DE69535645D1 - Gerät zur Abgabe einer festen Medikamentenzusammensetzung - Google Patents

Gerät zur Abgabe einer festen Medikamentenzusammensetzung

Info

Publication number
DE69535645D1
DE69535645D1 DE69535645T DE69535645T DE69535645D1 DE 69535645 D1 DE69535645 D1 DE 69535645D1 DE 69535645 T DE69535645 T DE 69535645T DE 69535645 T DE69535645 T DE 69535645T DE 69535645 D1 DE69535645 D1 DE 69535645D1
Authority
DE
Germany
Prior art keywords
solid drug
dispensing
microplunger
drug composition
needle
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69535645T
Other languages
English (en)
Other versions
DE69535645T2 (de
Inventor
Roland Cherif-Cheikh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ipsen Pharma SAS
Original Assignee
Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS filed Critical Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS
Publication of DE69535645D1 publication Critical patent/DE69535645D1/de
Application granted granted Critical
Publication of DE69535645T2 publication Critical patent/DE69535645T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08Peptides having 5 to 11 amino acids
    • A61K38/09Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/25Growth hormone-releasing factor [GH-RF] (Somatoliberin)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/28Insulins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/31Somatostatins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2013Organic compounds, e.g. phospholipids, fats
    • A61K9/2018Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0069Devices for implanting pellets, e.g. markers or solid medicaments
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M5/14244Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14248Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M5/145Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00Anaesthetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/02Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14Details; Accessories therefor
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006Piercing means
    • A61J1/201Piercing means having one piercing end
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M5/14244Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M2005/14268Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body with a reusable and a disposable component
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/315Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31525Dosing
    • A61M5/31531Microsyringes, e.g. having piston bore diameter close or equal to needle shaft diameter
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/315Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31566Means improving security or handling thereof
    • A61M5/31573Accuracy improving means
    • A61M5/31575Accuracy improving means using scaling up or down transmissions, e.g. gearbox
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/315Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/3159Dose expelling manners
    • A61M5/31593Multi-dose, i.e. individually set dose repeatedly administered from the same medicament reservoir
    • A61M5/31595Pre-defined multi-dose administration by repeated overcoming of means blocking the free advancing movement of piston rod, e.g. by tearing or de-blocking
DE1995635645 1994-09-02 1995-08-31 Gerät zur Abgabe einer festen Medikamentenzusammensetzung Expired - Lifetime DE69535645T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US08/300,713 US5582591A (en) 1994-09-02 1994-09-02 Delivery of solid drug compositions
US300713 1994-09-02
US31746594A 1994-10-04 1994-10-04
US317465 1994-10-04

Publications (2)

Publication Number Publication Date
DE69535645D1 true DE69535645D1 (de) 2007-12-27
DE69535645T2 DE69535645T2 (de) 2008-10-30

Family

ID=26971933

Family Applications (3)

Application Number Title Priority Date Filing Date
DE1995633709 Expired - Lifetime DE69533709T2 (de) 1994-09-02 1995-08-31 Gerät zur parenteralen Abgabe fester Wirkstoffzusammensetzungen
DE1995629415 Expired - Lifetime DE69529415T2 (de) 1994-09-02 1995-08-31 Verabreichung von festen arzneizubereitungen
DE1995635645 Expired - Lifetime DE69535645T2 (de) 1994-09-02 1995-08-31 Gerät zur Abgabe einer festen Medikamentenzusammensetzung

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DE1995633709 Expired - Lifetime DE69533709T2 (de) 1994-09-02 1995-08-31 Gerät zur parenteralen Abgabe fester Wirkstoffzusammensetzungen
DE1995629415 Expired - Lifetime DE69529415T2 (de) 1994-09-02 1995-08-31 Verabreichung von festen arzneizubereitungen

Country Status (16)

Country Link
US (2) US5582591A (de)
EP (3) EP1270032B1 (de)
JP (1) JP4072867B2 (de)
KR (1) KR100491424B1 (de)
CN (1) CN1212830C (de)
AT (3) ATE280599T1 (de)
AU (1) AU712916B2 (de)
BR (1) BR9508688A (de)
CA (1) CA2198916C (de)
DE (3) DE69533709T2 (de)
DK (2) DK0778767T3 (de)
ES (3) ES2295745T3 (de)
HK (1) HK1067870A1 (de)
PT (2) PT1270032E (de)
WO (1) WO1996007397A2 (de)
ZA (1) ZA957356B (de)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5837276A (en) * 1994-09-02 1998-11-17 Delab Apparatus for the delivery of elongate solid drug compositions
US5980945A (en) * 1996-01-16 1999-11-09 Societe De Conseils De Recherches Et D'applications Scientifique S.A. Sustained release drug formulations
JP2000511161A (ja) 1996-05-24 2000-08-29 アンジオテック ファーマシュウティカルズ,インコーポレイテッド 身体通路の疾患を処置または予防するための組成物および方法
FR2756493B1 (fr) 1996-12-02 2001-04-13 Delab Dispositif d'administration locale de formulations solides ou semi-solides
US5968895A (en) * 1996-12-11 1999-10-19 Praecis Pharmaceuticals, Inc. Pharmaceutical formulations for sustained drug delivery
SE9700423D0 (sv) * 1997-02-07 1997-02-07 Astra Ab Disposable inhaler
FR2783433B1 (fr) * 1998-09-18 2001-02-16 Delab Seringues pour l'administration de formulations pateuses ou semi-solides
GB2345010B (en) * 1998-12-17 2002-12-31 Electrosols Ltd A delivery device
ATE244558T1 (de) 1999-04-16 2003-07-15 Novo Nordisk As Trockene formbare arzneistoffformulierung
US20020156453A1 (en) * 1999-10-14 2002-10-24 Pettis Ronald J. Method and device for reducing therapeutic dosage
US8465468B1 (en) 2000-06-29 2013-06-18 Becton, Dickinson And Company Intradermal delivery of substances
US20020095134A1 (en) * 1999-10-14 2002-07-18 Pettis Ronald J. Method for altering drug pharmacokinetics based on medical delivery platform
AU783685B2 (en) * 1999-12-23 2005-11-24 Pfizer Products Inc. Hydrogel-driven drug dosage form
US20010041869A1 (en) * 2000-03-23 2001-11-15 Causey James D. Control tabs for infusion devices and methods of using the same
US20040175360A1 (en) * 2000-06-29 2004-09-09 Pettis Ronald J. Method for altering drug pharmacokinetics based on medical delivery platform
US20050008683A1 (en) * 2000-06-29 2005-01-13 Becton Dickinson And Company Method for delivering interferons to the intradermal compartment
DE60127139T2 (de) * 2000-07-14 2007-12-13 Novo Nordisk A/S Verfahren zum formen einer pharmazeutischen zusammensetzung in einem verpackungsmaterial
BR0116972A (pt) * 2001-04-13 2004-12-21 Becton Dickinson Co Métodos e dispositivos para administração de substâncias na camada intradérmica da pele para absorção sistêmica
US20050010193A1 (en) * 2002-05-06 2005-01-13 Laurent Philippe E. Novel methods for administration of drugs and devices useful thereof
US20030073609A1 (en) * 2001-06-29 2003-04-17 Pinkerton Thomas C. Enhanced pharmacokinetic profile of intradermally delivered substances
MXPA03011611A (es) 2001-06-29 2004-07-01 Becton Dickinson Co Administracion intradermica de vacunas y agentes terapeuticos genicos a traves de microcanula.
US20040120964A1 (en) * 2001-10-29 2004-06-24 Mikszta John A. Needleless vaccination using chimeric yellow fever vaccine-vectored vaccines against heterologous flaviviruses
US8454997B2 (en) 2001-12-18 2013-06-04 Novo Nordisk A/S Solid dose micro implant
US20060264886A9 (en) * 2002-05-06 2006-11-23 Pettis Ronald J Method for altering insulin pharmacokinetics
JP4764626B2 (ja) 2002-05-06 2011-09-07 ベクトン・ディキンソン・アンド・カンパニー 薬剤の薬物動力学を制御する方法およびデバイス
US20090035260A1 (en) * 2002-07-29 2009-02-05 Therapicon Srl Enhanced nasal composition of active peptide
JP2005537054A (ja) * 2002-08-30 2005-12-08 ベクトン・ディキンソン・アンド・カンパニー 免疫調節化合物の薬物動態を制御する方法
US7637891B2 (en) * 2002-09-12 2009-12-29 Children's Hospital Medical Center Method and device for painless injection of medication
US9376479B2 (en) 2002-12-31 2016-06-28 Anjinomoto Althea, Inc. Human growth hormone crystals and methods for preparing them
ES2737835T3 (es) 2003-04-23 2020-01-16 Valeritas Inc Bomba accionada hidráulicamente para la administración de medicamentos de larga duración
US20050163711A1 (en) * 2003-06-13 2005-07-28 Becton, Dickinson And Company, Inc. Intra-dermal delivery of biologically active agents
MXPA06002159A (es) * 2003-08-26 2006-05-22 Becton Dickinson Co Metodos para la administracion intradermica de agentes terapeuticos.
IL157981A (en) 2003-09-17 2014-01-30 Elcam Medical Agricultural Cooperative Ass Ltd Auto injector
ITMI20040235A1 (it) * 2004-02-13 2004-05-13 Therapicon Srl Preparazione farmaceutica per il cavo orale
US7896841B2 (en) * 2004-02-17 2011-03-01 Children's Hospital Medical Center Injection device for administering a vaccine
US20050256499A1 (en) * 2004-03-03 2005-11-17 Pettis Ronald J Methods and devices for improving delivery of a substance to skin
IL160891A0 (en) 2004-03-16 2004-08-31 Auto-mix needle
WO2005115360A2 (en) * 2004-05-11 2005-12-08 Becton, Dickinson And Company Formulations of anti-pain agents and methods of using the same
WO2006014425A1 (en) 2004-07-02 2006-02-09 Biovalve Technologies, Inc. Methods and devices for delivering glp-1 and uses thereof
KR20070100820A (ko) * 2005-01-31 2007-10-11 가부시키가이샤 바이오세렌택 경피 흡수 제제, 경피 흡수 제제 유지 시트 및 경피 흡수제제 유지 용구
EP1704883B1 (de) * 2005-03-24 2008-11-12 Disetronic Licensing AG Vorrichtung für die dosierte Verabreichung eines fluiden Produkts
EP1704884B1 (de) * 2005-03-24 2008-11-12 Disetronic Licensing AG Vorrichtung für die dosierte Verabreichung eines fluiden Produkts
EP1704885A1 (de) * 2005-03-24 2006-09-27 Disetronic Licensing AG Vorrichtung für die dosierte Verabreichung eines fluiden Produkts
EP1704886B1 (de) * 2005-03-24 2008-02-06 Disetronic Licensing AG Vorrichtung für die dosierte Verabreichung eines fluiden Produkts
US8545445B2 (en) * 2006-02-09 2013-10-01 Deka Products Limited Partnership Patch-sized fluid delivery systems and methods
WO2007075839A2 (en) * 2005-12-19 2007-07-05 Diobex, Inc. Glucagon injector for emergency treatment of hypoglycemia
WO2007104755A1 (en) 2006-03-13 2007-09-20 Novo Nordisk A/S Secure pairing of electronic devices using dual means of communication
CA2646324C (en) 2006-03-30 2016-06-07 Valeritas, Llc Multi-cartridge fluid delivery device
US9399094B2 (en) 2006-06-06 2016-07-26 Novo Nordisk A/S Assembly comprising skin-mountable device and packaging therefore
US8668676B2 (en) * 2006-06-19 2014-03-11 Allergan, Inc. Apparatus and methods for implanting particulate ocular implants
US20100058480A1 (en) * 2006-07-13 2010-03-04 Sven-Erik Hedberg Information management in devices worn by a user
US9039761B2 (en) * 2006-08-04 2015-05-26 Allergan, Inc. Ocular implant delivery assemblies with distal caps
EP2114492A1 (de) * 2007-03-06 2009-11-11 Novo Nordisk A/S Pumpenanordnung mit betätigungssystem
US8529521B2 (en) * 2007-04-23 2013-09-10 Ultimed Inc. Low-dosage syringe
DK2200684T3 (en) 2007-08-17 2016-12-12 Medtronic Minimed Inc Injection device for making an injection in a pre-determined depth in the skin
US8986253B2 (en) 2008-01-25 2015-03-24 Tandem Diabetes Care, Inc. Two chamber pumps and related methods
US8408421B2 (en) 2008-09-16 2013-04-02 Tandem Diabetes Care, Inc. Flow regulating stopcocks and related methods
AU2009293019A1 (en) 2008-09-19 2010-03-25 Tandem Diabetes Care Inc. Solute concentration measurement device and related methods
US8545554B2 (en) 2009-01-16 2013-10-01 Allergan, Inc. Intraocular injector
US9250106B2 (en) 2009-02-27 2016-02-02 Tandem Diabetes Care, Inc. Methods and devices for determination of flow reservoir volume
WO2010099490A2 (en) 2009-02-27 2010-09-02 Tandem Diabetes Care, Inc. Methods and devices for determination of flow reservoir volume
WO2010109004A1 (en) * 2009-03-27 2010-09-30 Novo Nordisk A/S Solid dose delivery device
EP3284494A1 (de) 2009-07-30 2018-02-21 Tandem Diabetes Care, Inc. Tragbares infusionspumpensystem
WO2011046857A1 (en) * 2009-10-15 2011-04-21 Mallinckrodt Inc. Piezoelectrically-driven power injector
EP2452638A1 (de) * 2010-11-15 2012-05-16 forteq Nidau AG Vorrichtung zur Feststoffinjektion
WO2012125999A2 (en) * 2011-03-17 2012-09-20 Emory University Delivery devices and methods for delivering therapeutic agents
US9180242B2 (en) 2012-05-17 2015-11-10 Tandem Diabetes Care, Inc. Methods and devices for multiple fluid transfer
EP2968695A1 (de) * 2013-03-14 2016-01-20 Allergan, Inc. Polymersystem zum befestigen von implantaten in spritzennadeln
US9173998B2 (en) 2013-03-14 2015-11-03 Tandem Diabetes Care, Inc. System and method for detecting occlusions in an infusion pump
GB2545880A (en) * 2015-10-20 2017-07-05 Glide Pharmaceutical Tech Ltd Solid formulation
JP2020528296A (ja) * 2017-07-25 2020-09-24 アムジエン・インコーポレーテツド ギヤモジュールを有する薬物送達デバイス及び関連する組立方法
US11585042B2 (en) 2020-09-30 2023-02-21 Haier Us Appliance Solutions, Inc. Dryer appliance with additive dispenser
GB202200706D0 (en) * 2022-01-20 2022-03-09 Cambridge Univ Hospitals Nhs Foundation Trust A surgical instrument

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2513014A (en) * 1946-11-18 1950-06-27 Abbott Lab Apparatus for implanting medicinal pellets subcutaneously
US3760806A (en) * 1971-01-13 1973-09-25 Alza Corp Helical osmotic dispenser with non-planar membrane
US3995631A (en) * 1971-01-13 1976-12-07 Alza Corporation Osmotic dispenser with means for dispensing active agent responsive to osmotic gradient
US4177256A (en) * 1973-04-25 1979-12-04 Alza Corporation Osmotic bursting drug delivery device
US3995632A (en) * 1973-05-04 1976-12-07 Alza Corporation Osmotic dispenser
FR2239989A1 (en) * 1973-08-08 1975-03-07 Aries Robert Pellets for subcutaneous treatment of animals - pref. implanted from a cartridge contg. several, by means of an injection force
US4093708A (en) * 1974-12-23 1978-06-06 Alza Corporation Osmotic releasing device having a plurality of release rate patterns
US4273122A (en) * 1976-11-12 1981-06-16 Whitney Douglass G Self contained powered injection system
US4086914A (en) * 1977-02-11 1978-05-02 Edwin Bailey Moore Implant injector
US4263910A (en) * 1978-09-27 1981-04-28 Eli Lilly And Company Implantate package, system and method
US4313439A (en) * 1980-03-24 1982-02-02 Biotek, Inc. Automated, spring-powered medicament infusion system
EP0047013B1 (de) * 1980-09-02 1986-01-22 Medtronic, Inc. Subkutan implantierbare Leitung mit Mitteln zum Verabreichen eines Medikaments
US4326524A (en) * 1980-09-30 1982-04-27 Minnesota Mining And Manufacturing Company Solid dose ballistic projectile
US4327725A (en) * 1980-11-25 1982-05-04 Alza Corporation Osmotic device with hydrogel driving member
US4451253A (en) * 1980-12-18 1984-05-29 Harman Sherman M Means and method for administering medicinals
US4340054A (en) * 1980-12-29 1982-07-20 Alza Corporation Dispenser for delivering fluids and solids
US4525164A (en) * 1981-04-24 1985-06-25 Biotek, Inc. Wearable medication infusion system with arcuated reservoir
US4529401A (en) * 1982-01-11 1985-07-16 Cardiac Pacemakers, Inc. Ambulatory infusion pump having programmable parameters
DE3317536A1 (de) * 1983-05-13 1984-11-15 Siemens AG, 1000 Berlin und 8000 München Dosiervorrichtung fuer ein medikament
CA1196864A (en) * 1983-06-10 1985-11-19 Mattheus F.A. Goosen Controlled release of injectable and implantable insulin compositions
US4753636A (en) * 1983-08-02 1988-06-28 Endocon, Inc. Subcutaneous implant kit
EP0139286B1 (de) * 1983-10-14 1991-08-21 Sumitomo Pharmaceuticals Company, Limited Verlängerte Präparate mit verzögerter Abgabe
US4685903A (en) * 1984-01-06 1987-08-11 Pacesetter Infusion, Ltd. External infusion pump apparatus
US4595583A (en) * 1984-03-19 1986-06-17 Alza Corporation Delivery system controlled administration of beneficial agent to ruminants
GB8423749D0 (en) * 1984-09-19 1984-10-24 Sutherland I A Powered infusion apparatus
US4720384A (en) * 1985-05-03 1988-01-19 E. I. Du Pont De Nemours And Company Manufacture of hollow fine tubular drug delivery systems
US4655766A (en) * 1985-08-01 1987-04-07 Alza Corporation Fluid imbibing pump with self-regulating skin patch
DE3688188T2 (de) * 1985-12-27 1993-10-14 Sumitomo Pharma Verfahren zur Herstellung einer Formulierung mit verzögerter Freisetzung.
US4661103A (en) * 1986-03-03 1987-04-28 Engineering Development Associates, Ltd. Multiple implant injector
US4723958A (en) * 1986-05-23 1988-02-09 Merck & Co., Inc. Pulsatile drug delivery system
DE3789320T2 (de) * 1986-07-30 1994-06-09 Sumitomo Pharma Verabreichungsinstrument zum Einführen von festen Medikamenten.
US4693706A (en) * 1986-08-11 1987-09-15 Mark L. Anderson Two compartment mixing syringe
US4863736A (en) * 1987-03-16 1989-09-05 Monsanto Company Somatotropin prolonged release
US4994028A (en) * 1987-03-18 1991-02-19 Endocon, Inc. Injector for inplanting multiple pellet medicaments
US4950234A (en) * 1987-05-26 1990-08-21 Sumitomo Pharmaceuticals Company, Limited Device for administering solid preparations
FR2618329B1 (fr) * 1987-07-22 1997-03-28 Dow Corning Sa Procede de fabrication d'un anneau capable d'assurer la liberation d'un agent therapeutique, et anneau fabrique par ce procede
DE3802158A1 (de) * 1987-08-11 1989-02-23 Hoechst Ag Vorrichtung zur applikation von implantaten
US4936827A (en) * 1988-04-11 1990-06-26 Ivy Laboratories, Inc. Implanter applicator
US4834704A (en) * 1988-04-13 1989-05-30 Eaton Corporation Injectable infusion pump apparatus for implanting long-term dispensing module and medication in an animal and method therefor
US4976966A (en) * 1988-12-29 1990-12-11 Alza Corporation Delayed release osmotically driven fluid dispenser
US5226895A (en) * 1989-06-05 1993-07-13 Eli Lilly And Company Multiple dose injection pen
US5284479A (en) * 1989-08-30 1994-02-08 N.V. Nederlandsche Apparatenfabriek Nedap Implanter
US5086787A (en) * 1989-12-06 1992-02-11 Medtronic, Inc. Steroid eluting intramuscular lead
US5030216A (en) * 1989-12-15 1991-07-09 Alza Corporation Osmotically driven syringe
KR930001079B1 (ko) * 1990-07-18 1993-02-15 한국과학기술연구원 자가 방출 조절형 인슐린 제형
KR930008048B1 (ko) * 1991-06-05 1993-08-25 윤영우 요청신호개수에 독립적인 중재시간의 중재기
IL105553A (en) * 1992-05-06 1998-01-04 Janssen Pharmaceutica Inc Solid dosage forms consisting of a porous network of matrix that releases a substance that dissipates rapidly in water
JPH0631181A (ja) * 1992-07-06 1994-02-08 Stonehard Assoc Inc 高分散金属微粒子担持触媒の製造方法
DK42093D0 (da) * 1993-04-07 1993-04-07 Bukh Meditec Administrationsmetode
CA2183684C (en) * 1994-02-18 2008-07-15 Richard D. Hansen Inoculation of animals with dried, pelleted biological materials

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CN1165477A (zh) 1997-11-19
JP4072867B2 (ja) 2008-04-09
CA2198916A1 (en) 1996-03-14
AU712916B2 (en) 1999-11-18
DE69533709D1 (de) 2004-12-02
EP0778767A2 (de) 1997-06-18
EP1270032B1 (de) 2004-10-27
KR100491424B1 (ko) 2005-05-24
CA2198916C (en) 2008-07-22
EP0778767B1 (de) 2003-01-15
EP1498150B1 (de) 2007-11-14
AU3398195A (en) 1996-03-27
HK1067870A1 (en) 2005-04-22
WO1996007397A3 (en) 1996-08-15
JPH10508293A (ja) 1998-08-18
PT1270032E (pt) 2005-02-28
DK0778767T3 (da) 2003-04-07
PT1498150E (pt) 2008-02-19
US5616123A (en) 1997-04-01
US5582591A (en) 1996-12-10
DK1270032T3 (da) 2005-01-31
ATE280599T1 (de) 2004-11-15
EP1270032A1 (de) 2003-01-02
KR20030096434A (ko) 2003-12-31
DE69529415D1 (de) 2003-02-20
ATE378082T1 (de) 2007-11-15
ES2295745T3 (es) 2008-04-16
WO1996007397A2 (en) 1996-03-14
CN1212830C (zh) 2005-08-03
ES2230431T3 (es) 2005-05-01
ZA957356B (en) 1996-04-02
ATE230977T1 (de) 2003-02-15
DE69529415T2 (de) 2003-11-13
BR9508688A (pt) 1997-10-28
DE69533709T2 (de) 2005-10-20
DE69535645T2 (de) 2008-10-30
EP1498150A1 (de) 2005-01-19
ES2188669T3 (es) 2003-07-01

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Owner name: IPSEN PHARMA S.A.S., BOULOGNE-BILLANCOURT, FR