DE69530676D1 - Gleichzeitige Verabreichung von Interleukin 3 Mutantpolypeptiden mit CSF Faktoren für die hematopoietische Multi-Zelllinien Herstellung - Google Patents

Gleichzeitige Verabreichung von Interleukin 3 Mutantpolypeptiden mit CSF Faktoren für die hematopoietische Multi-Zelllinien Herstellung

Info

Publication number
DE69530676D1
DE69530676D1 DE69530676T DE69530676T DE69530676D1 DE 69530676 D1 DE69530676 D1 DE 69530676D1 DE 69530676 T DE69530676 T DE 69530676T DE 69530676 T DE69530676 T DE 69530676T DE 69530676 D1 DE69530676 D1 DE 69530676D1
Authority
DE
Germany
Prior art keywords
interleukin
cell line
simultaneous administration
line production
mutant polypeptides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69530676T
Other languages
English (en)
Other versions
DE69530676T2 (de
Inventor
Christopher S Bauer
Allen Abrams
Ruth Braford-Goldberg
Helena Caparon
Michael Easton
Kure Klein
Patrick Mckearn
O Olins
Kumnan Paik
Warren Thomas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GD Searle LLC filed Critical GD Searle LLC
Publication of DE69530676D1 publication Critical patent/DE69530676D1/de
Application granted granted Critical
Publication of DE69530676T2 publication Critical patent/DE69530676T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5403—IL-3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1816—Erythropoietin [EPO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/193—Colony stimulating factors [CSF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
DE69530676T 1994-02-04 1995-02-02 Gleichzeitige Verabreichung von Interleukin 3 Mutantpolypeptiden mit CSF Faktoren für die hematopoietische Multi-Zelllinien Herstellung Expired - Fee Related DE69530676T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/193,373 US6153183A (en) 1992-11-24 1994-02-04 Co-administration of interleukin-3 mutant polypeptides with CSF's or cytokines for multi-lineage hematopoietic cell production
PCT/US1995/001184 WO1995020977A1 (en) 1994-02-04 1995-02-02 Co-administration of interleukin-3 mutant polypeptides with csf's for multi-lineage hematopoietic cell production
US193373 1998-11-17

Publications (2)

Publication Number Publication Date
DE69530676D1 true DE69530676D1 (de) 2003-06-12
DE69530676T2 DE69530676T2 (de) 2004-03-18

Family

ID=22713377

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69530676T Expired - Fee Related DE69530676T2 (de) 1994-02-04 1995-02-02 Gleichzeitige Verabreichung von Interleukin 3 Mutantpolypeptiden mit CSF Faktoren für die hematopoietische Multi-Zelllinien Herstellung

Country Status (10)

Country Link
US (4) US6153183A (de)
EP (1) EP0742720B1 (de)
AT (1) ATE239496T1 (de)
AU (1) AU1909995A (de)
CA (1) CA2182474A1 (de)
DE (1) DE69530676T2 (de)
DK (1) DK0742720T3 (de)
ES (1) ES2199242T3 (de)
PT (1) PT742720E (de)
WO (1) WO1995020977A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5581476A (en) * 1993-01-28 1996-12-03 Amgen Inc. Computer-based methods and articles of manufacture for preparing G-CSF analogs
WO1999041382A2 (en) * 1998-02-17 1999-08-19 Hyseq, Inc. A novel interleukin-3 and uses thereof
US6831158B2 (en) * 2000-01-10 2004-12-14 Maxygen Holdings Ltd. G-CSF conjugates
US6646110B2 (en) * 2000-01-10 2003-11-11 Maxygen Holdings Ltd. G-CSF polypeptides and conjugates
AU2002325819B2 (en) * 2001-07-11 2008-06-19 Maxygen, Inc. G-CSF Conjugates
US20050054054A1 (en) * 2002-11-12 2005-03-10 Foss Francine M. Interleukin-7 molecules with altered biological properties
EP1773981A1 (de) * 2004-07-12 2007-04-18 Sorin Group Italia S.R.L. Vorrichtung und verfahren zur anzucht menschlicher zellen
BRPI0611221A2 (pt) 2005-06-01 2010-08-24 Maxygen Holdings Ltd polipeptÍdeos de g-csf peguilados e mÉtodos de produÇço dos mesmos
US8226162B2 (en) * 2009-09-11 2012-07-24 Campbell Corey A Child safety seat

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4438032A (en) * 1981-01-30 1984-03-20 The Regents Of The University Of California Unique T-lymphocyte line and products derived therefrom
WO1986000639A1 (en) * 1984-07-06 1986-01-30 Sandoz Ag Lymphokine production and purification
AU588819B2 (en) * 1984-10-29 1989-09-28 Immunex Corporation Cloning of human granulocyte-macrophage colony stimulating factor gene
US4810643A (en) * 1985-08-23 1989-03-07 Kirin- Amgen Inc. Production of pluripotent granulocyte colony-stimulating factor
JPS63500636A (ja) * 1985-08-23 1988-03-10 麒麟麦酒株式会社 多分化能性顆粒球コロニー刺激因子をコードするｄｎａ
US4935233A (en) * 1985-12-02 1990-06-19 G. D. Searle And Company Covalently linked polypeptide cell modulators
GR871029B (en) 1986-07-14 1987-11-02 Genetics Inst Novel osteoinductive factors
US4959455A (en) * 1986-07-14 1990-09-25 Genetics Institute, Inc. Primate hematopoietic growth factors IL-3 and pharmaceutical compositions
US4877729A (en) * 1986-07-14 1989-10-31 Genetics Institute, Inc. Recombinant DNA encoding novel family of primate hematopoietic growth factors
US5032395A (en) * 1986-07-14 1991-07-16 Genetics Institute, Inc. Method of inducing leukocytosis with a combination of IL-3 and GM-CSF
EP0275598B1 (de) * 1986-12-16 1998-01-07 Gist-Brocades N.V. Molekulare Klonierung und Expression von menschlichem IL-3
JPH02501925A (ja) * 1987-01-20 1990-06-28 イミュネックス・コーポレーション ヒト　インターロイキン‐３　蛋白質
EP0345249A1 (de) * 1987-02-12 1989-12-13 Peter Herbrig Badeplattform für boote
OA09736A (en) * 1987-02-18 1993-11-30 Schering Biotech Corp "Human interleukin-3 and muteins thereof".
WO1990001039A1 (en) * 1988-07-20 1990-02-08 Immunex Corporation Nonglycosylated human interleukin-3 compositions
US5218092A (en) * 1988-09-29 1993-06-08 Kyowa Hakko Kogyo Co., Ltd. Modified granulocyte-colony stimulating factor polypeptide with added carbohydrate chains
AU5355790A (en) * 1989-04-19 1990-11-16 Cetus Corporation Multifunctional m-csf proteins and genes encoding therefor
US5166322A (en) * 1989-04-21 1992-11-24 Genetics Institute Cysteine added variants of interleukin-3 and chemical modifications thereof
US5128450A (en) 1989-06-30 1992-07-07 Urdal David L Nonglycosylated human interleukin-3 analog proteins
DK0413383T3 (da) * 1989-08-14 1997-07-07 Gist Brocades Nv Mutanter af humant interleukin-3.
US5516512A (en) * 1989-08-14 1996-05-14 Gist-Brocades, N.V. N- and C-terminal truncation and deletion mutants of human interleukin-3
IL96477A0 (en) * 1989-12-01 1991-08-16 Amgen Inc Megakaryocyte production
JPH0463595A (ja) * 1990-04-03 1992-02-28 Kirin Brewery Co Ltd ヒトインターロイキン３誘導体
JPH05502463A (ja) 1990-09-28 1993-04-28 オーソ・フアーマシユーチカル・コーポレーシヨン ハイブリツド成長因子
US5199942A (en) * 1991-06-07 1993-04-06 Immunex Corporation Method for improving autologous transplantation
AU668364B2 (en) * 1991-10-07 1996-05-02 Medvet Science Pty. Ltd. Human IL-3 variants
CA2150117A1 (en) * 1992-11-24 1994-06-09 S. Christopher Bauer Interleukin-3 (il-3) mutant polypeptides
US5772992A (en) * 1992-11-24 1998-06-30 G.D. Searle & Co. Compositions for co-administration of interleukin-3 mutants and other cytokines and hematopoietic factors
US5501962A (en) * 1993-06-21 1996-03-26 G. D. Searle & Co. Interleuken-3 (IL-3) human/murine hybrid polypeptides and recombinant production of the same

Also Published As

Publication number Publication date
ES2199242T3 (es) 2004-02-16
PT742720E (pt) 2003-09-30
WO1995020977A1 (en) 1995-08-10
EP0742720B1 (de) 2003-05-07
US6153183A (en) 2000-11-28
ATE239496T1 (de) 2003-05-15
US6093395A (en) 2000-07-25
DK0742720T3 (da) 2003-08-25
AU1909995A (en) 1995-08-21
EP0742720A1 (de) 1996-11-20
DE69530676T2 (de) 2004-03-18
US6060047A (en) 2000-05-09
CA2182474A1 (en) 1995-08-10
US6379662B1 (en) 2002-04-30

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee