DE69637096D1 - Stabile n-propargyl-1-aminoindan enthaltende zusammensetzungen - Google Patents
Stabile n-propargyl-1-aminoindan enthaltende zusammensetzungenInfo
- Publication number
- DE69637096D1 DE69637096D1 DE69637096T DE69637096T DE69637096D1 DE 69637096 D1 DE69637096 D1 DE 69637096D1 DE 69637096 T DE69637096 T DE 69637096T DE 69637096 T DE69637096 T DE 69637096T DE 69637096 D1 DE69637096 D1 DE 69637096D1
- Authority
- DE
- Germany
- Prior art keywords
- pct
- aminoindan
- propargyl
- stable
- containing compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL11535795 | 1995-09-20 | ||
IL11535795A IL115357A (en) | 1995-09-20 | 1995-09-20 | Stable compositions containing N-propargyl-1-aminoindan and polyhydric alcohols |
PCT/IL1996/000115 WO1997012583A2 (en) | 1995-09-20 | 1996-09-18 | Stable compositions containing n-propargyl-1-aminoindan |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69637096D1 true DE69637096D1 (de) | 2007-07-05 |
DE69637096T2 DE69637096T2 (de) | 2008-01-31 |
Family
ID=11068003
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69637096T Expired - Lifetime DE69637096T2 (de) | 1995-09-20 | 1996-09-18 | Stabile n-propargyl-1-aminoindan enthaltende zusammensetzungen |
Country Status (13)
Country | Link |
---|---|
US (1) | US6126968A (de) |
EP (1) | EP0858328B1 (de) |
JP (1) | JP4108750B2 (de) |
AT (1) | ATE362755T1 (de) |
AU (1) | AU728524B2 (de) |
CA (1) | CA2232310C (de) |
DE (1) | DE69637096T2 (de) |
DK (1) | DK0858328T3 (de) |
ES (1) | ES2287940T3 (de) |
HU (1) | HU225859B1 (de) |
IL (1) | IL115357A (de) |
PT (1) | PT858328E (de) |
WO (1) | WO1997012583A2 (de) |
Families Citing this family (54)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5744500A (en) * | 1990-01-03 | 1998-04-28 | Teva Pharmaceutical Industries, Ltd. | Use of R-enantiomer of N-propargyl-1-aminoindan, salts, and compositions thereof |
IL118836A (en) | 1996-07-11 | 2001-01-11 | Teva Pharma | Pharmaceutical compositions comprising s-(-)-n-propargyl-1-aminoindan |
AU775885B2 (en) | 1999-10-27 | 2004-08-19 | Teva Pharmaceutical Industries Ltd. | Use of 1-aminoindan derivatives for treatment of mania in bipolar mood disorder |
WO2004045515A2 (en) * | 2002-11-15 | 2004-06-03 | Teva Pharmaceutical Industries, Ltd. | Use of rasagiline with or without riluzole to treat amyotrophic lateral sclerosis |
GB2411355B (en) | 2004-02-27 | 2006-02-22 | Niche Generics Ltd | Pharmaceutical composition |
WO2006014973A2 (en) * | 2004-07-26 | 2006-02-09 | Teva Pharmaceutical Industries, Ltd. | Pharmaceutical dosage forms including rasagiline |
WO2006052254A2 (en) * | 2004-11-10 | 2006-05-18 | Teva Pharmaceutical Industries Ltd. | Compressed solid dosage form manufacturing process well-suited for use with drugs of low aqueous solubility and compressed solid dosage forms made thereby |
US8367105B2 (en) | 2004-11-10 | 2013-02-05 | Teva Pharmaceutical Industries, Ltd. | Compressed solid dosage form manufacturing process well-suited for use with drugs of low aqueous solubility and compressed solid dosage forms made thereby |
CN103494766A (zh) * | 2004-11-24 | 2014-01-08 | 特瓦制药工业有限公司 | 雷沙吉兰经口崩解组合物 |
US20100167983A1 (en) * | 2007-10-22 | 2010-07-01 | Teva Pharmaceutical Industries, Ltd. | Combination therapy with glatiramer acetate and rasagiline for the treatment of multiple sclerosis |
PT1848415E (pt) * | 2005-02-17 | 2013-06-27 | Teva Pharma | Terapia de combinação com acetato de glatirâmero e rasagilina para o tratamento da esclerose múltipla |
NZ560660A (en) | 2005-02-23 | 2010-11-26 | Teva Pharma | Rasagiline ( R(+)-N-propargyl-1-aminodan ) formulations of improved content uniformity |
JP2009521402A (ja) | 2005-11-17 | 2009-06-04 | テバ ファーマシューティカル インダストリーズ リミティド | プロパルギル化アミノインダンの分離のための方法 |
US7572834B1 (en) | 2005-12-06 | 2009-08-11 | Teva Pharmaceutical Industries, Ltd. | Rasagiline formulations and processes for their preparation |
JP2009518433A (ja) | 2005-12-09 | 2009-05-07 | イッサム リサーチ ディベロップメント カンパニー オブ ザ ヘブライ ユニバーシティー オブ エルサレム | 神経保護用の低用量ラドスチギルの使用 |
WO2007098264A2 (en) | 2006-02-21 | 2007-08-30 | Teva Pharmaceutical Industries, Ltd. | Use of rasagiline for the treatment of multiple system atrophy |
TW200744576A (en) | 2006-02-24 | 2007-12-16 | Teva Pharma | Propargylated aminoindans, processes for preparation, and uses thereof |
JP5769923B2 (ja) | 2006-04-03 | 2015-08-26 | テバ ファーマシューティカル インダストリーズ リミティド | レストレスレッグス症候群の治療のためのラサギリンの使用 |
DE202006020710U1 (de) | 2006-05-09 | 2009-12-31 | Teva Pharmaceutical Industries Ltd. | Zusammensetzungen mit Rosiglitazonmaleat |
EP1892233A1 (de) * | 2006-08-18 | 2008-02-27 | Ratiopharm GmbH | Neue Salze des Wirkstoffs Rasagilin |
ZA200903904B (en) | 2006-12-14 | 2010-08-25 | Teva Pharma | Tannate salt of rasagiline |
MX2009006251A (es) * | 2006-12-14 | 2009-10-12 | Teva Pharma | Base de rasagilina solida cristalina. |
EP1987816A1 (de) * | 2007-04-30 | 2008-11-05 | Ratiopharm GmbH | Adsorbate eines Rasagilinsalzes mit einem wasserlöslichen Hilfsstoff |
CA2698695A1 (en) * | 2007-09-05 | 2009-03-12 | Teva Pharmaceutical Industries Ltd. | Method of treating glaucoma using rasagiline |
US8188149B2 (en) * | 2007-09-17 | 2012-05-29 | Teva Pharmaceutical Industries, Ltd. | Use of R(+)-N-propargy1-1-aminoindan to treat or prevent hearing loss |
US20090181086A1 (en) * | 2008-01-11 | 2009-07-16 | Muhammad Safadi | Rasagiline formulations, their preparation and use |
US20090247537A1 (en) * | 2008-03-25 | 2009-10-01 | William Dale Overfield | Methods for preventing or treating bruxism using dopaminergic agents |
WO2009122301A2 (en) * | 2008-03-31 | 2009-10-08 | Actavis Group Ptc Ehf | Rasagiline mesylate particles and process for the preparation thereof |
CN103893160A (zh) * | 2008-06-13 | 2014-07-02 | 泰华制药工业有限公司 | 雷沙吉兰用于改善帕金森氏症 |
JP2011525489A (ja) * | 2008-06-19 | 2011-09-22 | テバ ファーマシューティカル インダストリーズ リミティド | ラサリジン塩基の精製方法 |
NZ589547A (en) | 2008-06-19 | 2013-03-28 | Teva Pharma | Dried rasagiline base having a water content less than 0.5 % by weight |
EP2218444A3 (de) | 2009-01-23 | 2010-08-25 | Teva Pharmaceutical Industries, Ltd. | Rasagilinformulierung mit verzögerter Freisetzung |
US20100189788A1 (en) | 2009-01-23 | 2010-07-29 | Teva Pharmaceutical Industries, Ltd. | Delayed release rasagiline base formulation |
KR20110130410A (ko) | 2009-03-05 | 2011-12-05 | 산도즈 아게 | 라사길린 메실레이트를 함유하는 제약 조성물 |
EP2451771B1 (de) | 2009-07-09 | 2014-06-18 | Ratiopharm GmbH | Rasagilin-salze und pharmazeutische zubereitungen daraus |
CN102048717B (zh) † | 2009-10-29 | 2014-02-19 | 重庆医药工业研究院有限责任公司 | 一种稳定的雷沙吉兰组合物 |
WO2011087791A1 (en) | 2009-12-22 | 2011-07-21 | Teva Pharmaceutical Industries Ltd. | 3-keto-n-propargyl-1-aminoindan |
WO2011139420A2 (en) | 2010-04-30 | 2011-11-10 | Teikoku Pharma Usa, Inc. | Propynylaminoindan transdermal compositions |
EP2389927A1 (de) | 2010-05-30 | 2011-11-30 | Abdi Ibrahim Ilac Sanayi ve Ticaret Anonim Sirketi | Pharmazeutische Formulationen von Rasagilin |
RU2013108256A (ru) | 2010-07-27 | 2014-09-10 | Тева Фармасьютикал Индастриз Лтд. | Дисперсии цитрата разагилина |
CA2806740A1 (en) | 2010-07-27 | 2012-02-02 | Teva Pharmaceutical Industries Ltd. | Use of rasagiline for the treatment of olfactory dysfunction |
WO2012129429A2 (en) | 2011-03-24 | 2012-09-27 | Teikoku Pharma Usa, Inc. | Transdermal compositions comprising an active agent layer and an active agent conversion layer |
EA201490756A1 (ru) * | 2011-10-10 | 2014-09-30 | Тева Фармасьютикал Индастриз, Лтд. | Разагилина цитрамид |
EA201490761A1 (ru) * | 2011-10-10 | 2014-11-28 | Тева Фармасьютикал Индастриз Лтд. | R(+)-n-формилпропаргиламиноиндан |
EA201490760A1 (ru) | 2011-10-10 | 2014-09-30 | Тева Фармасьютикал Индастриз Лтд. | R(+)-n-метилпропаргиламиноиндан |
WO2013070526A1 (en) | 2011-11-09 | 2013-05-16 | Teikoku Pharma Usa, Inc. | Methods for the treatment of skin neoplasms |
DE102012000786A1 (de) | 2012-01-18 | 2013-07-18 | Stada Arzneimittel Ag | Verfahren zur Herstellung einer festen pharmazeutischen Zusammensetzung, enthaltend den Wirkstoff Rasagilin |
EA201491734A1 (ru) | 2012-03-21 | 2015-01-30 | Синтон Бв | Стабилизированные фармацевтические композиции, содержащие соли разагилина |
WO2013175493A1 (en) | 2012-04-09 | 2013-11-28 | Cadila Healthcare Limited | Stable oral pharmaceutical compositions |
TW201412304A (zh) | 2012-08-17 | 2014-04-01 | Teva Pharma | 瑞沙吉林之非經腸調配物 |
SG11201502681WA (en) | 2012-11-02 | 2015-05-28 | Teikoku Pharma Usa Inc | Propynylaminoindan transdermal compositions |
ES2524865T1 (es) * | 2013-02-06 | 2014-12-15 | Galenicum Health S.L. | Composiciones farmacéuticas estables en forma de comprimidos de liberación inmediata |
EP2764862A1 (de) * | 2013-02-06 | 2014-08-13 | Galenicum Health S.L. | Tabletten mit unmittelbarer Freisetzung von Rasagilin Hemitartrate |
CN115400090A (zh) * | 2022-10-09 | 2022-11-29 | 北京新领先医药科技发展有限公司 | 一种雷沙吉兰的口崩片组合物及其制备方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1187017A (en) * | 1966-07-16 | 1970-04-08 | Aspro Nicholas Ltd | Substituted 1-Amino Indanes and Tetrahydronaphthalens |
GB8909793D0 (en) * | 1989-04-28 | 1989-06-14 | Beecham Group Plc | Pharmaceutical formulation |
IL92952A (en) * | 1990-01-03 | 1994-06-24 | Teva Pharma | R-enantiomers of n-propargyl-1-aminoindan compounds, their preparation and pharmaceutical compositions containing them |
CA2039742A1 (en) * | 1990-04-23 | 1991-10-24 | Andrew B. Dennis | Tablet composition and method for problem pharmaceutical materials |
IL112819A (en) * | 1991-10-16 | 2001-11-25 | Teva Pharma | Fluorinated 1-aminoindan compounds and a process for their preparation |
IL111240A (en) * | 1993-10-18 | 2001-10-31 | Teva Pharma | Salts of r(+) - enantiomers of n- propargyl-1-aminoindan and pharmaceutical compositions comprising them |
IL112779A (en) * | 1994-03-01 | 1999-11-30 | Gergely Gerhard | Granular product or tablet containing an efferescent system and an active pharmaceutical substance and its preparation |
SK284383B6 (sk) * | 1995-03-02 | 2005-02-04 | R.P. Scherer Limited | Farmaceutický prostriedok na orálne podávanie obsahujúci inhibítory monoaminoxidázy B a jeho použitie |
-
1995
- 1995-09-20 IL IL11535795A patent/IL115357A/xx not_active IP Right Cessation
-
1996
- 1996-09-18 WO PCT/IL1996/000115 patent/WO1997012583A2/en active IP Right Grant
- 1996-09-18 US US09/043,475 patent/US6126968A/en not_active Expired - Lifetime
- 1996-09-18 ES ES96930344T patent/ES2287940T3/es not_active Expired - Lifetime
- 1996-09-18 PT PT96930344T patent/PT858328E/pt unknown
- 1996-09-18 CA CA002232310A patent/CA2232310C/en not_active Expired - Lifetime
- 1996-09-18 DE DE69637096T patent/DE69637096T2/de not_active Expired - Lifetime
- 1996-09-18 HU HU9802999A patent/HU225859B1/hu unknown
- 1996-09-18 JP JP51411997A patent/JP4108750B2/ja not_active Expired - Lifetime
- 1996-09-18 AT AT96930344T patent/ATE362755T1/de active
- 1996-09-18 AU AU69427/96A patent/AU728524B2/en not_active Expired
- 1996-09-18 DK DK96930344T patent/DK0858328T3/da active
- 1996-09-18 EP EP96930344A patent/EP0858328B1/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ES2287940T3 (es) | 2007-12-16 |
IL115357A (en) | 2000-01-31 |
CA2232310A1 (en) | 1997-04-10 |
EP0858328A2 (de) | 1998-08-19 |
EP0858328A4 (de) | 2001-07-11 |
HUP9802999A2 (hu) | 1999-04-28 |
AU728524B2 (en) | 2001-01-11 |
HUP9802999A3 (en) | 1999-05-28 |
WO1997012583A2 (en) | 1997-04-10 |
WO1997012583A3 (en) | 1997-06-05 |
DK0858328T3 (da) | 2007-09-03 |
EP0858328B1 (de) | 2007-05-23 |
JPH11512736A (ja) | 1999-11-02 |
HU225859B1 (en) | 2007-11-28 |
JP4108750B2 (ja) | 2008-06-25 |
US6126968A (en) | 2000-10-03 |
CA2232310C (en) | 2008-01-08 |
DE69637096T2 (de) | 2008-01-31 |
ATE362755T1 (de) | 2007-06-15 |
PT858328E (pt) | 2007-08-20 |
IL115357A0 (en) | 1995-12-31 |
AU6942796A (en) | 1997-04-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69637096D1 (de) | Stabile n-propargyl-1-aminoindan enthaltende zusammensetzungen | |
UA26455C2 (uk) | Лікарський препарат у формі таблеток із сповільhеhим вивільhеhhям активhого іhгредієhта | |
YU13695A (sh) | Upotreba 2-fenil-3-aroilbenzotiofena i njihove farmaceutske formulacije | |
TR27835A (tr) | Sübstitüe edilmis azadiokzasikloalkenler. | |
AU4264396A (en) | Cosmetic or pharmaceutical compositions containing mangiferin or derivatives thereof | |
PT881901E (pt) | Novas associacoes de principios activos contendo clopidogrel e um agente anti-trombotico | |
HK1010722A1 (en) | Benzoyl guanidines, their production and their use in medicaments | |
FI972434A (fi) | Lamotrigiiniä sisältävä farmaseuttinen koostumus | |
CA2203310A1 (fr) | Comprime matriciel permettant la liberation prolongee du sel de sodium de tianeptine apres administration par voie orale | |
TR200000153T2 (tr) | İl-5 inhibite eden 6-azaurasil türevleri. | |
ATE246515T1 (de) | Verfahren zur herstellung von oralen dosierungsformulierungen enthaltend diclofenac | |
CA2152998A1 (en) | Anti-hyperglycemia pharmaceutical composition | |
ES2078175A1 (es) | Formulacion farmaceutica conteniendo clobetasona y tobramicina y sus aplicaciones. | |
AU2774292A (en) | Toiletries composition | |
AU7470098A (en) | Antithrombotic agents | |
MX9304403A (es) | Derivados farmacologicamente activos de ó-(aminometilo terciario)-bencenmetanol | |
IL122853A0 (en) | Use of allylamines | |
SI0805817T1 (de) | ||
AU7274198A (en) | Antithrombotic agents | |
MX9605633A (es) | Composicion farmaceutica, metodo y dispositivo para prevenir o tratar resequedad de los ojos o enfermedad ocasionada por la misma. | |
TW333453B (en) | Pharmaceutical composition comprising toremifene for use in the treatment of autoimmune diseases |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |