DE69521907T2 - Gehinderte n-oxid ester von rapamycin und ihre verwendung als arzneimittel - Google Patents

Gehinderte n-oxid ester von rapamycin und ihre verwendung als arzneimittel

Info

Publication number
DE69521907T2
DE69521907T2 DE69521907T DE69521907T DE69521907T2 DE 69521907 T2 DE69521907 T2 DE 69521907T2 DE 69521907 T DE69521907 T DE 69521907T DE 69521907 T DE69521907 T DE 69521907T DE 69521907 T2 DE69521907 T2 DE 69521907T2
Authority
DE
Germany
Prior art keywords
rapamycin
prevented
medicinal products
oxide esters
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69521907T
Other languages
English (en)
Other versions
DE69521907D1 (de
Inventor
Christy Nelson
Alan Schiehser
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
American Home Products Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Products Corp filed Critical American Home Products Corp
Publication of DE69521907D1 publication Critical patent/DE69521907D1/de
Application granted granted Critical
Publication of DE69521907T2 publication Critical patent/DE69521907T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
DE69521907T 1994-11-28 1995-11-22 Gehinderte n-oxid ester von rapamycin und ihre verwendung als arzneimittel Expired - Fee Related DE69521907T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/345,972 US5491231A (en) 1994-11-28 1994-11-28 Hindered N-oxide esters of rapamycin
PCT/US1995/015318 WO1996016967A1 (en) 1994-11-28 1995-11-22 Hindered n-oxide esters of rapamycin and their use as medicaments

Publications (2)

Publication Number Publication Date
DE69521907D1 DE69521907D1 (de) 2001-08-30
DE69521907T2 true DE69521907T2 (de) 2001-11-29

Family

ID=23357367

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69521907T Expired - Fee Related DE69521907T2 (de) 1994-11-28 1995-11-22 Gehinderte n-oxid ester von rapamycin und ihre verwendung als arzneimittel

Country Status (19)

Country Link
US (5) US5491231A (de)
EP (1) EP0794955B1 (de)
JP (1) JPH10509977A (de)
KR (1) KR100377278B1 (de)
AT (1) ATE203539T1 (de)
AU (1) AU712998B2 (de)
BR (1) BR9509825A (de)
CA (1) CA2205577A1 (de)
DE (1) DE69521907T2 (de)
DK (1) DK0794955T3 (de)
ES (1) ES2158959T3 (de)
FI (1) FI972240A (de)
GR (1) GR3036712T3 (de)
HK (1) HK1002281A1 (de)
HU (1) HUT77139A (de)
MX (1) MX9703893A (de)
NZ (1) NZ297661A (de)
PT (1) PT794955E (de)
WO (1) WO1996016967A1 (de)

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Also Published As

Publication number Publication date
ATE203539T1 (de) 2001-08-15
BR9509825A (pt) 1997-09-30
ES2158959T3 (es) 2001-09-16
FI972240A0 (fi) 1997-05-27
US5521194A (en) 1996-05-28
DK0794955T3 (da) 2001-09-24
WO1996016967A1 (en) 1996-06-06
PT794955E (pt) 2001-12-28
DE69521907D1 (de) 2001-08-30
US5491231A (en) 1996-02-13
US5508290A (en) 1996-04-16
GR3036712T3 (en) 2001-12-31
JPH10509977A (ja) 1998-09-29
US5559122A (en) 1996-09-24
HK1002281A1 (en) 1998-08-14
MX9703893A (es) 1997-08-30
US5508285A (en) 1996-04-16
AU712998B2 (en) 1999-11-18
EP0794955A1 (de) 1997-09-17
HUT77139A (hu) 1998-03-02
FI972240A (fi) 1997-05-27
CA2205577A1 (en) 1996-06-06
EP0794955B1 (de) 2001-07-25
AU4287796A (en) 1996-06-19
NZ297661A (en) 2000-01-28
KR100377278B1 (ko) 2003-10-04

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8364 No opposition during term of opposition
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Owner name: WYETH (N.D.GES.D. STAATES DELAWARE), MADISON, N.J.

8339 Ceased/non-payment of the annual fee