DE69528058D1 - Bmp-9 zusammensetzungen - Google Patents
Bmp-9 zusammensetzungenInfo
- Publication number
- DE69528058D1 DE69528058D1 DE69528058T DE69528058T DE69528058D1 DE 69528058 D1 DE69528058 D1 DE 69528058D1 DE 69528058 T DE69528058 T DE 69528058T DE 69528058 T DE69528058 T DE 69528058T DE 69528058 D1 DE69528058 D1 DE 69528058D1
- Authority
- DE
- Germany
- Prior art keywords
- bmp
- compositions
- proteins
- bone
- processes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 102000037280 Growth Differentiation Factor 2 Human genes 0.000 title abstract 2
- 108010090290 Growth Differentiation Factor 2 Proteins 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title 1
- 210000000988 bone and bone Anatomy 0.000 abstract 1
- 210000000845 cartilage Anatomy 0.000 abstract 1
- 230000007547 defect Effects 0.000 abstract 1
- 230000012010 growth Effects 0.000 abstract 1
- 230000002440 hepatic effect Effects 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 230000017423 tissue regeneration Effects 0.000 abstract 1
- 230000029663 wound healing Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/30—Insulin-like growth factors (Somatomedins), e.g. IGF-1, IGF-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/84—Bones; tendons; teeth; cartilage
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/12—Growth hormone, growth factor other than t-cell or b-cell growth factor, and growth hormone releasing factor; related peptides
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/254,353 US6287816B1 (en) | 1991-06-25 | 1994-06-06 | BMP-9 compositions |
PCT/US1995/007084 WO1995033830A1 (en) | 1994-06-06 | 1995-06-05 | Bmp-9 compositions |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69528058D1 true DE69528058D1 (de) | 2002-10-10 |
DE69528058T2 DE69528058T2 (de) | 2003-05-28 |
Family
ID=22963968
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69528058T Expired - Fee Related DE69528058T2 (de) | 1994-06-06 | 1995-06-05 | Bmp-9 zusammensetzungen |
Country Status (8)
Country | Link |
---|---|
US (2) | US6287816B1 (de) |
EP (2) | EP0764208B1 (de) |
JP (1) | JP3706133B2 (de) |
KR (1) | KR100255417B1 (de) |
AT (1) | ATE223486T1 (de) |
AU (1) | AU709869B2 (de) |
DE (1) | DE69528058T2 (de) |
WO (1) | WO1995033830A1 (de) |
Families Citing this family (78)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6150328A (en) * | 1986-07-01 | 2000-11-21 | Genetics Institute, Inc. | BMP products |
US5656593A (en) * | 1991-03-11 | 1997-08-12 | Creative Biomolecules, Inc. | Morphogen induced periodontal tissue regeneration |
US20080139474A1 (en) * | 1991-11-04 | 2008-06-12 | David Israel | Recombinant bone morphogenetic protein heterodimers, compositions and methods of use |
AU674500B2 (en) | 1991-11-04 | 1997-01-02 | Genetics Institute, Llc | Recombinant bone morphogenetic protein heterodimers, compositions and methods of use |
US6291206B1 (en) * | 1993-09-17 | 2001-09-18 | Genetics Institute, Inc. | BMP receptor proteins |
US5902785A (en) * | 1995-06-06 | 1999-05-11 | Genetics Institute, Inc. | Cartilage induction by bone morphogenetic proteins |
US6498142B1 (en) | 1996-05-06 | 2002-12-24 | Curis, Inc. | Morphogen treatment for chronic renal failure |
AU6267798A (en) | 1997-02-07 | 1998-08-26 | Stryker Corporation | Matrix-free osteogenic devices, implants and methods of use thereof |
US6034062A (en) * | 1997-03-13 | 2000-03-07 | Genetics Institute, Inc. | Bone morphogenetic protein (BMP)-9 compositions and their uses |
US20010016646A1 (en) | 1998-03-20 | 2001-08-23 | David C. Rueger | Osteogenic devices and methods of use thereof for repair of endochondral bone, osteochondral and chondral defects |
US7041641B2 (en) | 1997-03-20 | 2006-05-09 | Stryker Corporation | Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects |
JP5033276B2 (ja) | 1997-05-05 | 2012-09-26 | ストライカー コーポレイション | 急性腎不全の治療 |
JP2001526788A (ja) | 1997-05-30 | 2001-12-18 | クリエイティブ バイオモレキュールズ,インコーポレイテッド | 組織形態形成および活性を評価するための方法 |
US7147839B2 (en) | 1998-05-29 | 2006-12-12 | Curis, Inc. | Methods for evaluating tissue morphogenesis and activity |
EP1131087B2 (de) * | 1998-11-13 | 2009-04-01 | Stryker Corporation | Verminderung von prostatakrebssymptomen |
US6727224B1 (en) * | 1999-02-01 | 2004-04-27 | Genetics Institute, Llc. | Methods and compositions for healing and repair of articular cartilage |
JP2003508493A (ja) * | 1999-09-08 | 2003-03-04 | ジェネティックス・インスチチュート・インコーポレーテッド | Bmp−9組成物およびコリン作動性ニューロンの分化誘導方法 |
US6723334B1 (en) * | 2000-03-01 | 2004-04-20 | Iowa State University Research Foundation, Inc. | Biologically compatible bone cements and orthopedic methods |
WO2002077006A1 (en) * | 2001-03-23 | 2002-10-03 | Human Genome Sciences, Inc. | Bone morphogenic protein polynucleotides, polypeptides, and antibodies |
US20030082233A1 (en) * | 2000-12-01 | 2003-05-01 | Lyons Karen M. | Method and composition for modulating bone growth |
US20020114795A1 (en) | 2000-12-22 | 2002-08-22 | Thorne Kevin J. | Composition and process for bone growth and repair |
CA2438934A1 (en) * | 2001-02-23 | 2002-09-06 | Wyeth | Chondrogenic potential of human bone marrow-derived cd105+ cells by bmp |
ATE393573T1 (de) * | 2001-06-01 | 2008-05-15 | Wyeth Corp | Zusammensetzungen für die systemische verabreichung von sequenzen, die für knochenmorphogenese-proteinen kodieren |
TWI267378B (en) * | 2001-06-08 | 2006-12-01 | Wyeth Corp | Calcium phosphate delivery vehicles for osteoinductive proteins |
KR20050010778A (ko) * | 2002-05-03 | 2005-01-28 | 밀레늄 바이올로직스 인코포레이티드 | 결합조직 자극 펩티드 |
TWI282283B (en) * | 2002-05-17 | 2007-06-11 | Wyeth Corp | Injectable solid hyaluronic acid carriers for delivery of osteogenic proteins |
BRPI0408787A (pt) * | 2003-03-27 | 2006-03-28 | Childrens Hosp Medical Center | uso de proteìna fgf-18, proteìnas alvo e suas respectivas seqüências de nucleotìdeos codificantes para indução de formação de cartilagem |
PL1675608T3 (pl) | 2003-09-12 | 2007-11-30 | Wyeth Corp | Stałe fosforanowo wapniowe pałeczki do wstrzyknięć dla dostarczania białek osteogennych |
DK1737734T3 (da) | 2004-03-10 | 2010-11-08 | Scil Technology Gmbh | Overtrukne implantater, deres fremstilling og anvendelse deraf |
ES2369629T3 (es) | 2004-05-25 | 2011-12-02 | Stryker Corporation | Uso de op-1 para tratar defectos del cartílago. |
EP2314617B1 (de) | 2004-07-23 | 2015-06-24 | Acceleron Pharma Inc. | ActRII-Rezeptor-Polypeptide |
WO2006081379A1 (en) * | 2005-01-26 | 2006-08-03 | Wyeth | Use of sfrps as markers of bmp activity |
BRPI0609504A2 (pt) * | 2005-03-30 | 2010-04-13 | Wyeth Corp | métodos para estimular o crescimento capilar administrando proteìnas morfogenéticas ósseas (bmps) |
US8128933B2 (en) | 2005-11-23 | 2012-03-06 | Acceleron Pharma, Inc. | Method of promoting bone growth by an anti-activin B antibody |
KR20190097310A (ko) | 2005-11-23 | 2019-08-20 | 악셀레론 파마 인코포레이티드 | 액티빈-actrⅱa 길항제 및 골 성장을 촉진하기 위한 이들의 용도 |
JP5362554B2 (ja) | 2006-05-17 | 2013-12-11 | ストライカー コーポレイション | 軟骨の欠損を処置するための可溶性形態形成タンパク質の使用 |
AU2007234612B2 (en) | 2006-12-14 | 2013-06-27 | Johnson & Johnson Regenerative Therapeutics, Llc | Protein stabilization formulations |
US8895016B2 (en) | 2006-12-18 | 2014-11-25 | Acceleron Pharma, Inc. | Antagonists of activin-actriia and uses for increasing red blood cell levels |
AU2007339280B2 (en) | 2006-12-21 | 2013-12-05 | Stryker Corporation | Sustained-release formulations comprising crystals, macromolecular gels, and particulate suspensions of biologic agents |
US7718616B2 (en) | 2006-12-21 | 2010-05-18 | Zimmer Orthobiologics, Inc. | Bone growth particles and osteoinductive composition thereof |
TR200906131T1 (tr) | 2007-02-01 | 2009-11-23 | Acceleron Pharma Inc. | Aktivin -actrIIa antagonistleri ve göğüs kanserinin tedavi e |
TWI782836B (zh) | 2007-02-02 | 2022-11-01 | 美商艾瑟勒朗法瑪公司 | 衍生自ActRIIB的變體與其用途 |
TW201934141A (zh) | 2007-02-09 | 2019-09-01 | 美商艾瑟勒朗法瑪公司 | 包含ActRIIa-Fc融合蛋白的醫藥組合物;ActRIIa-Fc融合蛋白於治療或預防與癌症相關的骨質流失之用途;ActRIIa-Fc融合蛋白於治療或預防多發性骨髓瘤之用途 |
DE102007006843A1 (de) | 2007-02-12 | 2008-08-14 | Bioregeneration Gmbh | Verfahren und Stützstruktur zum Kultivieren lebender Zellen |
US7678764B2 (en) | 2007-06-29 | 2010-03-16 | Johnson & Johnson Regenerative Therapeutics, Llc | Protein formulations for use at elevated temperatures |
WO2009020744A1 (en) | 2007-08-07 | 2009-02-12 | Johnson & Johnson Regenerative Therapeutics, Llc | Protein formulations comprising gdf-5 in aqueous acidic solution |
CN103877564A (zh) | 2007-09-18 | 2014-06-25 | 阿塞勒隆制药公司 | 活化素-actriia拮抗剂和减少或抑制fsh分泌的用途 |
CA2718592A1 (en) | 2008-02-13 | 2009-08-20 | Keith Hruska | Method of treating vascular sclerosis |
CA2720845A1 (en) | 2008-04-14 | 2009-10-22 | Advanced Technologies And Regenerative Medicine, Llc | Liquid buffered gdf-5 formulations |
DK3494986T3 (da) | 2008-08-14 | 2020-08-03 | Acceleron Pharma Inc | GDF fanger |
US8216997B2 (en) | 2008-08-14 | 2012-07-10 | Acceleron Pharma, Inc. | Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators |
US8138142B2 (en) | 2009-01-13 | 2012-03-20 | Acceleron Pharma Inc. | Methods for increasing adiponectin in a patient in need thereof |
JP5819733B2 (ja) | 2009-02-12 | 2015-11-24 | ストライカー コーポレイションStryker Corporation | 障害および疾患に対する全身治療のためのTGF−βスーパーファミリーメンバー含有タンパク質の末梢投与 |
WO2010093941A2 (en) | 2009-02-12 | 2010-08-19 | Stryker Corporation | COMPOSITIONS AND METHODS FOR MINIMALLY-INVASIVE SYSTEMIC DELIVERY OF PROTEINS INCLUDING TGF-β SUPERFAMILY MEMBERS |
US20120148539A1 (en) | 2009-03-24 | 2012-06-14 | Moulay Hicham Alaoui-Ismaili | Methods and Compositions for Tissue Engineering |
AU2010258931B2 (en) | 2009-06-08 | 2015-04-23 | Acceleron Pharma Inc. | Methods for increasing thermogenic adipocytes |
KR20120028358A (ko) | 2009-06-12 | 2012-03-22 | 악셀레론 파마 인코포레이티드 | 절두된 ActRIIB-FC 융합 단백질 |
US20110224138A1 (en) | 2009-09-09 | 2011-09-15 | Julie Krop | Methods for treating pain induced by injuries and diseases of an articular joint |
MX340451B (es) * | 2009-09-09 | 2016-07-08 | Acceleron Pharma Inc | Antagonistas de actriib y dosificacion y usos de los mismos. |
JP2013518808A (ja) | 2009-09-17 | 2013-05-23 | ストライカー コーポレイション | 骨形成タンパク質のpHを制御するための緩衝液 |
ES2869864T3 (es) * | 2009-11-03 | 2021-10-26 | Acceleron Pharma Inc | Procedimientos para el tratamiento de la enfermedad del hígado graso |
JP6267425B2 (ja) | 2009-11-17 | 2018-01-24 | アクセルロン ファーマ, インコーポレイテッド | 筋ジストロフィー治療のためのユートロフィン誘導に関するactriibタンパク質およびその改変体およびその使用 |
CA2785038A1 (en) | 2009-12-22 | 2011-07-21 | Stryker Corporation | Bmp-7 variants with reduced immunogenicity |
TW201138808A (en) | 2010-05-03 | 2011-11-16 | Bristol Myers Squibb Co | Serum albumin binding molecules |
US9688735B2 (en) | 2010-08-20 | 2017-06-27 | Wyeth Llc | Designer osteogenic proteins |
CN103079585B (zh) | 2010-08-20 | 2015-09-30 | 惠氏有限责任公司 | 经设计的成骨蛋白 |
AU2011326586A1 (en) | 2010-11-08 | 2013-05-30 | Acceleron Pharma, Inc. | ActRIIA binding agents and uses thereof |
CN103313733A (zh) | 2010-11-15 | 2013-09-18 | 捷迈整形外科生物材料有限公司 | 骨空隙填充剂 |
US9809636B2 (en) | 2012-04-06 | 2017-11-07 | Acceleron Pharma Inc. | Methods for increasing red blood cell levels comprising administering BMP9 |
CA2918486C (en) * | 2012-07-20 | 2020-12-08 | The Regents Of The University Of California | Methods for producing cartilage and bone |
US9833481B2 (en) * | 2012-09-01 | 2017-12-05 | Ken Muneoka | Method for articular cartilage and joint formation |
KR20210091358A (ko) | 2012-11-02 | 2021-07-21 | 셀진 코포레이션 | 골 및 다른 장애를 치료하기 위한 액티빈-actrii 길항제 및 용도 |
KR20160078375A (ko) * | 2013-10-17 | 2016-07-04 | 재단법인 제이씨비 공동생물과학연구소 | 박테리아로부터 발현 및 분리된 생체활성 재조합 bmp-9 단백질인 mb109 |
MX2016016531A (es) | 2014-06-13 | 2017-04-25 | Acceleron Pharma Inc | Metodos y composiciones para el tratamiento de las ulceras. |
GB201412290D0 (en) | 2014-07-10 | 2014-08-27 | Cambridge Entpr Ltd | Novel use |
MA41052A (fr) | 2014-10-09 | 2017-08-15 | Celgene Corp | Traitement d'une maladie cardiovasculaire à l'aide de pièges de ligands d'actrii |
EP3227675B1 (de) | 2014-12-03 | 2023-03-15 | Celgene Corporation | Activin-actrii-antagonisten und verwendungen davon zur behandlung von myelodysplastischem syndrom |
WO2016193872A2 (en) | 2015-06-05 | 2016-12-08 | Novartis Ag | Antibodies targeting bone morphogenetic protein 9 (bmp9) and methods therefor |
Family Cites Families (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4455256A (en) | 1981-05-05 | 1984-06-19 | The Regents Of The University Of California | Bone morphogenetic protein |
US4789732A (en) | 1980-08-04 | 1988-12-06 | Regents Of The University Of California | Bone morphogenetic protein composition |
US4294753A (en) | 1980-08-04 | 1981-10-13 | The Regents Of The University Of California | Bone morphogenetic protein process |
US4761471A (en) | 1980-08-04 | 1988-08-02 | The Regents Of The University Of California | Bone morphogenetic protein composition |
US4619989A (en) | 1981-05-05 | 1986-10-28 | The Regents Of The University Of Cal. | Bone morphogenetic protein composition |
US4434094A (en) | 1983-04-12 | 1984-02-28 | Collagen Corporation | Partially purified osteogenic factor and process for preparing same from demineralized bone |
US4795804A (en) | 1983-08-16 | 1989-01-03 | The Regents Of The University Of California | Bone morphogenetic agents |
US4804744A (en) | 1984-01-04 | 1989-02-14 | International Genetic Engineering, Inc. | Osteogenic factors |
US4608199A (en) | 1984-03-20 | 1986-08-26 | Arnold Caplan | Bone protein purification process |
US4627982A (en) | 1984-07-16 | 1986-12-09 | Collagen Corporation | Partially purified bone-inducing factor |
US4843063A (en) | 1984-07-16 | 1989-06-27 | Collagen Corporation | Polypeptide cartilage-inducing factors found in bone |
ATE128715T1 (de) | 1984-07-16 | 1995-10-15 | Celtrix Pharma | Polypeptide induzierende faktoren in knochen und knorpel. |
US4563350A (en) | 1984-10-24 | 1986-01-07 | Collagen Corporation | Inductive collagen based bone repair preparations |
US4886747A (en) | 1985-03-22 | 1989-12-12 | Genentech, Inc. | Nucleic acid encoding TGF-β and its uses |
US4681763A (en) | 1985-06-11 | 1987-07-21 | University Of Medicine And Dentistry Of New Jersey | Composition for stimulating bone growth |
US4798885A (en) | 1986-02-07 | 1989-01-17 | Genentech, Inc. | Compositions of hormonally active human and porcine inhibin containing an α chain and 62 chain |
US4737578A (en) | 1986-02-10 | 1988-04-12 | The Salk Institute For Biological Studies | Human inhibin |
AU3433989A (en) | 1988-04-06 | 1989-11-03 | Celtrix Laboratories, Inc. | Bone-inducing protein |
EP0362367B1 (de) | 1988-04-08 | 1996-02-28 | Stryker Corporation | Osteogene vorrichtungen |
US4968590A (en) | 1988-04-08 | 1990-11-06 | Stryker Corporation | Osteogenic proteins and polypeptides |
US5108753A (en) | 1988-04-08 | 1992-04-28 | Creative Biomolecules | Osteogenic devices |
US5011691A (en) | 1988-08-15 | 1991-04-30 | Stryker Corporation | Osteogenic devices |
FR2636063B1 (fr) * | 1988-09-05 | 1993-04-30 | Centre Nat Rech Scient | Composes phenylpyrroliques utiles en tant que medicaments, leur preparation et leur application |
US5106626A (en) | 1988-10-11 | 1992-04-21 | International Genetic Engineering, Inc. | Osteogenic factors |
CA2017466A1 (en) | 1989-06-02 | 1990-12-02 | Michael C. Kiefer | Bone calcification factor |
CA2020729A1 (en) | 1989-07-19 | 1991-01-20 | Michael C. Kiefer | Bone morphogenetic protein |
EP0489062A4 (en) | 1989-08-21 | 1992-08-12 | Celtrix Laboratories, Inc. | Bone-specific protein |
JP3045398B2 (ja) | 1989-09-06 | 2000-05-29 | 武田薬品工業株式会社 | 蛋白質、dnaおよびその用途 |
ES2118723T3 (es) | 1989-10-17 | 1998-10-01 | Stryker Corp | Dispositivos osteogenicos. |
US5168050A (en) | 1990-05-24 | 1992-12-01 | Genentech, Inc. | Mammalian expression of the bone morphogenetic protein-2b using bmp2a/bmp2b fusion |
AU8941791A (en) | 1990-10-18 | 1992-05-20 | Creative Biomolecules, Inc. | Osteogenic protein |
DE69129865T2 (de) | 1990-10-18 | 1999-03-04 | Stryker Corp | Osteogene peptide |
EP0592562B1 (de) * | 1991-06-25 | 1999-01-07 | Genetics Institute, Inc. | Bmp-9 zusammensetzungen |
EP0601135B1 (de) | 1991-08-30 | 2005-11-02 | Curis, Inc. | Osteogenische proteine in der behandlung von metabolischen knochenkrankheiten |
ES2149776T5 (es) | 1991-08-30 | 2004-07-01 | Curis, Inc. | Modulacion, inducida por un morfogeno, de la respuesta inflamatoria. |
ES2114073T3 (es) * | 1992-09-16 | 1998-05-16 | Creative Biomolecules Inc | Regeneracion del higado inducida por morfogenes. |
US5902785A (en) * | 1995-06-06 | 1999-05-11 | Genetics Institute, Inc. | Cartilage induction by bone morphogenetic proteins |
-
1994
- 1994-06-06 US US08/254,353 patent/US6287816B1/en not_active Expired - Fee Related
-
1995
- 1995-06-05 EP EP95923706A patent/EP0764208B1/de not_active Expired - Lifetime
- 1995-06-05 DE DE69528058T patent/DE69528058T2/de not_active Expired - Fee Related
- 1995-06-05 KR KR1019960707067A patent/KR100255417B1/ko not_active IP Right Cessation
- 1995-06-05 AU AU28170/95A patent/AU709869B2/en not_active Ceased
- 1995-06-05 WO PCT/US1995/007084 patent/WO1995033830A1/en active IP Right Grant
- 1995-06-05 EP EP01129313A patent/EP1230930A3/de not_active Withdrawn
- 1995-06-05 AT AT95923706T patent/ATE223486T1/de not_active IP Right Cessation
- 1995-06-05 JP JP50125096A patent/JP3706133B2/ja not_active Expired - Fee Related
-
1996
- 1996-12-04 US US08/750,222 patent/US6034061A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US6034061A (en) | 2000-03-07 |
EP0764208B1 (de) | 2002-09-04 |
JP3706133B2 (ja) | 2005-10-12 |
EP0764208A1 (de) | 1997-03-26 |
EP1230930A2 (de) | 2002-08-14 |
JPH10503927A (ja) | 1998-04-14 |
WO1995033830A1 (en) | 1995-12-14 |
EP1230930A3 (de) | 2002-11-27 |
AU2817095A (en) | 1996-01-04 |
AU709869B2 (en) | 1999-09-09 |
ATE223486T1 (de) | 2002-09-15 |
US6287816B1 (en) | 2001-09-11 |
DE69528058T2 (de) | 2003-05-28 |
KR100255417B1 (ko) | 2000-05-01 |
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