DE69529288D1 - Wasserlösliche polyen-konjugate - Google Patents

Wasserlösliche polyen-konjugate

Info

Publication number
DE69529288D1
DE69529288D1 DE69529288T DE69529288T DE69529288D1 DE 69529288 D1 DE69529288 D1 DE 69529288D1 DE 69529288 T DE69529288 T DE 69529288T DE 69529288 T DE69529288 T DE 69529288T DE 69529288 D1 DE69529288 D1 DE 69529288D1
Authority
DE
Germany
Prior art keywords
polyen
conjugates
soluble
water
soluble polyen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69529288T
Other languages
English (en)
Other versions
DE69529288T2 (de
Inventor
Galina Linden
J Domb
Itzhack Polacheck
Shimon Benita
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hadasit Medical Research Services and Development Co
Yissum Research Development Co of Hebrew University of Jerusalem
Original Assignee
Hadasit Medical Research Services and Development Co
Yissum Research Development Co of Hebrew University of Jerusalem
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hadasit Medical Research Services and Development Co, Yissum Research Development Co of Hebrew University of Jerusalem filed Critical Hadasit Medical Research Services and Development Co
Application granted granted Critical
Publication of DE69529288D1 publication Critical patent/DE69529288D1/de
Publication of DE69529288T2 publication Critical patent/DE69529288T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0021—Dextran, i.e. (alpha-1,4)-D-glucan; Derivatives thereof, e.g. Sephadex, i.e. crosslinked dextran
DE69529288T 1994-08-16 1995-08-16 Wasserlösliche polyen-konjugate Expired - Lifetime DE69529288T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/291,292 US5567685A (en) 1994-08-16 1994-08-16 Water-Soluble polyene conjugate
PCT/US1995/010522 WO1996005212A1 (en) 1994-08-16 1995-08-16 Water-soluble polyene conjugate

Publications (2)

Publication Number Publication Date
DE69529288D1 true DE69529288D1 (de) 2003-02-06
DE69529288T2 DE69529288T2 (de) 2003-07-31

Family

ID=23119719

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69529288T Expired - Lifetime DE69529288T2 (de) 1994-08-16 1995-08-16 Wasserlösliche polyen-konjugate

Country Status (7)

Country Link
US (1) US5567685A (de)
EP (1) EP0776329B1 (de)
JP (1) JP4228052B2 (de)
AU (1) AU3367395A (de)
DE (1) DE69529288T2 (de)
IL (1) IL114796A (de)
WO (1) WO1996005212A1 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6465188B1 (en) * 1990-06-11 2002-10-15 Gilead Sciences, Inc. Nucleic acid ligand complexes
US8071737B2 (en) * 1995-05-04 2011-12-06 Glead Sciences, Inc. Nucleic acid ligand complexes
US6011008A (en) * 1997-01-08 2000-01-04 Yissum Research Developement Company Of The Hebrew University Of Jerusalem Conjugates of biologically active substances
JP2001518556A (ja) * 1997-10-03 2001-10-16 ガレニカ ファーマシューティカルズ， インコーポレイテッド イミン形成ポリサッカライド、その調製、ならびにアジュバントおよび免疫刺激剤としてのその使用
EP1076547A4 (de) 1998-04-27 2001-09-26 Larex Inc Arabinogalactanderivate und zusammenstellungen die diese enthalten
EP1073667A2 (de) 1998-04-28 2001-02-07 Galenica Pharmaceuticals, Inc. Polysaccharid-antigen-konjugate
US6670520B2 (en) 1999-05-28 2003-12-30 Ethicon, Inc. Reductive amination for aldehyde neutralization
US20040084060A1 (en) * 1999-05-28 2004-05-06 Peter Zhu Method and kit for removing aldehyde-based stains
IL131074A0 (en) 1999-07-23 2001-03-19 Polygene Ltd A biodegradable polycation composition for delivery of an anionic macromolecule
JP2003519662A (ja) 2000-01-14 2003-06-24 イントラバイオティクス ファーマシューティカルズ，インコーポレイテッド ポリエン・マクロライド誘導体並びにその製法及び使用
ES2369473T3 (es) 2004-10-07 2011-12-01 Actamax Surgical Materials Llc Adhesivo tisular polimérico basado en polisacárido para uso médico.
WO2007034495A2 (en) * 2005-09-22 2007-03-29 Hadasit Medical Research Services & Development Limited Dextran and arabinogalactan conjugates of therapeutically active compounds
CN101541857B (zh) * 2006-11-27 2012-12-12 阿克塔马克斯手术器材有限责任公司 多官能聚环氧烷、水凝胶和组织粘合剂
US20100112063A1 (en) * 2007-06-28 2010-05-06 Figuly Garret D Method for preparing a hydrogel adhesive having extended gelation time and decreased degradation time
US20090035249A1 (en) * 2007-08-02 2009-02-05 Bhatia Sujata K Method of inhibiting proliferation of Escherichia coli
WO2009064963A2 (en) * 2007-11-14 2009-05-22 E. I. Du Pont De Nemours And Company Oxidized cationic polysaccharide-based polymer tissue adhesive for medical use
US8551136B2 (en) 2008-07-17 2013-10-08 Actamax Surgical Materials, Llc High swell, long-lived hydrogel sealant
US8466327B2 (en) 2008-11-19 2013-06-18 Actamax Surgical Materials, Llc Aldehyde-functionalized polyethers and method of making same
WO2010059279A2 (en) * 2008-11-19 2010-05-27 E. I. Du Pont De Nemours And Company Hydrogel tissue adhesive formed from aminated polysaccharide and aldehyde-functionalized multi-arm polyether
CN102239001B (zh) 2008-12-03 2014-03-12 株式会社钟化 含有甲酰基的多孔性载体、使用该多孔性载体的吸附体以及它们的制造方法
US20100160960A1 (en) * 2008-12-19 2010-06-24 E. I. Du Pont De Nemours And Company Hydrogel tissue adhesive having increased degradation time
WO2010118284A1 (en) 2009-04-09 2010-10-14 E. I. Du Pont De Nemours And Company Hydrogel tissue adhesive having reduced degradation time
US8580951B2 (en) 2009-07-02 2013-11-12 Actamax Surgical Materials, Llc Aldehyde-functionalized polysaccharides
WO2011002888A2 (en) 2009-07-02 2011-01-06 E. I. Du Pont De Nemours And Company Hydrogel tissue adhesive for medical use
US8580950B2 (en) 2009-07-02 2013-11-12 Actamax Surgical Materials, Llc Aldehyde-functionalized polysaccharides
US8796242B2 (en) 2009-07-02 2014-08-05 Actamax Surgical Materials, Llc Hydrogel tissue adhesive for medical use
WO2011061747A1 (en) 2009-11-23 2011-05-26 Conjugate Ltd. Antifungal and anti parasitic conjugates of amphotericin b derivatives
US9744191B2 (en) 2012-03-19 2017-08-29 Yale University Antimicrobial compositions and methods
US8859705B2 (en) 2012-11-19 2014-10-14 Actamax Surgical Materials Llc Hydrogel tissue adhesive having decreased gelation time and decreased degradation time
WO2015017340A2 (en) 2013-07-29 2015-02-05 Actamax Surgical Materials, Llc Low swell tissue adhesive and sealant formulations

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD87778A (de) *
GB844289A (en) * 1956-03-13 1960-08-10 Konink Nl Gist & Spiritusfabri Pimaricin and process of producing same
GB809105A (en) * 1956-06-08 1959-02-18 Olin Mathieson Processes for solubilising amorphous nystatin and compositions containing the same
GB978170A (en) * 1961-08-04 1964-12-16 Koninklijke Gist Spiritus Process for the preparation of water-soluble derivatives of polyene antibiotics
GB1509587A (en) * 1975-08-19 1978-05-04 Ajinomoto Kk Anti-tumour composition
SE7702261L (sv) * 1976-03-02 1977-09-07 Pharmaco Inc Forfarande for att immobilisera antimikrobiella emnen
SU822551A1 (ru) * 1979-08-30 1986-07-30 Всесоюзный кардиологический научный центр АМН СССР Стабилизированна стрептокиназа,обладающа тромболитической активностью
SU1002356A1 (ru) * 1980-12-31 1983-03-07 Всесоюзный кардиологический научный центр АМН СССР Способ получени иммобилизованного фибринолизина
SE456911B (sv) * 1983-12-19 1988-11-14 Olle Larm Vattenloeslig, aminerad beta-1,3-bunden d-glukan och makrofagstimulerande komposition innehaallande densamma
JPS6164701A (ja) * 1984-09-06 1986-04-03 Meito Sangyo Kk カチオン化デキストラン誘導体とポリウロン酸の高分子電解質錯体及びその利用
US4587122A (en) * 1985-04-23 1986-05-06 The Green Cross Corporation Fibronectin-dextran-drug complex and method of preparation thereof
IT1223362B (it) * 1987-11-20 1990-09-19 Texcontor Ets Derivati cationizzati polisaccaridi ad attivita' ipocolesterolemizzante
FR2640141B1 (fr) * 1988-12-14 1993-04-16 Merieux Inst Conjugues macromoleculaires d'hemoglobine, leur procede de preparation et leurs applications
WO1990015628A1 (en) * 1989-06-14 1990-12-27 Cetus Corporation Polymer/antibiotic conjugate
US5332567A (en) * 1989-08-24 1994-07-26 Immunomedics Detection and treatment of infections with immunoconjugates
US5177059A (en) * 1989-11-15 1993-01-05 Sandoz Ltd. Polymyxin B conjugates
CA2044663A1 (en) * 1990-07-12 1992-01-13 Makoto Tanaka Water-dispersible polyene antifungal complexes
CA2135295A1 (en) * 1992-06-17 1993-12-23 Chu Jung Arabinogalactan derivatives and uses thereof
EP0574638A1 (de) * 1992-06-19 1993-12-22 Europharma, S.A. Lösliche Dextran-Glutathion-Komplexen, Verfahren zu deren Herstellung und deren Verwendung
AU8129894A (en) * 1993-11-01 1995-05-23 Alpha-Beta Technology, Inc. Derivatized polysaccharide bile acid sequestrant for reducing cholesterol

Also Published As

Publication number Publication date
DE69529288T2 (de) 2003-07-31
EP0776329A1 (de) 1997-06-04
IL114796A (en) 2000-02-17
JPH10504347A (ja) 1998-04-28
US5567685A (en) 1996-10-22
IL114796A0 (en) 1995-12-08
AU3367395A (en) 1996-03-07
EP0776329A4 (de) 1998-06-10
EP0776329B1 (de) 2003-01-02
JP4228052B2 (ja) 2009-02-25
WO1996005212A1 (en) 1996-02-22

Similar Documents

Publication Publication Date Title
DE69529288T2 (de) Wasserlösliche polyen-konjugate
ATE235920T1 (de) Interferon-konjugate
DK1075281T3 (da) Polyol-IFN-beta-konjugater
ATA166795A (de) Bis-resorcinyltriazine
DE69516124T2 (de) Stereotaktische zieleinrichtung
DE69524185T2 (de) Zwei-walzen-giessverfahren
DE69710914T2 (de) Fahrzeugwagenvorderbau
NO972868D0 (no) Oligonukleotid-dendrimer konjugater
DE59805315D1 (de) Wasserlösliche chinacridone
DE59505691D1 (de) Wasserlösliche Haftklebemasse
DE69430692T2 (de) Steckerstift
FI970195A (fi) Trifluormetyylikinoliinikarboksyylihappojohdannainen
DE69711912D1 (de) Fahrzeugwagenvorderbau
DE9402404U1 (de) Sprossen-Abstandshalter-Verbindung
DK60694A (da) Liftophængt redskab
KR970054947U (ko) 텐프폴대의 연결구
DE9420089U1 (de) Medaillon
DE9417313U1 (de) Rohr-Muffe-Verbindung
KR960004092U (ko) 완력기
DE9411502U1 (de) Zurichtstreifen
SE9403235D0 (sv) Måtten
FI944403A0 (fi) Stigkaelke II
DE69516583D1 (de) Amboss
BR7400944U (pt) Rojão de confetes
FI942861A0 (fi) Baerande form

Legal Events

Date Code Title Description
8364 No opposition during term of opposition