DE69714448D1 - Verfahren zur herstellung von präparaten mit kontrollierter wirkstofffreisetzung auf basis von polymeren - Google Patents

Verfahren zur herstellung von präparaten mit kontrollierter wirkstofffreisetzung auf basis von polymeren

Info

Publication number
DE69714448D1
DE69714448D1 DE69714448T DE69714448T DE69714448D1 DE 69714448 D1 DE69714448 D1 DE 69714448D1 DE 69714448 T DE69714448 T DE 69714448T DE 69714448 T DE69714448 T DE 69714448T DE 69714448 D1 DE69714448 D1 DE 69714448D1
Authority
DE
Germany
Prior art keywords
polymer
drug
polymers
active substance
substance release
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69714448T
Other languages
English (en)
Other versions
DE69714448T2 (de
Inventor
A Burke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alkermes Inc
Alkermes Controlled Therapeutics Inc
Original Assignee
Alkermes Inc
Alkermes Controlled Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alkermes Inc, Alkermes Controlled Therapeutics Inc filed Critical Alkermes Inc
Publication of DE69714448D1 publication Critical patent/DE69714448D1/de
Application granted granted Critical
Publication of DE69714448T2 publication Critical patent/DE69714448T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1816—Erythropoietin [EPO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
DE69714448T 1996-05-14 1997-05-01 Verfahren zur herstellung von präparaten mit kontrollierter wirkstofffreisetzung auf basis von polymeren Expired - Fee Related DE69714448T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/649,128 US5817343A (en) 1996-05-14 1996-05-14 Method for fabricating polymer-based controlled-release devices
PCT/US1997/007441 WO1997042940A1 (en) 1996-05-14 1997-05-01 Method for fabricating polymer-based controlled-release devices

Publications (2)

Publication Number Publication Date
DE69714448D1 true DE69714448D1 (de) 2002-09-05
DE69714448T2 DE69714448T2 (de) 2002-11-14

Family

ID=24603582

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69714448T Expired - Fee Related DE69714448T2 (de) 1996-05-14 1997-05-01 Verfahren zur herstellung von präparaten mit kontrollierter wirkstofffreisetzung auf basis von polymeren

Country Status (11)

Country Link
US (3) US5817343A (de)
EP (1) EP0914095B1 (de)
JP (1) JP2000513333A (de)
AT (1) ATE221373T1 (de)
AU (1) AU718866B2 (de)
CA (1) CA2253667A1 (de)
DE (1) DE69714448T2 (de)
DK (1) DK0914095T3 (de)
ES (1) ES2180982T3 (de)
PT (1) PT914095E (de)
WO (1) WO1997042940A1 (de)

Families Citing this family (174)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5989463A (en) * 1997-09-24 1999-11-23 Alkermes Controlled Therapeutics, Inc. Methods for fabricating polymer-based controlled release devices
US6183746B1 (en) 1997-10-09 2001-02-06 Zycos Inc. Immunogenic peptides from the HPV E7 protein
US6013258A (en) * 1997-10-09 2000-01-11 Zycos Inc. Immunogenic peptides from the HPV E7 protein
AU5532699A (en) * 1998-09-05 2000-03-27 Seung Jin Lee Biodegradable particulate polymeric preparation and process for producing thereof
KR20000022894A (ko) * 1998-09-05 2000-04-25 이승진 생분해성 고분자 미립자형 제제 및 그 제조방법
DE19848849A1 (de) * 1998-10-22 2000-04-27 Knoll Ag Verfahren zur Herstellung von festen, sphärischen Formen, enthaltend eine biologisch aktive Substanz
EP1058539A1 (de) * 1999-01-06 2000-12-13 Korea Research Institute Of Chemical Technology Methode zur herstellung eines pharmazeutisch aktiven bestandteils beinhaltend einen wasserunlöslichen wirkstoff sowie eine pharmazeutische zusammensetzung zur oralen verabreichung die diesen bestandteil enthält
US6159491A (en) * 1999-02-12 2000-12-12 Biovector Technologies, Inc. Prolonged release bioadhesive vaginal gel dosage form
KR100372751B1 (ko) * 1999-11-16 2003-02-17 한국과학기술원 생체조직공학용 다공성 생분해성 고분자 지지체의 제조방법
ES2261195T3 (es) * 1999-04-05 2006-11-16 Mannkind Corporation Metodo de formacion de particulas finas.
WO2000062759A1 (en) * 1999-04-16 2000-10-26 Novo Nordisk A/S Dry, mouldable drug formulation
US7371400B2 (en) 2001-01-02 2008-05-13 The General Hospital Corporation Multilayer device for tissue engineering
AU772484B2 (en) * 1999-04-30 2004-04-29 Massachusetts General Hospital Fabrication of vascularized tissue using microfabricated two-dimensional molds
US7759113B2 (en) * 1999-04-30 2010-07-20 The General Hospital Corporation Fabrication of tissue lamina using microfabricated two-dimensional molds
US6291013B1 (en) 1999-05-03 2001-09-18 Southern Biosystems, Inc. Emulsion-based processes for making microparticles
US6444223B1 (en) * 1999-05-28 2002-09-03 Alkermes Controlled Therapeutics, Inc. Method of producing submicron particles of a labile agent and use thereof
JP2003501375A (ja) * 1999-06-04 2003-01-14 アルザ・コーポレーション 移植可能なゲル組成物および製造方法
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
EP1074248A1 (de) * 1999-07-08 2001-02-07 Arnold Hilgers Verabreichungssystem für biologisches Material
US6822086B1 (en) * 1999-08-09 2004-11-23 The General Hospital Corporation Drug-carrier complexes and methods of use thereof
US8106098B2 (en) * 1999-08-09 2012-01-31 The General Hospital Corporation Protein conjugates with a water-soluble biocompatible, biodegradable polymer
WO2001010416A1 (en) * 1999-08-11 2001-02-15 Alkermes Controlled Therapeutics, Inc. Method of delivering a chemotherapeutic agent to a solid tumor
US6284283B1 (en) 1999-10-21 2001-09-04 Alkermes Controlled Therapeutics, Inc. Method of producing sub-micron particles of biologically active agents and uses thereof
AU1226901A (en) * 1999-10-22 2001-05-08 Amgen, Inc. Biodegradable microparticles with novel erythropoietin stimulating protein
WO2001047572A2 (en) * 1999-12-29 2001-07-05 Advanced Cardiovascular Systems, Inc. Device and active component for inhibiting formation of thrombus-inflammatory cell matrix
US7029700B2 (en) * 2000-01-14 2006-04-18 Brown University Research Foundation Micronized freeze-dried particles
US7833549B2 (en) * 2000-01-19 2010-11-16 Mannkind Corporation Dry powder formulations of antihistamine for nasal administration
EP1261427B1 (de) * 2000-03-02 2011-03-02 Microchips, Inc. Mikromechanische geräte und verfahren zur speicherung und zur selektiven exposition von chemikalien
US7074803B2 (en) * 2001-03-02 2006-07-11 Durect Corporation Opioid formulations
US6582713B2 (en) 2000-04-06 2003-06-24 Univ. Of Colorado - Colorado Springs Compositions and methods for promoting wound healing
US7776021B2 (en) 2000-04-28 2010-08-17 The Charles Stark Draper Laboratory Micromachined bilayer unit for filtration of small molecules
DE60127139T2 (de) * 2000-07-14 2007-12-13 Novo Nordisk A/S Verfahren zum formen einer pharmazeutischen zusammensetzung in einem verpackungsmaterial
US6362308B1 (en) 2000-08-10 2002-03-26 Alkermes Controlled Therapeutics Inc. Ii Acid end group poly(d,l-lactide-co-glycolide) copolymers high glycolide content
KR100867392B1 (ko) * 2000-08-15 2008-11-06 더 보드 오브 트러스티즈 오브 더 유니버시티 오브 일리노이 마이크로입자
US6565888B1 (en) 2000-08-23 2003-05-20 Alkermes Controlled Therapeutics, Inc. Methods and compositions for the targeted delivery of biologically active agents
AU8734901A (en) * 2000-09-01 2002-03-13 Palmaya Pty Ltd Slow release pharmaceutical preparation and method of administering same
US7666445B2 (en) 2000-10-20 2010-02-23 The Trustees Of The University Of Pennsylvania Polymer-based surgically implantable haloperidol delivery systems and methods for their production and use
WO2002042325A2 (en) 2000-10-31 2002-05-30 Zycos Inc. Cyp1b1 nucleic acids and methods of use
WO2002062352A2 (en) * 2001-02-07 2002-08-15 Durect Corporation Devices and methods for management of bone density
PT1392248E (pt) * 2001-05-23 2007-10-11 Hexal Ag Processo para a preparação de implantes por meio da preparação de um homogeneizado sem solvente
US6730772B2 (en) 2001-06-22 2004-05-04 Venkatram P. Shastri Degradable polymers from derivatized ring-opened epoxides
US7268190B2 (en) * 2001-08-03 2007-09-11 Toray Industries, Inc. Resin composition comprising polylactic acid and polyacetal and a molded article, film, and fiber each comprising the same
US7687053B2 (en) * 2001-08-20 2010-03-30 Boston Scientific Scimed, Inc. Embolic compositions with non-cyanoacrylate rheology modifying agents
US8454997B2 (en) 2001-12-18 2013-06-04 Novo Nordisk A/S Solid dose micro implant
US7190781B2 (en) * 2002-01-04 2007-03-13 Telefonaktiebolaget Lm Ericsson (Publ) Message transfer part point code mapping method and node
DE60323936D1 (de) * 2002-01-14 2008-11-20 Gen Hospital Corp Bioabbaubare polyketale, verfahren zu ihrer herstellung sowie ihre verwendung
WO2003070905A2 (en) * 2002-02-15 2003-08-28 Zycos, Inc. Electroporation methods for introducing bioactive agents into cells
US8728510B1 (en) 2002-03-15 2014-05-20 Advanced Cardiovascular Systems, Inc. Biocompatible carrier containing a bioadhesive material
WO2003080149A2 (en) 2002-03-20 2003-10-02 Mannkind Corporation Inhalation apparatus
US7776314B2 (en) 2002-06-17 2010-08-17 Grunenthal Gmbh Abuse-proofed dosage system
CA2492803C (en) * 2002-07-19 2013-11-05 The General Hospital Corporation Oxime conjugates and methods for their formation and use
GB2399084B (en) * 2002-07-30 2007-01-31 Univ Liverpool Porous beads and method of production thereof
GB0222522D0 (en) 2002-09-27 2002-11-06 Controlled Therapeutics Sct Water-swellable polymers
AU2003279070A1 (en) * 2002-09-30 2004-04-23 Acusphere Inc Sustained release porous microparticles for inhalation
US6800663B2 (en) * 2002-10-18 2004-10-05 Alkermes Controlled Therapeutics Inc. Ii, Crosslinked hydrogel copolymers
ATE439039T1 (de) 2003-01-16 2009-08-15 Gen Hospital Corp Verwendung von dreidimensionalen, mikrogefertigten, mittels gewebetechnologie hergestellten systemen für pharmakologische anwendungen
US7658998B2 (en) * 2003-01-22 2010-02-09 Alkermes Controlled Therapeutics, Inc. Method of preparing sustained release microparticles
DE10303584A1 (de) * 2003-01-30 2004-08-12 Stauss, Robert, Dr. Verwendung von Erythropoietin (EPO) als ein Beschichtungsmaterial auf medizinischen Implantaten
US7736391B2 (en) 2003-02-06 2010-06-15 Tonaba Healthscience Ii, Llc Cosmetic and reconstructive prostheses with a microencapsulated biologically compatible rupture indicator for sustained release and methods of detecting compromise of a prosthesis
WO2004084819A2 (en) * 2003-03-19 2004-10-07 University Of Kentucky Research Foundation Poly(acryloyl-hydroxyethyl starch)-plga composite microspheres
US7051485B2 (en) * 2003-04-29 2006-05-30 Greg Burnette Ceiling panel system
US7960166B2 (en) 2003-05-21 2011-06-14 The General Hospital Corporation Microfabricated compositions and processes for engineering tissues containing multiple cell types
DE10336400A1 (de) 2003-08-06 2005-03-24 Grünenthal GmbH Gegen Missbrauch gesicherte Darreichungsform
US20070048228A1 (en) 2003-08-06 2007-03-01 Elisabeth Arkenau-Maric Abuse-proofed dosage form
DE102005005446A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Bruchfeste Darreichungsformen mit retardierter Freisetzung
DE10361596A1 (de) * 2003-12-24 2005-09-29 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
ATE507845T1 (de) * 2003-09-05 2011-05-15 Gen Hospital Corp Polyacetal-arzneimittelkonjugate als freisetzungssystem
EP1667659A1 (de) * 2003-09-30 2006-06-14 Acusphere, Inc. Injizierbare, orale oder topische pharmazeutische formulierungen mit verzögerter freisetzung
EP1675571A2 (de) * 2003-09-30 2006-07-05 Spherics, Inc. Therapeutische biologische wirkstoffe in nanoteilchenform
US7309500B2 (en) * 2003-12-04 2007-12-18 The Board Of Trustees Of The University Of Illinois Microparticles
PL2233150T3 (pl) * 2003-12-30 2017-06-30 Bader Erytropoetyna do zastosowania w leczeniu ran lub transplantacji komórek
US8329203B2 (en) * 2004-01-12 2012-12-11 The Trustees Of The University Of Pennsylvania Drug-containing implants and methods of use thereof
US8221778B2 (en) 2005-01-12 2012-07-17 The Trustees Of The University Of Pennsylvania Drug-containing implants and methods of use thereof
CA2553254C (en) * 2004-01-12 2013-12-17 The Trustees Of The University Of Pennsylvania Long-term delivery formulations and methods of use thereof
WO2005072702A2 (en) * 2004-01-20 2005-08-11 Alkermes Controlled Therapeutics, Inc. Method for milling frozen microparticles
US20050188921A1 (en) * 2004-02-27 2005-09-01 Anthony Malone Matrix assisted pulsed-laser evaporation technique for coating a medical device and associated system and medical device
ATE413398T1 (de) * 2004-04-08 2008-11-15 Wyeth Corp Thioamidderivate als progesteronrezeptormodulatoren
US7514466B2 (en) 2004-04-27 2009-04-07 Wyeth Purification of progesterone receptor modulators
CA2565296C (en) * 2004-04-30 2014-06-03 Abraxis Bioscience, Inc. Sustained-release microspheres and methods of making and using same
EP1773293B1 (de) * 2004-06-17 2015-04-15 Endo Pharmaceuticals Solutions Inc. Zusammensetzungen und verfahren zur behandlung von zentraler vorzeitiger pubertät
DE102004032049A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Gegen Missbrauch gesicherte, orale Darreichungsform
PT1781264E (pt) 2004-08-04 2013-10-16 Evonik Corp Métodos para o fabrico de dispositivis de administração e dispositivos para a mesma
GB0417401D0 (en) 2004-08-05 2004-09-08 Controlled Therapeutics Sct Stabilised prostaglandin composition
JP5078014B2 (ja) 2004-08-20 2012-11-21 マンカインド コーポレイション ジケトピペラジン合成の触媒反応
HUE026797T2 (en) 2004-08-23 2016-07-28 Mannkind Corp Diceto-piperazine salts for drug delivery
US9012506B2 (en) 2004-09-28 2015-04-21 Atrium Medical Corporation Cross-linked fatty acid-based biomaterials
US8367099B2 (en) 2004-09-28 2013-02-05 Atrium Medical Corporation Perforated fatty acid films
US8312836B2 (en) 2004-09-28 2012-11-20 Atrium Medical Corporation Method and apparatus for application of a fresh coating on a medical device
US9000040B2 (en) 2004-09-28 2015-04-07 Atrium Medical Corporation Cross-linked fatty acid-based biomaterials
WO2006036982A2 (en) * 2004-09-28 2006-04-06 Atrium Medical Corporation Drug delivery coating for use with a stent
US9801982B2 (en) 2004-09-28 2017-10-31 Atrium Medical Corporation Implantable barrier device
WO2006036969A2 (en) 2004-09-28 2006-04-06 Atrium Medical Corporation Formation of barrier layer
CN101437856A (zh) * 2004-10-14 2009-05-20 塔夫茨大学信托人 可电化学降解的聚合物
US7748343B2 (en) 2004-11-22 2010-07-06 The Board Of Trustees Of The University Of Illinois Electrohydrodynamic spraying system
WO2006078841A1 (en) * 2005-01-21 2006-07-27 President And Fellows Of Harvard College Systems and methods for forming fluidic droplets encapsulated in particles such as colloidal particles
DE102005005449A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
JP4584331B2 (ja) * 2005-03-11 2010-11-17 インデバス ファーマシューティカルズ、インク． オクトレオチドの放出制御製剤
US7759312B2 (en) * 2005-03-11 2010-07-20 Endo Pharmaceuticals Solutions Inc. Delivery of dry formulations of octreotide
KR20120060245A (ko) 2005-09-14 2012-06-11 맨카인드 코포레이션 활성제에 대한 결정질 미립자 표면의 친화력의 증가를 기반으로 하는 약물 제제화의 방법
US9278161B2 (en) 2005-09-28 2016-03-08 Atrium Medical Corporation Tissue-separating fatty acid adhesion barrier
US8574627B2 (en) 2006-11-06 2013-11-05 Atrium Medical Corporation Coated surgical mesh
US9427423B2 (en) * 2009-03-10 2016-08-30 Atrium Medical Corporation Fatty-acid based particles
CA2626030A1 (en) 2005-10-15 2007-04-26 Atrium Medical Corporation Hydrophobic cross-linked gels for bioabsorbable drug carrier coatings
US7669732B2 (en) * 2005-10-25 2010-03-02 Imi Cornelius Inc. Cup lid dispenser
EP2497484A3 (de) 2006-02-22 2012-11-07 MannKind Corporation Verfahren zur Verbesserung der pharmazeutischen Eigenschaften von Mikropartikeln mit Diketopiperazin und einem Wirkstoff
EP2012751A4 (de) * 2006-03-21 2010-11-24 Morehouse School Of Medicine Neue nanopartikel zur wirkstofffreisetzung
US8747870B2 (en) 2006-04-20 2014-06-10 University Of Utah Research Foundation Polymeric compositions and methods of making and using thereof
EP2012803A4 (de) * 2006-04-20 2012-08-01 Univ Utah Res Found Polymerzusammensetzungen sowie verfahren zu ihrer herstellung und verwendung
GB0613333D0 (en) 2006-07-05 2006-08-16 Controlled Therapeutics Sct Hydrophilic polyurethane compositions
GB0613638D0 (en) 2006-07-08 2006-08-16 Controlled Therapeutics Sct Polyurethane elastomers
US20080075777A1 (en) * 2006-07-31 2008-03-27 Kennedy Michael T Apparatus and methods for preparing solid particles
ITMI20061545A1 (it) * 2006-08-02 2008-02-03 Mediolanum Pharmaceuticals Ltd Particelle in grado di rilasciare il principio attivo per un periodo prolungato di tempo
ITMI20061538A1 (it) * 2006-08-02 2008-02-03 Mediolanum Pharmaceuticals Ltd Impianti sottocutanei in grado di rilasciare il principio attivo per un periodo prolungato di tempo
GB0620685D0 (en) 2006-10-18 2006-11-29 Controlled Therapeutics Sct Bioresorbable polymers
US9492596B2 (en) 2006-11-06 2016-11-15 Atrium Medical Corporation Barrier layer with underlying medical device and one or more reinforcing support structures
PE20090167A1 (es) * 2007-03-09 2009-02-11 Wyeth Corp Sintesis y caracterizacion de la forma iii polimorfica de 4-(2-(4,4-dimetil-2-oxooxazolidin-3-il)tiazol-4-il)benzonitrilo
CA2685397C (en) * 2007-04-27 2016-07-26 Endo Pharmaceuticals Solutions Inc. Implant device release agents and methods of using same
PT2868315T (pt) 2007-12-04 2017-09-04 Remedy Pharmaceuticals Inc Formulações melhoradas e métodos para liofilização e liofilizados assim produzidos
JP5502751B2 (ja) 2007-12-20 2014-05-28 エボニック コーポレイション 低残留溶媒濃度を有する微粒子を調製するためのプロセス
KR101616246B1 (ko) 2008-01-25 2016-05-02 그뤼넨탈 게엠베하 약제학적 투여형
MX2010012039A (es) * 2008-05-09 2010-11-30 Gruenenthal Gmbh Proceso para la preparacion de una formulacion de polvo intermedia y una forma de dosificacion solida final bajo el uso de un paso de congelacion por rocio.
WO2009143404A1 (en) * 2008-05-23 2009-11-26 Wyeth Piperazine metabotropic glutamate receptor 5 (mglur5) negative allosteric modulators for anxiety/depression
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
EP3281663B8 (de) 2008-06-13 2022-09-21 MannKind Corporation Atemluftbetriebener trockenpulverinhalator zur verabreichung von medikamenten
US9364619B2 (en) 2008-06-20 2016-06-14 Mannkind Corporation Interactive apparatus and method for real-time profiling of inhalation efforts
JP5622725B2 (ja) 2008-06-25 2014-11-12 エンド ファーマスーティカルズ ソリューションズ インコーポレイテッド．Ｅｎｄｏ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｓｏｌｕｔｉｏｎｓｉｎｃ． エキセナチド及び他のポリペプチド類の持続的送達
UA104866C2 (uk) * 2008-06-25 2014-03-25 Ендо Фармас'Ютікалз Солюшнз Інк. Імплантат октреотиду, який містить вивільняючу речовину
TWI494123B (zh) 2008-08-11 2015-08-01 Mannkind Corp 超快起作用胰島素之用途
CL2009002167A1 (es) * 2008-12-10 2010-10-15 Mersana Therapeutics Inc Formulacion farmaceutica para administracion endovenosa que comprende un compuesto derivado de conjugados de camptotecina-polimero biocompatibles y biodegradables, un agente de estabilizacion, uno o varios tampones y un tensoactivo, util para el tratamiento del cancer.
WO2010066203A1 (en) 2008-12-10 2010-06-17 Anhui Zhongren Technology Co., Ltd. Controlled releasing composition
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
WO2010085607A1 (en) * 2009-01-23 2010-07-29 Surmodics Pharmaceuticals, Inc. Continuous double emulsion process for making microparticles
CA2754595C (en) 2009-03-11 2017-06-27 Mannkind Corporation Apparatus, system and method for measuring resistance of an inhaler
WO2010144789A2 (en) 2009-06-12 2010-12-16 Mannkind Corporation Diketopiperazine microparticles with defined specific surface areas
MX2012000317A (es) 2009-07-22 2012-02-08 Gruenenthal Gmbh Forma de dosificacion de liberacion controlada extruida por fusion en caliente.
RU2015138422A (ru) 2009-07-22 2018-12-25 Грюненталь Гмбх Стабильная при окислении, прочная на излом лекарственная форма
US20110038910A1 (en) 2009-08-11 2011-02-17 Atrium Medical Corporation Anti-infective antimicrobial-containing biomaterials
EP2470019A4 (de) * 2009-08-25 2013-03-13 Cardiokine Biopharma Llc Zusammensetzungen zur verabreichung nichtlöslicher mittel
RU2545865C2 (ru) * 2009-09-22 2015-04-10 Евоник Корпорейшн Имплантируемые устройства с различными вариантами загрузки биологически активного компонента
CA2778698A1 (en) 2009-11-03 2011-05-12 Mannkind Corporation An apparatus and method for simulating inhalation efforts
WO2011095314A2 (en) * 2010-02-03 2011-08-11 Grünenthal GmbH Preparation of a powdery pharmaceutical composition by means of an extruder
AU2011271097B2 (en) 2010-06-21 2014-11-27 Mannkind Corporation Dry powder drug delivery system and methods
US10322213B2 (en) 2010-07-16 2019-06-18 Atrium Medical Corporation Compositions and methods for altering the rate of hydrolysis of cured oil-based materials
ES2487244T3 (es) 2010-09-02 2014-08-20 Grünenthal GmbH Forma de dosificación resistente a la manipulación que comprende un polímero aniónico
CA2808219C (en) 2010-09-02 2019-05-14 Gruenenthal Gmbh Tamper resistant dosage form comprising inorganic salt
US10669522B2 (en) 2011-02-07 2020-06-02 Life Technologies Corporation Compositions and methods for stabilizing susceptible compounds
CN105667994B (zh) 2011-04-01 2018-04-06 曼金德公司 用于药物药盒的泡罩包装
WO2012172449A1 (en) 2011-06-13 2012-12-20 Pfizer Inc. Lactams as beta secretase inhibitors
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
AU2012292418B2 (en) 2011-07-29 2017-02-16 Grunenthal Gmbh Tamper-resistant tablet providing immediate drug release
CA2839123A1 (en) 2011-07-29 2013-02-07 Grunenthal Gmbh Tamper-resistant tablet providing immediate drug release
WO2013025418A1 (en) * 2011-08-15 2013-02-21 Morehouse School Of Medicine Delivery system for specifically targeting cancer cells and method of use thereof
KR20140095483A (ko) 2011-10-24 2014-08-01 맨카인드 코포레이션 통증을 치료하기 위한 방법 및 조성물
EP2790667B1 (de) 2011-12-16 2017-03-22 DSM IP Assets B.V. Verfahren zur herstellung eines arzneimittelabgabesystems basierend auf einem polymer, umfassend einen dispergierten bioaktiven wirkstoff
MX356421B (es) 2012-02-28 2018-05-29 Gruenenthal Gmbh Forma de dosificacion resistente a la manipulacion indebida que comprende un compuesto farmacologicamente activo y un polimero anionico.
CN104394851B (zh) 2012-04-18 2017-12-01 格吕伦塔尔有限公司 抗篡改和抗剂量‑倾泻药物剂型
US10064945B2 (en) 2012-05-11 2018-09-04 Gruenenthal Gmbh Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
US9867880B2 (en) 2012-06-13 2018-01-16 Atrium Medical Corporation Cured oil-hydrogel biomaterial compositions for controlled drug delivery
DK2872205T3 (en) 2012-07-12 2017-02-27 Mannkind Corp DRY POWDER FORMAL ADMINISTRATION SYSTEM
WO2014066856A1 (en) 2012-10-26 2014-05-01 Mannkind Corporation Inhalable influenza vaccine compositions and methods
KR102499439B1 (ko) 2013-03-15 2023-02-13 맨카인드 코포레이션 미세결정성 디케토피페라진 조성물 및 방법
AR096438A1 (es) 2013-05-29 2015-12-30 Gruenenthal Gmbh Forma de dosificación resistente al uso indebido con perfil de liberación bimodal, proceso
CA2907950A1 (en) 2013-05-29 2014-12-04 Grunenthal Gmbh Tamper-resistant dosage form containing one or more particles
BR112016000194A8 (pt) 2013-07-12 2019-12-31 Gruenenthal Gmbh forma de dosagem resistente à violação contendo o polímero de acetato de etileno-vinila
WO2015010092A1 (en) 2013-07-18 2015-01-22 Mannkind Corporation Heat-stable dry powder pharmaceutical compositions and methods
JP2016530930A (ja) 2013-08-05 2016-10-06 マンカインド コーポレイション 通気装置及び方法
CN105934241B (zh) 2013-11-26 2020-06-05 格吕伦塔尔有限公司 通过低温研磨制备粉末状药物组合物
WO2015148905A1 (en) 2014-03-28 2015-10-01 Mannkind Corporation Use of ultrarapid acting insulin
WO2015173195A1 (en) 2014-05-12 2015-11-19 Grünenthal GmbH Tamper resistant immediate release capsule formulation comprising tapentadol
JP2017516789A (ja) 2014-05-26 2017-06-22 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング エタノール過量放出に対して防護されている多粒子
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
EP3285745A1 (de) 2015-04-24 2018-02-28 Grünenthal GmbH Manipulationssichere darreichungsform mit sofortiger freisetzung und widerstand gegen lösungsmittelextraktion
CA2998259A1 (en) 2015-09-10 2017-03-16 Grunenthal Gmbh Protecting oral overdose with abuse deterrent immediate release formulations
US10953103B2 (en) 2015-11-06 2021-03-23 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V Composition comprising a biocompatible and biodegradable polymer, nanocarriers and a drug and methods of making and using the same

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4293539A (en) * 1979-09-12 1981-10-06 Eli Lilly And Company Controlled release formulations and method of treatment
IE52535B1 (en) * 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
US4818542A (en) * 1983-11-14 1989-04-04 The University Of Kentucky Research Foundation Porous microspheres for drug delivery and methods for making same
US4703008A (en) * 1983-12-13 1987-10-27 Kiren-Amgen, Inc. DNA sequences encoding erythropoietin
CH665558A5 (en) 1985-10-09 1988-05-31 Debiopharm Sa Phase sepn. prodn. of microcapsules for water soluble pharmaceuticals - using fluoro-substd. aliphatic hydrocarbon as non-solvent in the hardening stage
JPS62223112A (ja) 1986-03-25 1987-10-01 Rooto Seiyaku Kk 歯周病治療剤
ES2053549T3 (es) 1986-08-11 1994-08-01 Innovata Biomed Ltd Un proceso para la preparacion de una formulacion farmaceutica apropiada para inhalacion.
GB2209937B (en) * 1987-09-21 1991-07-03 Depiopharm S A Water insoluble polypeptides
AU2902289A (en) 1987-12-08 1989-07-05 Mark Chasin Method of forming bioerodible implants for improved controlled drug release
FR2634376B1 (fr) * 1988-07-21 1992-04-17 Farmalyoc Nouvelle forme unitaire, solide et poreuse comprenant des microparticules et/ou des nanoparticules, ainsi que sa preparation
US5019400A (en) * 1989-05-01 1991-05-28 Enzytech, Inc. Very low temperature casting of controlled release microspheres
HU221294B1 (en) * 1989-07-07 2002-09-28 Novartis Ag Process for producing retarde compositions containing the active ingredient in a polymeric carrier
PH30995A (en) 1989-07-07 1997-12-23 Novartis Inc Sustained release formulations of water soluble peptides.
US5439688A (en) * 1989-07-28 1995-08-08 Debio Recherche Pharmaceutique S.A. Process for preparing a pharmaceutical composition
US5478564A (en) * 1990-02-22 1995-12-26 Teva Pharmaceutical Industries, Ltd. Preparation of microparticles for controlled release of water-soluble substances
JPH05194253A (ja) 1992-01-16 1993-08-03 Kirin Brewery Co Ltd 水溶性ポリペプチドホルモンを含む徐放性微小粒子状製剤及びその製造法
DE4201179A1 (de) * 1992-01-17 1993-07-22 Alfatec Pharma Gmbh Wirkstoff(e) enthaltendes granulat oder pellet mit einem geruest aus hydrophilen makromolekuelen und verfahren zu seiner herstellung
ATE154240T1 (de) * 1992-03-12 1997-06-15 Alkermes Inc Acth enthaltende mikrokugeln mit gesteuerter abgabe
US5674534A (en) * 1992-06-11 1997-10-07 Alkermes, Inc. Composition for sustained release of non-aggregated erythropoietin
US5723508A (en) * 1996-01-25 1998-03-03 Northwestern University Method of fabricating emulsion freeze-dried scaffold bodies and resulting products

Also Published As

Publication number Publication date
ES2180982T3 (es) 2003-02-16
DE69714448T2 (de) 2002-11-14
ATE221373T1 (de) 2002-08-15
WO1997042940A1 (en) 1997-11-20
US6183781B1 (en) 2001-02-06
AU718866B2 (en) 2000-04-20
AU2751797A (en) 1997-12-05
CA2253667A1 (en) 1997-11-20
US20030031701A1 (en) 2003-02-13
EP0914095B1 (de) 2002-07-31
PT914095E (pt) 2002-11-29
US5817343A (en) 1998-10-06
JP2000513333A (ja) 2000-10-10
EP0914095A1 (de) 1999-05-12
DK0914095T3 (da) 2002-11-11

Similar Documents

Publication Publication Date Title
DE69714448D1 (de) Verfahren zur herstellung von präparaten mit kontrollierter wirkstofffreisetzung auf basis von polymeren
DE69814885D1 (de) Verfahren zur herstellung von arzneiformen mit kontrollierter wirkstoffabgabe auf polymerbasis
DK0946169T3 (da) Fremgangsmåde til fremstilling af et præparat med vedvarende frigivelse
ATE198982T1 (de) Verfahren zur herstellung von festen pharmazeutischen dosierungsformen hydrophobischen substanzen
ATE204469T1 (de) Verfahren zur herstellung von morphologisch einheitlichen mikrokapseln sowie nach diesem verfahren hergestellte mikrokapseln
ES2090836T3 (es) Procedimiento para la preparacion de microcapsulas polimeras que contienen substancias biologicamente activas.
DE69332310T2 (de) Verfahren zur herstellung von vorgefüllten, sterilen abgabevorrichtungen.
DE69534163D1 (de) Polymerteilchen zur arzneimittelabgabe
DE3686057T2 (de) Verfahren zur herstellung von polymerteilchen, diese polymerteilchen und ihre verwendung.
DE69003152T2 (de) Verfahren und Vorrichtung zur kontinuierlichen Herstellung von mit fibrilliertem Polymer gebundenen Elektrodenkomponenten.
DE59803468D1 (de) Verfahren zur herstellung von lösungsmittelfreien nicht-kristallinen biologisch aktiven substanzen
ATE223206T1 (de) Verfahren zur herstellung von mikropartikeln
DE60119914D1 (de) Verfahren zur herstellung von zusammensetzungen mit beschleunigter abgabe unter verwendung von komprimierten fluiden
DE3850262D1 (de) Verfahren zur herstellung einer physiologisch aktiven substanz aus samenschalen von föhren und ein gegen infektionen aktives mittel, hauptsächlich auf der basis von diesem extrakt.
ES513422A0 (es) Procedimiento para la obtencion de un preparado medicamentoso de accion retardada que contiene un polimero hidrofilo de celulosa
ATE136312T1 (de) Verfahren zur herstellung von vernetztem polybeta-alanin in einem einzigen schritt aus acrylamid und einer polyfunktionalen copolymerisierbaren verbindung
DE68911725T2 (de) Verfahren und Vorrichtung zur Herstellung von Polymeren.
DE69943225D1 (de) Flüssige Polymerlosung zur Kontrollierten freisetzung von bioaktiven substanzen
DE3851321T2 (de) Aromatisches Sulfidamid-Polymer und Verfahren zu dessen Herstellung.
IT1293087B1 (it) Microparticelle a base di materiali polimerici ibridi per il rilascio controllato di molecole biologicamente attive, procedimento per la
DE3868238D1 (de) Verfahren zur kontinuierlichen herstellung von polymeren von konjugierten diolefinen mit niedrigem molekulargewicht.
RU94023245A (ru) Способ приготовления препарата с постепенным высвобождением лекарственного агента, препарат с постепенным высвобождением лекарственного агента

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee