DE69528704T2 - Lipidsenkende 1,4-benzothiazepin-1,1-dioxide - Google Patents

Lipidsenkende 1,4-benzothiazepin-1,1-dioxide

Info

Publication number
DE69528704T2
DE69528704T2 DE69528704T DE69528704T DE69528704T2 DE 69528704 T2 DE69528704 T2 DE 69528704T2 DE 69528704 T DE69528704 T DE 69528704T DE 69528704 T DE69528704 T DE 69528704T DE 69528704 T2 DE69528704 T2 DE 69528704T2
Authority
DE
Germany
Prior art keywords
benzothiazepine
lipid
dioxide
reducing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69528704T
Other languages
English (en)
Other versions
DE69528704D1 (de
Inventor
Lawrence Edward Brieaddy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Publication of DE69528704D1 publication Critical patent/DE69528704D1/de
Application granted granted Critical
Publication of DE69528704T2 publication Critical patent/DE69528704T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
DE69528704T 1994-08-10 1995-08-09 Lipidsenkende 1,4-benzothiazepin-1,1-dioxide Expired - Fee Related DE69528704T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28852794A 1994-08-10 1994-08-10
PCT/GB1995/001884 WO1996005188A1 (en) 1994-08-10 1995-08-09 Hypolipidemic 1,4-benzothiazepine-1,1-dioxides

Publications (2)

Publication Number Publication Date
DE69528704D1 DE69528704D1 (de) 2002-12-05
DE69528704T2 true DE69528704T2 (de) 2003-06-12

Family

ID=23107516

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69528704T Expired - Fee Related DE69528704T2 (de) 1994-08-10 1995-08-09 Lipidsenkende 1,4-benzothiazepin-1,1-dioxide

Country Status (31)

Country Link
US (1) US5910494A (de)
EP (2) EP0775126B1 (de)
JP (1) JP2935756B2 (de)
KR (1) KR100354288B1 (de)
CN (1) CN1059673C (de)
AP (1) AP720A (de)
AT (1) ATE226946T1 (de)
AU (1) AU696073B2 (de)
BG (1) BG62048B1 (de)
BR (1) BR9508586A (de)
CA (1) CA2197099A1 (de)
CZ (1) CZ37397A3 (de)
DE (1) DE69528704T2 (de)
DK (1) DK0775126T3 (de)
EE (1) EE9700028A (de)
ES (1) ES2185711T3 (de)
FI (1) FI970531A0 (de)
HK (1) HK1003936A1 (de)
HU (1) HUT77129A (de)
IL (1) IL114877A (de)
IS (1) IS4418A (de)
MX (1) MX9700890A (de)
NO (1) NO308131B1 (de)
NZ (1) NZ290911A (de)
OA (1) OA10597A (de)
PL (1) PL184512B1 (de)
PT (1) PT775126E (de)
RU (1) RU2156245C2 (de)
SK (1) SK17797A3 (de)
WO (1) WO1996005188A1 (de)
ZA (1) ZA956647B (de)

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US6268392B1 (en) 1994-09-13 2001-07-31 G. D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors
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Also Published As

Publication number Publication date
CZ37397A3 (en) 1997-08-13
WO1996005188A1 (en) 1996-02-22
AU4426096A (en) 1996-03-07
CA2197099A1 (en) 1996-02-22
ATE226946T1 (de) 2002-11-15
FI970531A (fi) 1997-02-07
CN1059673C (zh) 2000-12-20
DE69528704D1 (de) 2002-12-05
PT775126E (pt) 2003-02-28
EE9700028A (et) 1997-08-15
AP9700920A0 (en) 1997-01-31
ZA956647B (en) 1997-02-10
KR100354288B1 (ko) 2003-01-06
SK17797A3 (en) 1997-09-10
ES2185711T3 (es) 2003-05-01
PL318496A1 (en) 1997-06-23
JP2935756B2 (ja) 1999-08-16
EP0775126B1 (de) 2002-10-30
HUT77129A (hu) 1998-03-02
IL114877A (en) 1999-07-14
AU696073B2 (en) 1998-09-03
BG62048B1 (bg) 1999-01-29
HK1003936A1 (en) 1998-11-13
NZ290911A (en) 1998-07-28
CN1161035A (zh) 1997-10-01
PL184512B1 (pl) 2002-11-29
MX9700890A (es) 1997-04-30
AP720A (en) 1999-01-08
NO970585L (no) 1997-04-07
RU2156245C2 (ru) 2000-09-20
BR9508586A (pt) 1998-07-14
DK0775126T3 (da) 2003-03-03
FI970531A0 (fi) 1997-02-07
US5910494A (en) 1999-06-08
NO308131B1 (no) 2000-07-31
NO970585D0 (no) 1997-02-07
EP1203769A1 (de) 2002-05-08
OA10597A (en) 2002-08-22
EP0775126A1 (de) 1997-05-28
JPH10504035A (ja) 1998-04-14
BG101209A (en) 1997-08-29
IL114877A0 (en) 1995-12-08
IS4418A (is) 1997-01-24

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