DE69612093T2 - Auf antigen verarbeitende zellen zielgerichtete konjugate ein polyaminosäure rückgrat und ein nicht-steroidales antiphlogistikum enthaltend - Google Patents

Auf antigen verarbeitende zellen zielgerichtete konjugate ein polyaminosäure rückgrat und ein nicht-steroidales antiphlogistikum enthaltend

Info

Publication number
DE69612093T2
DE69612093T2 DE69612093T DE69612093T DE69612093T2 DE 69612093 T2 DE69612093 T2 DE 69612093T2 DE 69612093 T DE69612093 T DE 69612093T DE 69612093 T DE69612093 T DE 69612093T DE 69612093 T2 DE69612093 T2 DE 69612093T2
Authority
DE
Germany
Prior art keywords
cells containing
polyamino acid
acid backbone
processing cells
targeted conjugates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69612093T
Other languages
English (en)
Other versions
DE69612093D1 (de
Inventor
Joel K Swadesh
Martin Sevoian
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Application granted granted Critical
Publication of DE69612093D1 publication Critical patent/DE69612093D1/de
Publication of DE69612093T2 publication Critical patent/DE69612093T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
DE69612093T 1995-06-07 1996-05-23 Auf antigen verarbeitende zellen zielgerichtete konjugate ein polyaminosäure rückgrat und ein nicht-steroidales antiphlogistikum enthaltend Expired - Fee Related DE69612093T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47552895A 1995-06-07 1995-06-07
PCT/US1996/007563 WO1996040123A1 (en) 1995-06-07 1996-05-23 Antigen-processing cell-targeted conjugates

Publications (2)

Publication Number Publication Date
DE69612093D1 DE69612093D1 (de) 2001-04-19
DE69612093T2 true DE69612093T2 (de) 2001-10-31

Family

ID=23887976

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69612093T Expired - Fee Related DE69612093T2 (de) 1995-06-07 1996-05-23 Auf antigen verarbeitende zellen zielgerichtete konjugate ein polyaminosäure rückgrat und ein nicht-steroidales antiphlogistikum enthaltend

Country Status (5)

Country Link
US (1) US5898033A (de)
EP (1) EP0831817B1 (de)
JP (1) JP4256932B2 (de)
DE (1) DE69612093T2 (de)
WO (1) WO1996040123A1 (de)

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US7018654B2 (en) 1999-03-05 2006-03-28 New River Pharmaceuticals Inc. Pharmaceutical composition containing an active agent in an amino acid copolymer structure
US6716452B1 (en) * 2000-08-22 2004-04-06 New River Pharmaceuticals Inc. Active agent delivery systems and methods for protecting and administering active agents
US7060708B2 (en) * 1999-03-10 2006-06-13 New River Pharmaceuticals Inc. Active agent delivery systems and methods for protecting and administering active agents
US6828412B1 (en) * 1999-09-03 2004-12-07 School Of Pharmacy, University Of London Degradable polymers
JP2003528939A (ja) * 1999-09-03 2003-09-30 スクール オブ ファーマシー， ユニヴァーシティ オブ ロンドン 分解性ポリマー
US20020099013A1 (en) * 2000-11-14 2002-07-25 Thomas Piccariello Active agent delivery systems and methods for protecting and administering active agents
EP2080511A3 (de) * 2000-08-22 2009-09-30 Shire LLC Aktivmittelzufuhrsysteme und Verfahren zum Schutz und zur Lieferung von Aktivmitteln
CN1476325B (zh) * 2000-08-22 2012-09-05 希拉有限责任公司 活性物质的输送系统和活性物质的保护和施用方法
US7163918B2 (en) 2000-08-22 2007-01-16 New River Pharmaceuticals Inc. Iodothyronine compositions
JP2004523480A (ja) * 2000-08-22 2004-08-05 ニュー リバー ファーマシューティカルズ， インコーポレイテッド 活性作用物質送達系ならびに活性作用物質の保護および投与方法
EP1188446B1 (de) 2000-09-15 2009-08-05 Institut Pasteur Proteinhaltigen Vektoren zur Einführung von Moleküle in CD11b exprimirende Zellen
US8394813B2 (en) 2000-11-14 2013-03-12 Shire Llc Active agent delivery systems and methods for protecting and administering active agents
JP2006516948A (ja) * 2000-11-14 2006-07-13 ニュー リバー ファーマシューティカルズ インコーポレイテッド 硫酸アバカビルを含有する新規な薬剤化合物および同化合物の製造ならびに使用方法
EP1401374B1 (de) * 2000-11-14 2010-03-31 Shire LLC Neue pharmazeutische verbindung mit atenolol und verfahren zu ihrer herstellung und verwendung
US7375083B2 (en) * 2003-09-30 2008-05-20 Shire Llc Pharmaceutical compositions for prevention of overdose or abuse
US20070066537A1 (en) * 2002-02-22 2007-03-22 New River Pharmaceuticals Inc. Compounds and compositions for prevention of overdose of oxycodone
US7338939B2 (en) * 2003-09-30 2008-03-04 New River Pharmaceuticals Inc. Abuse-resistant hydrocodone compounds
US20060014697A1 (en) * 2001-08-22 2006-01-19 Travis Mickle Pharmaceutical compositions for prevention of overdose or abuse
US7169752B2 (en) * 2003-09-30 2007-01-30 New River Pharmaceuticals Inc. Compounds and compositions for prevention of overdose of oxycodone
US7375082B2 (en) * 2002-02-22 2008-05-20 Shire Llc Abuse-resistant hydrocodone compounds
US7105486B2 (en) * 2002-02-22 2006-09-12 New River Pharmaceuticals Inc. Abuse-resistant amphetamine compounds
US7700561B2 (en) * 2002-02-22 2010-04-20 Shire Llc Abuse-resistant amphetamine prodrugs
EP1481078A4 (de) * 2002-02-22 2006-08-16 New River Pharmaceuticals Inc Verwendung einer peptid-arzneistoff-konjugation zur reduzierung der variabilität von arzneistoff-serumspiegeln zwischen patienten
AU2003219863C1 (en) * 2002-02-22 2009-03-05 Shire Llc Novel sustained release pharmaceutical compounds to prevent abuse of controlled substances
US7659253B2 (en) 2002-02-22 2010-02-09 Shire Llc Abuse-resistant amphetamine prodrugs
AU2002249486A1 (en) * 2002-03-26 2003-10-08 Council Of Scientific And Industrial Research Macromolecular compounds as potential anti-inflammatory agents
US8133881B2 (en) 2003-01-13 2012-03-13 Shire Llc Carbohydrate conjugates to prevent abuse of controlled substances
WO2005007804A2 (en) * 2003-04-10 2005-01-27 President And Fellows Of Harvard College Anthrax conjugate vaccine and antibodies
JP4898445B2 (ja) 2003-05-29 2012-03-14 シャイア エルエルシー 乱用抵抗性アンフェタミン化合物類
JP2006036721A (ja) * 2004-07-29 2006-02-09 Ajinomoto Co Inc 透過吸収促進剤
JP2011178764A (ja) * 2010-03-04 2011-09-15 Ajinomoto Co Inc 腸内ビフィズス菌増殖促進剤および腸管バリア機能改善剤
KR101297815B1 (ko) * 2010-11-18 2013-09-03 충남대학교산학협력단 폴리감마글루탐산과 광학영상다이의 복합체를 함유하는 센티넬 림프노드 감지용 광학영상 프로브
KR102091588B1 (ko) * 2013-05-27 2020-03-24 주식회사 바이오리더스 폴리감마글루탐산을 함유하는 점액 분산 또는 수화용 조성물

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US4356166A (en) * 1978-12-08 1982-10-26 University Of Utah Time-release chemical delivery system
US4349530A (en) * 1980-12-11 1982-09-14 The Ohio State University Implants, microbeads, microcapsules, preparation thereof and method of administering a biologically-active substance to an animal
US4386026A (en) * 1981-04-20 1983-05-31 Merck & Co., Inc. Cell-specific glycopeptide ligands
US4587046A (en) * 1982-05-18 1986-05-06 The Regents Of The University Of California Drug-carrier conjugates
CH667874A5 (fr) * 1985-12-19 1988-11-15 Battelle Memorial Institute Polypeptide synthetique biodegradable et son utilisation pour la preparation de medicaments.
US5030834A (en) * 1987-12-01 1991-07-09 Quantex Corporation Fiber optic dosimeter system using electron trapping materials
JP2848898B2 (ja) * 1990-02-08 1999-01-20 明治製菓株式会社 ポリ‐γ‐グルタミン酸エステルおよびその成形体
DE69126124T2 (de) * 1990-09-28 1997-08-28 Neorx Corp Polymere träger zur freisetzung kovalent gebundener wirkstoffe
AU650914B2 (en) * 1990-11-06 1994-07-07 Fgn, Inc. Esters and amides of substituted phenyl acetic acids
AU658373B2 (en) * 1990-11-06 1995-04-13 Fgn, Inc. Esters and amides of substituted pyrrole acetic acids
US5432260A (en) * 1991-05-03 1995-07-11 Washington University High affinity mannose receptor ligands
US5225182A (en) * 1991-10-31 1993-07-06 Sharma Yash P Vectored drug delivery system using a cephaloplastin linking agent and a methed of using the system

Also Published As

Publication number Publication date
US5898033A (en) 1999-04-27
EP0831817B1 (de) 2001-03-14
JP4256932B2 (ja) 2009-04-22
WO1996040123A1 (en) 1996-12-19
EP0831817A1 (de) 1998-04-01
JPH11507034A (ja) 1999-06-22
DE69612093D1 (de) 2001-04-19
EP0831817A4 (de) 1998-06-10

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Legal Events

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8339 Ceased/non-payment of the annual fee