 (de) 1995-11-24 1997-06-19 Schering Ag Verfahren zur Herstellung von morphologisch einheitlichen Mikrokapseln sowie nach diesem Verfahren hergestellte Mikrokapseln
US6730735B2 (en) 1997-07-03 2004-05-04 West Pharmaceutical Services Drug Delivery & Clinical Research Centre Limited Conjugate of polyethylene glycol and chitosan
DE19745950A1 (de) * 1997-10-17 1999-04-22 Dds Drug Delivery Service Ges Arzneistoffträgerpartikel für die gewebespezifische Arzneistoffapplikation
US20030180368A1 (en) * 1998-03-14 2003-09-25 Cenes Drug Delivery Limited Production of microparticles
IL139030A0 (en) * 1998-04-17 2001-11-25 Angiogenix Inc Therapeutic angiogenic factors and methods for their use
US6270806B1 (en) * 1999-03-03 2001-08-07 Elan Pharma International Limited Use of peg-derivatized lipids as surface stabilizers for nanoparticulate compositions
CA2337187C (en) * 1999-05-29 2011-02-22 Guanghui Zhang Bioabsorbable blends and surgical articles therefrom
ES2292634T3 (es) 2000-12-21 2008-03-16 Alrise Biosystems Gmbh Procedimiento de transicion de fase inducida para la produccion de microparticulas que contienen agentes hidrofilos activos.
US20040126900A1 (en) * 2001-04-13 2004-07-01 Barry Stephen E High affinity peptide- containing nanoparticles
US7713932B2 (en) 2001-06-04 2010-05-11 Biocon Limited Calcitonin drug-oligomer conjugates, and uses thereof
US6828297B2 (en) 2001-06-04 2004-12-07 Nobex Corporation Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6713452B2 (en) 2001-06-04 2004-03-30 Nobex Corporation Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6835802B2 (en) 2001-06-04 2004-12-28 Nobex Corporation Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties
US6828305B2 (en) 2001-06-04 2004-12-07 Nobex Corporation Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
CO5390081A1 (es) * 2001-11-28 2004-04-30 Novartis Ag Compuestos organicos
JP2005513145A (ja) * 2001-12-21 2005-05-12 セラター テクノロジーズ インコーポレイテッド 改変されたポリマー脂質送達ビヒクル
AU2003272284B2 (en) * 2002-09-05 2009-03-05 Catherine G. Ambrose Antibiotic microspheres for treatment of infections and osteomyelitis
US8986737B2 (en) * 2002-09-05 2015-03-24 Wm. Marsh Rice University Antibiotic microspheres for treatment and prevention of osteomyelitis and enhancement of bone regrowth
US6938589B2 (en) * 2002-11-07 2005-09-06 Powervantage Engines, Inc. Variable displacement engine
GB2407500A (en) * 2003-11-03 2005-05-04 Ist Superiore Sanita Use of microparticles for antigen delivery
EP1701751B1 (de) * 2003-11-14 2011-12-21 Interventional Therapies, LLC Verbesserte zwinge
US7875700B2 (en) 2004-07-19 2011-01-25 Biocon Limited Cation complexes of insulin compound conjugates, formulation and uses thereof
US7405002B2 (en) * 2004-08-04 2008-07-29 Agency For Science, Technology And Research Coated water-soluble nanoparticles comprising semiconductor core and silica coating
US7534489B2 (en) * 2004-09-24 2009-05-19 Agency For Science, Technology And Research Coated composites of magnetic material and quantum dots
KR100665672B1 (ko) * 2005-04-13 2007-01-09 성균관대학교산학협력단 새로운 온도 및 ｐＨ 민감성 블록 공중합체 및 이를 이용한고분자 하이드로겔
US8663686B2 (en) 2005-05-09 2014-03-04 University Of Washington Biodegradable chitosan-PEG compositions and methods of use
WO2007007403A1 (ja) * 2005-07-13 2007-01-18 Miyoshi Kasei, Inc. 表面処理粉体及びこれを含有する化粧料
CN101283025B (zh) 2005-10-27 2014-12-10 东丽株式会社 生物降解性粒子及其制造方法
US8021689B2 (en) * 2006-02-21 2011-09-20 Ecole Polytechnique Federale de Lausanne (“EPFL”) Nanoparticles for immunotherapy
GB0701896D0 (en) * 2007-02-01 2007-03-14 Regentec Ltd Composition
JP2010517638A (ja) * 2007-02-02 2010-05-27 トアニエ， インコーポレイテッド 腱および靱帯を修復するシステムおよび方法
KR101529894B1 (ko) * 2007-08-21 2015-06-18 더 리전츠 오브 더 유니버시티 오브 캘리포니아 코폴리머-안정화된 에멀션
MX2010003979A (es) 2007-10-16 2010-06-02 Biocon Ltd Composicion farmaceutica oralmente administrable y proceso para su preparacion.
WO2009085952A1 (en) 2007-12-20 2009-07-09 Brookwood Pharmaceuticals, Inc. Process for preparing microparticles having a low residual solvent volume
EP2285901B1 (de) 2008-05-06 2020-07-22 CJ CheilJedang Corporation Biologisch abbaubare polyestermischungen
EP2376060B1 (de) * 2008-12-15 2012-09-19 Novartis AG Nanopartikelzusammensetzungen
AU2009329820B2 (en) * 2008-12-22 2012-12-06 The University Of Melbourne Method for controlling water evaporation
EP4008355A1 (de) 2012-05-03 2022-06-08 Kala Pharmaceuticals, Inc. Pharmazeutische nanopartikel mit verbessertem mukosalem transport
US11596599B2 (en) 2012-05-03 2023-03-07 The Johns Hopkins University Compositions and methods for ophthalmic and/or other applications
US9827191B2 (en) 2012-05-03 2017-11-28 The Johns Hopkins University Compositions and methods for ophthalmic and/or other applications
EP3808339A1 (de) 2012-05-03 2021-04-21 Kala Pharmaceuticals, Inc. Pharmazeutische nanopartikel mit verbessertem mukosalem transport
US9475930B2 (en) 2012-08-17 2016-10-25 Metabolix, Inc. Biobased rubber modifiers for polymer blends
US9353122B2 (en) 2013-02-15 2016-05-31 Kala Pharmaceuticals, Inc. Therapeutic compounds and uses thereof
ES2831625T3 (es) 2013-02-20 2021-06-09 Kala Pharmaceuticals Inc Compuestos terapéuticos y sus usos
US9688688B2 (en) 2013-02-20 2017-06-27 Kala Pharmaceuticals, Inc. Crystalline forms of 4-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinazolin-7-yl)oxy)-1-(2-oxa-7-azaspiro[3.5]nonan-7-yl)butan-1-one and uses thereof
EP3004225A1 (de) 2013-05-30 2016-04-13 Metabolix, Inc. Rezyklatmischungen
CA2923753C (en) 2013-09-19 2021-10-12 Terumo Corporation Polymer particles
AU2014321278B2 (en) 2013-09-19 2016-11-10 Microvention, Inc. Polymer films
US9890173B2 (en) 2013-11-01 2018-02-13 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
AU2014342042B2 (en) 2013-11-01 2017-08-17 KALA BIO, Inc. Crystalline forms of therapeutic compounds and uses thereof
AU2014346486B2 (en) 2013-11-08 2016-12-08 Terumo Corporation Polymer particles
US10611903B2 (en) 2014-03-27 2020-04-07 Cj Cheiljedang Corporation Highly filled polymer systems
WO2016154592A1 (en) 2015-03-26 2016-09-29 Microvention, Inc. Embiolic particles
US10392399B2 (en) 2016-09-08 2019-08-27 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
EP3509421A4 (de) 2016-09-08 2020-05-20 Kala Pharmaceuticals, Inc. Kristalline formen therapeutischer verbindungen und verwendungen davon
US10253036B2 (en) 2016-09-08 2019-04-09 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
US10201632B2 (en) 2016-09-28 2019-02-12 Terumo Corporation Polymer particles
CA3119291A1 (en) * 2018-11-13 2020-05-22 Arysta Lifescience Inc. Encapsulation of cyclohexanediones process and product

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4581337A (en) * 1983-07-07 1986-04-08 E. I. Du Pont De Nemours And Company Polyether polyamines as linking agents for particle reagents useful in immunoassays
FR2615194B1 (fr) * 1987-05-11 1991-06-14 Rhone Poulenc Chimie Particules de polymere comportant, implantees a leur surface des molecules amphiphiles portant des groupes ionogenes ou reactifs, leur procede de preparation et leur application en biologie
US5545823A (en) * 1991-06-11 1996-08-13 Yung Chi Paint & Varnish Mfg. Co., Ltd. Self-polishing type antifouling coating composition containing film-formable metal soap compound
US5565215A (en) * 1993-07-23 1996-10-15 Massachusettes Institute Of Technology Biodegradable injectable particles for imaging
US5468526A (en) * 1993-09-20 1995-11-21 The Dow Chemical Company Multilayer barrier film for ostomy applications
US5612052A (en) * 1995-04-13 1997-03-18 Poly-Med, Inc. Hydrogel-forming, self-solvating absorbable polyester copolymers, and methods for use thereof
US5795864A (en) * 1995-06-27 1998-08-18 Neurex Corporation Stable omega conopetide formulations

Also Published As

Publication number Publication date
GB9406094D0 (en) 1994-05-18
EP0797615B1 (de) 1999-01-13
EP0797615A2 (de) 1997-10-01
JPH09511002A (ja) 1997-11-04
DE69507339D1 (de) 1999-02-25
ATE175699T1 (de) 1999-01-15
WO1995026376A3 (en) 1995-11-16
US5922357A (en) 1999-07-13
WO1995026376A2 (en) 1995-10-05

Similar Documents

Publication Publication Date Title
DE69507339D1 (de) Polymer-mikrokugeln und verfahren zu deren herstellung
Bader et al. Watersoluble polymers in medicine
Kowalczuk et al. Loading of polymer nanocarriers: Factors, mechanisms and applications
DE69327490T2 (de) Arzneimittel aus Polymer-Micellen mit physikalischer Einschlusswirkung
DE69534780T2 (de) Flüssige Zusammensetzungen zur Arzneistoffabgabe
JP5502751B2 (ja) 低残留溶媒濃度を有する微粒子を調製するためのプロセス
DE69735435T2 (de) Ester-terminierte polyamidgele
ATE141788T1 (de) Mikrosphäre enthaltende pharmazeutische zusammensetzung mit kontrollierter freigabe und verfahren zur herstellung
DE3913734C2 (de) Verwendung einer wäßrigen Hauthaftkleberlösung zur Herstellung einer mit Wasser leicht abwaschbaren Klebschicht
JPH10512287A (ja) 生分解性高分子ミセル−タイプ薬物組成物およびその製造方法
GB2273657B (en) Preparation of solid microspheres or air-filled microcapsules
DE69509671T2 (de) Pharmazeutische zusammensetzung mit einem schmelzbaren traegermaterial und verfahren zu seiner herstellung
BRPI9711856B8 (pt) métodos para preparação de um agente ativo, substancialmente insolúvel em água e composição para liberação in vivo de um agente ativo
JP2000191505A (ja) 水―分散性アニオン性ポリマ―を主体とするナノカプセル、その製造方法及びそれを含む化粧品又は皮膚用組成物
CA2430481A1 (en) Compositions for sustained delivery of hydrophobic drugs and process for the preparation thereof
WO2004035923A3 (en) Tissue paper softening compositions and tissue papers comprising the same
JPH0657005A (ja) ナノカプセルあるいはナノ粒子の分散コロイダル系の連続製造方法
WO2003020824A1 (de) Gelmatrix aus polyacrylsäure und polyvinylpyrrolidon
DE69828513D1 (de) Verfahren zur herstellung von nanokapseln des vesikulären typs
CA2187898A1 (fr) Microspheres biodegradables a liberation controlee et leur procede de preparation
BR9915462A (pt) Processos para preparação de partìculas dedroga revestidas e as suas formulaçõesfarmacêuticas
KR970704428A (ko) 활성성분의 선택적 방출을 제공하는 합성물(composition providing selective release of an active ingredient)
DE10215858A1 (de) Verfahren zur Haarbehandlung mit Formgedächtnispolymeren
DE69924829T2 (de) Zusammensetzungen, die ein Polykondensat mit mindestens einer Polyurethan- und/oder Polyharnstoffeinheit und ein Silicon mit mindestens einer Carboxyfunktion enthalten
ATE258794T1 (de) Ein chinolonderivat enthaltendes arzneimittel und verfahren zu dessen herstellung

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee