DE69530004D1 - Transdermale verabreichung von apomorphin - Google Patents
Transdermale verabreichung von apomorphinInfo
- Publication number
- DE69530004D1 DE69530004D1 DE69530004T DE69530004T DE69530004D1 DE 69530004 D1 DE69530004 D1 DE 69530004D1 DE 69530004 T DE69530004 T DE 69530004T DE 69530004 T DE69530004 T DE 69530004T DE 69530004 D1 DE69530004 D1 DE 69530004D1
- Authority
- DE
- Germany
- Prior art keywords
- apomorphine
- transdermal administration
- transdermal
- administration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7092—Transdermal patches having multiple drug layers or reservoirs, e.g. for obtaining a specific release pattern, or for combining different drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/362,831 US5562917A (en) | 1994-12-23 | 1994-12-23 | Transdermal administration of apomorphine |
US362831 | 1994-12-23 | ||
PCT/US1995/016798 WO1996019956A1 (en) | 1994-12-23 | 1995-12-22 | Transdermal administration of apomorphine |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69530004D1 true DE69530004D1 (de) | 2003-04-24 |
DE69530004T2 DE69530004T2 (de) | 2004-03-04 |
Family
ID=23427711
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69530004T Expired - Fee Related DE69530004T2 (de) | 1994-12-23 | 1995-12-22 | Transdermale verabreichung von apomorphin |
Country Status (4)
Country | Link |
---|---|
US (2) | US5562917A (de) |
EP (1) | EP0800364B1 (de) |
DE (1) | DE69530004T2 (de) |
WO (1) | WO1996019956A1 (de) |
Families Citing this family (68)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9609794D0 (en) | 1996-05-10 | 1996-07-17 | Smithkline Beecham Plc | Novel compounds |
WO1999009828A1 (en) * | 1997-08-25 | 1999-03-04 | Pentech Pharmaceuticals, Inc. | Method for amelioration of social phobia |
US7629384B2 (en) * | 1997-09-17 | 2009-12-08 | Strategic Science & Technologies, Llc | Topical delivery of L-arginine to cause beneficial effects |
US7914814B2 (en) * | 1997-09-17 | 2011-03-29 | Strategic Science & Technologies, Llc | Topical delivery of arginine of cause beneficial effects |
US5945117A (en) * | 1998-01-30 | 1999-08-31 | Pentech Pharmaceuticals, Inc. | Treatment of female sexual dysfunction |
US6280851B1 (en) * | 1998-03-23 | 2001-08-28 | Sentrex Company, Inc. | Multilayer product for printed circuit boards |
US5994363A (en) * | 1998-08-24 | 1999-11-30 | Pentech Pharmaceuticals, Inc. | Amelioration of apomorphine adverse effects |
US6291471B1 (en) | 1998-12-17 | 2001-09-18 | Abb Holdings, Inc. | Use of apomorphine for the treatment of organic erectile dysfunction in males |
US6586000B2 (en) * | 1999-12-16 | 2003-07-01 | Dermatrends, Inc. | Hydroxide-releasing agents as skin permeation enhancers |
US6562369B2 (en) * | 1999-12-16 | 2003-05-13 | Dermatrends, Inc. | Transdermal administration of androgenic drugs hydroxide-releasing agents as permeation enhancers |
US6562370B2 (en) | 1999-12-16 | 2003-05-13 | Dermatrends, Inc. | Transdermal administration of steroid drugs using hydroxide-releasing agents as permeation enhancers |
US6645520B2 (en) * | 1999-12-16 | 2003-11-11 | Dermatrends, Inc. | Transdermal administration of nonsteroidal anti-inflammatory drugs using hydroxide-releasing agents as permeation enhancers |
US6582724B2 (en) * | 1999-12-16 | 2003-06-24 | Dermatrends, Inc. | Dual enhancer composition for topical and transdermal drug delivery |
US6673363B2 (en) | 1999-12-16 | 2004-01-06 | Dermatrends, Inc. | Transdermal and topical administration of local anesthetic agents using basic enhancers |
US20030104041A1 (en) * | 1999-12-16 | 2003-06-05 | Tsung-Min Hsu | Transdermal and topical administration of drugs using basic permeation enhancers |
US6558695B2 (en) | 1999-12-16 | 2003-05-06 | Dermatrends, Inc. | Topical and transdermal administration of peptidyl drugs using hydroxide releasing agents as permeation enhancers |
US6565879B1 (en) | 1999-12-16 | 2003-05-20 | Dermatrends, Inc. | Topical and transdermal administration of peptidyl drugs with hydroxide-releasing agents as skin permeation enhancers |
US6562368B2 (en) * | 1999-12-16 | 2003-05-13 | Dermatrends, Inc. | Transdermal administration of oxybutynin using hydroxide-releasing agents as permeation enhancers |
KR20030036157A (ko) | 2000-04-07 | 2003-05-09 | 탭 파마슈티칼 프로덕츠 인코포레이티드 | 아포모르핀 유도체 및 이의 사용 방법 |
MXPA02010542A (es) * | 2000-04-26 | 2003-10-14 | Watson Pharmaceuticals Inc | Minimizacion de experiencias adversas asociadas con la terapia con oxibutinina. |
US7179483B2 (en) * | 2000-04-26 | 2007-02-20 | Watson Pharmaceuticals, Inc. | Compositions and methods for transdermal oxybutynin therapy |
US7029694B2 (en) * | 2000-04-26 | 2006-04-18 | Watson Laboratories, Inc. | Compositions and methods for transdermal oxybutynin therapy |
US6387383B1 (en) * | 2000-08-03 | 2002-05-14 | Dow Pharmaceutical Sciences | Topical low-viscosity gel composition |
EP1341536A4 (de) | 2000-11-15 | 2007-08-01 | Tap Pharmaceutical Prod Inc | Behandlung von durch antidepressiva ausgelöster sexueller dysfunktion mit apomorphin |
KR20030074810A (ko) * | 2001-02-08 | 2003-09-19 | 파마시아 코포레이션 | 성 기능장애의 치료를 위한 신속-발현 약 |
ITMI20011321A1 (it) * | 2001-06-22 | 2002-12-22 | Chiesi Farma Spa | Composizione farmaceutica in forma di microemulsione atta alla somministrazione per via transdermale di apomorfina utile nel trattamento del |
GB0116860D0 (en) * | 2001-07-10 | 2001-09-05 | Univ Montfort | Gel compositions |
FR2829028B1 (fr) * | 2001-08-29 | 2004-12-17 | Aventis Pharma Sa | Association d'un antagoniste du recepteur cb1 et d'un produit qui active la neurotransmission dopaminergique dans le cerveau, les compositions pharmaceutiques les contenant et leur utilisation pour le traitement de la maladie de |
EP1496915A1 (de) * | 2002-03-19 | 2005-01-19 | Brain 'N' Beyond Biotech | Glycosid und orthoester-glycosid-derivate von apomorphin, analoga und ihre verwendungen |
DK2561860T3 (en) * | 2002-05-31 | 2018-04-30 | Titan Pharmaceuticals Inc | Implantable polymer device for prolonged release of buprenorphine |
SE522979C2 (sv) * | 2002-07-03 | 2004-03-23 | Moelnlycke Health Care Ab | Sårförband innefattande en icke-enzymatisk antioxidant |
US20040057983A1 (en) | 2002-09-25 | 2004-03-25 | David Schmidt | Biomolecular wearable apparatus |
NZ542548A (en) | 2003-03-31 | 2009-04-30 | Titan Pharmaceuticals Inc | Implantable polymeric device for sustained release of dopamine agonist |
EP1644004A4 (de) | 2003-06-20 | 2010-10-06 | Ronald Aung-Din | Topische therapie zur behandlung von migräne, muskelzerrungen, muskelspasmus, spastizität und verwandten zuständen |
DE10333393A1 (de) * | 2003-07-23 | 2005-02-24 | Lts Lohmann Therapie-Systeme Ag | Transdermales Therapeutisches System mit dem Wirkstoff Pramipexol |
EP1732577B1 (de) * | 2004-02-23 | 2013-04-10 | Strategic Science & Technologies, LLC | Topische verabreichung von l-arginin zur verbesserung des aussehens von körper und haut |
US20050202073A1 (en) * | 2004-03-09 | 2005-09-15 | Mylan Technologies, Inc. | Transdermal systems containing multilayer adhesive matrices to modify drug delivery |
US9205062B2 (en) | 2004-03-09 | 2015-12-08 | Mylan Pharmaceuticals, Inc. | Transdermal systems containing multilayer adhesive matrices to modify drug delivery |
US9226909B2 (en) | 2004-04-19 | 2016-01-05 | Strategic Science & Technologies, Llc | Beneficial effects of increasing local blood flow |
AU2012201048B2 (en) * | 2004-04-19 | 2013-06-06 | Strategic Science & Technologies, Llc | Transdermal delivery of beneficial substances effected by a hostile biophysical environment |
US20090105336A1 (en) * | 2004-04-19 | 2009-04-23 | Strategic Science & Technologies, Llc | Beneficial Effects of Increasing Local Blood Flow |
WO2005102307A2 (en) * | 2004-04-19 | 2005-11-03 | Strategic Science & Technologies, Llc | Beneficial effects of increasing local blood flow |
US20110028548A1 (en) * | 2004-04-19 | 2011-02-03 | Strategic Science & Technologies, Llc | Beneficial effects of increasing local blood flow |
US20060105950A1 (en) * | 2004-10-25 | 2006-05-18 | Caritas St. Elizabeth's Medical Center Of Boston, Inc. | Morphogen compositions and use thereof to treat wounds |
JP2009149524A (ja) * | 2006-03-16 | 2009-07-09 | Kyushu Univ | アルツハイマー病の予防・治療剤 |
US20070259029A1 (en) * | 2006-05-08 | 2007-11-08 | Mcentire Edward Enns | Water-dispersible patch containing an active agent for dermal delivery |
US20070258935A1 (en) * | 2006-05-08 | 2007-11-08 | Mcentire Edward Enns | Water dispersible films for delivery of active agents to the epidermis |
US20080057090A1 (en) * | 2006-09-01 | 2008-03-06 | Mcentire Edward Enns | Wrinkle masking film composition for skin |
US7879942B2 (en) | 2006-10-05 | 2011-02-01 | Eastman Chemical Company | Switchable adhesive article for attachment to skin and method of using the same |
ITMI20061918A1 (it) * | 2006-10-06 | 2008-04-07 | Nanovector S R L | Formulazioni adatte ad essere somministrate per via transdermica contenenti principi attivi incorporati in sln |
DE102007061873A1 (de) | 2007-01-15 | 2008-07-17 | Bayer Innovation Gmbh | Kieselsol-Material zur Herstellung von biologisch degradierbaren und/oder resorbierbaren Kieselgel-Materialien dessen Herstellung und Verwendung |
JP5542665B2 (ja) * | 2007-06-08 | 2014-07-09 | サムヤン バイオファーマシューティカルズ コーポレイション | マトリックス型経皮投与剤およびその製造方法 |
US8602961B2 (en) | 2008-05-15 | 2013-12-10 | Lifewave Products Llc | Apparatus and method of stimulating elevation of glutathione levels in a subject |
CA2729346A1 (en) * | 2008-06-30 | 2010-01-14 | Afgin Pharma, Llc | Topical regional neuro-affective therapy |
WO2010022326A2 (en) * | 2008-08-22 | 2010-02-25 | Us Worldmeds Llc | Transdermal delivery of apomorphine using microneedles |
WO2010151241A1 (en) | 2009-06-24 | 2010-12-29 | Strategic Science & Technologies, Llc | Topical composition containing naproxen |
WO2012092528A1 (en) | 2010-12-29 | 2012-07-05 | Strategic Science & Technologies, Llc | Treatment of erectile dysfunction and other indications |
US11684624B2 (en) | 2009-06-24 | 2023-06-27 | Strategic Science & Technologies, Llc | Treatment of erectile dysfunction and other indications |
MA33454B1 (fr) * | 2009-06-24 | 2012-07-03 | Strategic Science & Tech Llc | Composition topique contenant de l'ibuprofène |
CN105878172A (zh) | 2010-12-29 | 2016-08-24 | 战略科学与技术有限责任公司 | 治疗变态反应和其它适应症的系统和方法 |
EP2545905A1 (de) * | 2011-07-11 | 2013-01-16 | Britannia Pharmaceuticals Limited | Neue therapeutische Zusammensetzung mit Apomorphin als aktiver Inhaltsstoff |
US10383816B2 (en) | 2015-03-02 | 2019-08-20 | Afgin Pharma, Llc | Topical regional neuro-affective therapy with cannabinoid combination products |
JP2018507262A (ja) | 2015-03-02 | 2018-03-15 | アフギン ファーマ, エルエルシーAfgin Pharma, Llc | カンナビノイドを用いた、局所局部的神経作用療法 |
WO2017055337A1 (en) | 2015-09-28 | 2017-04-06 | Ever Neuro Pharma Gmbh | Aqueous composition of apomorphine for subcutaneous administration |
US20180049994A1 (en) | 2016-08-16 | 2018-02-22 | Afgin Pharma, Llc | Topical regional neuro-affective therapy with caryophyllene |
JPWO2021235436A1 (de) * | 2020-05-20 | 2021-11-25 | ||
IT202100009857A1 (it) | 2021-04-19 | 2022-10-19 | Univ Degli Studi Di Torino | Formulazione a rilascio controllato e prolungato di apomorfina |
WO2023242355A1 (en) | 2022-06-15 | 2023-12-21 | Ever Neuro Pharma Gmbh | Apomorphine prodrugs and uses thereof |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2542334A (en) * | 1946-04-24 | 1951-02-20 | Corning Glass Works | Condensation of siloxanes |
US2490357A (en) * | 1946-04-24 | 1949-12-06 | Corning Glass Works | Polymerization of siloxanes |
US2676182A (en) * | 1950-09-13 | 1954-04-20 | Dow Corning | Copolymeric siloxanes and methods of preparing them |
US2927907A (en) * | 1957-01-07 | 1960-03-08 | Dow Corning | Siloxane elastomers |
US3002951A (en) * | 1959-04-27 | 1961-10-03 | Dow Corning | Method of polymerizing cyclic diorganosiloxanes |
US3186967A (en) * | 1961-04-12 | 1965-06-01 | Wacker Chemie Gmbh | Method of preparing high molecular weight organosiloxane polymers |
BE623603A (de) * | 1961-10-16 | |||
US3459731A (en) * | 1966-12-16 | 1969-08-05 | Corn Products Co | Cyclodextrin polyethers and their production |
US3509191A (en) * | 1968-04-29 | 1970-04-28 | Dow Corning | Silacyclopentenes and a method for making same |
US3697473A (en) * | 1971-01-04 | 1972-10-10 | Dow Corning | Composition curable through si-h and si-ch equals ch2 with improved properties |
JPS59130811A (ja) * | 1983-01-17 | 1984-07-27 | Nitto Electric Ind Co Ltd | 粘着性貼付製剤用膏体 |
FR2541019B1 (fr) * | 1983-02-10 | 1986-07-18 | Mecelec Sa | Procede optique pour determiner les dimensions d'un objet en mouvement relatif, et plus particulierement d'une piece de monnaie dans un appareil a pre-paiement, et dispositif pour sa mise en oeuvre |
US4584355A (en) * | 1984-10-29 | 1986-04-22 | Dow Corning Corporation | Silicone pressure-sensitive adhesive process and product with improved lap-shear stability-I |
US4585836A (en) * | 1984-10-29 | 1986-04-29 | Dow Corning Corporation | Silicone pressure-sensitive adhesive process and product with improved lap-shear stability-II |
US4655767A (en) * | 1984-10-29 | 1987-04-07 | Dow Corning Corporation | Transdermal drug delivery devices with amine-resistant silicone adhesives |
US4591622A (en) * | 1984-10-29 | 1986-05-27 | Dow Corning Corporation | Silicone pressure-sensitive adhesive process and product thereof |
US4645502A (en) * | 1985-05-03 | 1987-02-24 | Alza Corporation | Transdermal delivery of highly ionized fat insoluble drugs |
FI873429A (fi) * | 1986-08-18 | 1988-02-19 | Houston Biotechnology | Oftalmologiska kompositioner foer behandling av nervdegenerationer. |
US4837027A (en) * | 1987-11-09 | 1989-06-06 | Alza Corporation | Transdermal drug delivery device |
US4978532A (en) * | 1989-08-11 | 1990-12-18 | Pharmedic Co. | Dosage form for administration of dehydroepiandrosterone |
-
1994
- 1994-12-23 US US08/362,831 patent/US5562917A/en not_active Expired - Fee Related
-
1995
- 1995-12-22 EP EP95944522A patent/EP0800364B1/de not_active Expired - Lifetime
- 1995-12-22 DE DE69530004T patent/DE69530004T2/de not_active Expired - Fee Related
- 1995-12-22 WO PCT/US1995/016798 patent/WO1996019956A1/en active IP Right Grant
-
1996
- 1996-10-08 US US08/727,189 patent/US5939094A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
WO1996019956A1 (en) | 1996-07-04 |
EP0800364B1 (de) | 2003-03-19 |
US5939094A (en) | 1999-08-17 |
EP0800364A4 (de) | 1998-04-01 |
DE69530004T2 (de) | 2004-03-04 |
EP0800364A1 (de) | 1997-10-15 |
US5562917A (en) | 1996-10-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |