DE69514497D1 - Modafinilpartikel mit definierter Korngrössenverteilung - Google Patents
Modafinilpartikel mit definierter KorngrössenverteilungInfo
- Publication number
- DE69514497D1 DE69514497D1 DE69514497T DE69514497T DE69514497D1 DE 69514497 D1 DE69514497 D1 DE 69514497D1 DE 69514497 T DE69514497 T DE 69514497T DE 69514497 T DE69514497 T DE 69514497T DE 69514497 D1 DE69514497 D1 DE 69514497D1
- Authority
- DE
- Germany
- Prior art keywords
- size distribution
- grain size
- defined grain
- modafinil particles
- modafinil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- YFGHCGITMMYXAQ-UHFFFAOYSA-N 2-[(diphenylmethyl)sulfinyl]acetamide Chemical compound C=1C=CC=CC=1C(S(=O)CC(=O)N)C1=CC=CC=C1 YFGHCGITMMYXAQ-UHFFFAOYSA-N 0.000 title abstract 3
- 229960001165 modafinil Drugs 0.000 title abstract 3
- 239000002245 particle Substances 0.000 title abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/319,124 US5618845A (en) | 1994-10-06 | 1994-10-06 | Acetamide derivative having defined particle size |
PCT/US1995/012944 WO1996011001A1 (en) | 1994-10-06 | 1995-10-04 | Modafinil having defined particle size |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69514497D1 true DE69514497D1 (de) | 2000-02-17 |
DE69514497T2 DE69514497T2 (de) | 2000-08-10 |
Family
ID=23240954
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69535786T Expired - Lifetime DE69535786D1 (de) | 1994-10-06 | 1995-10-04 | Modafinil mit definierter Korngrössenverteilung |
DE69520161T Expired - Lifetime DE69520161T2 (de) | 1994-10-06 | 1995-10-04 | Modafinilpartikel mit definierter Korngrössenverteilung |
DE69514497T Expired - Lifetime DE69514497T2 (de) | 1994-10-06 | 1995-10-04 | Modafinilpartikel mit definierter Korngrössenverteilung |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69535786T Expired - Lifetime DE69535786D1 (de) | 1994-10-06 | 1995-10-04 | Modafinil mit definierter Korngrössenverteilung |
DE69520161T Expired - Lifetime DE69520161T2 (de) | 1994-10-06 | 1995-10-04 | Modafinilpartikel mit definierter Korngrössenverteilung |
Country Status (34)
Country | Link |
---|---|
US (2) | US5618845A (de) |
EP (3) | EP0966962B1 (de) |
JP (1) | JP2915146B2 (de) |
KR (1) | KR100249360B1 (de) |
AT (3) | ATE199216T1 (de) |
AU (1) | AU703087B2 (de) |
BG (1) | BG62952B1 (de) |
BR (1) | BR9509257A (de) |
CA (2) | CA2201967C (de) |
CZ (1) | CZ291700B6 (de) |
DE (3) | DE69535786D1 (de) |
DK (3) | DK1088549T3 (de) |
EE (1) | EE9700082A (de) |
ES (3) | ES2156457T3 (de) |
FI (1) | FI121454B (de) |
GB (1) | GB2293103B (de) |
GR (2) | GR3033152T3 (de) |
HK (3) | HK1003561A1 (de) |
HU (1) | HU226411B1 (de) |
IS (1) | IS1987B (de) |
LT (1) | LT4303B (de) |
LV (1) | LV11852B (de) |
MD (1) | MD970143A (de) |
MX (1) | MX9602176A (de) |
NO (1) | NO318818B1 (de) |
NZ (1) | NZ295869A (de) |
PL (1) | PL181523B1 (de) |
PT (3) | PT1088549E (de) |
RO (1) | RO118928B1 (de) |
RU (1) | RU2287987C2 (de) |
SI (1) | SI9520106B (de) |
SK (1) | SK283632B6 (de) |
UA (1) | UA42023C2 (de) |
WO (1) | WO1996011001A1 (de) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6821975B1 (en) | 1999-08-03 | 2004-11-23 | Lilly Icos Llc | Beta-carboline drug products |
UA71629C2 (en) * | 1999-08-03 | 2004-12-15 | Lilli Icos Llc | Composition containing free drug particulate form of ?-carboline (variants), method for its manufacture (variants), and method for treating sexual dysfunction |
US6346548B1 (en) | 1999-08-16 | 2002-02-12 | Cephalon, Inc. | Compositions including modafinil for treatment of attention deficit hyperactivity disorder and multiple sclerosis fatigue |
US6455588B1 (en) | 1999-08-20 | 2002-09-24 | Cephalon, Inc. | Compositions including modafinil for treatment of eating disorders and for appetite stimulation |
FR2804322B1 (fr) * | 2000-01-31 | 2002-04-19 | Lafon Labor | Utilisation du modafinil pour la fabrication d'un medicament destine a corriger les troubles de la vigilance associes aux myopathies |
US20010034373A1 (en) * | 2000-02-09 | 2001-10-25 | Matthew Miller | Low dose modafinil for enhancement of cognitive function |
US6492396B2 (en) | 2000-05-16 | 2002-12-10 | Cephalon, Inc. | Substituted thioacetamides |
CA2416792C (en) * | 2000-07-27 | 2010-02-09 | Teva Pharmaceutical Industries Ltd. | Crystalline and pure modafinil, and process of preparing the same |
PT1330244E (pt) * | 2000-10-11 | 2009-01-27 | Cephalon Inc | Composições compreendendo compostos de modafinil |
EA005591B1 (ru) * | 2000-10-11 | 2005-04-28 | Сефалон, Инк. | Композиции, включающие соединения модафинила |
US6919378B2 (en) * | 2000-10-11 | 2005-07-19 | Cephalon, Inc. | Pharmaceutical solutions of modafinil compounds |
US6489363B2 (en) | 2000-10-11 | 2002-12-03 | Cephalon, Inc. | Pharmaceutical solutions of modafinil compounds |
US7704975B2 (en) * | 2000-12-19 | 2010-04-27 | Cephalon, Inc. | Modafinil compound and cyclodextrin mixtures |
US7141555B2 (en) | 2000-12-19 | 2006-11-28 | Cephalon, Inc. | Modafinil compound and cyclodextrin mixtures |
KR100911779B1 (ko) * | 2001-05-25 | 2009-08-12 | 세파론, 인코포레이티드 | 모다피닐을 포함하는 고형 제약 제제 |
US20080058424A1 (en) * | 2002-05-23 | 2008-03-06 | Cephalon, Inc. | Novel pharmaceutical formulations of modafinil |
US7576133B2 (en) | 2002-03-11 | 2009-08-18 | Carl Henry Lawyer | Methods and compositions for nasal administration of modafinil |
US7229644B2 (en) * | 2002-05-23 | 2007-06-12 | Cephalon, Inc. | Pharmaceutical formulations of modafinil |
MY137846A (en) * | 2002-07-08 | 2009-03-31 | Ranbaxy Lab Ltd | Processes for the preparation of oral dosage formulations of modafinil |
US20040048931A1 (en) * | 2002-07-12 | 2004-03-11 | Craig Heacock | Modafinil pharmaceutical compositions |
EP1526842A1 (de) * | 2002-07-25 | 2005-05-04 | Ranbaxy Laboratories, Ltd. | Verfahren zur herstellung oraler modafinilarzneimittel |
US6992219B2 (en) * | 2002-08-09 | 2006-01-31 | Cephalon France | Modafinil polymorphic forms |
US20040116532A1 (en) | 2002-09-13 | 2004-06-17 | Craig Heacock | Pharmaceutical formulations of modafinil |
US20040138180A1 (en) * | 2002-10-03 | 2004-07-15 | Barr Laboratories, Inc. | Bisphosphonate composition and process for the preparation thereof |
IL153098A0 (en) * | 2002-11-26 | 2003-06-24 | Chemagis Ltd | Pharmaceutical compositions containing modafinil |
CA2420180A1 (en) * | 2003-02-28 | 2004-08-28 | Bernard Charles Sherman | Tablets comprising modafinil |
CA2519117C (en) * | 2003-03-17 | 2010-03-02 | Neurohealing Pharmaceuticals, Inc. | High potency dopaminergic treatment of neurological impairment associated with brain injury |
US20040253308A1 (en) * | 2003-04-29 | 2004-12-16 | Barr Laboratories, Inc. | Surface-treated modafinil particles |
ATE442352T1 (de) * | 2003-05-16 | 2009-09-15 | Cephalon France | Verfahren zur herstellung von modafinil |
US7368591B2 (en) | 2003-09-19 | 2008-05-06 | Cephalon France | Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation |
US20050137264A1 (en) * | 2003-12-22 | 2005-06-23 | Patel Ashish A. | Modafinil compositions |
EP2292213A1 (de) | 2004-02-06 | 2011-03-09 | Cephalon, Inc. | Armodafinil Polymorph enthaltende Zusammensetzungen |
US20060024370A1 (en) * | 2004-07-29 | 2006-02-02 | Cephalon France | Modafinil oral lyophilizate |
GT200600008A (es) * | 2005-01-18 | 2006-08-09 | Formulacion de compresion directa y proceso | |
US20090123545A1 (en) * | 2005-07-21 | 2009-05-14 | Ron Eyal S | Rapid Onset and Short Term Modafinil Compositions and Methods of Use Thereof |
US9034381B2 (en) * | 2005-11-10 | 2015-05-19 | Alphapharm Pty Ltd | Process to control particle size |
KR20090031618A (ko) * | 2006-07-12 | 2009-03-26 | 엘란 코포레이션, 피엘씨 | 나노입자형 모다피닐 제제 |
JP5395663B2 (ja) | 2006-08-14 | 2014-01-22 | ニューロヒーリング・ファーマシューティカルズ・インコーポレーテッド | モダフィニルによる早漏の治療 |
US20080181966A1 (en) * | 2006-10-18 | 2008-07-31 | Cephalon, Inc. | Modafinil pharmaceutical compositions |
WO2008074097A1 (en) | 2006-12-21 | 2008-06-26 | Alphapharm Pty Ltd | Pharmaceutical compound and composition |
US8173169B2 (en) * | 2007-07-11 | 2012-05-08 | Hikma Pharmaceuticals | Formulation and process for the preparation of modafinil |
US20090325999A1 (en) * | 2008-06-27 | 2009-12-31 | Jie Du | Personalized pharmaceutical kits, packaging and compositions for the treatment of allergic conditions |
CN102105427A (zh) * | 2008-07-25 | 2011-06-22 | 阿尔法制药有限公司 | 粒度直径范围(D90)为大于3μm至约10μm的阿托伐醌 |
US20100036164A1 (en) * | 2008-08-06 | 2010-02-11 | Srinivas Areveli | Preparation of armodafinil form i |
EP2238973A1 (de) | 2009-04-07 | 2010-10-13 | Cephalon France | Lyophilisierte Präparate von Proteasominhibitoren |
FR2987267B1 (fr) * | 2012-02-28 | 2015-01-16 | Debregeas Et Associes Pharma | Application du modafinil dans le traitement de substitution des cacainomanes |
FR2987266B1 (fr) * | 2012-02-28 | 2014-12-19 | Debregeas Et Associes Pharma | Procede d'obtention d'une composition pharmaceutique a base de modafinil, composition pharmaceutique ainsi obtenue et son application |
FR2987265B1 (fr) * | 2012-02-28 | 2014-02-28 | Debregeas Et Associes Pharma | Composition pharmaceutique sous forme de sirop a base de modafinil, son procede de fabrication et son application |
US10058542B1 (en) | 2014-09-12 | 2018-08-28 | Thioredoxin Systems Ab | Composition comprising selenazol or thiazolone derivatives and silver and method of treatment therewith |
Family Cites Families (20)
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US4002718A (en) * | 1974-10-16 | 1977-01-11 | Arnar-Stone Laboratories, Inc. | Gelatin-encapsulated digoxin solutions and method of preparing the same |
FR2408345A1 (fr) * | 1976-11-30 | 1979-06-08 | Besins Jean Louis | Nouvelle composition a action anti-conceptionnelle |
US4122157A (en) * | 1977-03-04 | 1978-10-24 | Richardson-Merrell Inc. | Nitrofurantoin sustained release tablet |
GB1584462A (en) * | 1977-03-31 | 1981-02-11 | Lafon Labor | N-diaryl-malonamide and diarylmethyl-sulphinyl-acetamide derivatives and pharmaceutical compositions containing them |
IT1130924B (it) * | 1980-03-06 | 1986-06-18 | Secifarma Spa | Procedimento per la preparazione di spironolattone micronizzato |
US4600614A (en) * | 1983-09-12 | 1986-07-15 | The Dow Chemical Company | High-frequency heatable plastics |
US4713246A (en) * | 1984-03-19 | 1987-12-15 | Bristol-Myers Company | Etoposide oral dosage form |
IT1187751B (it) * | 1985-10-15 | 1987-12-23 | Eurand Spa | Procedimento per la preparazione di formulazioni solidi di nifedipina ad elevata biodisponibilita' e ad effetto prolungato e formulazioni cosi' ottenute |
FR2593809B1 (fr) * | 1986-01-31 | 1988-07-22 | Lafon Labor | Benzhydrylsulfinylacetamide, procede de preparation et utilisation en therapeutique |
DE3720493A1 (de) * | 1987-06-20 | 1989-01-26 | Nattermann A & Cie | Arzneizubereitungen mit mikronisierten ebselen-kristallen |
FR2627696B1 (fr) * | 1988-02-26 | 1991-09-13 | Fournier Innovation Synergie | Nouvelle forme galenique du fenofibrate |
JP2642486B2 (ja) * | 1989-08-04 | 1997-08-20 | 田辺製薬株式会社 | 難溶性薬物の超微粒子化法 |
FR2663225B1 (fr) * | 1990-06-14 | 1994-11-04 | Lafon Labor | Nouvelle utilisation du modafinil. |
FR2684875B1 (fr) * | 1991-12-13 | 1995-05-24 | Lafon Labor | Utilisation du modafinil pour la fabrication d'un medicament ayant un effet anti-ischemique. |
FR2697162B1 (fr) * | 1992-10-23 | 1995-01-13 | Lafon Labor | Utilisation du modafinil pour la fabrication d'un médicament pour le traitement de l'incontinence urinaire et des troubles sphinctériens urétro vésicaux. |
FR2702968B1 (fr) * | 1993-03-23 | 1995-06-23 | Lafon Labor | Procédé de préparation de particules renfermant un ingrédient actif par extrusion et lyophilisation . |
ES2181716T3 (es) | 1993-04-05 | 2003-03-01 | Sds Pty Ltd | Mejoras de sondeo por percusion. |
FR2706767B1 (de) * | 1993-06-22 | 1995-09-08 | Lafon Labor | |
FR2708201B1 (fr) * | 1993-06-30 | 1995-10-20 | Lafon Labor | Utilisation de dérivés d'acétamide pour la fabrication de médicaments. |
US5493146A (en) | 1994-07-14 | 1996-02-20 | Vlsi Technology, Inc. | Anti-fuse structure for reducing contamination of the anti-fuse material |
-
1994
- 1994-10-06 US US08/319,124 patent/US5618845A/en not_active Ceased
-
1995
- 1995-10-04 MX MX9602176A patent/MX9602176A/es unknown
- 1995-10-04 CA CA002201967A patent/CA2201967C/en not_active Expired - Lifetime
- 1995-10-04 DE DE69535786T patent/DE69535786D1/de not_active Expired - Lifetime
- 1995-10-04 DE DE69520161T patent/DE69520161T2/de not_active Expired - Lifetime
- 1995-10-04 GB GB9524328A patent/GB2293103B/en not_active Revoked
- 1995-10-04 DK DK00125091T patent/DK1088549T3/da active
- 1995-10-04 SI SI9520106A patent/SI9520106B/sl unknown
- 1995-10-04 KR KR1019970702247A patent/KR100249360B1/ko not_active IP Right Cessation
- 1995-10-04 AT AT99202603T patent/ATE199216T1/de active
- 1995-10-04 AT AT95937389T patent/ATE188607T1/de active
- 1995-10-04 EP EP99202603A patent/EP0966962B1/de not_active Expired - Lifetime
- 1995-10-04 HU HU9800737A patent/HU226411B1/hu unknown
- 1995-10-04 BR BR9509257A patent/BR9509257A/pt not_active IP Right Cessation
- 1995-10-04 NZ NZ295869A patent/NZ295869A/en not_active IP Right Cessation
- 1995-10-04 PL PL95319480A patent/PL181523B1/pl unknown
- 1995-10-04 ES ES99202603T patent/ES2156457T3/es not_active Expired - Lifetime
- 1995-10-04 DE DE69514497T patent/DE69514497T2/de not_active Expired - Lifetime
- 1995-10-04 JP JP8512675A patent/JP2915146B2/ja not_active Expired - Lifetime
- 1995-10-04 PT PT00125091T patent/PT1088549E/pt unknown
- 1995-10-04 ES ES00125091T patent/ES2308960T3/es not_active Expired - Lifetime
- 1995-10-04 CZ CZ19971032A patent/CZ291700B6/cs not_active IP Right Cessation
- 1995-10-04 EP EP95937389A patent/EP0731698B1/de not_active Expired - Lifetime
- 1995-10-04 RO RO97-00664A patent/RO118928B1/ro unknown
- 1995-10-04 UA UA97041604A patent/UA42023C2/uk unknown
- 1995-10-04 AT AT00125091T patent/ATE400260T1/de active
- 1995-10-04 CA CA002382275A patent/CA2382275C/en not_active Expired - Lifetime
- 1995-10-04 DK DK95937389T patent/DK0731698T3/da active
- 1995-10-04 DK DK200001006T patent/DK0966962T3/da active
- 1995-10-04 PT PT95937389T patent/PT731698E/pt unknown
- 1995-10-04 WO PCT/US1995/012944 patent/WO1996011001A1/en active IP Right Grant
- 1995-10-04 ES ES95937389T patent/ES2142499T3/es not_active Expired - Lifetime
- 1995-10-04 EP EP00125091A patent/EP1088549B1/de not_active Expired - Lifetime
- 1995-10-04 SK SK445-97A patent/SK283632B6/sk not_active IP Right Cessation
- 1995-10-04 MD MD97-0143A patent/MD970143A/ro unknown
- 1995-10-04 PT PT99202603T patent/PT966962E/pt unknown
- 1995-10-04 AU AU39514/95A patent/AU703087B2/en not_active Expired
- 1995-10-04 EE EE9700082A patent/EE9700082A/xx unknown
-
1997
- 1997-03-24 IS IS4451A patent/IS1987B/is unknown
- 1997-04-03 LT LT97-060A patent/LT4303B/lt not_active IP Right Cessation
- 1997-04-04 BG BG101389A patent/BG62952B1/bg unknown
- 1997-04-04 FI FI971417A patent/FI121454B/fi not_active IP Right Cessation
- 1997-04-04 LV LVP-97-55A patent/LV11852B/xx unknown
- 1997-04-04 NO NO19971541A patent/NO318818B1/no not_active IP Right Cessation
-
1998
- 1998-03-27 HK HK98102611A patent/HK1003561A1/xx not_active IP Right Cessation
-
1999
- 1999-04-01 US US09/285,166 patent/USRE37516E1/en not_active Expired - Lifetime
-
2000
- 2000-04-04 GR GR20000400845T patent/GR3033152T3/el unknown
- 2000-06-19 HK HK00103669A patent/HK1024625A1/xx not_active IP Right Cessation
-
2001
- 2001-02-22 GR GR20010400165T patent/GR3035451T3/el unknown
- 2001-05-17 RU RU2001113686/15A patent/RU2287987C2/ru active
- 2001-08-01 HK HK01105376A patent/HK1034676A1/xx not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |