DE69707672T2 - Dibenzo-oxazepin- und dioxepin-derivate und ihre verwendung als antitumormittel - Google Patents

Dibenzo-oxazepin- und dioxepin-derivate und ihre verwendung als antitumormittel

Info

Publication number
DE69707672T2
DE69707672T2 DE69707672T DE69707672T DE69707672T2 DE 69707672 T2 DE69707672 T2 DE 69707672T2 DE 69707672 T DE69707672 T DE 69707672T DE 69707672 T DE69707672 T DE 69707672T DE 69707672 T2 DE69707672 T2 DE 69707672T2
Authority
DE
Germany
Prior art keywords
lower alkyl
oxazepine
dibenzo
substituted
unsubstituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69707672T
Other languages
English (en)
Other versions
DE69707672D1 (de
Inventor
Hooda Dhingra
Haruyoshi Shirai
Yuki Takehana
Michael Wovkulich
Nami Yabuki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of DE69707672D1 publication Critical patent/DE69707672D1/de
Application granted granted Critical
Publication of DE69707672T2 publication Critical patent/DE69707672T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D267/02—Seven-membered rings
    • C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D267/16—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D267/20—[b, f]-condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D321/00—Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00
    • C07D321/02—Seven-membered rings
    • C07D321/10—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/08—Oxygen as only ring hetero atoms containing a hetero ring of at least seven ring members, e.g. zearalenone, macrolide aglycons
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/14—Nitrogen or oxygen as hetero atom and at least one other diverse hetero ring atom in the same ring
DE69707672T 1996-06-07 1997-05-30 Dibenzo-oxazepin- und dioxepin-derivate und ihre verwendung als antitumormittel Expired - Fee Related DE69707672T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP96109115 1996-06-07
PCT/EP1997/002806 WO1997047611A1 (en) 1996-06-07 1997-05-30 Dibenzo-oxazepine and -dioxepine derivatives and their use as anti-tumor agents

Publications (2)

Publication Number Publication Date
DE69707672D1 DE69707672D1 (de) 2001-11-29
DE69707672T2 true DE69707672T2 (de) 2002-08-08

Family

ID=8222857

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69707672T Expired - Fee Related DE69707672T2 (de) 1996-06-07 1997-05-30 Dibenzo-oxazepin- und dioxepin-derivate und ihre verwendung als antitumormittel

Country Status (30)

Country Link
US (1) US5811420A (de)
EP (1) EP0906295B1 (de)
JP (1) JP3199752B2 (de)
KR (1) KR100300152B1 (de)
CN (1) CN1072650C (de)
AT (1) ATE207471T1 (de)
AU (1) AU725649B2 (de)
BR (1) BR9709773A (de)
CA (1) CA2257422A1 (de)
CO (1) CO4940487A1 (de)
CZ (1) CZ397498A3 (de)
DE (1) DE69707672T2 (de)
DK (1) DK0906295T3 (de)
ES (1) ES2166087T3 (de)
HK (1) HK1019063A1 (de)
HR (1) HRP970313A2 (de)
HU (1) HUP0001792A3 (de)
IL (1) IL127137A0 (de)
MA (1) MA24197A1 (de)
NO (1) NO985685L (de)
NZ (1) NZ332997A (de)
PE (1) PE69598A1 (de)
PL (1) PL330346A1 (de)
PT (1) PT906295E (de)
RU (1) RU2167871C2 (de)
TR (1) TR199802517T2 (de)
UY (1) UY24578A1 (de)
WO (1) WO1997047611A1 (de)
YU (1) YU55898A (de)
ZA (1) ZA974886B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPQ307399A0 (en) * 1999-09-24 1999-10-21 Luminis Pty Limited Cell cycle control
CA2404540A1 (en) * 2002-09-20 2004-03-20 Institut Pasteur A method for measuring a marker indicative of the exposure of a patient to nicotine; a kit for measuring such a marker
US20130203715A1 (en) 2010-07-20 2013-08-08 Pulmatrix, Inc. Use of trp channel agonists to treat infections
CN109722389B (zh) * 2017-10-31 2021-05-14 鲁南新时代生物技术有限公司 一种烟曲霉菌液体培养基
CN108165590B (zh) * 2017-12-20 2021-11-23 河南科技学院 一种烟曲霉发酵产烟曲霉素的培养基及培养方法
WO2022187611A1 (en) * 2021-03-04 2022-09-09 Lifemine Therapeutics Cdk inhibitor compounds for use in methods of treatment

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9120640D0 (en) * 1991-09-27 1991-11-06 Ici Plc Tricyclic heterocycles
US5350763A (en) * 1993-06-11 1994-09-27 Merck & Co., Inc. Unguinol and analogs are animal growth permittants
JPH0769882A (ja) * 1993-08-27 1995-03-14 Nippon Paint Co Ltd エプスタイン−バーウィルス活性化抑制剤
ATE210653T1 (de) * 1993-10-15 2001-12-15 Schering Corp Tricyclische sulfonamide-derivate zur inhibierung der g-protein funktion und fur die bekandlung von proliferativen erkrantungen

Also Published As

Publication number Publication date
YU55898A (sh) 2001-12-26
HK1019063A1 (en) 2000-01-21
DE69707672D1 (de) 2001-11-29
CA2257422A1 (en) 1997-12-18
ATE207471T1 (de) 2001-11-15
DK0906295T3 (da) 2002-02-11
US5811420A (en) 1998-09-22
PL330346A1 (en) 1999-05-10
CZ397498A3 (cs) 1999-03-17
CO4940487A1 (es) 2000-07-24
NO985685L (no) 1999-02-04
PT906295E (pt) 2002-04-29
BR9709773A (pt) 1999-08-10
TR199802517T2 (xx) 1999-02-22
JPH11511760A (ja) 1999-10-12
KR20000016432A (ko) 2000-03-25
EP0906295B1 (de) 2001-10-24
RU2167871C2 (ru) 2001-05-27
HUP0001792A2 (hu) 2000-12-28
CN1221409A (zh) 1999-06-30
EP0906295A1 (de) 1999-04-07
HUP0001792A3 (en) 2001-10-29
NO985685D0 (no) 1998-12-04
PE69598A1 (es) 1998-11-14
NZ332997A (en) 2000-05-26
UY24578A1 (es) 2000-12-29
AU725649B2 (en) 2000-10-19
WO1997047611A1 (en) 1997-12-18
KR100300152B1 (ko) 2001-09-06
ES2166087T3 (es) 2002-04-01
JP3199752B2 (ja) 2001-08-20
CN1072650C (zh) 2001-10-10
ZA974886B (en) 1997-12-08
IL127137A0 (en) 1999-09-22
HRP970313A2 (en) 1998-04-30
MA24197A1 (fr) 1997-12-31
AU3169697A (en) 1998-01-07

Similar Documents

Publication Publication Date Title
FR18C1006I2 (fr) Derives de quinoline ayant un groupe azolyle et derives de quinazoline
UY26899A1 (es) Derivados de pirazol fusionados
TR200000065T2 (tr) Epotilon türevleri.
DE69821985D1 (de) Ortho-anthranilamide derivate als antikoagulantien
DE69819173D1 (de) Indole und 2,3-dihydroindolderivate, ihre herstellung und verwendung
NO20004978D0 (no) Semi-syntetiske ecteinascidiner
TR199902897T2 (xx) S�v� benz-izo-kuinolin t�revleri.
DE69813605D1 (de) Benzofuranderivate
IT1315267B1 (it) Derivati di 2-(1h-indol-3-il)-2-oxo-acetammidi ad attivita'antitumorale
TR199802160T2 (xx) Ateroskleroz tedavisi i�in azetidinon t�revleri.
ES2099800T3 (es) Dihidropiridinas utilizables en la terapia antitumoral.
ES2188134T3 (es) Derivados de ciclohexandiol.
ATE207471T1 (de) Dibenzo-oxazepin- und dioxepin-derivate und ihre verwendung als antitumormittel
ES2056194T3 (es) Compuestos tetraciclicos antidepresivos.
ATE201412T1 (de) Pteridinderivate als no synthase-hemmer
PL349933A1 (en) Novel compounds beta-hydroxyalylamides, method of obtaining them and their application
ATE218138T1 (de) N-substituierte azabicycloheptan-derivate, ihre herstellung und verwendung
DE60237652D1 (de) Variolinderivate und ihre Verwendung als Cytostatika

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee