DE69535979D1 - Multipol-ionenleiter für massenspektrometrie - Google Patents

Multipol-ionenleiter für massenspektrometrie

Info

Publication number
DE69535979D1
DE69535979D1 DE69535979T DE69535979T DE69535979D1 DE 69535979 D1 DE69535979 D1 DE 69535979D1 DE 69535979 T DE69535979 T DE 69535979T DE 69535979 T DE69535979 T DE 69535979T DE 69535979 D1 DE69535979 D1 DE 69535979D1
Authority
DE
Germany
Prior art keywords
multipol
mass spectrometry
ion conductor
conductor
ion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69535979T
Other languages
English (en)
Inventor
Craig M Whitehouse
Erol Gulcicek
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Revvity Health Sciences Inc
Original Assignee
Analytica of Branford Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22750166&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69535979(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Analytica of Branford Inc filed Critical Analytica of Branford Inc
Application granted granted Critical
Publication of DE69535979D1 publication Critical patent/DE69535979D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D59/00—Separation of different isotopes of the same chemical element
    • B01D59/44—Separation by mass spectrography
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0468—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components with means for heating or cooling the sample
    • H01J49/0481—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components with means for heating or cooling the sample with means for collisional cooling
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/06—Electron- or ion-optical arrangements
    • H01J49/062—Ion guides
    • H01J49/063—Multipole ion guides, e.g. quadrupoles, hexapoles
DE69535979T 1994-02-28 1995-02-27 Multipol-ionenleiter für massenspektrometrie Expired - Lifetime DE69535979D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20250594A 1994-02-28 1994-02-28
PCT/US1995/002378 WO1995023018A1 (en) 1994-02-28 1995-02-27 Multipole ion guide for mass spectrometry

Publications (1)

Publication Number Publication Date
DE69535979D1 true DE69535979D1 (de) 2009-08-20

Family

ID=22750166

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69535979T Expired - Lifetime DE69535979D1 (de) 1994-02-28 1995-02-27 Multipol-ionenleiter für massenspektrometrie

Country Status (9)

Country Link
US (6) US5652427A (de)
EP (3) EP1533829A3 (de)
JP (1) JP3671354B2 (de)
AU (1) AU1932095A (de)
CA (1) CA2656956C (de)
DE (1) DE69535979D1 (de)
DK (1) DK0748249T3 (de)
ES (1) ES2331494T3 (de)
WO (1) WO1995023018A1 (de)

Families Citing this family (171)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7176455B1 (en) * 1994-02-23 2007-02-13 Analytica Of Branford, Inc. Multipole ion guide for mass spectrometry
US6897439B1 (en) * 1994-02-28 2005-05-24 Analytica Of Branford, Inc. Multipole ion guide for mass spectrometry
US8610056B2 (en) 1994-02-28 2013-12-17 Perkinelmer Health Sciences Inc. Multipole ion guide ion trap mass spectrometry with MS/MSn analysis
EP1533829A3 (de) * 1994-02-28 2006-06-07 Analytica Of Branford, Inc. Multipol-Ionenleiter für Massenspektrometrie
US5689111A (en) * 1995-08-10 1997-11-18 Analytica Of Branford, Inc. Ion storage time-of-flight mass spectrometer
US7019285B2 (en) * 1995-08-10 2006-03-28 Analytica Of Branford, Inc. Ion storage time-of-flight mass spectrometer
US6011259A (en) * 1995-08-10 2000-01-04 Analytica Of Branford, Inc. Multipole ion guide ion trap mass spectrometry with MS/MSN analysis
JP3274302B2 (ja) * 1994-11-28 2002-04-15 株式会社日立製作所 質量分析計
US6002127A (en) * 1995-05-19 1999-12-14 Perseptive Biosystems, Inc. Time-of-flight mass spectrometry analysis of biomolecules
US5625184A (en) * 1995-05-19 1997-04-29 Perseptive Biosystems, Inc. Time-of-flight mass spectrometry analysis of biomolecules
DE19520319A1 (de) * 1995-06-02 1996-12-12 Bruker Franzen Analytik Gmbh Verfahren und Vorrichtung für die Einführung von Ionen in Quadrupol-Ionenfallen
DE19520276C2 (de) * 1995-06-02 1999-08-26 Bruker Daltonik Gmbh Vorrichtung für die Einführung von Ionen in ein Massenspektrometer
GB2301704A (en) * 1995-06-02 1996-12-11 Bruker Franzen Analytik Gmbh Introducing ions into a high-vacuum chamber, e.g. of a mass spectrometer
US8847157B2 (en) 1995-08-10 2014-09-30 Perkinelmer Health Sciences, Inc. Multipole ion guide ion trap mass spectrometry with MS/MSn analysis
EP0888169A4 (de) * 1996-01-19 2006-06-14 Univ Northeastern Probenbereitstellungskammer mit variablem unterdruck für elektrosprayionisierung/masenspektrometrie sowie andere anwendungen
US5672868A (en) * 1996-02-16 1997-09-30 Varian Associates, Inc. Mass spectrometer system and method for transporting and analyzing ions
CA2253370C (en) * 1996-05-14 2006-11-07 Analytica Of Branford, Inc. Ion transfer from multipole ion guides into multipole ion guides and ion traps
GB9612070D0 (en) * 1996-06-10 1996-08-14 Micromass Ltd Plasma mass spectrometer
JPH1097838A (ja) * 1996-07-30 1998-04-14 Yokogawa Analytical Syst Kk 誘導結合プラズマ質量分析装置
US5726448A (en) * 1996-08-09 1998-03-10 California Institute Of Technology Rotating field mass and velocity analyzer
JP3648906B2 (ja) * 1997-02-14 2005-05-18 株式会社日立製作所 イオントラップ質量分析計を用いた分析装置
US6469295B1 (en) * 1997-05-30 2002-10-22 Bruker Daltonics Inc. Multiple reflection time-of-flight mass spectrometer
DE69829398T2 (de) * 1997-09-12 2006-04-13 Analytica of Branford, Inc., Branford Mehrprobeneinführungs-massenspektrometrie
JP4463978B2 (ja) 1997-12-04 2010-05-19 ユニヴァーシティー オブ マニトバ 四重極イオンガイド中でイオンを選択的に衝突誘発解離する方法および装置
US6987264B1 (en) * 1998-01-23 2006-01-17 Analytica Of Branford, Inc. Mass spectrometry with multipole ion guides
US6753523B1 (en) * 1998-01-23 2004-06-22 Analytica Of Branford, Inc. Mass spectrometry with multipole ion guides
USRE39099E1 (en) * 1998-01-23 2006-05-23 University Of Manitoba Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use
WO1999038193A1 (en) * 1998-01-23 1999-07-29 Analytica Of Branford, Inc. Mass spectrometry with multipole ion guide
US6331702B1 (en) 1999-01-25 2001-12-18 University Of Manitoba Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use
US5973322A (en) * 1998-03-14 1999-10-26 Sensar Corporation Collisional axialization of ions in a supersonic expansion for ion injection into time of flight mass spectrometers
US6069355A (en) * 1998-05-14 2000-05-30 Varian, Inc. Ion trap mass pectrometer with electrospray ionization
EP1090412B1 (de) 1998-05-29 2014-03-05 PerkinElmer Health Sciences, Inc. Massenspektrometrie mit multipolionenleitern
US6222186B1 (en) * 1998-06-25 2001-04-24 Agilent Technologies, Inc. Power-modulated inductively coupled plasma spectrometry
GB9820210D0 (en) 1998-09-16 1998-11-11 Vg Elemental Limited Means for removing unwanted ions from an ion transport system and mass spectrometer
CN1312473C (zh) 1998-09-17 2007-04-25 阿德文生物科学公司 液相色谱系统
US6245227B1 (en) 1998-09-17 2001-06-12 Kionix, Inc. Integrated monolithic microfabricated electrospray and liquid chromatography system and method
US6392225B1 (en) * 1998-09-24 2002-05-21 Thermo Finnigan Llc Method and apparatus for transferring ions from an atmospheric pressure ion source into an ion trap mass spectrometer
US6194717B1 (en) * 1999-01-28 2001-02-27 Mds Inc. Quadrupole mass analyzer and method of operation in RF only mode to reduce background signal
US6633031B1 (en) * 1999-03-02 2003-10-14 Advion Biosciences, Inc. Integrated monolithic microfabricated dispensing nozzle and liquid chromatography-electrospray system and method
US6410914B1 (en) 1999-03-05 2002-06-25 Bruker Daltonics Inc. Ionization chamber for atmospheric pressure ionization mass spectrometry
JP3137953B2 (ja) * 1999-03-30 2001-02-26 科学技術振興事業団 エレクトロスプレー質量分析方法及びその装置
CA2305071C (en) * 1999-04-12 2009-03-24 Mds Inc. High intensity ion source
DE19937439C1 (de) * 1999-08-07 2001-05-17 Bruker Daltonik Gmbh Vorrichtung zum abwechselnden Betrieb mehrerer Ionenquellen
US6911650B1 (en) * 1999-08-13 2005-06-28 Bruker Daltonics, Inc. Method and apparatus for multiple frequency multipole
US6486469B1 (en) 1999-10-29 2002-11-26 Agilent Technologies, Inc. Dielectric capillary high pass ion filter
US6528784B1 (en) 1999-12-03 2003-03-04 Thermo Finnigan Llc Mass spectrometer system including a double ion guide interface and method of operation
WO2001050499A1 (en) 1999-12-30 2001-07-12 Advion Biosciences, Inc. Multiple electrospray device, systems and methods
US6596988B2 (en) 2000-01-18 2003-07-22 Advion Biosciences, Inc. Separation media, multiple electrospray nozzle system and method
US6794644B2 (en) * 2000-02-18 2004-09-21 Melvin A. Park Method and apparatus for automating an atmospheric pressure ionization (API) source for mass spectrometry
US6787764B2 (en) 2000-02-18 2004-09-07 Bruker Daltonics, Inc. Method and apparatus for automating a matrix-assisted laser desorption/ionization (MALDI) mass spectrometer
US6753521B1 (en) * 2000-02-18 2004-06-22 Bruker Daltonics, Inc. Method and apparatus for a nanoelectrosprayer for use in mass spectrometry
AU2001243328A1 (en) * 2000-02-29 2001-09-12 The Texas A And M University System A periodic field focusing ion mobility spectrometer
US20030089847A1 (en) * 2000-03-14 2003-05-15 Roger Guevremont Tandem high field asymmetric waveform ion mobility spectrometry ( faims)/ion mobility spectrometry
US6809312B1 (en) 2000-05-12 2004-10-26 Bruker Daltonics, Inc. Ionization source chamber and ion beam delivery system for mass spectrometry
US6593570B2 (en) * 2000-05-24 2003-07-15 Agilent Technologies, Inc. Ion optic components for mass spectrometers
SE0002066D0 (sv) * 2000-05-31 2000-05-31 Amersham Pharm Biotech Ab Method and device for preforming analyses in parallel
US6417511B1 (en) 2000-07-17 2002-07-09 Agilent Technologies, Inc. Ring pole ion guide apparatus, systems and method
US6797948B1 (en) 2000-08-10 2004-09-28 Bruker Daltonics, Inc. Multipole ion guide
US6660999B2 (en) * 2000-10-11 2003-12-09 Pfizer Inc. Helium droplet mass spectrometry (HDMS)
GB2370685B (en) * 2000-11-29 2003-01-22 Micromass Ltd Mass spectrometers and methods of mass spectrometry
US6700120B2 (en) * 2000-11-30 2004-03-02 Mds Inc. Method for improving signal-to-noise ratios for atmospheric pressure ionization mass spectrometry
US6646258B2 (en) * 2001-01-22 2003-11-11 Agilent Technologies, Inc. Concave electrode ion pipe
US6683301B2 (en) * 2001-01-29 2004-01-27 Analytica Of Branford, Inc. Charged particle trapping in near-surface potential wells
US6627883B2 (en) * 2001-03-02 2003-09-30 Bruker Daltonics Inc. Apparatus and method for analyzing samples in a dual ion trap mass spectrometer
US6649907B2 (en) * 2001-03-08 2003-11-18 Wisconsin Alumni Research Foundation Charge reduction electrospray ionization ion source
US6803565B2 (en) * 2001-05-18 2004-10-12 Battelle Memorial Institute Ionization source utilizing a multi-capillary inlet and method of operation
CA2448335C (en) 2001-05-25 2010-01-26 Analytica Of Branford, Inc. Atmospheric and vacuum pressure maldi ion source
CA2652064C (en) 2001-05-25 2010-10-05 Analytica Of Branford, Inc. Multiple detection systems
US7041967B2 (en) * 2001-05-25 2006-05-09 Mds Inc. Method of mass spectrometry, to enhance separation of ions with different charges
US6744040B2 (en) 2001-06-13 2004-06-01 Bruker Daltonics, Inc. Means and method for a quadrupole surface induced dissociation quadrupole time-of-flight mass spectrometer
US6956205B2 (en) * 2001-06-15 2005-10-18 Bruker Daltonics, Inc. Means and method for guiding ions in a mass spectrometer
US7586088B2 (en) * 2001-06-21 2009-09-08 Micromass Uk Limited Mass spectrometer and method of mass spectrometry
CA2391140C (en) * 2001-06-25 2008-10-07 Micromass Limited Mass spectrometer
US6995024B2 (en) * 2001-08-27 2006-02-07 Sri International Method and apparatus for electrostatic dispensing of microdroplets
US6649908B2 (en) 2001-09-20 2003-11-18 Agilent Technologies, Inc. Multiplexing capillary array for atmospheric pressure ionization-mass spectrometry
US6717135B2 (en) 2001-10-12 2004-04-06 Agilent Technologies, Inc. Ion mirror for time-of-flight mass spectrometer
US6797950B2 (en) * 2002-02-04 2004-09-28 Thermo Finnegan Llc Two-dimensional quadrupole ion trap operated as a mass spectrometer
US6649909B2 (en) 2002-02-20 2003-11-18 Agilent Technologies, Inc. Internal introduction of lock masses in mass spectrometer systems
US7132670B2 (en) * 2002-02-22 2006-11-07 Agilent Technologies, Inc. Apparatus and method for ion production enhancement
US6825462B2 (en) * 2002-02-22 2004-11-30 Agilent Technologies, Inc. Apparatus and method for ion production enhancement
US6858841B2 (en) * 2002-02-22 2005-02-22 Agilent Technologies, Inc. Target support and method for ion production enhancement
US7135689B2 (en) * 2002-02-22 2006-11-14 Agilent Technologies, Inc. Apparatus and method for ion production enhancement
US7372043B2 (en) * 2002-02-22 2008-05-13 Agilent Technologies, Inc. Apparatus and method for ion production enhancement
US6777699B1 (en) 2002-03-25 2004-08-17 George H. Miley Methods, apparatus, and systems involving ion beam generation
US7405397B2 (en) * 2002-03-28 2008-07-29 Mds Sciex Inc. Laser desorption ion source with ion guide coupling for ion mass spectroscopy
GB0210930D0 (en) 2002-05-13 2002-06-19 Thermo Electron Corp Improved mass spectrometer and mass filters therefor
JP2003340386A (ja) * 2002-05-23 2003-12-02 Toshiba Corp 超音波洗浄装置及び超音波洗浄方法
JP3971958B2 (ja) * 2002-05-28 2007-09-05 株式会社日立ハイテクノロジーズ 質量分析装置
US6794641B2 (en) 2002-05-30 2004-09-21 Micromass Uk Limited Mass spectrometer
US7095013B2 (en) * 2002-05-30 2006-08-22 Micromass Uk Limited Mass spectrometer
US6800846B2 (en) 2002-05-30 2004-10-05 Micromass Uk Limited Mass spectrometer
WO2003102508A1 (en) 2002-05-31 2003-12-11 Analytica Of Branford, Inc. Mass spectrometry with segmented rf multiple ion guides in various pressure regions
JP5073168B2 (ja) * 2002-05-31 2012-11-14 ウオーターズ・テクノロジーズ・コーポレイシヨン 質量分析計用の高速組合せマルチモードイオン源
US7034292B1 (en) * 2002-05-31 2006-04-25 Analytica Of Branford, Inc. Mass spectrometry with segmented RF multiple ion guides in various pressure regions
US6791078B2 (en) 2002-06-27 2004-09-14 Micromass Uk Limited Mass spectrometer
US6884995B2 (en) * 2002-07-03 2005-04-26 Micromass Uk Limited Mass spectrometer
US7271397B2 (en) * 2002-07-18 2007-09-18 The Johns Hopkins University Combined chemical/biological agent detection system and method utilizing mass spectrometry
US7071467B2 (en) * 2002-08-05 2006-07-04 Micromass Uk Limited Mass spectrometer
JP3791479B2 (ja) * 2002-09-17 2006-06-28 株式会社島津製作所 イオンガイド
US6914242B2 (en) * 2002-12-06 2005-07-05 Agilent Technologies, Inc. Time of flight ion trap tandem mass spectrometer system
US20040108213A1 (en) * 2002-12-09 2004-06-10 Talasek Robert T. Plating bath composition control
JP2004259452A (ja) * 2003-02-24 2004-09-16 Hitachi High-Technologies Corp 質量分析装置及び質量分析方法
US6794647B2 (en) 2003-02-25 2004-09-21 Beckman Coulter, Inc. Mass analyzer having improved mass filter and ion detection arrangement
US6900431B2 (en) * 2003-03-21 2005-05-31 Predicant Biosciences, Inc. Multiplexed orthogonal time-of-flight mass spectrometer
US20040195503A1 (en) * 2003-04-04 2004-10-07 Taeman Kim Ion guide for mass spectrometers
US7425700B2 (en) * 2003-05-22 2008-09-16 Stults John T Systems and methods for discovery and analysis of markers
US20040236603A1 (en) * 2003-05-22 2004-11-25 Biospect, Inc. System of analyzing complex mixtures of biological and other fluids to identify biological state information
CA2431603C (en) * 2003-06-10 2012-03-27 Micromass Uk Limited Mass spectrometer
CA2472492A1 (en) * 2003-06-27 2004-12-27 Ionalytics Corporation Method of separating ions
US7015466B2 (en) * 2003-07-24 2006-03-21 Purdue Research Foundation Electrosonic spray ionization method and device for the atmospheric ionization of molecules
US7186972B2 (en) 2003-10-23 2007-03-06 Beckman Coulter, Inc. Time of flight mass analyzer having improved mass resolution and method of operating same
US7217919B2 (en) * 2004-11-02 2007-05-15 Analytica Of Branford, Inc. Method and apparatus for multiplexing plural ion beams to a mass spectrometer
US20050133712A1 (en) * 2003-12-18 2005-06-23 Predicant Biosciences, Inc. Scan pipelining for sensitivity improvement of orthogonal time-of-flight mass spectrometers
US7458786B2 (en) * 2004-03-04 2008-12-02 Robert George Mac Donald Oil well pumping unit and method therefor
JP4193734B2 (ja) * 2004-03-11 2008-12-10 株式会社島津製作所 質量分析装置
US6958473B2 (en) * 2004-03-25 2005-10-25 Predicant Biosciences, Inc. A-priori biomarker knowledge based mass filtering for enhanced biomarker detection
US20050244973A1 (en) * 2004-04-29 2005-11-03 Predicant Biosciences, Inc. Biological patterns for diagnosis and treatment of cancer
WO2005106921A1 (en) * 2004-05-05 2005-11-10 Mds Inc. Doing Business Through Its Mds Sciex Division Ion guide for mass spectrometer
EP1759402B1 (de) 2004-05-21 2015-07-08 Craig M. Whitehouse Hf-oberflächen und hf-ionenführungen
US7189967B1 (en) * 2004-06-16 2007-03-13 Analytica Of Branford, Inc. Mass spectrometry with multipole ion guides
GB0424426D0 (en) 2004-11-04 2004-12-08 Micromass Ltd Mass spectrometer
US7259371B2 (en) * 2005-01-10 2007-08-21 Applera Corporation Method and apparatus for improved sensitivity in a mass spectrometer
US7256395B2 (en) * 2005-01-10 2007-08-14 Applera Corporation Method and apparatus for improved sensitivity in a mass spectrometer
US20060232369A1 (en) * 2005-04-14 2006-10-19 Makrochem, Ltd. Permanent magnet structure with axial access for spectroscopy applications
US7535329B2 (en) * 2005-04-14 2009-05-19 Makrochem, Ltd. Permanent magnet structure with axial access for spectroscopy applications
US7166836B1 (en) 2005-09-07 2007-01-23 Agilent Technologies, Inc. Ion beam focusing device
US7518108B2 (en) * 2005-11-10 2009-04-14 Wisconsin Alumni Research Foundation Electrospray ionization ion source with tunable charge reduction
JP5233670B2 (ja) * 2005-11-16 2013-07-10 株式会社島津製作所 質量分析装置
JP5107263B2 (ja) * 2006-01-11 2012-12-26 ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド 質量分析計におけるイオンの断片化
US20080067349A1 (en) * 2006-05-26 2008-03-20 Science & Engineering Services, Inc. Multi-channel time-of-flight mass spectrometer
EP2084730A4 (de) * 2006-09-28 2011-12-07 Mds Analytical Tech Bu Mds Inc Verfahren für axialauswurf und in-trap-fragmentierung unter verwendung von hilfselektroden in einem multipol-massenspektrometer
JP4730439B2 (ja) * 2006-10-11 2011-07-20 株式会社島津製作所 四重極型質量分析装置
GB0626025D0 (en) 2006-12-29 2007-02-07 Thermo Electron Bremen Gmbh Ion trap
US8507850B2 (en) * 2007-05-31 2013-08-13 Perkinelmer Health Sciences, Inc. Multipole ion guide interface for reduced background noise in mass spectrometry
US8334506B2 (en) 2007-12-10 2012-12-18 1St Detect Corporation End cap voltage control of ion traps
US7973277B2 (en) 2008-05-27 2011-07-05 1St Detect Corporation Driving a mass spectrometer ion trap or mass filter
GB2454962B (en) * 2008-07-25 2009-10-28 Kratos Analytical Ltd Method and apparatus for ion axial spatial distribution focusing
US8124930B2 (en) * 2009-06-05 2012-02-28 Agilent Technologies, Inc. Multipole ion transport apparatus and related methods
US9105457B2 (en) * 2010-02-24 2015-08-11 Perkinelmer Health Sciences, Inc. Cone-shaped orifice arrangement for inductively coupled plasma sample introduction system
SG10201501031YA (en) 2010-02-26 2015-04-29 Perkinelmer Health Sci Inc Fluid chromatography injectors and injector inserts
SG183179A1 (en) * 2010-02-26 2012-09-27 Perkinelmer Health Sci Inc Plasma mass spectrometry with ion suppression
US20110260048A1 (en) * 2010-04-22 2011-10-27 Wouters Eloy R Ion Transfer Tube for a Mass Spectrometer Having a Resistive Tube Member and a Conductive Tube Member
WO2012135351A2 (en) * 2011-03-28 2012-10-04 Tokyo Electron Limited Ion energy analyzer, methods of electrical signaling therein, and methods of manufacturing and operating the same
US8461524B2 (en) * 2011-03-28 2013-06-11 Thermo Finnigan Llc Ion guide with improved gas dynamics and combined noise reduction device
CN103718270B (zh) * 2011-05-05 2017-10-03 岛津研究实验室（欧洲）有限公司 操纵带电粒子的装置
US8927940B2 (en) * 2011-06-03 2015-01-06 Bruker Daltonics, Inc. Abridged multipole structure for the transport, selection and trapping of ions in a vacuum system
US9184040B2 (en) 2011-06-03 2015-11-10 Bruker Daltonics, Inc. Abridged multipole structure for the transport and selection of ions in a vacuum system
US8969798B2 (en) * 2011-07-07 2015-03-03 Bruker Daltonics, Inc. Abridged ion trap-time of flight mass spectrometer
US8481929B2 (en) 2011-07-14 2013-07-09 Bruker Daltonics, Inc. Lens free collision cell with improved efficiency
US8618473B2 (en) 2011-07-14 2013-12-31 Bruker Daltonics, Inc. Mass spectrometer with precisely aligned ion optic assemblies
US8680462B2 (en) 2011-07-14 2014-03-25 Bruker Daltonics, Inc. Curved heated ion transfer optics
US9105438B2 (en) * 2012-05-31 2015-08-11 Fei Company Imaging and processing for plasma ion source
CN103219220B (zh) * 2013-03-26 2016-01-20 复旦大学 用于产生等离子体与离子间反应的质谱装置及方法
US9899199B2 (en) * 2016-06-30 2018-02-20 Bruker Daltonics, Inc. Mass spectrometer comprising a radio frequency ion guide having continuous electrodes
US10475634B2 (en) * 2017-04-12 2019-11-12 Graduate School At Shenzhen, Tsinghua University Vacuum electro-spray ion source and mass spectrometer
US10964521B2 (en) 2017-07-18 2021-03-30 Shimadzu Corporation Mass spectrometer
US11817303B2 (en) 2017-08-06 2023-11-14 Micromass Uk Limited Accelerator for multi-pass mass spectrometers
EP3662501A1 (de) 2017-08-06 2020-06-10 Micromass UK Limited Ionenspiegel für multireflektierendes massenspektrometer
GB201715777D0 (en) * 2017-09-29 2017-11-15 Shimadzu Corp ION Trap
US10794861B2 (en) * 2018-02-23 2020-10-06 Bruker Scientific Llc Tandem ion mobility spectrometer
CN116273534A (zh) * 2018-03-01 2023-06-23 Dh科技发展私人贸易有限公司 集成电喷射发射器及其制造方法
EP3776623B1 (de) 2018-04-05 2022-12-28 Technische Universität München Teilweise abgedichtete ionenleitung und ionenstrahlenabscheidungssystem
EP3550588A1 (de) * 2018-04-05 2019-10-09 Technische Universität München Ionenleiter mit elektrodendrähten und ionenstrahlabscheidungssystem
GB201807626D0 (en) 2018-05-10 2018-06-27 Micromass Ltd Multi-reflecting time of flight mass analyser
GB201808530D0 (en) 2018-05-24 2018-07-11 Verenchikov Anatoly TOF MS detection system with improved dynamic range
GB201810573D0 (en) 2018-06-28 2018-08-15 Verenchikov Anatoly Multi-pass mass spectrometer with improved duty cycle
GB201812329D0 (en) 2018-07-27 2018-09-12 Verenchikov Anatoly Improved ion transfer interace for orthogonal TOF MS
US11887831B2 (en) * 2018-12-13 2024-01-30 Dh Technologies Development Pte. Ltd. Automated ion optics charging compensation
US10804088B1 (en) 2019-05-30 2020-10-13 Thermo Finnigan Llc Methods and system for optimizing ion transmission through a mass spectrometer
WO2021026172A1 (en) 2019-08-05 2021-02-11 Seer, Inc. Systems and methods for sample preparation, data generation, and protein corona analysis
WO2023091594A1 (en) * 2021-11-19 2023-05-25 MOBILion Systems, Inc. Systems and methods for two-dimensional mobility based filtering of ions

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3334225A (en) 1964-04-24 1967-08-01 California Inst Res Found Quadrupole mass filter with means to generate a noise spectrum exclusive of the resonant frequency of the desired ions to deflect stable ions
US4234791A (en) * 1978-11-13 1980-11-18 Research Corporation Tandem quadrupole mass spectrometer for selected ion fragmentation studies and low energy collision induced dissociator therefor
US4328420A (en) * 1980-07-28 1982-05-04 French John B Tandem mass spectrometer with open structure AC-only rod sections, and method of operating a mass spectrometer system
JPS5819848A (ja) * 1981-07-29 1983-02-05 Denshi Kagaku Kk 質量分析装置
DE3130276A1 (de) * 1981-07-31 1983-02-17 Hermann Prof. Dr. 6301 Fernwald Wollnik Einrichtung zur vollelektrischen justierung von teilchenspektrometern und abbildungssystemen
US4542293A (en) 1983-04-20 1985-09-17 Yale University Process and apparatus for changing the energy of charged particles contained in a gaseous medium
US4535235A (en) * 1983-05-06 1985-08-13 Finnigan Corporation Apparatus and method for injection of ions into an ion cyclotron resonance cell
CA1245778A (en) * 1985-10-24 1988-11-29 John B. French Mass analyzer system with reduced drift
JPH0678271B2 (ja) * 1986-07-12 1994-10-05 三菱油化株式会社 シユウ酸銀の製造法
US4731533A (en) 1986-10-15 1988-03-15 Vestec Corporation Method and apparatus for dissociating ions by electron impact
US4885076A (en) * 1987-04-06 1989-12-05 Battelle Memorial Institute Combined electrophoresis-electrospray interface and method
US4842701A (en) * 1987-04-06 1989-06-27 Battelle Memorial Institute Combined electrophoretic-separation and electrospray method and system
US4861988A (en) 1987-09-30 1989-08-29 Cornell Research Foundation, Inc. Ion spray apparatus and method
WO1989006044A1 (en) * 1987-12-24 1989-06-29 Unisearch Limited Mass spectrometer
US5026987A (en) 1988-06-02 1991-06-25 Purdue Research Foundation Mass spectrometer with in-line collision surface means
US4851669A (en) * 1988-06-02 1989-07-25 The Regents Of The University Of California Surface-induced dissociation for mass spectrometry
CA1307859C (en) * 1988-12-12 1992-09-22 Donald James Douglas Mass spectrometer and method with improved ion transmission
US4988869A (en) * 1989-08-21 1991-01-29 The Regents Of The University Of California Method and apparatus for electron-induced dissociation of molecular species
US4977320A (en) * 1990-01-22 1990-12-11 The Rockefeller University Electrospray ionization mass spectrometer with new features
US5073713A (en) * 1990-05-29 1991-12-17 Battelle Memorial Institute Detection method for dissociation of multiple-charged ions
US5070240B1 (en) * 1990-08-29 1996-09-10 Univ Brigham Young Apparatus and methods for trace component analysis
US5134286A (en) 1991-02-28 1992-07-28 Teledyne Cme Mass spectrometry method using notch filter
US5157260A (en) * 1991-05-17 1992-10-20 Finnian Corporation Method and apparatus for focusing ions in viscous flow jet expansion region of an electrospray apparatus
US5179278A (en) 1991-08-23 1993-01-12 Mds Health Group Limited Multipole inlet system for ion traps
US5160840A (en) * 1991-10-25 1992-11-03 Vestal Marvin L Time-of-flight analyzer and method
US5349186A (en) * 1993-06-25 1994-09-20 The Governors Of The University Of Alberta Electrospray interface for mass spectrometer and method of supplying analyte to a mass spectrometer
US5663560A (en) 1993-09-20 1997-09-02 Hitachi, Ltd. Method and apparatus for mass analysis of solution sample
EP1533829A3 (de) * 1994-02-28 2006-06-07 Analytica Of Branford, Inc. Multipol-Ionenleiter für Massenspektrometrie
US5689111A (en) 1995-08-10 1997-11-18 Analytica Of Branford, Inc. Ion storage time-of-flight mass spectrometer
US6011259A (en) 1995-08-10 2000-01-04 Analytica Of Branford, Inc. Multipole ion guide ion trap mass spectrometry with MS/MSN analysis
US5420425A (en) 1994-05-27 1995-05-30 Finnigan Corporation Ion trap mass spectrometer system and method
US5572022A (en) 1995-03-03 1996-11-05 Finnigan Corporation Method and apparatus of increasing dynamic range and sensitivity of a mass spectrometer
DE19523859C2 (de) 1995-06-30 2000-04-27 Bruker Daltonik Gmbh Vorrichtung für die Reflektion geladener Teilchen
DE19608963C2 (de) 1995-03-28 2001-03-22 Bruker Daltonik Gmbh Verfahren zur Ionisierung schwerer Moleküle bei Atmosphärendruck
DE19511333C1 (de) 1995-03-28 1996-08-08 Bruker Franzen Analytik Gmbh Verfahren und Vorrichtung für orthogonalen Einschuß von Ionen in ein Flugzeit-Massenspektrometer
EP0843887A1 (de) 1995-08-11 1998-05-27 Mds Health Group Limited Spektrometer mit axialfeld
US5576540A (en) 1995-08-11 1996-11-19 Mds Health Group Limited Mass spectrometer with radial ejection
US5672868A (en) 1996-02-16 1997-09-30 Varian Associates, Inc. Mass spectrometer system and method for transporting and analyzing ions

Also Published As

Publication number Publication date
EP1533830A2 (de) 2005-05-25
US6744047B2 (en) 2004-06-01
CA2656956C (en) 2011-10-11
US6403953B2 (en) 2002-06-11
US8598519B2 (en) 2013-12-03
ES2331494T3 (es) 2010-01-05
US20010038069A1 (en) 2001-11-08
EP0748249B1 (de) 2009-07-08
CA2656956A1 (en) 1995-08-31
US6188066B1 (en) 2001-02-13
EP1533830A3 (de) 2006-06-07
DK0748249T3 (da) 2009-11-09
JP3671354B2 (ja) 2005-07-13
JPH09509781A (ja) 1997-09-30
EP0748249A4 (de) 1997-05-02
EP1533829A2 (de) 2005-05-25
WO1995023018A1 (en) 1995-08-31
US20030034451A1 (en) 2003-02-20
US5652427A (en) 1997-07-29
US20110303840A1 (en) 2011-12-15
US5962851A (en) 1999-10-05
EP1533829A3 (de) 2006-06-07
AU1932095A (en) 1995-09-11
EP0748249A1 (de) 1996-12-18

Similar Documents

Publication Publication Date Title
DE69535979D1 (de) Multipol-ionenleiter für massenspektrometrie
DE69722717D1 (de) Ionenspeicherungsvorrichtung für Massenspektrometrie
DE59712999D1 (de) Photoionisations-Ionenmobilitätsspektrometrie
IL113468A (en) Ion mobility spectrometer
DE69629920D1 (de) Massenspektrometer
DE69536105D1 (de) Massenspektrometer
DE69518386T2 (de) Spektrometer
DE69617592T2 (de) Feuerfestes Gehäuse für eine elektrische Leitung
GB2315155B (en) Ion mobility spectrometer
DE69936800D1 (de) Massenspektrometer
DE69623728D1 (de) Massenspektrometer
DE69208242T2 (de) Verbesserungen für Ionenbeweglichkeitsspektrometer
DE69402513T2 (de) Quadrupolmassenspektrometer
DE69603868T2 (de) Abdeckhaube für elektrische verbinder
GB2288061B (en) Electrospraying method for mass spectrometric analysis
BR9504208A (pt) Contactor elétrico giratório
DE69525563T2 (de) Ionenimplantierungsgerät
DE59910750D1 (de) Ionenmobilitätsspektrometer
DE9400424U1 (de) Hilfsvorrichtung für mehrpolige Stecker oder Steckdosen
DE69817929D1 (de) Ionisationszelle für Massenspektrometer
IT1271230B (it) Isolatore per conduttore passante
BR9504093A (pt) Contactor elétrico giratório
DE29511859U1 (de) Isolator für Elektroweidezäune
DE29612215U1 (de) Isolator für Elektroweidezäune
KR950025875U (ko) 이온 주입기

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: PERKINELMER HEALTH SCIENCES, INC., WALTHAM, MA, US

8328 Change in the person/name/address of the agent

Representative=s name: HAUCK PATENT- UND RECHTSANWAELTE, 80339 MUENCHEN

8328 Change in the person/name/address of the agent

Representative=s name: HEYER, V., DIPL.-PHYS. DR.RER.NAT., PAT.-ANW., 806