DE69530374D1 - Blutbildendes fusionprotein mit il-3 varianten - Google Patents
Blutbildendes fusionprotein mit il-3 variantenInfo
- Publication number
- DE69530374D1 DE69530374D1 DE69530374T DE69530374T DE69530374D1 DE 69530374 D1 DE69530374 D1 DE 69530374D1 DE 69530374 T DE69530374 T DE 69530374T DE 69530374 T DE69530374 T DE 69530374T DE 69530374 D1 DE69530374 D1 DE 69530374D1
- Authority
- DE
- Germany
- Prior art keywords
- variants
- blooding
- fusion protein
- hil
- variant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5403—IL-3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/14—Lymphokine; related peptides
- Y10S930/141—Interleukin
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/192,299 US5738849A (en) | 1992-11-24 | 1994-02-04 | Interleukin-3 (IL-3) variant fusion proteins, their recombinant production, and therapeutic compositions comprising them |
PCT/US1995/000549 WO1995021197A1 (en) | 1994-02-04 | 1995-01-25 | Il-3 variant hematopoiesis fusion protein |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69530374D1 true DE69530374D1 (de) | 2003-05-22 |
DE69530374T2 DE69530374T2 (de) | 2003-12-18 |
Family
ID=22709107
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69530374T Expired - Fee Related DE69530374T2 (de) | 1994-02-04 | 1995-01-25 | Blutbildendes fusionprotein mit il-3 varianten |
Country Status (13)
Country | Link |
---|---|
US (4) | US5738849A (de) |
EP (2) | EP1323737A3 (de) |
JP (1) | JPH09508524A (de) |
AT (1) | ATE237641T1 (de) |
AU (1) | AU700220B2 (de) |
CA (1) | CA2182483C (de) |
DE (1) | DE69530374T2 (de) |
DK (1) | DK0742796T3 (de) |
ES (1) | ES2197191T3 (de) |
HK (1) | HK1013655A1 (de) |
NZ (1) | NZ279624A (de) |
PT (1) | PT742796E (de) |
WO (1) | WO1995021197A1 (de) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5738849A (en) * | 1992-11-24 | 1998-04-14 | G. D. Searle & Co. | Interleukin-3 (IL-3) variant fusion proteins, their recombinant production, and therapeutic compositions comprising them |
US5581476A (en) * | 1993-01-28 | 1996-12-03 | Amgen Inc. | Computer-based methods and articles of manufacture for preparing G-CSF analogs |
CZ295518B6 (cs) * | 1995-10-05 | 2005-08-17 | G. D. Searle & Co. | Multifunkční agonisté hematopoetických receptorů |
US6066318A (en) * | 1995-10-05 | 2000-05-23 | G.D. Searle & Co. | Multi-functional hematopoietic fusion proteins between sequence rearranged C-MPL receptor agonists and other hematopoietic factors |
US6967092B1 (en) | 1996-10-25 | 2005-11-22 | Mc Kearn John P | Multi-functional chimeric hematopoietic receptor agonists |
WO1998017810A2 (en) * | 1996-10-25 | 1998-04-30 | G.D. Searle & Co. | Multi-functional chimeric hematopoietic receptor agonists |
WO1998018926A1 (en) * | 1996-10-25 | 1998-05-07 | G.D. Searle & Co. | Circularly permuted erythropoietin receptor agonists |
US6165476A (en) * | 1997-07-10 | 2000-12-26 | Beth Israel Deaconess Medical Center | Fusion proteins with an immunoglobulin hinge region linker |
DE69824039T2 (de) | 1997-12-08 | 2005-08-18 | Lexigen Pharmaceuticals Corp., Lexington | Heterodimäre fusionsproteine zur verwendung für gezielte immuntherapie und allgemeine immunerregung |
US20030105294A1 (en) * | 1998-02-25 | 2003-06-05 | Stephen Gillies | Enhancing the circulating half life of antibody-based fusion proteins |
HUP0101352A3 (en) * | 1998-04-15 | 2003-08-28 | Lexigen Pharmaceuticals Corp L | Enhancement of antibody-cytokine fusion protein mediated immune responses by co-administration with angiogenesis inhibitor |
US7067110B1 (en) | 1999-07-21 | 2006-06-27 | Emd Lexigen Research Center Corp. | Fc fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
SK782002A3 (en) | 1999-07-21 | 2003-08-05 | Lexigen Pharm Corp | FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
SK1842002A3 (en) * | 1999-08-09 | 2003-09-11 | Lexigen Pharm Corp | A fusion protein, a multi-function protein complex, a multi-function fusion protein, a nucleic acid, a cell, their use, method for preparing a fusion protein and method of targeting cytokines |
AU7825500A (en) * | 1999-10-07 | 2001-04-23 | Pharmacia Corporation | Inhibition enzyme linked immunosorbent assay (iELISA) for the detection and quantification of antibodies in biological samples |
AU2154401A (en) | 1999-11-12 | 2001-05-30 | Merck Patent Gmbh | Erythropoietin forms with improved properties |
US6831158B2 (en) * | 2000-01-10 | 2004-12-14 | Maxygen Holdings Ltd. | G-CSF conjugates |
US6646110B2 (en) * | 2000-01-10 | 2003-11-11 | Maxygen Holdings Ltd. | G-CSF polypeptides and conjugates |
US6555660B2 (en) * | 2000-01-10 | 2003-04-29 | Maxygen Holdings Ltd. | G-CSF conjugates |
MXPA02007733A (es) | 2000-02-11 | 2004-09-10 | Merck Patent Gmbh | Mejoramiento de la vida media circulante de proteinas de fusion basadas en anticuerpos. |
AU2001289307A1 (en) * | 2000-04-06 | 2001-10-23 | Pharmacia Corporation | Chemically-modified myelopoietin conjugates |
WO2001077332A2 (en) * | 2000-04-07 | 2001-10-18 | Heska Corporation | Compositions and methods related to canine igg and canine il-13 receptors |
CN1270775C (zh) * | 2000-06-29 | 2006-08-23 | 默克专利有限公司 | 通过与免疫细胞因子摄入促进剂联合治疗来增强抗体-细胞因子融合蛋白介导的免疫反应 |
US7118737B2 (en) * | 2000-09-08 | 2006-10-10 | Amylin Pharmaceuticals, Inc. | Polymer-modified synthetic proteins |
AU7338801A (en) * | 2000-09-08 | 2002-03-22 | Gryphon Sciences | "pseudo"-native chemical ligation |
RU2003129528A (ru) * | 2001-03-07 | 2005-04-10 | Мерк Патент ГмбХ (DE) | Способ экспрессии белков, содержащих в качестве компонента гибридный изотип антитела |
US6992174B2 (en) | 2001-03-30 | 2006-01-31 | Emd Lexigen Research Center Corp. | Reducing the immunogenicity of fusion proteins |
WO2002090566A2 (en) | 2001-05-03 | 2002-11-14 | Merck Patent Gmbh | Recombinant tumor specific antibody and use thereof |
PL371781A1 (en) * | 2001-07-11 | 2005-06-27 | Maxygen Holdings, Ltd. | G-csf conjugates |
HU229098B1 (hu) * | 2001-12-04 | 2013-07-29 | Merck Patent Gmbh | Megváltoztatott szelektivitású immuncitokinek |
US7332158B2 (en) * | 2002-05-29 | 2008-02-19 | Demao Yang | Compositions and treatments for myelosuppression by ex vivo activated immune cells |
US7048922B2 (en) * | 2002-05-29 | 2006-05-23 | Demao Yang | Stimulation of hematopoiesis by ex vivo activated immune cells |
ATE471946T1 (de) * | 2002-12-17 | 2010-07-15 | Merck Patent Gmbh | Humanisierter antikörper (h14.18) des maus antikörpers 14.18, der gd2 bindet und seine fusion mit il-2 |
WO2005066348A2 (en) * | 2004-01-05 | 2005-07-21 | Emd Lexigen Research Center Corp. | Interleukin-12 targeted to oncofoetal fibronectin |
CN1993460A (zh) * | 2004-07-12 | 2007-07-04 | 索林集团意大利有限公司 | 用于培养人细胞的装置和方法 |
US7597884B2 (en) | 2004-08-09 | 2009-10-06 | Alios Biopharma, Inc. | Hyperglycosylated polypeptide variants and methods of use |
CA2607844C (en) | 2005-06-01 | 2012-07-10 | Maxygen Holdings Ltd. | Pegylated g-csf polypeptides and methods of producing same |
KR101435420B1 (ko) * | 2005-08-02 | 2014-09-25 | 플래닛 바이오테크놀로지, 인코포레이티드 | 개선된 키메라 독소 수용체 단백질 및 탄저병의 예방 및치료를 위한 키메라 독소 수용체 단백질 |
SI1966238T1 (sl) * | 2005-12-30 | 2012-08-31 | Merck Patent Gmbh | Variante interlevkina-12P40 z izboljšano stabilnostjo |
WO2008036374A2 (en) * | 2006-09-21 | 2008-03-27 | Medistem Laboratories, Inc. | Allogeneic stem cell transplants in non-conditioned recipients |
EP2522728A1 (de) * | 2007-09-21 | 2012-11-14 | Cadila Healthcare Limited | Zur hohen Expression von Peptiden geeignete GCSF-Fusionsproteinsysteme |
WO2011151716A1 (en) | 2010-06-04 | 2011-12-08 | Lupin Limited | Process for the purification of recombinant human il-11 |
Family Cites Families (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993007171A1 (en) * | 1991-10-07 | 1993-04-15 | Medvet Science Pty. Ltd. | Human il-3 variants |
US4438032A (en) * | 1981-01-30 | 1984-03-20 | The Regents Of The University Of California | Unique T-lymphocyte line and products derived therefrom |
UA39161C2 (uk) * | 1984-07-06 | 2001-06-15 | Новартіс Аг | Рекомбінантний білок gm-csf для збільшення продукції гранулоцитів і макрофагів у пацієнтів, вектор і кднк, що його кодують |
AU588819B2 (en) * | 1984-10-29 | 1989-09-28 | Immunex Corporation | Cloning of human granulocyte-macrophage colony stimulating factor gene |
US4810643A (en) * | 1985-08-23 | 1989-03-07 | Kirin- Amgen Inc. | Production of pluripotent granulocyte colony-stimulating factor |
JPS63500636A (ja) * | 1985-08-23 | 1988-03-10 | 麒麟麦酒株式会社 | 多分化能性顆粒球コロニー刺激因子をコードするdna |
GR871029B (en) * | 1986-07-14 | 1987-11-02 | Genetics Inst | Novel osteoinductive factors |
US4877729A (en) * | 1986-07-14 | 1989-10-31 | Genetics Institute, Inc. | Recombinant DNA encoding novel family of primate hematopoietic growth factors |
US4959455A (en) * | 1986-07-14 | 1990-09-25 | Genetics Institute, Inc. | Primate hematopoietic growth factors IL-3 and pharmaceutical compositions |
US5032395A (en) * | 1986-07-14 | 1991-07-16 | Genetics Institute, Inc. | Method of inducing leukocytosis with a combination of IL-3 and GM-CSF |
PT86381B (pt) * | 1986-12-16 | 1990-11-20 | Gist Brocades Nv | Processo de clonagem molecular e de expressao de interleuquina-3 (il-3) humana |
EP0275598B1 (de) * | 1986-12-16 | 1998-01-07 | Gist-Brocades N.V. | Molekulare Klonierung und Expression von menschlichem IL-3 |
EP0342206A4 (en) * | 1987-01-20 | 1990-09-19 | Immunex Corporation | Human interleukin-3 proteins |
OA09736A (en) * | 1987-02-18 | 1993-11-30 | Schering Biotech Corp | "Human interleukin-3 and muteins thereof". |
GB2210883B (en) * | 1987-10-08 | 1992-01-02 | British Bio Technology | Synthetic interleukin-3 gene |
US4904584A (en) * | 1987-12-23 | 1990-02-27 | Genetics Institute, Inc. | Site-specific homogeneous modification of polypeptides |
EP0425536A4 (en) * | 1988-07-20 | 1992-01-02 | Immunex Corporation | Nonglycosylated human interleukin-3 compositions |
US5218092A (en) * | 1988-09-29 | 1993-06-08 | Kyowa Hakko Kogyo Co., Ltd. | Modified granulocyte-colony stimulating factor polypeptide with added carbohydrate chains |
NZ232913A (en) * | 1989-03-15 | 1992-08-26 | Gist Brocades Nv | Il-3 produced recombinantly and purified to homogeneity; vectors and pharmaceutical preparations |
WO1990012877A1 (en) * | 1989-04-19 | 1990-11-01 | Cetus Corporation | Multifunctional m-csf proteins and genes encoding therefor |
US5166322A (en) * | 1989-04-21 | 1992-11-24 | Genetics Institute | Cysteine added variants of interleukin-3 and chemical modifications thereof |
US5128450A (en) * | 1989-06-30 | 1992-07-07 | Urdal David L | Nonglycosylated human interleukin-3 analog proteins |
EP0413383B1 (de) * | 1989-08-14 | 1997-06-18 | Gist-Brocades N.V. | Mutanten von Interleukin-3 |
US5516512A (en) * | 1989-08-14 | 1996-05-14 | Gist-Brocades, N.V. | N- and C-terminal truncation and deletion mutants of human interleukin-3 |
JP3115318B2 (ja) * | 1989-08-22 | 2000-12-04 | イミュネックス・コーポレーション | Gm―csf及びil―3を含む融合タンパク質 |
US5073627A (en) * | 1989-08-22 | 1991-12-17 | Immunex Corporation | Fusion proteins comprising GM-CSF and IL-3 |
US5108910A (en) * | 1989-08-22 | 1992-04-28 | Immunex Corporation | DNA sequences encoding fusion proteins comprising GM-CSF and IL-3 |
JPH03236400A (ja) * | 1990-02-09 | 1991-10-22 | Kirin Brewery Co Ltd | 化学修飾ポリペプチド及びその用途 |
JPH0463595A (ja) * | 1990-04-03 | 1992-02-28 | Kirin Brewery Co Ltd | ヒトインターロイキン3誘導体 |
CA2089553C (en) * | 1990-08-29 | 2000-06-27 | Paul Schendel | Multidomain hematopoiesis stimulators |
AU8735991A (en) * | 1990-09-28 | 1992-04-28 | Ortho Pharmaceutical Corporation | Hybrid growth factors |
DE4030850A1 (de) * | 1990-09-29 | 1992-04-02 | Henkel Kgaa | Bleichmittelzubereitung |
AU1372692A (en) * | 1991-02-08 | 1992-09-07 | Immunex Corporation | Method of inhibiting replication of hiv in macrophages |
US5199942A (en) * | 1991-06-07 | 1993-04-06 | Immunex Corporation | Method for improving autologous transplantation |
US5376367A (en) * | 1991-11-22 | 1994-12-27 | Immunex Corporation | Fusion proteins comprising MGF and IL-3 |
EP0672145B1 (de) * | 1992-11-24 | 2003-04-23 | G.D. Searle & Co. | Interleukin-3 (il-3)-polypeptide mith mehreren mutationen |
US5772992A (en) * | 1992-11-24 | 1998-06-30 | G.D. Searle & Co. | Compositions for co-administration of interleukin-3 mutants and other cytokines and hematopoietic factors |
US5738849A (en) * | 1992-11-24 | 1998-04-14 | G. D. Searle & Co. | Interleukin-3 (IL-3) variant fusion proteins, their recombinant production, and therapeutic compositions comprising them |
US5667149A (en) * | 1995-07-03 | 1997-09-16 | Foster Wheeler Energy Corporation | Solids pulverizer mill and process utilizing interactive air port nozzles |
-
1994
- 1994-02-04 US US08/192,299 patent/US5738849A/en not_active Expired - Fee Related
-
1995
- 1995-01-25 CA CA002182483A patent/CA2182483C/en not_active Expired - Fee Related
- 1995-01-25 JP JP7520622A patent/JPH09508524A/ja active Pending
- 1995-01-25 WO PCT/US1995/000549 patent/WO1995021197A1/en active IP Right Grant
- 1995-01-25 EP EP03002133A patent/EP1323737A3/de not_active Withdrawn
- 1995-01-25 ES ES95908514T patent/ES2197191T3/es not_active Expired - Lifetime
- 1995-01-25 DK DK95908514T patent/DK0742796T3/da active
- 1995-01-25 AU AU16805/95A patent/AU700220B2/en not_active Ceased
- 1995-01-25 NZ NZ279624A patent/NZ279624A/en unknown
- 1995-01-25 PT PT95908514T patent/PT742796E/pt unknown
- 1995-01-25 EP EP95908514A patent/EP0742796B1/de not_active Expired - Lifetime
- 1995-01-25 DE DE69530374T patent/DE69530374T2/de not_active Expired - Fee Related
- 1995-01-25 AT AT95908514T patent/ATE237641T1/de not_active IP Right Cessation
- 1995-06-06 US US08/470,775 patent/US5858347A/en not_active Expired - Fee Related
- 1995-06-06 US US08/469,124 patent/US6132991A/en not_active Expired - Fee Related
- 1995-11-15 US US08/559,267 patent/US6074639A/en not_active Expired - Fee Related
-
1998
- 1998-12-23 HK HK98114924A patent/HK1013655A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DE69530374T2 (de) | 2003-12-18 |
JPH09508524A (ja) | 1997-09-02 |
US5738849A (en) | 1998-04-14 |
CA2182483A1 (en) | 1995-08-10 |
ATE237641T1 (de) | 2003-05-15 |
EP0742796B1 (de) | 2003-04-16 |
NZ279624A (en) | 1998-05-27 |
US6132991A (en) | 2000-10-17 |
EP1323737A3 (de) | 2003-10-15 |
US6074639A (en) | 2000-06-13 |
PT742796E (pt) | 2003-08-29 |
US5858347A (en) | 1999-01-12 |
AU700220B2 (en) | 1998-12-24 |
HK1013655A1 (en) | 1999-09-03 |
AU1680595A (en) | 1995-08-21 |
ES2197191T3 (es) | 2004-01-01 |
EP1323737A2 (de) | 2003-07-02 |
DK0742796T3 (da) | 2003-08-11 |
EP0742796A1 (de) | 1996-11-20 |
CA2182483C (en) | 2002-04-02 |
WO1995021197A1 (en) | 1995-08-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |