DE69525241T2 - Arzneizubereitungen enthaltend mikronisiertes nebivolol - Google Patents

Arzneizubereitungen enthaltend mikronisiertes nebivolol

Info

Publication number: DE69525241T2
Authority: DE; Germany
Prior art keywords: pct; preparations containing; medicinal preparations; containing micronized; micronized nebivolol
Prior art date: 1994-02-17
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE69525241T

Other languages

English (en)

Other versions

DE69525241D1 (de

Inventor

Eugeen Jans

Franciscus Smans

Marie Gilis

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Janssen Pharmaceutica NV

Original Assignee

Janssen Pharmaceutica NV

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-02-17

Filing date

1995-02-10

Publication date

2002-08-29

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22731545&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69525241(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1995-02-10 Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV

2002-03-14 Publication of DE69525241D1 publication Critical patent/DE69525241D1/de

2002-08-29 Application granted granted Critical

2002-08-29 Publication of DE69525241T2 publication Critical patent/DE69525241T2/de

2015-02-11 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

KOHIRBRYDXPAMZ-YHBROIRLSA-N (S,R,R,R)-nebivolol Chemical compound C1CC2=CC(F)=CC=C2O[C@H]1[C@H](O)CNC[C@@H](O)[C@H]1OC2=CC=C(F)C=C2CC1 KOHIRBRYDXPAMZ-YHBROIRLSA-N 0.000 title abstract 2
229960000619 nebivolol Drugs 0.000 title abstract 2
238000002360 preparation method Methods 0.000 title 1
239000004480 active ingredient Substances 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

DE69525241T 1994-02-17 1995-02-10 Arzneizubereitungen enthaltend mikronisiertes nebivolol Expired - Lifetime DE69525241T2 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US19798894A	1994-02-17	1994-02-17
PCT/EP1995/000489 WO1995022325A1 (en)	1994-02-17	1995-02-10	Compositions containing micronized nebivolol

Publications (2)

Publication Number	Publication Date
DE69525241D1 DE69525241D1 (de)	2002-03-14
DE69525241T2 true DE69525241T2 (de)	2002-08-29

Family

ID=22731545

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69525241T Expired - Lifetime DE69525241T2 (de)	1994-02-17	1995-02-10	Arzneizubereitungen enthaltend mikronisiertes nebivolol

Country Status (30)

Country	Link
US (1)	US5759580A (de)
EP (1)	EP0744946B1 (de)
JP (1)	JP3810079B2 (de)
KR (1)	KR100361636B1 (de)
CN (1)	CN1112921C (de)
AT (1)	ATE212547T1 (de)
AU (1)	AU688860B2 (de)
BR (1)	BR9506828A (de)
CA (1)	CA2182582C (de)
CY (1)	CY2329B1 (de)
CZ (1)	CZ290844B6 (de)
DE (1)	DE69525241T2 (de)
DK (1)	DK0744946T3 (de)
ES (1)	ES2171533T3 (de)
FI (1)	FI117888B (de)
HU (1)	HU221848B1 (de)
IL (1)	IL112659A (de)
MX (1)	MX9603314A (de)
MY (1)	MY115339A (de)
NO (1)	NO314712B1 (de)
NZ (1)	NZ279822A (de)
PL (1)	PL178505B1 (de)
PT (1)	PT744946E (de)
RU (1)	RU2137473C1 (de)
SG (1)	SG47487A1 (de)
SI (1)	SI0744946T1 (de)
SK (1)	SK283250B6 (de)
TW (1)	TW355683B (de)
WO (1)	WO1995022325A1 (de)
ZA (1)	ZA951294B (de)

Families Citing this family (35)

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Publication number	Priority date	Publication date	Assignee	Title
EP0801564B1 (de) *	1994-12-28	2002-03-27	Janssen Pharmaceutica N.V.	Verwendung von nebivolol als anti-atherogenisches mittel
EP0869772B1 (de)	1995-12-27	2001-10-04	Janssen Pharmaceutica N.V.	Bioadhesive feste arzneimittelform
DE19637082A1 (de) *	1996-09-12	1998-03-19	Boehringer Mannheim Gmbh	Schnellzerfallende Pellets
ES2218685T3 (es) *	1997-06-13	2004-11-16	Nanodel Technologies Gmbh	Sistema para direccion de farmaco, procedimiento para su preparacion y su utilizacion.
AR016827A1 (es)	1997-08-22	2001-08-01	Smithkline Beecham Corp	PROCEDIMIENTO PARA LA PREPARACIoN DE UNA TABLETA FARMACÉUTICA
AR017512A1 (es) *	1997-08-22	2001-09-12	Smithkline Beecham Corp	Tabletas de metilcelulosa rapidamente desintegrables para administracion por via oral y procedimiento para prepararlas
US20030152636A1 (en) *	2000-02-23	2003-08-14	Nanopharm Ag	Method of treating cancer
US6531158B1 (en) *	2000-08-09	2003-03-11	Impax Laboratories, Inc.	Drug delivery system for enhanced bioavailability of hydrophobic active ingredients
WO2002087508A2 (en)	2001-05-02	2002-11-07	Nitromed, Inc.	Nitrosated and nitrosylated nebivolol and its metabolites, compositions and methods of use
US7803838B2 (en) *	2004-06-04	2010-09-28	Forest Laboratories Holdings Limited	Compositions comprising nebivolol
WO2006025070A2 (en)	2004-07-30	2006-03-09	Torrent Pharmaceuticals Limited	Nebivolol and its pharmaceutically acceptable salts, process for preparation and pharmaceutical compositions of nebivolol
WO2006016376A1 (en) *	2004-08-11	2006-02-16	Hetero Drugs Limited	A novel process for preparation of nebivolol intermediates
US7344907B2 (en) *	2004-11-19	2008-03-18	International Business Machines Corporation	Apparatus and methods for encapsulating microelectromechanical (MEM) devices on a wafer scale
AP2764A (en) *	2005-01-31	2013-09-30	Mylan Lab Inc	Hydroxylated nebivolol metabolites
EP1850842A1 (de) *	2005-02-11	2007-11-07	Stada Arzneimittel Ag	Pharmazeutische zusammensetzungen nebivolo und ein hydrophiles polymer
EP1803716B1 (de) *	2005-12-28	2012-07-25	Acino Pharma AG	Ein Verfahren zur Herstellung von racemischem Nebivolol
US7560575B2 (en) *	2005-12-28	2009-07-14	Acino Pharma Ag	Process for preparation of racemic Nebivolol
EP1973895A1 (de) *	2006-01-18	2008-10-01	Hetero Drugs Limited	Verfahren zur isolierung gewünschter isomere von nebivolol-zwischenprodukten
EP1839658A1 (de) *	2006-03-30	2007-10-03	Hexal A/S	Pharmazeutische Zusammensetzungen enthaltend mikronisiertes Nebivolol
EP1886674B1 (de) *	2006-08-04	2010-03-31	Alfred, E. Tiefenbacher Gmbh & Co. Kg	Pharmazeutische Zusammensetzung enthaltend Nebivolol
DE102006036579A1 (de) *	2006-08-04	2008-02-07	Alfred E. Tiefenbacher Gmbh & Co.Kg	Pharmazeutische Zusammensetzung
UA97813C2 (uk) *	2006-12-05	2012-03-26	Янссен Фармацевтика Н.В.	Фумаратна сіль (альфа s, бета r)-6-бром-альфа-[2-(диметиламіно)етил]-2-метоксі-альфа-1-нафталеніл-бета-феніл-3-хінолінетанолу
EP2124931A4 (de) *	2007-01-22	2013-08-28	Mylan Pharmaceuticals Ulc	Pharmazeutische zusammensetzung mit nebivolol oder einem nebivolol-analog
WO2009004649A2 (en) *	2007-05-21	2009-01-08	Sun Pharmaceutical Industries Limited	Enteric coated pharmaceutical compositions
CA2637979A1 (en) *	2007-07-26	2009-01-26	Mylan Laboratories, Inc.	Treatment of cardiovascular disease in mexican americans using nebivolol
CN101463024B (zh)	2007-12-21	2011-06-08	上海现代制药股份有限公司	一种制备rrrs和sssr型的奈必洛尔中间体混合物的方法
US20090181975A1 (en) *	2008-01-15	2009-07-16	Forest Laboratories Holdings Limited	Nebivolol in the treatment of sexual dysfunction
EP2163551B1 (de)	2008-09-08	2011-11-16	Cadila Pharmaceuticals Ltd.	Verbesserter Herstellungsprozess für Nebivolol-Hydrocholorid
IT1395354B1 (it)	2009-07-23	2012-09-14	Zach System Spa	Processo di preparazione di nebivololo
IT1397962B1 (it)	2010-02-11	2013-02-04	Menarini Int Operations Lu Sa	Processo per la preparazione del nebivololo.
KR20110130872A (ko) *	2010-05-28	2011-12-06	현대약품 주식회사	결정형 염산 네비볼롤을 포함하는 약학 조성물 및 제조방법
US20120003304A1 (en) *	2010-07-02	2012-01-05	Fmc Corporation	Solid Forms
CN105085499B (zh) *	2015-08-07	2018-09-25	上海现代制药海门有限公司	盐酸奈必洛尔中间体混合物的结晶分离方法
JP2020518565A (ja) *	2017-04-28	2020-06-25	アサナバイオサイエンシズ，リミティドライアビリティカンパニー	アトピー性皮膚炎の治療及び原薬の安定性を向上するための製剤、方法、キット、及び剤形
US20220016025A1 (en) *	2020-07-08	2022-01-20	Vinayak Dinesh DENDUKURI	Formulations of nebivolol

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS60107106A (ja) *	1983-11-15	1985-06-12	Mitsubishi Electric Corp	曲線補間装置
CA1337429C (en) *	1983-12-05	1995-10-24	Guy Rosalia Eugene Van Lommen	Derivatives of 2,2'-iminobisethanol
CA1337432C (en) *	1988-03-23	1995-10-24	Raymond M. Xhonneux	Method of lowering the blood pressure
JPH02264744A (ja) *	1989-04-04	1990-10-29	Kyowa Hakko Kogyo Co Ltd	光学活性なｐ―フルオロフェノキシ誘導体およびその製造法

1995
- 1995-01-17 TW TW084100357A patent/TW355683B/zh not_active IP Right Cessation
- 1995-02-10 KR KR1019960704263A patent/KR100361636B1/ko not_active IP Right Cessation
- 1995-02-10 BR BR9506828A patent/BR9506828A/pt not_active IP Right Cessation
- 1995-02-10 CA CA002182582A patent/CA2182582C/en not_active Expired - Fee Related
- 1995-02-10 AU AU17068/95A patent/AU688860B2/en not_active Expired
- 1995-02-10 DK DK95908927T patent/DK0744946T3/da active
- 1995-02-10 PT PT95908927T patent/PT744946E/pt unknown
- 1995-02-10 DE DE69525241T patent/DE69525241T2/de not_active Expired - Lifetime
- 1995-02-10 CN CN95191662A patent/CN1112921C/zh not_active Expired - Lifetime
- 1995-02-10 NZ NZ279822A patent/NZ279822A/en not_active IP Right Cessation
- 1995-02-10 SG SG1996002228A patent/SG47487A1/en unknown
- 1995-02-10 US US08/669,415 patent/US5759580A/en not_active Expired - Lifetime
- 1995-02-10 AT AT95908927T patent/ATE212547T1/de active
- 1995-02-10 EP EP95908927A patent/EP0744946B1/de not_active Expired - Lifetime
- 1995-02-10 PL PL95315973A patent/PL178505B1/pl unknown
- 1995-02-10 SK SK1058-96A patent/SK283250B6/sk not_active IP Right Cessation
- 1995-02-10 RU RU96118271A patent/RU2137473C1/ru active
- 1995-02-10 MX MX9603314A patent/MX9603314A/es unknown
- 1995-02-10 HU HU9602272A patent/HU221848B1/hu active IP Right Grant
- 1995-02-10 WO PCT/EP1995/000489 patent/WO1995022325A1/en active IP Right Grant
- 1995-02-10 ES ES95908927T patent/ES2171533T3/es not_active Expired - Lifetime
- 1995-02-10 CZ CZ19962346A patent/CZ290844B6/cs not_active IP Right Cessation
- 1995-02-10 JP JP52156295A patent/JP3810079B2/ja not_active Expired - Lifetime
- 1995-02-10 SI SI9530582T patent/SI0744946T1/xx unknown
- 1995-02-15 IL IL11265995A patent/IL112659A/xx not_active IP Right Cessation
- 1995-02-16 ZA ZA951294A patent/ZA951294B/xx unknown
- 1995-02-16 MY MYPI95000396A patent/MY115339A/en unknown
1996
- 1996-08-16 NO NO19963439A patent/NO314712B1/no not_active IP Right Cessation
- 1996-08-16 FI FI963227A patent/FI117888B/fi not_active IP Right Cessation
2002
- 2002-07-15 CY CY0200045A patent/CY2329B1/xx unknown

Also Published As

Publication number	Publication date
HUT75332A (en)	1997-05-28
SK283250B6 (sk)	2003-04-01
TW355683B (en)	1999-04-11
PL178505B1 (pl)	2000-05-31
RU2137473C1 (ru)	1999-09-20
FI963227A0 (fi)	1996-08-16
ATE212547T1 (de)	2002-02-15
ZA951294B (en)	1996-08-16
DE69525241D1 (de)	2002-03-14
SG47487A1 (en)	1998-04-17
FI117888B (fi)	2007-04-13
US5759580A (en)	1998-06-02
NO314712B1 (no)	2003-05-12
DK0744946T3 (da)	2002-05-06
CA2182582A1 (en)	1995-08-24
CY2329B1 (en)	2004-02-06
NO963439L (no)	1996-08-16
NZ279822A (en)	1997-04-24
PT744946E (pt)	2002-07-31
IL112659A (en)	1999-06-20
HU9602272D0 (en)	1996-10-28
PL315973A1 (en)	1996-12-23
SI0744946T1 (en)	2002-06-30
CN1112921C (zh)	2003-07-02
CN1140991A (zh)	1997-01-22
EP0744946B1 (de)	2002-01-30
KR100361636B1 (ko)	2003-02-11
CZ234696A3 (en)	1996-11-13
FI963227A (fi)	1996-08-16
JP3810079B2 (ja)	2006-08-16
JPH09508913A (ja)	1997-09-09
CZ290844B6 (cs)	2002-10-16
EP0744946A1 (de)	1996-12-04
MX9603314A (es)	1997-02-28
CA2182582C (en)	2005-03-29
AU1706895A (en)	1995-09-04
IL112659A0 (en)	1995-05-26
ES2171533T3 (es)	2002-09-16
WO1995022325A1 (en)	1995-08-24
SK105896A3 (en)	1997-05-07
BR9506828A (pt)	1997-09-30
HU221848B1 (hu)	2003-02-28
MY115339A (en)	2003-05-31
AU688860B2 (en)	1998-03-19

Legal Events

Date	Code	Title	Description
2003-02-27	8364	No opposition during term of opposition

Publication	Publication Date	Title
ATE212547T1 (de)	2002-02-15	Arzneizubereitungen enthaltend mikronisiertes nebivolol
NO963053L (no)	1996-09-20	Kosmetiske eller farmasöytiske preparater inneholdende mangiferin eller derivater derav
DE69522947T2 (de)	2002-04-11	Phenylxanthin-derivate
IL111861A (en)	1999-08-17	Phenyl-n-substituted azabicycloalkene derivatives and pharmaceutical compositions containing them
FI972434A0 (fi)	1997-06-06	Lamotrigiiniä sisältävä farmaseuttinen koostumus
CA2107485A1 (fr)	1994-04-03	Nouveaux derives d'ellipticine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
IL114719A0 (en)	1995-11-27	N-substituted azabicycloheptane derivatives their preparation and use thereof
NO950177D0 (no)	1995-01-17	Farmakologisk aktive erivater