DE69530389D1 - Dexanabinol-derivate und ihre verwendung als neuroprotektive pharmazeutische zusammensetzungen - Google Patents
Dexanabinol-derivate und ihre verwendung als neuroprotektive pharmazeutische zusammensetzungenInfo
- Publication number
- DE69530389D1 DE69530389D1 DE69530389T DE69530389T DE69530389D1 DE 69530389 D1 DE69530389 D1 DE 69530389D1 DE 69530389 T DE69530389 T DE 69530389T DE 69530389 T DE69530389 T DE 69530389T DE 69530389 D1 DE69530389 D1 DE 69530389D1
- Authority
- DE
- Germany
- Prior art keywords
- pharmaceutical compositions
- compositions
- neuroprotective pharmaceutical
- effective
- dexanabinol derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/192,886 US5521215A (en) | 1989-11-07 | 1994-02-07 | NMDA-blocking pharmaceuticals |
US192886 | 1994-02-07 | ||
PCT/US1995/001470 WO1995020958A1 (en) | 1994-02-07 | 1995-02-06 | Dexanabinol derivatives and their use as neuroprotective pharmaceutical compositions |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69530389D1 true DE69530389D1 (de) | 2003-05-22 |
DE69530389T2 DE69530389T2 (de) | 2004-03-25 |
Family
ID=22711431
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69530389T Expired - Fee Related DE69530389T2 (de) | 1994-02-07 | 1995-02-06 | Dexanabinol-derivate und ihre verwendung als neuroprotektive pharmazeutische zusammensetzungen |
Country Status (10)
Country | Link |
---|---|
US (1) | US5521215A (de) |
EP (1) | EP0765160B1 (de) |
JP (1) | JPH09511493A (de) |
AT (1) | ATE237324T1 (de) |
AU (1) | AU690221B2 (de) |
CA (1) | CA2183466A1 (de) |
DE (1) | DE69530389T2 (de) |
IL (1) | IL112572A0 (de) |
SG (1) | SG49625A1 (de) |
WO (1) | WO1995020958A1 (de) |
Families Citing this family (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5455279A (en) * | 1991-04-19 | 1995-10-03 | The Children's Medical Center Corporation | Regimen method of mediating neuronal damage using nitroglycerine |
US6299895B1 (en) | 1997-03-24 | 2001-10-09 | Neurotech S.A. | Device and method for treating ophthalmic diseases |
US5904144A (en) * | 1996-03-22 | 1999-05-18 | Cytotherapeutics, Inc. | Method for treating ophthalmic diseases |
US6017903A (en) | 1996-09-27 | 2000-01-25 | Guilford Pharmaceuticals Inc. | Pharmaceutical compositions and methods of treating a glutamate abnormality and effecting a neuronal activity in an animal using NAALADase inhibitors |
US5824662A (en) * | 1996-09-27 | 1998-10-20 | Guilford Pharmaceuticals Inc. | Treatment of global and focal ischemia using naaladase inhibitors |
IL128718A0 (en) | 1996-09-27 | 2000-01-31 | Guildford Pharmaceuticals Inc | Naaldase compositions |
DE19706903A1 (de) * | 1997-02-21 | 1998-08-27 | Bayer Ag | Verwendung von bekannten Agonisten des zentralen Cannabinoid-Rezeptors CB 1 |
JP2002501510A (ja) * | 1997-05-07 | 2002-01-15 | ユニメッド・ファーマシューティカルズ・インコーポレーテッド | ヒトにおける攪乱行動を改善し気分を高揚させる方法 |
AU727080B2 (en) * | 1997-06-30 | 2000-11-30 | Allergan, Inc. | Calcium blockers to treat proliferative vitreoretinopathy |
US20050009884A1 (en) * | 1997-06-30 | 2005-01-13 | Dreyer Evan B. | Calcium blockers to treat proliferative retinal diseases |
US6110139A (en) * | 1997-10-21 | 2000-08-29 | Loubser; Paul Gerhard | Retrograde perfusion monitoring and control system |
AU9797598A (en) * | 1997-11-14 | 1999-06-07 | Alcon Laboratories, Inc. | Treatment of diabetic retinopathy |
GB9807639D0 (en) | 1998-04-14 | 1998-06-10 | Kennedy Rheumatology Inst | Anti-inflammatory agents |
US6630507B1 (en) | 1998-04-21 | 2003-10-07 | The United States Of America As Represented By The Department Of Health And Human Services | Cannabinoids as antioxidants and neuroprotectants |
CA2340445A1 (en) * | 1998-05-04 | 1999-11-11 | The University Of Connecticut | Novel analgesic and immunomodulatory cannabinoids |
US7589220B2 (en) * | 1998-06-09 | 2009-09-15 | University Of Connecticut | Inhibitors of the anandamide transporter |
US7897598B2 (en) * | 1998-06-09 | 2011-03-01 | Alexandros Makriyannis | Inhibitors of the anandamide transporter |
US7161016B1 (en) | 1998-11-24 | 2007-01-09 | University Of Connecticut | Cannabimimetic lipid amides as useful medications |
US7276613B1 (en) | 1998-11-24 | 2007-10-02 | University Of Connecticut | Retro-anandamides, high affinity and stability cannabinoid receptor ligands |
US6900236B1 (en) | 1999-10-18 | 2005-05-31 | University Of Connecticut | Cannabimimetic indole derivatives |
US7741365B2 (en) * | 1999-10-18 | 2010-06-22 | University Of Connecticut | Peripheral cannabinoid receptor (CB2) selective ligands |
US7393842B2 (en) * | 2001-08-31 | 2008-07-01 | University Of Connecticut | Pyrazole analogs acting on cannabinoid receptors |
US7119108B1 (en) * | 1999-10-18 | 2006-10-10 | University Of Connecticut | Pyrazole derivatives as cannabinoid receptor antagonists |
EP1223808B1 (de) | 1999-10-18 | 2007-03-07 | The University Of Connecticut | Für periphäre cannabinoid-rezeptoren selektive liganden |
US6943266B1 (en) * | 1999-10-18 | 2005-09-13 | University Of Connecticut | Bicyclic cannabinoid agonists for the cannabinoid receptor |
US8084467B2 (en) * | 1999-10-18 | 2011-12-27 | University Of Connecticut | Pyrazole derivatives as cannabinoid receptor antagonists |
US7235584B2 (en) * | 2000-06-22 | 2007-06-26 | Pharmos Corporation | Non-psychotropic cannabinoids |
HUP0301628A3 (en) * | 2000-06-22 | 2007-05-29 | Pharmos Corp | Novel non-psychotropic cannabinoids |
EP1785417A3 (de) * | 2000-06-22 | 2007-08-01 | Pharmos Corporation | Neuartige nicht-psychotrope Cannabinoide |
US8449908B2 (en) * | 2000-12-22 | 2013-05-28 | Alltranz, Llc | Transdermal delivery of cannabidiol |
CA2435409A1 (en) * | 2001-01-26 | 2002-08-01 | University Of Connecticut | Novel cannabimimetic ligands |
CA2436133A1 (en) | 2001-01-29 | 2002-08-08 | University Of Connecticut | Receptor selective cannabimimetic aminoalkylindoles |
DE60234246D1 (de) * | 2001-04-06 | 2009-12-17 | Univ Illinois | Cannabinoiden zur behandlung von während des schlafens auftretenden atmungsstörungen |
AU2002320430A1 (en) * | 2001-07-13 | 2003-01-29 | University Of Connecticut | Novel bicyclic and tricyclic cannabinoids |
EP1448557A4 (de) * | 2001-10-26 | 2005-02-02 | Univ Connecticut | Heteroindane: eine neue klasse hochwirksamer cannabimimetischer liganden |
US7029918B2 (en) * | 2002-01-25 | 2006-04-18 | Roche Diagnostics Operations, Inc. | Water-soluble derivatives of lipophilic drugs |
EP1545502A4 (de) | 2002-08-23 | 2008-12-24 | Univ Connecticut | Keto-cannabinoide mit therapeutischen indikationen |
JP2006502159A (ja) * | 2002-09-05 | 2006-01-19 | ファーモス コーポレイション | 認知障害を予防するための向精神性のないカンナビノイド |
US20050192341A1 (en) * | 2002-09-05 | 2005-09-01 | Seth Kindler | Non-psychotropic cannabinoids for prevention of cognitive impairment |
WO2004050011A2 (en) * | 2002-12-04 | 2004-06-17 | Pharmos Corporation | High enantiomeric purity dexanabinol for pharmaceutical copositions |
US8338648B2 (en) * | 2004-06-12 | 2012-12-25 | Signum Biosciences, Inc. | Topical compositions and methods for epithelial-related conditions |
WO2007041167A2 (en) * | 2005-09-29 | 2007-04-12 | Amr Technology, Inc. | Process for production of delta-9-tetrahydrocannabinol |
US8293786B2 (en) * | 2007-07-30 | 2012-10-23 | Alltranz Inc. | Prodrugs of cannabidiol, compositions comprising prodrugs of cannabidiol and methods of using the same |
US20090247619A1 (en) * | 2008-03-06 | 2009-10-01 | University Of Kentucky | Cannabinoid-Containing Compositions and Methods for Their Use |
MA40498A (fr) * | 2014-09-02 | 2021-05-19 | Texas A & M Univ Sys | Méthode de traitement de l'intoxication par organophosphates |
US9585867B2 (en) | 2015-08-06 | 2017-03-07 | Charles Everett Ankner | Cannabinod formulation for the sedation of a human or animal |
CA3070156A1 (en) | 2017-07-20 | 2019-01-24 | Yissum Research Development Company Of The Hebrew University Of Jerusam Ltd. | Pharmaceutical film compositions for delivery of lipophilic compounds into and/or across the skin |
EP3681474A1 (de) | 2017-09-11 | 2020-07-22 | Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. | Zusammensetzungen und verfahren zur nasalen verabreichung von medikamenten an das gehirn und zur systemischen wirkung |
CA3116187A1 (en) | 2017-11-29 | 2019-06-06 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Cannabinoids compositions and methods |
CA3116194A1 (en) | 2018-11-04 | 2020-05-07 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Orally administrable cannabinoids-containing compositions and methods |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1464695A (en) * | 1974-06-24 | 1977-02-16 | Smithkline Corp | Dibenzo-b,c-pyrans and pharmaceutical compositions thereof |
IL48824A (en) * | 1976-01-12 | 1980-05-30 | Yissum Res Dev Co | Pharmaceutical compositions containing (3s,js) tetrahydrocanabinol derivatives and some novel compounds of this type |
US4133819A (en) * | 1977-06-17 | 1979-01-09 | Pfizer Inc. | Hexahydro-1-hydroxy-9-hydroxymethyl-3-substituted-6H-dibenzo[b,d]pyrans as analgesic agents |
US4209520A (en) * | 1977-06-17 | 1980-06-24 | Pfizer Inc. | Hexahydro-1-hydroxy-9-hydroxymethyl-3-substituted-6H-dibenzo[b,d]pyrans as analgesic agents |
IL80411A (en) * | 1986-10-24 | 1991-08-16 | Raphael Mechoulam | Preparation of dibenzopyranol derivatives and pharmaceutical compositions containing them |
-
1994
- 1994-02-07 US US08/192,886 patent/US5521215A/en not_active Expired - Lifetime
-
1995
- 1995-02-06 WO PCT/US1995/001470 patent/WO1995020958A1/en active IP Right Grant
- 1995-02-06 EP EP95909482A patent/EP0765160B1/de not_active Expired - Lifetime
- 1995-02-06 SG SG1996001470A patent/SG49625A1/en unknown
- 1995-02-06 AU AU17433/95A patent/AU690221B2/en not_active Ceased
- 1995-02-06 DE DE69530389T patent/DE69530389T2/de not_active Expired - Fee Related
- 1995-02-06 JP JP7520787A patent/JPH09511493A/ja active Pending
- 1995-02-06 CA CA002183466A patent/CA2183466A1/en not_active Abandoned
- 1995-02-06 AT AT95909482T patent/ATE237324T1/de not_active IP Right Cessation
- 1995-02-07 IL IL11257295A patent/IL112572A0/xx active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
ATE237324T1 (de) | 2003-05-15 |
AU690221B2 (en) | 1998-04-23 |
IL112572A0 (en) | 1995-05-26 |
DE69530389T2 (de) | 2004-03-25 |
EP0765160A4 (de) | 1997-04-09 |
US5521215A (en) | 1996-05-28 |
CA2183466A1 (en) | 1995-08-10 |
AU1743395A (en) | 1995-08-21 |
EP0765160A1 (de) | 1997-04-02 |
WO1995020958A1 (en) | 1995-08-10 |
JPH09511493A (ja) | 1997-11-18 |
EP0765160B1 (de) | 2003-04-16 |
SG49625A1 (en) | 1998-06-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |