DE69614551D1 - Verfahren zur herstellung von monomeren calicheamicinderivaten/trägerkonjugaten - Google Patents

Verfahren zur herstellung von monomeren calicheamicinderivaten/trägerkonjugaten

Info

Publication number
DE69614551D1
DE69614551D1 DE69614551T DE69614551T DE69614551D1 DE 69614551 D1 DE69614551 D1 DE 69614551D1 DE 69614551 T DE69614551 T DE 69614551T DE 69614551 T DE69614551 T DE 69614551T DE 69614551 D1 DE69614551 D1 DE 69614551D1
Authority
DE
Germany
Prior art keywords
calicheamicine
derivatives
carrier conjugates
producing monomeric
monomeric
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69614551T
Other languages
English (en)
Other versions
DE69614551T2 (de
Inventor
Paul Kunstmann
Jack Hollander
Philip Hamann
Arthur Kunz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of DE69614551D1 publication Critical patent/DE69614551D1/de
Application granted granted Critical
Publication of DE69614551T2 publication Critical patent/DE69614551T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6881—Cluster-antibody conjugates, i.e. the modifying agent consists of a plurality of antibodies covalently linked to each other or of different antigen-binding fragments covalently linked to each other
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6807—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
    • A61K47/6809—Antibiotics, e.g. antitumor antibiotics anthracyclins, adriamycin, doxorubicin or daunomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
DE69614551T 1995-06-07 1996-05-10 Verfahren zur herstellung von monomeren calicheamicinderivaten/trägerkonjugaten Expired - Fee Related DE69614551T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/475,005 US5712374A (en) 1995-06-07 1995-06-07 Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates
PCT/US1996/006738 WO1996040261A1 (en) 1995-06-07 1996-05-10 Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates

Publications (2)

Publication Number Publication Date
DE69614551D1 true DE69614551D1 (de) 2001-09-20
DE69614551T2 DE69614551T2 (de) 2002-04-11

Family

ID=23885856

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69614551T Expired - Fee Related DE69614551T2 (de) 1995-06-07 1996-05-10 Verfahren zur herstellung von monomeren calicheamicinderivaten/trägerkonjugaten

Country Status (28)

Country Link
US (1) US5712374A (de)
EP (1) EP0837698B1 (de)
JP (2) JPH11508232A (de)
KR (1) KR100499648B1 (de)
CN (1) CN1094063C (de)
AR (1) AR002360A1 (de)
AT (1) ATE204180T1 (de)
AU (1) AU703862B2 (de)
BG (1) BG63492B1 (de)
BR (1) BR9608564A (de)
CA (1) CA2223329A1 (de)
CY (1) CY2355B1 (de)
CZ (1) CZ298024B6 (de)
DE (1) DE69614551T2 (de)
DK (1) DK0837698T3 (de)
ES (1) ES2160818T3 (de)
GR (1) GR3036930T3 (de)
HK (1) HK1016871A1 (de)
HU (1) HU221246B1 (de)
IL (1) IL118565A (de)
IN (1) IN182139B (de)
MX (1) MX9709316A (de)
NO (1) NO324609B1 (de)
NZ (1) NZ307926A (de)
PT (1) PT837698E (de)
TW (1) TW419377B (de)
WO (1) WO1996040261A1 (de)
ZA (1) ZA964614B (de)

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ES2160818T3 (es) 2001-11-16
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BG102100A (en) 1998-08-31
ATE204180T1 (de) 2001-09-15
ZA964614B (en) 1997-12-04
IN182139B (de) 1999-01-09
BG63492B1 (bg) 2002-03-29
AR002360A1 (es) 1998-03-11
NO324609B1 (no) 2007-11-26
NZ307926A (en) 1999-09-29
EP0837698B1 (de) 2001-08-16
JP2009073832A (ja) 2009-04-09
GR3036930T3 (en) 2002-01-31
JPH11508232A (ja) 1999-07-21
TW419377B (en) 2001-01-21
DE69614551T2 (de) 2002-04-11
CN1186442A (zh) 1998-07-01
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DK0837698T3 (da) 2001-11-12
AU703862B2 (en) 1999-04-01
US5712374A (en) 1998-01-27
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HUP9901351A2 (hu) 1999-08-30
CZ298024B6 (cs) 2007-05-30
KR100499648B1 (ko) 2006-04-21
HU221246B1 (en) 2002-09-28
WO1996040261A1 (en) 1996-12-19
BR9608564A (pt) 1999-07-06
CA2223329A1 (en) 1996-12-19
PT837698E (pt) 2001-12-28
CZ393997A3 (cs) 1998-03-18
IL118565A (en) 2004-06-20
EP0837698A1 (de) 1998-04-29
IL118565A0 (en) 1996-10-16
CN1094063C (zh) 2002-11-13
AU5742396A (en) 1996-12-30

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