DE69711894D1 - Lipoxinverbindungen und deren verwendung zur behandlung der zellenwucherungsstörung - Google Patents

Lipoxinverbindungen und deren verwendung zur behandlung der zellenwucherungsstörung

Info

Publication number
DE69711894D1
DE69711894D1 DE69711894T DE69711894T DE69711894D1 DE 69711894 D1 DE69711894 D1 DE 69711894D1 DE 69711894 T DE69711894 T DE 69711894T DE 69711894 T DE69711894 T DE 69711894T DE 69711894 D1 DE69711894 D1 DE 69711894D1
Authority
DE
Germany
Prior art keywords
cell growth
treating cell
growth disorders
lipoxin compounds
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69711894T
Other languages
English (en)
Other versions
DE69711894T2 (de
Inventor
N Serhan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Brigham and Womens Hospital Inc
Original Assignee
Brigham and Womens Hospital Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Brigham and Womens Hospital Inc filed Critical Brigham and Womens Hospital Inc
Publication of DE69711894D1 publication Critical patent/DE69711894D1/de
Application granted granted Critical
Publication of DE69711894T2 publication Critical patent/DE69711894T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A61K31/232—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having three or more double bonds, e.g. etretinate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/52—Esters of acyclic unsaturated carboxylic acids having the esterified carboxyl group bound to an acyclic carbon atom
    • C07C69/587—Monocarboxylic acid esters having at least two carbon-to-carbon double bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/734—Ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/734—Ethers
    • C07C69/736—Ethers the hydroxy group of the ester being etherified with a hydroxy compound having the hydroxy group bound to a carbon atom of a six-membered aromatic ring
DE69711894T 1996-09-13 1997-09-15 Lipoxinverbindungen und deren verwendung zur behandlung der zellenwucherungsstörung Expired - Lifetime DE69711894T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/712,610 US6048897A (en) 1993-06-15 1996-09-13 Lipoxin compounds and their use in treating cell proliferative disorders
PCT/US1997/016342 WO1998011049A1 (en) 1996-09-13 1997-09-15 Lipoxin compounds and their use in treating cell proliferative disorders

Publications (2)

Publication Number Publication Date
DE69711894D1 true DE69711894D1 (de) 2002-05-16
DE69711894T2 DE69711894T2 (de) 2002-11-14

Family

ID=24862848

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69711894T Expired - Lifetime DE69711894T2 (de) 1996-09-13 1997-09-15 Lipoxinverbindungen und deren verwendung zur behandlung der zellenwucherungsstörung
DE69738918T Expired - Lifetime DE69738918D1 (de) 1996-09-13 1997-09-15 Lipoxinverbindungen und deren Verwendung zur Behandlung der Zellenwucherungsstörung

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69738918T Expired - Lifetime DE69738918D1 (de) 1996-09-13 1997-09-15 Lipoxinverbindungen und deren Verwendung zur Behandlung der Zellenwucherungsstörung

Country Status (11)

Country Link
US (9) US6048897A (de)
EP (3) EP1201639B1 (de)
JP (1) JP4060366B2 (de)
AT (2) ATE215924T1 (de)
AU (1) AU723321B2 (de)
CA (1) CA2265708C (de)
DE (2) DE69711894T2 (de)
DK (2) DK1201639T3 (de)
ES (2) ES2175460T3 (de)
PT (2) PT1201639E (de)
WO (1) WO1998011049A1 (de)

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US6048897A (en) * 1993-06-15 2000-04-11 Brigham And Women's Hospital Lipoxin compounds and their use in treating cell proliferative disorders
WO2000002851A1 (en) * 1998-07-08 2000-01-20 Aventis Pharma Deutschland Gmbh Sulfur substituted sulfonylaminocarboxylic acid n-arylamides, their preparation, their use and pharmaceutical preparations comprising them
EP1616566A1 (de) * 1999-03-18 2006-01-18 The Brigham And Women's Hospital, Inc. Lipoxinverbindungen zur Behandlung von durch TNF-alpha hervorgerufenen Entzündungen
EP1586550A1 (de) * 1999-03-18 2005-10-19 The Brigham And Women's Hospital, Inc. Verbindungen auf Basis von Lipoxin und deren Verwendung
AU2004235617B2 (en) * 1999-03-18 2008-06-05 The Brigham And Women's Hospital, Inc. Lipoxin compounds and their use
ATE303355T1 (de) 1999-03-18 2005-09-15 Brigham & Womens Hospital Lipoxinverbindungen und ihre anwendung
CA2747376A1 (en) * 1999-03-18 2000-09-21 Brigham And Women's Hospital Use of lipoxin compounds for inhibiting of tnf-(alpha) initiated neutrophil response
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ATE344226T1 (de) 2000-02-16 2006-11-15 Brigham & Womens Hospital Aspirin-ausgelöste lipidmediatoren
WO2001070664A2 (en) 2000-03-20 2001-09-27 Trustees Of Boston University Lipoxin analogs and methods for the treatment of periodontal disease
EP1949937B1 (de) * 2001-03-02 2010-05-19 The Brigham and Women's Hospital Lipoxinanaloge als neuartige Restenose-Hemmer
US8722654B2 (en) 2001-03-02 2014-05-13 The Brigham And Women's Hospital, Inc. Lipoxin analogs as novel inhibitors of angiogenesis
JP2005508282A (ja) * 2001-03-02 2005-03-31 ザ・ブリガム・アンド・ウイメンズ・ホスピタル 新規な脈管形成抑制剤としてのリポキシン類似物
GB0119583D0 (en) * 2001-08-10 2001-10-03 Unilever Plc Cosmetic composition and method of treating skin
EP1441715B1 (de) * 2001-11-06 2013-02-27 The Brigham And Women's Hospital, Inc. Lipoxine und durch aspirin ausgelöste lipoxine und ihre stabilen analoga zur behandlung von asthma und entzündlichen atemkrankheiten
US6831186B2 (en) * 2001-11-06 2004-12-14 Schering Aktiengesellschft Lipoxin A4 analogs
EP1911448B1 (de) * 2001-11-06 2013-01-02 The Brigham and Women's Hospital, Inc. Aspirin-ausgelöste Lipoxine und ihre stabilen Analoga in der Behandlung von Asthma und entzündlichen Atemwegserkrankungen
US7030159B2 (en) * 2001-12-18 2006-04-18 The Brigham And Women's Hospital, Inc. Approach to anti-microbial host defense with molecular shields with EPA and DHA analogs
EP1941875B1 (de) * 2001-12-18 2012-09-12 The Brigham and Women's Hospital Verwendung von Lipoxinanaloga für Förderung der Zellverteidigung gegen gramnegative Infektionen
US20030195248A1 (en) * 2001-12-18 2003-10-16 Serhan Charles N. Novel approach to anti-microbial host defense with molecular shields with lipoxin compounds
US7582785B2 (en) * 2002-04-01 2009-09-01 University Of Southern California Trihydroxy polyunsaturated eicosanoid derivatives
US8481772B2 (en) 2002-04-01 2013-07-09 University Of Southern California Trihydroxy polyunsaturated eicosanoid derivatives
US7902257B2 (en) 2002-04-01 2011-03-08 University Of Southern California Trihydroxy polyunsaturated eicosanoid
AU2003258194B2 (en) 2002-08-12 2009-11-12 The Brigham And Women's Hospital, Inc. Resolvins: biotemplates for therapeutic interventions
US7759395B2 (en) 2002-08-12 2010-07-20 The Brigham And Women's Hospital, Inc. Use of docosatrienes, resolvins and their stable analogs in the treatment of airway diseases and asthma
WO2004078143A2 (en) * 2003-03-05 2004-09-16 The Brigham And Women's Hospital Inc. Methods for identification and uses of anti-inflammatory receptors for eicosapentaenoic acid analogs
GB0313259D0 (en) * 2003-06-09 2003-07-16 Consejo Superior Investigacion Magnetic nanoparticles
US20050250694A1 (en) * 2003-10-10 2005-11-10 Ma Jian-Xing Compounds useful in inhibiting vascular leakage, inflammation and fibrosis and methods of making and using same
US20050130897A1 (en) * 2003-12-11 2005-06-16 Ma Jian-Xing Compounds useful in inhibiting vascular leakage, inflammation and fibrosis and methods of making and using same
EP1755537A4 (de) * 2004-04-14 2009-12-09 Univ Boston Verfahren und zusammensetzungen zur prävention oder behandlung von periodontopathien
DE602005020178D1 (de) * 2004-11-09 2010-05-06 Alcon Inc 5,6,7-trihydroxyheptansäure und analoge zur behandlung von augenkrankheiten und mit hyperproliferativen und angiogenen reaktionen verbundenen krankheiten
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US9439966B2 (en) 2011-10-12 2016-09-13 Case Western Reserve University Multi-component nanochains
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CN105439813B (zh) * 2014-08-08 2017-10-27 广州丹康医药生物有限公司 化合物的合成方法
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Also Published As

Publication number Publication date
EP0927150B1 (de) 2002-04-10
PT1201639E (pt) 2008-10-03
DK1201639T3 (da) 2008-11-24
US20010031882A1 (en) 2001-10-18
US6569075B2 (en) 2003-05-27
US20020091279A1 (en) 2002-07-11
US6653493B2 (en) 2003-11-25
US20020082435A1 (en) 2002-06-27
EP1201639A3 (de) 2003-01-02
US6750360B2 (en) 2004-06-15
WO1998011049A1 (en) 1998-03-19
EP1201639B1 (de) 2008-08-13
JP2001500866A (ja) 2001-01-23
JP4060366B2 (ja) 2008-03-12
ES2175460T3 (es) 2002-11-16
EP0927150A1 (de) 1999-07-07
PT927150E (pt) 2002-08-30
AU723321B2 (en) 2000-08-24
ATE215924T1 (de) 2002-04-15
US20030134901A1 (en) 2003-07-17
US6620919B2 (en) 2003-09-16
ATE404522T1 (de) 2008-08-15
EP1201639A2 (de) 2002-05-02
US20020010351A1 (en) 2002-01-24
DE69738918D1 (de) 2008-09-25
US20020111505A1 (en) 2002-08-15
US20030032827A1 (en) 2003-02-13
CA2265708C (en) 2003-06-10
EP2058293A1 (de) 2009-05-13
US6635776B2 (en) 2003-10-21
ES2312499T3 (es) 2009-03-01
US6316648B1 (en) 2001-11-13
DE69711894T2 (de) 2002-11-14
AU4271097A (en) 1998-04-02
US6048897A (en) 2000-04-11
DK0927150T3 (da) 2002-07-22
CA2265708A1 (en) 1998-03-19

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