DE69530374D1 - Blutbildendes fusionprotein mit il-3 varianten - Google Patents

Blutbildendes fusionprotein mit il-3 varianten

Info

Publication number
DE69530374D1
DE69530374D1 DE69530374T DE69530374T DE69530374D1 DE 69530374 D1 DE69530374 D1 DE 69530374D1 DE 69530374 T DE69530374 T DE 69530374T DE 69530374 T DE69530374 T DE 69530374T DE 69530374 D1 DE69530374 D1 DE 69530374D1
Authority
DE
Germany
Prior art keywords
variants
blooding
fusion protein
hil
variant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69530374T
Other languages
English (en)
Other versions
DE69530374T2 (de
Inventor
Christopher S Bauer
Mark Allen Abrams
Sarah Ruth Braford-Goldberg
Maire Helena Caparon
Alan Michael Easton
Barbara Kure Klein
Kearn John Patrick Mc
Peter O Olins
Kumnan Paik
John Warren Thomas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GD Searle LLC filed Critical GD Searle LLC
Application granted granted Critical
Publication of DE69530374D1 publication Critical patent/DE69530374D1/de
Publication of DE69530374T2 publication Critical patent/DE69530374T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/53Colony-stimulating factor [CSF]
    • C07K14/535Granulocyte CSF; Granulocyte-macrophage CSF
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06Antianaemics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/54Interleukins [IL]
    • C07K14/5403IL-3
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00Peptide or protein sequence
    • Y10S930/01Peptide or protein sequence
    • Y10S930/14Lymphokine; related peptides
    • Y10S930/141Interleukin
DE69530374T 1994-02-04 1995-01-25 Blutbildendes fusionprotein mit il-3 varianten Expired - Fee Related DE69530374T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/192,299 US5738849A (en) 1992-11-24 1994-02-04 Interleukin-3 (IL-3) variant fusion proteins, their recombinant production, and therapeutic compositions comprising them
PCT/US1995/000549 WO1995021197A1 (en) 1994-02-04 1995-01-25 Il-3 variant hematopoiesis fusion protein

Publications (2)

Publication Number Publication Date
DE69530374D1 true DE69530374D1 (de) 2003-05-22
DE69530374T2 DE69530374T2 (de) 2003-12-18

Family

ID=22709107

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69530374T Expired - Fee Related DE69530374T2 (de) 1994-02-04 1995-01-25 Blutbildendes fusionprotein mit il-3 varianten

Country Status (13)

Country Link
US (4) US5738849A (de)
EP (2) EP1323737A3 (de)
JP (1) JPH09508524A (de)
AT (1) ATE237641T1 (de)
AU (1) AU700220B2 (de)
CA (1) CA2182483C (de)
DE (1) DE69530374T2 (de)
DK (1) DK0742796T3 (de)
ES (1) ES2197191T3 (de)
HK (1) HK1013655A1 (de)
NZ (1) NZ279624A (de)
PT (1) PT742796E (de)
WO (1) WO1995021197A1 (de)

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US6967092B1 (en) 1996-10-25 2005-11-22 Mc Kearn John P Multi-functional chimeric hematopoietic receptor agonists
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WO1998018926A1 (en) * 1996-10-25 1998-05-07 G.D. Searle & Co. Circularly permuted erythropoietin receptor agonists
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DE69824039T2 (de) 1997-12-08 2005-08-18 Lexigen Pharmaceuticals Corp., Lexington Heterodimäre fusionsproteine zur verwendung für gezielte immuntherapie und allgemeine immunerregung
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US7067110B1 (en) 1999-07-21 2006-06-27 Emd Lexigen Research Center Corp. Fc fusion proteins for enhancing the immunogenicity of protein and peptide antigens
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AU2154401A (en) 1999-11-12 2001-05-30 Merck Patent Gmbh Erythropoietin forms with improved properties
US6831158B2 (en) * 2000-01-10 2004-12-14 Maxygen Holdings Ltd. G-CSF conjugates
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US7118737B2 (en) * 2000-09-08 2006-10-10 Amylin Pharmaceuticals, Inc. Polymer-modified synthetic proteins
AU7338801A (en) * 2000-09-08 2002-03-22 Gryphon Sciences "pseudo"-native chemical ligation
RU2003129528A (ru) * 2001-03-07 2005-04-10 Мерк Патент ГмбХ (DE) Способ экспрессии белков, содержащих в качестве компонента гибридный изотип антитела
US6992174B2 (en) 2001-03-30 2006-01-31 Emd Lexigen Research Center Corp. Reducing the immunogenicity of fusion proteins
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HU229098B1 (hu) * 2001-12-04 2013-07-29 Merck Patent Gmbh Megváltoztatott szelektivitású immuncitokinek
US7332158B2 (en) * 2002-05-29 2008-02-19 Demao Yang Compositions and treatments for myelosuppression by ex vivo activated immune cells
US7048922B2 (en) * 2002-05-29 2006-05-23 Demao Yang Stimulation of hematopoiesis by ex vivo activated immune cells
ATE471946T1 (de) * 2002-12-17 2010-07-15 Merck Patent Gmbh Humanisierter antikörper (h14.18) des maus antikörpers 14.18, der gd2 bindet und seine fusion mit il-2
WO2005066348A2 (en) * 2004-01-05 2005-07-21 Emd Lexigen Research Center Corp. Interleukin-12 targeted to oncofoetal fibronectin
CN1993460A (zh) * 2004-07-12 2007-07-04 索林集团意大利有限公司 用于培养人细胞的装置和方法
US7597884B2 (en) 2004-08-09 2009-10-06 Alios Biopharma, Inc. Hyperglycosylated polypeptide variants and methods of use
CA2607844C (en) 2005-06-01 2012-07-10 Maxygen Holdings Ltd. Pegylated g-csf polypeptides and methods of producing same
KR101435420B1 (ko) * 2005-08-02 2014-09-25 플래닛 바이오테크놀로지, 인코포레이티드 개선된 키메라 독소 수용체 단백질 및 탄저병의 예방 및치료를 위한 키메라 독소 수용체 단백질
SI1966238T1 (sl) * 2005-12-30 2012-08-31 Merck Patent Gmbh Variante interlevkina-12P40 z izboljšano stabilnostjo
WO2008036374A2 (en) * 2006-09-21 2008-03-27 Medistem Laboratories, Inc. Allogeneic stem cell transplants in non-conditioned recipients
EP2522728A1 (de) * 2007-09-21 2012-11-14 Cadila Healthcare Limited Zur hohen Expression von Peptiden geeignete GCSF-Fusionsproteinsysteme
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Also Published As

Publication number Publication date
DE69530374T2 (de) 2003-12-18
JPH09508524A (ja) 1997-09-02
US5738849A (en) 1998-04-14
CA2182483A1 (en) 1995-08-10
ATE237641T1 (de) 2003-05-15
EP0742796B1 (de) 2003-04-16
NZ279624A (en) 1998-05-27
US6132991A (en) 2000-10-17
EP1323737A3 (de) 2003-10-15
US6074639A (en) 2000-06-13
PT742796E (pt) 2003-08-29
US5858347A (en) 1999-01-12
AU700220B2 (en) 1998-12-24
HK1013655A1 (en) 1999-09-03
AU1680595A (en) 1995-08-21
ES2197191T3 (es) 2004-01-01
EP1323737A2 (de) 2003-07-02
DK0742796T3 (da) 2003-08-11
EP0742796A1 (de) 1996-11-20
CA2182483C (en) 2002-04-02
WO1995021197A1 (en) 1995-08-10

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