DE69623929T2 - Blut-pool bilderzeugungs-zusammensetzungen deren herstellung und verwendung - Google Patents

Blut-pool bilderzeugungs-zusammensetzungen deren herstellung und verwendung

Info

Publication number
DE69623929T2
DE69623929T2 DE69623929T DE69623929T DE69623929T2 DE 69623929 T2 DE69623929 T2 DE 69623929T2 DE 69623929 T DE69623929 T DE 69623929T DE 69623929 T DE69623929 T DE 69623929T DE 69623929 T2 DE69623929 T2 DE 69623929T2
Authority
DE
Germany
Prior art keywords
compositions
circulation
mixed micelles
mri
physiologically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69623929T
Other languages
English (en)
Other versions
DE69623929D1 (de
Inventor
Herve Tournier
Bernard Lamy
Roland Hyacinthe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bracco Research SA
Original Assignee
Bracco Research SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8221760&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69623929(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bracco Research SA filed Critical Bracco Research SA
Application granted granted Critical
Publication of DE69623929D1 publication Critical patent/DE69623929D1/de
Publication of DE69623929T2 publication Critical patent/DE69623929T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1806—Suspensions, emulsions, colloids, dispersions
DE69623929T 1995-06-15 1996-06-14 Blut-pool bilderzeugungs-zusammensetzungen deren herstellung und verwendung Expired - Lifetime DE69623929T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP95810403 1995-06-15
PCT/IB1996/000577 WO1997000087A1 (en) 1995-06-15 1996-06-14 Blood-pool imaging compositions use and method

Publications (2)

Publication Number Publication Date
DE69623929D1 DE69623929D1 (de) 2002-10-31
DE69623929T2 true DE69623929T2 (de) 2003-05-15

Family

ID=8221760

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69623929T Expired - Lifetime DE69623929T2 (de) 1995-06-15 1996-06-14 Blut-pool bilderzeugungs-zusammensetzungen deren herstellung und verwendung

Country Status (13)

Country Link
US (1) US5833948A (de)
EP (1) EP0804251B1 (de)
JP (1) JP4335976B2 (de)
KR (1) KR100399712B1 (de)
AT (1) ATE224737T1 (de)
AU (1) AU708328B2 (de)
CA (1) CA2195633C (de)
DE (1) DE69623929T2 (de)
ES (1) ES2180784T3 (de)
NO (1) NO314127B1 (de)
PT (1) PT804251E (de)
WO (1) WO1997000087A1 (de)
ZA (1) ZA965101B (de)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1297035B1 (it) * 1997-12-30 1999-08-03 Bracco Spa Derivati dell'acido 1,4,7,10-tetraazaciclododecan-1,4-diacetico
IT1297034B1 (it) * 1997-12-30 1999-08-03 Bracco Spa Acido 1,4,7,10-tetraazaciclododecan-1,4-diacetico
US6342598B1 (en) * 1998-11-26 2002-01-29 Bracco International B.V. Amphipatic polycarboxylic chelates and complexes with paramagnetic metals as MRI contrast agents
EP2286843A3 (de) 2000-06-02 2011-08-03 Bracco Suisse SA Arzneimitteln zur Zielgerichtung von Endothelzellen
US6984395B2 (en) * 2001-04-11 2006-01-10 Qlt, Inc. Drug delivery system for hydrophobic drugs
US6506413B1 (en) * 2001-04-30 2003-01-14 Joseph C. Ramaekers Compositions for treating animal diseases and syndromes
US20070128253A1 (en) * 2005-04-13 2007-06-07 Ramaekers Joseph C Encapsulated transfer factor compositions and methods of use
US20060073197A1 (en) * 2004-05-20 2006-04-06 Ramaekers Joseph C Encapsulated transfer factor compositions and methods of use
US6803046B2 (en) * 2002-08-16 2004-10-12 Bracco International B.V. Sincalide formulations
US20050130892A1 (en) * 2003-03-07 2005-06-16 Xencor, Inc. BAFF variants and methods thereof
US20060014248A1 (en) * 2003-01-06 2006-01-19 Xencor, Inc. TNF super family members with altered immunogenicity
US20050221443A1 (en) * 2003-01-06 2005-10-06 Xencor, Inc. Tumor necrosis factor super family agonists
US7553930B2 (en) * 2003-01-06 2009-06-30 Xencor, Inc. BAFF variants and methods thereof
EP1590006B1 (de) 2003-02-04 2010-09-08 Bracco Suisse SA Ultraschall kontrastmittel und verfahren zur erstellung
WO2005035564A2 (en) 2003-10-10 2005-04-21 Xencor, Inc. Protein based tnf-alpha variants for the treatment of tnf-alpha related disorders
CA2547024C (en) 2003-12-22 2013-12-17 Bracco Research Sa Gas-filled microvesicle assembly for contrast imaging
US20050152842A1 (en) * 2003-12-24 2005-07-14 Chun Li Poly (L-glutamic acid) paramagnetic material complex and use as a biodegradable MRI contrast agent
EP1750671B1 (de) * 2004-06-03 2008-10-15 Bracco Research S.A. Liposomale anordnung für die therapeutische und/oder diagnostische anwendung
JP4837663B2 (ja) 2004-08-18 2011-12-14 ブラッコ・シュイス・ソシエテ・アノニム 造影画像化のためのガス充填微小胞組成物
FR2883562B1 (fr) 2005-03-24 2009-02-27 Guerbet Sa Chelates lipophiles et leur utilisation en imagerie
AU2006232318A1 (en) * 2005-04-01 2006-10-12 The Board Of Regents Of The University Of Texas System Poly(peptide) as a chelator: methods of manufacture and uses
EP1898958A2 (de) * 2005-05-31 2008-03-19 INBIOS S.r.l. Supramolekulare aggregate mit cheliermitteln und bioaktiven peptiden als effektive und selektive abgabewerkzeuge für arzneimittel und kontrastmittel bei mrt oder in der nuklearmedizin
US20090053197A1 (en) * 2006-06-14 2009-02-26 Ramaekers Joseph C Transfer Factor Compositions and Methods
US9125874B2 (en) 2007-11-30 2015-09-08 The Ramaekers Family Trust Administration of transfer factor for improving reproductive health
WO2008028917A1 (en) 2006-09-05 2008-03-13 Bracco Research Sa Gas-filled microvesicles with polymer-modified lipids
GB0623838D0 (en) * 2006-11-29 2007-01-10 Malvern Cosmeceutics Ltd Novel compositions
US20090074751A1 (en) * 2007-09-18 2009-03-19 Ramaekers Nutrition, Inc. Growth factor fraction compositions and methods
KR101401217B1 (ko) * 2007-11-07 2014-05-28 충남대학교산학협력단 Ｐｅ－ｄｔｐａ의 새로운 용도
JP5547083B2 (ja) 2007-11-20 2014-07-09 アンブルックス，インコーポレイテッド 修飾されたインスリンポリペプチドおよびそれらの使用
EP2278984A4 (de) * 2007-11-30 2013-02-27 Ramaekers Family Trust Zusammensetzungen und verfahren zur verbesserung der fertilität
SG10201500237TA (en) 2008-01-30 2015-04-29 Histogen Inc Extracellular matrix compositions
CN106362171A (zh) * 2009-02-13 2017-02-01 华盛顿大学 用于磁共振成像的钆表现脂质纳米颗粒
WO2010139003A1 (en) * 2009-06-01 2010-12-09 Commonwealth Scientific And Industrial Research Organisation Chelating amphiphiles
AU2011291943B2 (en) 2010-08-17 2015-01-22 Ambrx, Inc. Modified relaxin polypeptides and their uses
EP2639227A1 (de) 2012-03-14 2013-09-18 Bracco Imaging S.p.A Neue Klasse von Diazepinderivatchelatbildnern und Komplexe mit paramagnetischen Metallen als MRI-Kontrastmittel
WO2014037498A2 (en) 2012-09-07 2014-03-13 Bracco Imaging Spa Paramagnetic solid lipid nanoparticles (pslns) containing metal amphiphilic complexes for mri.
DK2892547T3 (da) 2012-09-10 2020-10-26 Xencor Inc Dominant, negativ tnf-alpha-hæmmer til anvendelse i behandling af neurologiske cns-forstyrrelser
CN105026030B (zh) 2012-12-21 2017-04-12 博莱科瑞士股份有限公司 充气微泡
US11352606B2 (en) 2014-02-10 2022-06-07 The Johns Hopkins University Low oxygen tension enhances endothelial fate of human pluripotent stem cells
WO2016201409A1 (en) 2015-06-12 2016-12-15 Georgia State University Research Foundation Compositions and methods for treating opioid tolerance
US11110063B2 (en) 2017-08-25 2021-09-07 MAIA Pharmaceuticals, Inc. Storage stable sincalide formulations

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5387410A (en) * 1983-03-18 1995-02-07 Mallinckrodt, Inc. Method for enhancing magnetic resonance with compositions containing paramagnetic elements carried by liposomes
US4728575A (en) * 1984-04-27 1988-03-01 Vestar, Inc. Contrast agents for NMR imaging
US5215680A (en) * 1990-07-10 1993-06-01 Cavitation-Control Technology, Inc. Method for the production of medical-grade lipid-coated microbubbles, paramagnetic labeling of such microbubbles and therapeutic uses of microbubbles
JPH06507904A (ja) * 1991-05-23 1994-09-08 イマアーレクス・フアーマシユーチカル・コーポレーシヨン 磁気共鳴画像形成用の油脂可溶化合物
US5464696A (en) * 1992-08-13 1995-11-07 Bracco International B.V. Particles for NMR imaging
US5534241A (en) * 1993-07-23 1996-07-09 Torchilin; Vladimir P. Amphipathic polychelating compounds and methods of use
US5567410A (en) * 1994-06-24 1996-10-22 The General Hospital Corporation Composotions and methods for radiographic imaging

Also Published As

Publication number Publication date
CA2195633C (en) 2008-09-16
JP4335976B2 (ja) 2009-09-30
JPH10504044A (ja) 1998-04-14
AU5843196A (en) 1997-01-15
ZA965101B (en) 1997-01-22
NO314127B1 (no) 2003-02-03
CA2195633A1 (en) 1997-01-03
NO970665D0 (no) 1997-02-13
NO970665L (no) 1997-04-03
DE69623929D1 (de) 2002-10-31
WO1997000087A1 (en) 1997-01-03
ATE224737T1 (de) 2002-10-15
EP0804251B1 (de) 2002-09-25
ES2180784T3 (es) 2003-02-16
AU708328B2 (en) 1999-08-05
EP0804251A1 (de) 1997-11-05
KR970704477A (ko) 1997-09-06
KR100399712B1 (ko) 2004-02-18
US5833948A (en) 1998-11-10
PT804251E (pt) 2003-01-31

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