DE69514928T2 - Gegen protozoen wirksamezyklische tetrapeptide - Google Patents

Gegen protozoen wirksamezyklische tetrapeptide

Info

Publication number
DE69514928T2
DE69514928T2 DE69514928T DE69514928T DE69514928T2 DE 69514928 T2 DE69514928 T2 DE 69514928T2 DE 69514928 T DE69514928 T DE 69514928T DE 69514928 T DE69514928 T DE 69514928T DE 69514928 T2 DE69514928 T2 DE 69514928T2
Authority
DE
Germany
Prior art keywords
protocoes
cyclic tetrapeptides
effective cyclic
effective
tetrapeptides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69514928T
Other languages
English (en)
Other versions
DE69514928D1 (de
Inventor
Christine Lange Cannova
Anne W Dombrowski
Michael A Goetz
Sandra J Rattray
Sheo Bux Singh
Jon Polishook
Gerald F Bills
Joyce A Greene
Gary K Darland
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of DE69514928D1 publication Critical patent/DE69514928D1/de
Publication of DE69514928T2 publication Critical patent/DE69514928T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
    • C07K5/126—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungal isolates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • C12R2001/77—Fusarium
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
DE69514928T 1994-07-27 1995-07-24 Gegen protozoen wirksamezyklische tetrapeptide Expired - Fee Related DE69514928T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28132594A 1994-07-27 1994-07-27
US08/447,664 US5620953A (en) 1994-07-27 1995-05-23 Antiprotozoal cyclic tetrapeptides
PCT/US1995/009371 WO1996003428A1 (en) 1994-07-27 1995-07-24 Antiprotozoal cyclic tetrapeptides

Publications (2)

Publication Number Publication Date
DE69514928D1 DE69514928D1 (de) 2000-03-09
DE69514928T2 true DE69514928T2 (de) 2000-08-17

Family

ID=26960833

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69514928T Expired - Fee Related DE69514928T2 (de) 1994-07-27 1995-07-24 Gegen protozoen wirksamezyklische tetrapeptide

Country Status (9)

Country Link
US (2) US5620953A (de)
EP (1) EP0777683B1 (de)
JP (1) JPH10503368A (de)
AT (1) ATE189460T1 (de)
AU (1) AU687602B2 (de)
CA (1) CA2194999A1 (de)
CY (1) CY2183B1 (de)
DE (1) DE69514928T2 (de)
WO (1) WO1996003428A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5620953A (en) * 1994-07-27 1997-04-15 Merck & Co., Inc. Antiprotozoal cyclic tetrapeptides
US5922837A (en) * 1995-09-20 1999-07-13 Merck & Co., Inc. Antiprotozoal cyclic tetrapeptides
US6110697A (en) * 1995-09-20 2000-08-29 Merck & Co., Inc. Histone deacetylase as target for antiprotozoal agents
GB9903087D0 (en) * 1999-02-12 1999-03-31 Glaxo Group Ltd Process
CA2378849A1 (en) * 1999-07-23 2001-02-01 Merck & Co., Inc. Apicidin-derived cyclic tetrapeptides
CN100350036C (zh) * 2001-04-27 2007-11-21 宝洁公司 用于控制生物膜的装置和方法
EP3461488A1 (de) 2017-09-27 2019-04-03 Onxeo Kombination aus einem dbait-molekül und einem hdac-inhibitor zur behandlung von krebs
EP3461480A1 (de) 2017-09-27 2019-04-03 Onxeo Kombination von checkpoint-hemmern des dna-schädigungsantwort-zellzyklus und belinostat zur behandlung von krebs

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2410658A1 (fr) * 1977-11-30 1979-06-29 Science Union & Cie Nouveau produit biologique d'origine fongique, son obtention et son application a la therapeutique
US4338303A (en) * 1980-02-04 1982-07-06 Albert Einstein College Of Medicine Of Yeshiva University Treatment of parasitic diseases
FR2503182A1 (fr) * 1981-04-07 1982-10-08 Biofarma Sa Nouvelle souche de fusarium utilisable pour la production d'antibiotiques
JPH0334991A (ja) * 1989-06-30 1991-02-14 Shionogi & Co Ltd 環状テトラペプチドおよびその製造法
CA2032559C (en) * 1989-12-28 2001-11-06 Kiyofumi Ishikawa Endothelin antagonistic cyclic pentapeptides
US5049546A (en) * 1990-03-19 1991-09-17 Merck & Co., Inc. Antibiotic agents
US5369093A (en) * 1991-03-15 1994-11-29 Merck & Co., Inc. Lipopeptide derivatives
US5364788A (en) * 1991-07-01 1994-11-15 Ahc Inc. Pure culture of Bacillus subtilis FERM BP-3418
US5300491A (en) * 1991-10-31 1994-04-05 Apothekernes Laboratorium A.S. Treatment of protozoal infection
US5620953A (en) * 1994-07-27 1997-04-15 Merck & Co., Inc. Antiprotozoal cyclic tetrapeptides

Also Published As

Publication number Publication date
EP0777683A1 (de) 1997-06-11
EP0777683B1 (de) 2000-02-02
CY2183B1 (en) 2002-08-23
AU687602B2 (en) 1998-02-26
EP0777683A4 (de) 1997-08-27
US5861375A (en) 1999-01-19
CA2194999A1 (en) 1996-02-08
ATE189460T1 (de) 2000-02-15
JPH10503368A (ja) 1998-03-31
AU3200495A (en) 1996-02-22
WO1996003428A1 (en) 1996-02-08
US5620953A (en) 1997-04-15
DE69514928D1 (de) 2000-03-09

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Legal Events

Date Code Title Description
8339 Ceased/non-payment of the annual fee