DE69624109D1 - Vorrichtung zur iontophoretischen verabreichung von medikamenten mit spannungserhöher-schaltung - Google Patents

Vorrichtung zur iontophoretischen verabreichung von medikamenten mit spannungserhöher-schaltung

Info

Publication number
DE69624109D1
DE69624109D1 DE69624109T DE69624109T DE69624109D1 DE 69624109 D1 DE69624109 D1 DE 69624109D1 DE 69624109 T DE69624109 T DE 69624109T DE 69624109 T DE69624109 T DE 69624109T DE 69624109 D1 DE69624109 D1 DE 69624109D1
Authority
DE
Germany
Prior art keywords
medicines
voltage raising
raising circuit
voltage
iontophoretic administration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69624109T
Other languages
English (en)
Other versions
DE69624109T2 (de
Inventor
A Riddle
A Mcnichols
D Badzinski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alza Corp
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Publication of DE69624109D1 publication Critical patent/DE69624109D1/de
Application granted granted Critical
Publication of DE69624109T2 publication Critical patent/DE69624109T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/0404Electrodes for external use
    • A61N1/0408Use-related aspects
    • A61N1/0428Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0432Anode and cathode
    • A61N1/044Shape of the electrode
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/20Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/325Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/0404Electrodes for external use
    • A61N1/0408Use-related aspects
    • A61N1/0428Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0448Drug reservoir
DE69624109T 1995-06-02 1996-05-30 Vorrichtung zur iontophoretischen verabreichung von medikamenten mit spannungserhöher-schaltung Expired - Lifetime DE69624109T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46032295A 1995-06-02 1995-06-02
PCT/US1996/008258 WO1996038199A1 (en) 1995-06-02 1996-05-30 An electrotransport delivery device with voltage boosting circuit

Publications (2)

Publication Number Publication Date
DE69624109D1 true DE69624109D1 (de) 2002-11-07
DE69624109T2 DE69624109T2 (de) 2003-06-18

Family

ID=23828237

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69624109T Expired - Lifetime DE69624109T2 (de) 1995-06-02 1996-05-30 Vorrichtung zur iontophoretischen verabreichung von medikamenten mit spannungserhöher-schaltung
DE19681422T Withdrawn DE19681422T1 (de) 1995-06-02 1996-05-30 Elektrotransport-Abgabevorrichtung mit Spannungsverstärkungsschaltung

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE19681422T Withdrawn DE19681422T1 (de) 1995-06-02 1996-05-30 Elektrotransport-Abgabevorrichtung mit Spannungsverstärkungsschaltung

Country Status (18)

Country Link
US (4) US6035234A (de)
EP (1) EP0830176B1 (de)
JP (1) JPH11511677A (de)
KR (1) KR100454667B1 (de)
CN (1) CN1099300C (de)
AT (2) ATE225200T1 (de)
AU (1) AU700477B2 (de)
BE (1) BE1009518A5 (de)
CA (1) CA2217711C (de)
CH (1) CH690818A5 (de)
DE (2) DE69624109T2 (de)
DK (1) DK0830176T3 (de)
ES (1) ES2184867T3 (de)
IE (1) IE960312A1 (de)
MX (1) MX9709365A (de)
PT (1) PT830176E (de)
SE (1) SE520344C2 (de)
WO (1) WO1996038199A1 (de)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE960312A1 (en) 1995-06-02 1996-12-11 Alza Corp An electrotransport delivery device with voltage boosting¹circuit
US5983133A (en) * 1997-09-29 1999-11-09 Becton, Dickinson And Company Iontophoresis system with voltage step-up circuit
EP1039950A1 (de) * 1997-12-16 2000-10-04 Alza Corporation Regler mit künstlicher last zur gewährleistung einer regelmässigen verabreichung
US6520950B1 (en) * 1999-05-10 2003-02-18 Genetronics, Inc. Method of electroporation-enhanced delivery of active agents
US7171264B1 (en) * 1999-05-10 2007-01-30 Genetronics, Inc. Intradermal delivery of active agents by needle-free injection and electroporation
US6385488B1 (en) * 1999-05-20 2002-05-07 Vyteris, Inc. Circuits for increasing the reliability of an iontophoretic system
JP2001286569A (ja) * 2000-04-05 2001-10-16 Polytronics Ltd 経皮投薬装置
US6453195B1 (en) 2001-03-19 2002-09-17 Medtronic, Inc. Closed loop drug delivery system and remote management thereof
DE10141650C1 (de) 2001-08-24 2002-11-28 Lohmann Therapie Syst Lts Transdermales Therapeutisches System mit Fentanyl bzw. verwandten Substanzen
US20040098065A1 (en) * 2002-11-19 2004-05-20 Alliance Health Products, Llc Transcutaneous nerve and muscle stimulator and method of using the same
JP2006334164A (ja) * 2005-06-02 2006-12-14 Transcutaneous Technologies Inc イオントフォレーシス装置及びその制御方法
JP2007000342A (ja) * 2005-06-23 2007-01-11 Transcutaneous Technologies Inc 複数薬剤の投与量および投与時期を制御するイオントフォレーシス装置
WO2007010900A1 (ja) * 2005-07-15 2007-01-25 Transcu Ltd. 貼付位置表示機能付き経皮吸収用パッチ及びイオントフォレーシス装置
ITMI20051356A1 (it) 2005-07-15 2007-01-16 Getters Spa Dispositivo getter per sistemi attivi per il rilascio transdermico di farmaci
JP2007037868A (ja) * 2005-08-05 2007-02-15 Transcutaneous Technologies Inc 経皮投与装置及びその制御方法
US20070088331A1 (en) * 2005-08-18 2007-04-19 Transcutaneous Technologies Inc. Method and apparatus for managing active agent usage, and active agent injecting device
JPWO2007026671A1 (ja) * 2005-08-29 2009-03-05 Tti・エルビュー株式会社 センサからの情報により投与すべき薬剤の選定を行うイオントフォレーシス装置
JPWO2007032446A1 (ja) * 2005-09-15 2009-03-19 Tti・エルビュー株式会社 ロッド型イオントフォレーシス装置
US20070196456A1 (en) * 2005-09-15 2007-08-23 Visible Assets, Inc. Smart patch
US20070071807A1 (en) * 2005-09-28 2007-03-29 Hidero Akiyama Capsule-type drug-releasing device and capsule-type drug-releasing device system
EP1928539A1 (de) * 2005-09-30 2008-06-11 Tti Ellebeau, Inc. Transdermale funktionalisierte mikronadel-arzneiabgabesysteme, vorrichtungen und verfahren
US20090299265A1 (en) * 2005-09-30 2009-12-03 Tti Ellebeau, Inc. Electrode Assembly for Iontophoresis Having Shape-Memory Separator and Iontophoresis Device Using the Same
US20070078445A1 (en) * 2005-09-30 2007-04-05 Curt Malloy Synchronization apparatus and method for iontophoresis device to deliver active agents to biological interfaces
WO2007041115A1 (en) * 2005-09-30 2007-04-12 Tti Ellebeau Inc. Method and system to detect malfunctions in an iontophoresis device that delivers active agents to biological interfaces
US20070135754A1 (en) * 2005-09-30 2007-06-14 Hidero Akiyama Electrode assembly for iontophoresis for administering active agent enclosed in nanoparticle and iontophoresis device using the same
US20070197955A1 (en) * 2005-10-12 2007-08-23 Transcutaneous Technologies Inc. Mucous membrane adhesion-type iontophoresis device
EP1965858A2 (de) * 2005-12-30 2008-09-10 Tti Ellebeau, Inc. System und verfahren zur fernsteuerung eines iontophoresegerätes
CN104138634B (zh) * 2006-04-13 2016-09-07 梯瓦制药国际有限责任公司 递送抗偏头痛化合物的透皮方法和系统
US20090204056A1 (en) * 2006-05-17 2009-08-13 Zvi Nitzan Constant current treatment device
WO2008004204A1 (en) * 2006-07-06 2008-01-10 University Of Limerick An electrical stimulation device for nerves or muscles
US20080077076A1 (en) * 2006-08-29 2008-03-27 Transcutaneous Technologies Inc. Iontophoresis device and method for operation with a usb (universal serial bus) power source
MX2009002321A (es) * 2006-09-05 2009-03-23 Tti Ellebeau Inc Sistemas, dispositivos y metodos de suministro transdermico de farmacos que utilizan suministros de energia inductiva.
US8728059B2 (en) * 2006-09-29 2014-05-20 Covidien Lp System and method for assuring validity of monitoring parameter in combination with a therapeutic device
JP5383497B2 (ja) 2006-12-01 2014-01-08 Tti・エルビュー株式会社 装置、例として経皮送達装置に給電し且つ/又は当該装置を制御するシステム及び装置
US20080177219A1 (en) * 2007-01-23 2008-07-24 Joshi Ashok V Method for Iontophoretic Fluid Delivery
US20080188791A1 (en) * 2007-02-02 2008-08-07 Difiore Attilio E Active iontophoresis delivery system
US8095213B1 (en) * 2007-05-31 2012-01-10 Purdue Pharma L.P. Transdermal patch
US7853320B1 (en) 2007-05-31 2010-12-14 Purdue Pharma L.P. Transdermal device having mechanical assist for porator-to-skin contact
US8197844B2 (en) * 2007-06-08 2012-06-12 Activatek, Inc. Active electrode for transdermal medicament administration
US8047399B1 (en) 2007-07-05 2011-11-01 Purdue Pharma L.P. Dispenser for transdermal devices
US20090043244A1 (en) * 2007-08-08 2009-02-12 Inan Omer T Electrotransport Drug Delivery Device Adaptable to Skin Resistance Change
US8862223B2 (en) 2008-01-18 2014-10-14 Activatek, Inc. Active transdermal medicament patch and circuit board for same
US8366600B2 (en) * 2008-06-19 2013-02-05 Nupathe Inc. Polyamine enhanced formulations for triptan compound iontophoresis
US8155737B2 (en) 2008-06-19 2012-04-10 Nupathe, Inc. Pharmacokinetics of iontophoretic sumatriptan administration
US20100082219A1 (en) * 2008-09-30 2010-04-01 Gm Global Technology Operations, Inc. Engine Using Glow Plug Resistance For Estimating Combustion Temperature
ES2526118T3 (es) * 2008-12-30 2015-01-07 Nupathe Inc. Control electrónico de sistema de administración de fármacos
US8961492B2 (en) 2009-02-12 2015-02-24 Incube Labs, Llc System and method for controlling the iontophoretic delivery of therapeutic agents based on user inhalation
US8190252B2 (en) 2009-02-12 2012-05-29 Incube Labs, Llc Iontophoretic system for transdermal delivery of active agents for therapeutic and medicinal purposes
US8903485B2 (en) 2009-08-06 2014-12-02 Incube Labs, Llc Patch and patch assembly for iontophoretic transdermal delivery of active agents for therapeutic and medicinal purposes
CN105748401A (zh) * 2009-08-10 2016-07-13 泰华制药国际有限公司 用离子电渗疗法治疗恶心和偏头痛的方法
WO2011046927A1 (en) * 2009-10-13 2011-04-21 Nupathe,Inc. Transdermal methods and systems for the delivery of rizatriptan
US8685038B2 (en) 2009-12-07 2014-04-01 Incube Labs, Llc Iontophoretic apparatus and method for marking of the skin
WO2011100376A2 (en) 2010-02-10 2011-08-18 Incube Labs, Llc Methods and architecture for power optimization of iontophoretic transdermal drug delivery
CN101829407B (zh) * 2010-05-14 2012-03-28 武汉海纳川科技有限公司 一种半导体激光血氧治疗仪
KR200457838Y1 (ko) 2010-05-27 2012-01-05 주식회사 가람아이앤씨 1.5볼트 전지의 아날로그 승압회로를 사용한 휴대용 피부 마사지기
CN101869739A (zh) * 2010-07-20 2010-10-27 段峰 一种自适应控制的皮肤表面电刺激装置及方法
CA2817824A1 (en) 2010-11-23 2012-05-31 Nupathe, Inc. User-activated self-contained co-packaged iontophoretic drug delivery system
JP6133843B2 (ja) * 2011-03-24 2017-05-31 インキューブ ラブズ,リミテッド ライアビリティー カンパニーInCube Labs,LLC 治療剤の二相性経皮イオン泳動送達用のシステム及び方法
US9731121B2 (en) 2011-03-31 2017-08-15 Incline Therapeutics, Inc. Switch validation circuit and method
US8301238B2 (en) 2011-03-31 2012-10-30 Incline Therapeutics, Inc. Two-part electrotransport device
US8781571B2 (en) 2011-03-31 2014-07-15 Incline Therapeutics, Inc. Switch validation circuit and method
US8428709B1 (en) * 2012-06-11 2013-04-23 Incline Therapeutics, Inc. Current control for electrotransport drug delivery
US8428708B1 (en) 2012-05-21 2013-04-23 Incline Therapeutics, Inc. Self-test for analgesic product
WO2012154704A2 (en) * 2011-05-06 2012-11-15 Incube Labs, Llc System and method for biphasic transdermal iontophoretic delivery of therapeutic agents for the control of addictive cravings
GB201414695D0 (en) * 2014-08-19 2014-10-01 Femeda Ltd Electrostimulation related devices and methods
US10463854B2 (en) 2015-02-24 2019-11-05 Elira, Inc. Systems and methods for managing symptoms associated with dysmenorrhea using an electro-dermal patch
JP2018050879A (ja) * 2016-09-28 2018-04-05 株式会社大島製作所 電気的刺激装置
USD821593S1 (en) * 2016-11-23 2018-06-26 Elira, Inc. Electro-dermal patch for use as a medical device
EP3804823B1 (de) * 2017-11-28 2023-04-26 West & Bergh Holding AB Verbesserte bewegungstrainingshilfe mit stimulator
US11251635B2 (en) 2017-12-19 2022-02-15 Welch Allyn, Inc. Vital signs monitor with a removable and dischargable battery
WO2020087270A1 (zh) * 2018-10-30 2020-05-07 深圳市锐明技术股份有限公司 一种用于车载设备的断电保护电路、装置及系统
US20230195149A1 (en) * 2021-12-17 2023-06-22 ONiO AS Power saving in an embedded system

Family Cites Families (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR558409A (fr) * 1922-11-08 1923-08-27 équerre à niveau d'eau
US3618601A (en) * 1969-10-16 1971-11-09 Thatcher W Richardson Iontophoresis unit
US3991755A (en) * 1973-07-27 1976-11-16 Medicon, Inc. Iontophoresis apparatus for applying local anesthetics
US4019510A (en) * 1975-02-10 1977-04-26 Sybron Corporation Therapeutic method of using low intensity direct current generator with polarity reversal
US4141359A (en) * 1976-08-16 1979-02-27 University Of Utah Epidermal iontophoresis device
JPS5347192A (en) * 1976-10-13 1978-04-27 Matsushita Electric Ind Co Ltd Device for introducing fluorine ion to tooth
US4340047A (en) * 1978-10-18 1982-07-20 Robert Tapper Iontophoretic treatment apparatus
US4301794A (en) * 1978-10-18 1981-11-24 Robert Tapper Method for iontophoretic treatment
US4250878A (en) * 1978-11-22 1981-02-17 Motion Control, Inc. Non-invasive chemical species delivery apparatus and method
BR8008859A (pt) * 1979-10-10 1981-08-25 Cyclotech Med Ind Bandagem bloqueadora de dor
US4292968A (en) * 1979-11-26 1981-10-06 Sybron Corporation Electric supply for ion therapy
US4383529A (en) * 1980-11-03 1983-05-17 Wescor, Inc. Iontophoretic electrode device, method and gel insert
US4406658A (en) * 1981-03-06 1983-09-27 Medtronic, Inc. Iontophoretic device with reversible polarity
DE3137384A1 (de) * 1981-09-19 1983-04-07 Bayer Ag, 5090 Leverkusen Flockungsstabile mischphasenpigmente mit rutilstruktur, verfahren zu ihrer herstellung sowie ihre verwendung
US4457748A (en) * 1982-01-11 1984-07-03 Medtronic, Inc. Non-invasive diagnosis method
US4456012A (en) * 1982-02-22 1984-06-26 Medtronic, Inc. Iontophoretic and electrical tissue stimulation device
EP0092015A1 (de) * 1982-04-16 1983-10-26 Roland Brodard Ionisierungsvorrichtung
US5224928A (en) * 1983-08-18 1993-07-06 Drug Delivery Systems Inc. Mounting system for transdermal drug applicator
US4808152A (en) * 1983-08-18 1989-02-28 Drug Delivery Systems Inc. System and method for controlling rate of electrokinetic delivery of a drug
CA1262564A (en) * 1983-09-01 1989-10-31 Minoru Sasaki Iontophoresis device
EP0308572B1 (de) * 1983-09-01 1995-11-08 Hisamitsu Pharmaceutical Co., Inc. Iontophoresegerät
US4855243A (en) * 1983-09-26 1989-08-08 H.S.G. Venture (A Joint Venture Partnership) Neurological and biological molecular electro-optical devices and methods
JPS6222662A (ja) * 1985-07-19 1987-01-30 林原 健 イオン導入電子治療器
JPS62139672A (ja) * 1985-12-14 1987-06-23 林原 健 正負イオントホレ−ゼ用治療器
IE60941B1 (en) * 1986-07-10 1994-09-07 Elan Transdermal Ltd Transdermal drug delivery device
US5042975A (en) * 1986-07-25 1991-08-27 Rutgers, The State University Of New Jersey Iontotherapeutic device and process and iontotherapeutic unit dose
US5250022A (en) * 1990-09-25 1993-10-05 Rutgers, The State University Of New Jersey Iontotherapeutic devices, reservoir electrode devices therefore, process and unit dose
US4725263A (en) * 1986-07-31 1988-02-16 Medtronic, Inc. Programmable constant current source transdermal drug delivery system
JPS63145669A (ja) * 1986-10-11 1988-06-17 林原 健 正、負イオントホレ−ゼ用スイッチ
US4786277A (en) * 1986-11-21 1988-11-22 Trustees Of Boston University Electrodes, electrode assemblies, methods, and systems for tissue stimulation
US4822334A (en) * 1986-12-04 1989-04-18 Robert Tapper Electrical dosimetry control system
FR2607708B3 (fr) * 1986-12-05 1989-02-24 Bontemps Raymond Dispositif destine au transfert sous-cutane de substances medicinales
US4878892A (en) * 1987-02-10 1989-11-07 Drug Delivery Systems Inc. Electrolytic transdermal delivery of polypeptides
US4931046A (en) * 1987-05-15 1990-06-05 Newman Martin H Iontophoresis drug delivery system
US5013293A (en) * 1987-05-28 1991-05-07 Drug Delivery Systems Inc. Pulsating transdermal drug delivery system
US5312325A (en) * 1987-05-28 1994-05-17 Drug Delivery Systems Inc Pulsating transdermal drug delivery system
US4866442A (en) * 1987-06-01 1989-09-12 Steim Joseph M Analog to digital converter employing delta-sigma modulation
US4764168A (en) * 1987-08-28 1988-08-16 Suh Ku W Tympanic membrane implant
US4942883A (en) * 1987-09-29 1990-07-24 Newman Martin H Drug delivery device
US4997418A (en) * 1988-04-21 1991-03-05 C. P. Chambers Epidermal iontophoresis device
GB2219210A (en) * 1988-05-31 1989-12-06 S G Daniel Apparatus for modulating electro-dynamic fields associated with living tissue
US4927408A (en) 1988-10-03 1990-05-22 Alza Corporation Electrotransport transdermal system
US5006108A (en) * 1988-11-16 1991-04-09 Noven Pharmaceuticals, Inc. Apparatus for iontophoretic drug delivery
US5135478A (en) * 1989-05-10 1992-08-04 Drug Delivery Systems Inc. Multi-signal electrical transdermal drug applicator
CA2071321C (en) * 1989-05-10 2000-12-12 Dan Sibalis Multi-signal electrical transdermal drug applicator
JPH0366384A (ja) * 1989-08-04 1991-03-22 Senjiyu Seiyaku Kk 生理活性物質放出制御システム
US5246387A (en) * 1989-10-12 1993-09-21 Siemens Aktiengesellschaft Filter plug connector
EP0497919B1 (de) * 1989-10-23 1996-12-11 THERATECH, INC. (a Delaware Corporation) Vorrichtung für Iontophorese unter Verwendung einer Durchfluss-kontrollierenden Membran
IT1244030B (it) * 1989-12-21 1994-06-28 Elan Corp Plc Dispostitivo in due parti per la somministrazione controllata di un ingrediente
US5047007A (en) * 1989-12-22 1991-09-10 Medtronic, Inc. Method and apparatus for pulsed iontophoretic drug delivery
DE4028125A1 (de) * 1990-01-17 1991-07-18 Klimke Markus Applikationsvorrichtung fuer die geregelte dosierung verschiedener pharmakons mittels elektrischem strom zum perkutanen transport zur lokalen und systemischen therapie
JPH05506165A (ja) * 1990-03-30 1993-09-16 アルザ・コーポレーション イオン導入用送出装置
US5213568A (en) * 1990-03-30 1993-05-25 Medtronic Inc. Activity controlled electrotransport drug delivery device
US5207752A (en) * 1990-03-30 1993-05-04 Alza Corporation Iontophoretic drug delivery system with two-stage delivery profile
WO1991015261A1 (en) * 1990-03-30 1991-10-17 Medtronic, Inc. Activity controlled electrotransport drug delivery device
EP0533816B1 (de) * 1990-06-15 1995-06-14 Cortrak Medical, Inc. Vorrichtung zur abgabe von medikamenten
US5160316A (en) * 1990-09-10 1992-11-03 Henley Julian L Iontophoretic drug delivery apparatus
US5224927A (en) * 1990-11-01 1993-07-06 Robert Tapper Iontophoretic treatment system
US5254081A (en) * 1991-02-01 1993-10-19 Empi, Inc. Multiple site drug iontophoresis electronic device and method
US5169384A (en) * 1991-08-16 1992-12-08 Bosniak Stephen L Apparatus for facilitating post-traumatic, post-surgical, and/or post-inflammatory healing of tissue
CA2122150A1 (en) * 1991-08-26 1993-03-04 Yie W. Chien Iontotherapeutic device and process
ATE143279T1 (de) * 1991-12-03 1996-10-15 Alza Corp Iontophoretische verbreichungsvorrichtung und versorgungsnetz dafür
CA2084734C (en) * 1991-12-17 1998-12-01 John L. Haynes Iontophoresis system having features for reducing skin irritation
US5256137A (en) * 1992-03-10 1993-10-26 Becton Dickinson And Company Biphasic power source for use in an iontophoretic drug delivery system
US5246418A (en) * 1991-12-17 1993-09-21 Becton Dickinson And Company Iontophresis system having features for reducing skin irritation
US5499967A (en) * 1992-02-27 1996-03-19 Societe Anonyme Dite: Laboratoires D'hygiene Societe Anonyme Dite: Et De Dietetique (L.H.D.) Transdermal drug delivery device with waveshape generator
FR2688106B1 (fr) * 1992-02-27 1994-09-09 Lhd Lab Hygiene Dietetique Dispositif de generation d'une tension electrique de forme d'onde predeterminee, appareil ionophoretique d'administration transdermique de medicaments.
GB2265088B (en) 1992-03-10 1996-02-07 Kyosti Eero Antero Kontturi Electrochemical device for drug delivery
US5189307A (en) * 1992-03-13 1993-02-23 Empi, Inc. Isolated current mirror with optical insulator generating feedback signal
US5306235A (en) * 1992-09-30 1994-04-26 Becton Dickinson And Company Failsafe iontophoresis drug delivery system
US5533971A (en) 1993-09-03 1996-07-09 Alza Corporation Reduction of skin irritation during electrotransport
US5540654A (en) 1994-09-02 1996-07-30 North Carolina State University Iontophoretic electrode
US5697896A (en) 1994-12-08 1997-12-16 Alza Corporation Electrotransport delivery device
US5879322A (en) 1995-03-24 1999-03-09 Alza Corporation Self-contained transdermal drug delivery device
IE960312A1 (en) * 1995-06-02 1996-12-11 Alza Corp An electrotransport delivery device with voltage boosting¹circuit
PT836511E (pt) 1995-06-05 2004-08-31 Alza Corp Dispositivo para distribuicao de fentanilo e sufentanilo por electrotransporte percutaneo
US6167301A (en) * 1995-08-29 2000-12-26 Flower; Ronald J. Iontophoretic drug delivery device having high-efficiency DC-to-DC energy conversion circuit
KR100281171B1 (ko) 1995-08-31 2001-03-02 나까도미 히로다카 이온토포레시스장치 및 그 전류제어방법
FR2755842B1 (fr) 1996-11-19 1999-04-23 Lhd Lab Hygiene Dietetique Procede de mesure de la resistance electrique cutanee d'un patient soumis a une administration transdermique de medicament
EP1039950A1 (de) 1997-12-16 2000-10-04 Alza Corporation Regler mit künstlicher last zur gewährleistung einer regelmässigen verabreichung
JP2001286569A (ja) 2000-04-05 2001-10-16 Polytronics Ltd 経皮投薬装置

Also Published As

Publication number Publication date
CH690818A5 (de) 2001-01-31
BE1009518A5 (fr) 1997-04-01
CA2217711A1 (en) 1996-12-05
KR100454667B1 (ko) 2005-01-17
US20020087193A1 (en) 2002-07-04
US6842640B2 (en) 2005-01-11
US20030018296A1 (en) 2003-01-23
CN1099300C (zh) 2003-01-22
SE9704478D0 (sv) 1997-12-02
CN1186449A (zh) 1998-07-01
EP0830176A1 (de) 1998-03-25
ATA903496A (de) 2001-06-15
EP0830176B1 (de) 2002-10-02
WO1996038199A1 (en) 1996-12-05
SE9704478L (sv) 1997-12-02
KR19990014954A (ko) 1999-02-25
CA2217711C (en) 2009-05-19
DE19681422T1 (de) 1998-05-20
PT830176E (pt) 2003-02-28
US20050075623A1 (en) 2005-04-07
US7708731B2 (en) 2010-05-04
IE960312A1 (en) 1996-12-11
DE69624109T2 (de) 2003-06-18
US6035234A (en) 2000-03-07
ATE225200T1 (de) 2002-10-15
AU700477B2 (en) 1999-01-07
AT408616B (de) 2002-01-25
ES2184867T3 (es) 2003-04-16
AU5963096A (en) 1996-12-18
JPH11511677A (ja) 1999-10-12
DK0830176T3 (da) 2003-02-03
MX9709365A (es) 1998-02-28
SE520344C2 (sv) 2003-07-01

Similar Documents

Publication Publication Date Title
DE69624109T2 (de) Vorrichtung zur iontophoretischen verabreichung von medikamenten mit spannungserhöher-schaltung
ES2012944A6 (es) Procedimiento y su dispositivo para la admionistracion de farmacos mediante ionoforesis, para tratamiento loco-regionales.
DE69324680T2 (de) Elektrische stimulierung zur behandlung von inkontinenz und anderen neuromuskularerkrankungen
ATE224753T1 (de) Vorrichtung zur verabreichung von medikamenten durch elektrotransport
MX9204304A (es) Dispositivo de suministro transdermico.
KR930700181A (ko) 2단계 전달 프로파일을 갖는 전리요법적 약물 전달계
EP0337642A3 (de) Vorrichtung zur transdermalen Applikation von Arzneimitteln
DE69422511D1 (de) Elektronische vorrichtung zur adrenergischen reizung des sympathischen nervensystems im venösen umfeld
DE69424413T2 (de) Tragbares iontophoresis system
EP1302218A3 (de) Iontophoretische auslösbare Lieferungsvorrichtung zur Verminderung von elektrischen Empfindungen
ATE173942T1 (de) Vorrichtung zur iontophorestischen verabreichung versehen mit verbesserter sicherheit und vermeidung von missbräuchlichem potential
ES2158850T3 (es) Un dispositivo implantable para la monitorizacion y el control de la actividad simpato-vagal.
AU2003224993A1 (en) Electrical stimulation for thrombolytic therapy
DE69829281D1 (de) Implantierbarer dreiphasenwellenformdefibrillator
US5310403A (en) Iontophoretic drug delivery device and circuit therefor
DE69328256T2 (de) Vorrichtung zur implantierung von defibrillations-elektroden
ATE48234T1 (de) Knochenwachstumsstimulator.
CA2247681A1 (en) Methods for implementing current delivery profiles used in an iontophoretic system
ATE153244T1 (de) Benutzeraktivierte, iontophoretische vorrichtung
CA2339371A1 (en) Electrically mediated angiogenesis
DE69806794D1 (de) Kombinierte elektroporation-und iontophoresevorrichtung zur medikament-und genverabreichung
TR27201A (tr) Crt elektrod saglama birimi icin voltaj takviye cihazi.
JPS521444A (en) Constant current power supply system
ATE86871T1 (de) Reizstromgeraet.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: KUDLEK & GRUNERT PATENTANWAELTE PARTNERSCHAFT, 803