DE69718438T2 - Verfahren und vorrichtung zur maldi analyse - Google Patents

Verfahren und vorrichtung zur maldi analyse

Info

Publication number
DE69718438T2
DE69718438T2 DE69718438T DE69718438T DE69718438T2 DE 69718438 T2 DE69718438 T2 DE 69718438T2 DE 69718438 T DE69718438 T DE 69718438T DE 69718438 T DE69718438 T DE 69718438T DE 69718438 T2 DE69718438 T2 DE 69718438T2
Authority
DE
Germany
Prior art keywords
analyte
specimen
matrix
compartment
desorbed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69718438T
Other languages
English (en)
Other versions
DE69718438D1 (de
Inventor
Franz Hillenkamp
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sequenom Inc
Original Assignee
Sequenom Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sequenom Inc filed Critical Sequenom Inc
Publication of DE69718438D1 publication Critical patent/DE69718438D1/de
Application granted granted Critical
Publication of DE69718438T2 publication Critical patent/DE69718438T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H01J49/161—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission using photoionisation, e.g. by laser
    • H01J49/164—Laser desorption/ionisation, e.g. matrix-assisted laser desorption/ionisation [MALDI]
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0409—Sample holders or containers
    • H01J49/0418—Sample holders or containers for laser desorption, e.g. matrix-assisted laser desorption/ionisation [MALDI] plates or surface enhanced laser desorption/ionisation [SELDI] plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00387—Applications using probes
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
DE69718438T 1996-09-19 1997-09-19 Verfahren und vorrichtung zur maldi analyse Expired - Lifetime DE69718438T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/710,565 US5777324A (en) 1996-09-19 1996-09-19 Method and apparatus for maldi analysis
PCT/US1997/016115 WO1998012734A1 (en) 1996-09-19 1997-09-19 Method and apparatus for maldi analysis

Publications (2)

Publication Number Publication Date
DE69718438D1 DE69718438D1 (de) 2003-02-20
DE69718438T2 true DE69718438T2 (de) 2003-10-23

Family

ID=24854565

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69718438T Expired - Lifetime DE69718438T2 (de) 1996-09-19 1997-09-19 Verfahren und vorrichtung zur maldi analyse

Country Status (8)

Country Link
US (4) US5777324A (de)
EP (2) EP0868740B1 (de)
JP (1) JP3601834B2 (de)
AT (1) ATE231284T1 (de)
AU (1) AU724884B2 (de)
CA (1) CA2237946C (de)
DE (1) DE69718438T2 (de)
WO (1) WO1998012734A1 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102021105327B3 (de) 2021-03-05 2022-05-12 Bruker Daltonics GmbH & Co. KG Desorptions-Ionenquelle mit Postdesorptions-Ionisierung in Transmissionsgeometrie

Families Citing this family (255)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6436635B1 (en) * 1992-11-06 2002-08-20 Boston University Solid phase sequencing of double-stranded nucleic acids
US5795714A (en) * 1992-11-06 1998-08-18 Trustees Of Boston University Method for replicating an array of nucleic acid probes
EP1262564A3 (de) 1993-01-07 2004-03-31 Sequenom, Inc. Dns-Sequenzierung durch Massenspektrometrie
US6194144B1 (en) 1993-01-07 2001-02-27 Sequenom, Inc. DNA sequencing by mass spectrometry
US5605798A (en) 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
US20060063193A1 (en) * 1995-04-11 2006-03-23 Dong-Jing Fu Solid phase sequencing of double-stranded nucleic acids
US7803529B1 (en) 1995-04-11 2010-09-28 Sequenom, Inc. Solid phase sequencing of biopolymers
US5830655A (en) 1995-05-22 1998-11-03 Sri International Oligonucleotide sizing using cleavable primers
US6146854A (en) * 1995-08-31 2000-11-14 Sequenom, Inc. Filtration processes, kits and devices for isolating plasmids
AU2069597A (en) 1996-03-04 1997-09-22 Genetrace Systems, Inc. Methods of screening nucleic acids using mass spectrometry
US6828435B2 (en) 1996-04-17 2004-12-07 Hk Pharmaceuticals, Inc. Combinatorial protecting group strategy for multifunctional molecules
US5965363A (en) 1996-09-19 1999-10-12 Genetrace Systems Inc. Methods of preparing nucleic acids for mass spectrometric analysis
US5777324A (en) * 1996-09-19 1998-07-07 Sequenom, Inc. Method and apparatus for maldi analysis
US7285422B1 (en) * 1997-01-23 2007-10-23 Sequenom, Inc. Systems and methods for preparing and analyzing low volume analyte array elements
EP0954612A2 (de) * 1996-11-06 1999-11-10 Sequenom, Inc. Dna-diagnostik mittels massenspektrometrie
CA2268740C (en) 1996-11-06 2010-07-20 Sequenom, Inc. High density immobilization of nucleic acids
US6140053A (en) * 1996-11-06 2000-10-31 Sequenom, Inc. DNA sequencing by mass spectrometry via exonuclease degradation
WO1998026095A1 (en) 1996-12-10 1998-06-18 Genetrace Systems Inc. Releasable nonvolatile mass-label molecules
DE69824586T2 (de) * 1997-06-26 2005-06-23 PerSeptive Biosystems, Inc., Framingham Probenträger hoher dichte für die analyse biologischer proben
US6207370B1 (en) 1997-09-02 2001-03-27 Sequenom, Inc. Diagnostics based on mass spectrometric detection of translated target polypeptides
US20110166040A1 (en) * 1997-09-05 2011-07-07 Ibis Biosciences, Inc. Compositions for use in identification of strains of e. coli o157:h7
DE19741874A1 (de) * 1997-09-23 1999-04-01 Henkel Ecolab Gmbh & Co Ohg Alkoholathaltiger Reiniger
US6331702B1 (en) 1999-01-25 2001-12-18 University Of Manitoba Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use
USRE39099E1 (en) * 1998-01-23 2006-05-23 University Of Manitoba Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use
US6723564B2 (en) 1998-05-07 2004-04-20 Sequenom, Inc. IR MALDI mass spectrometry of nucleic acids using liquid matrices
JP4106751B2 (ja) * 1998-08-04 2008-06-25 ソニー株式会社 画像表示装置及びその製造方法
WO2000054309A1 (en) 1999-03-09 2000-09-14 The Scripps Research Institute Improved desorption/ionization of analytes from porous light-absorbing semiconductor
US6225061B1 (en) 1999-03-10 2001-05-01 Sequenom, Inc. Systems and methods for performing reactions in an unsealed environment
US6436640B1 (en) 1999-03-18 2002-08-20 Exiqon A/S Use of LNA in mass spectrometry
US20020009394A1 (en) 1999-04-02 2002-01-24 Hubert Koster Automated process line
JP4564696B2 (ja) * 1999-06-11 2010-10-20 アプライド バイオシステムズ， エルエルシー 不安定な分子の分子量を決定するための方法および装置
DE19937438C2 (de) * 1999-08-07 2001-09-13 Bruker Daltonik Gmbh Kopplung Dünnschicht-Chromatographie und Massenspektrometrie (TLC/MS)
GB9922837D0 (en) * 1999-09-27 1999-11-24 Ludwig Inst Cancer Res Modified ion source targets for use in liquid maldi ms
JP2003519829A (ja) 1999-10-13 2003-06-24 シークエノム・インコーポレーテツド データベースを作成する方法および多型遺伝的マーカーを同定するためのデータベース
US7917301B1 (en) 2000-09-19 2011-03-29 Sequenom, Inc. Method and device for identifying a biological sample
US7668658B2 (en) 1999-10-13 2010-02-23 Sequenom, Inc. Methods for generating databases and databases for identifying polymorphic genetic markers
US20030207297A1 (en) * 1999-10-13 2003-11-06 Hubert Koster Methods for generating databases and databases for identifying polymorphic genetic markers
WO2001062887A1 (en) * 2000-02-23 2001-08-30 Zyomyx, Inc. Chips having elevated sample surfaces
US7122790B2 (en) * 2000-05-30 2006-10-17 The Penn State Research Foundation Matrix-free desorption ionization mass spectrometry using tailored morphology layer devices
DE10027794A1 (de) * 2000-06-07 2001-12-13 Basf Ag Verfahren zur Analyse Enzym-katalysierter Umsetzungen mit MALDI-TOF-Massenspektrometrie
US7375319B1 (en) 2000-06-09 2008-05-20 Willoughby Ross C Laser desorption ion source
EP1373561B1 (de) 2000-06-13 2009-02-18 The Trustees of Boston University Verwendung von mass-matched nukleotide in der analyse von oligonukleotidmischungen sowie in der hoch-multiplexen nukleinsäuresequenzierung
DE60125596T2 (de) * 2000-07-11 2007-10-04 Kirk Madison Hogan Verfahren und zusammensetzungen zur bestimmung von perioperativen genomprofile
US20020195555A1 (en) * 2000-10-11 2002-12-26 Weinberger Scot R. Apparatus and methods for affinity capture tandem mass spectrometry
WO2002031484A2 (en) * 2000-10-11 2002-04-18 Ciphergen Biosystems, Inc. Methods for characterizing molecular interactions using affinity capture tandem mass spectrometry
US7060442B2 (en) * 2000-10-30 2006-06-13 Regents Of The University Of Michigan Modulators on Nod2 signaling
KR100649342B1 (ko) 2000-10-30 2006-11-27 시쿼넘, 인코포레이티드 기판 상으로 서브마이크로리터 볼륨들을 전달하기 위한 방법 및 장치
US6969757B2 (en) * 2001-01-26 2005-11-29 Syngenta Participations Ag Differential labeling for quantitative analysis of complex protein mixtures
US7166436B2 (en) 2001-01-26 2007-01-23 Syngenta Participations, Ag Differential labeling for quantitative analysis of complex protein mixtures
US7450618B2 (en) 2001-01-30 2008-11-11 Board Of Trustees Operating Michigan State University Laser system using ultrashort laser pulses
US7973936B2 (en) 2001-01-30 2011-07-05 Board Of Trustees Of Michigan State University Control system and apparatus for use with ultra-fast laser
WO2002061799A2 (en) * 2001-01-30 2002-08-08 Board Of Trustees Operating Michigan State University Control system and apparatus for use with laser excitation or ionization
US7567596B2 (en) 2001-01-30 2009-07-28 Board Of Trustees Of Michigan State University Control system and apparatus for use with ultra-fast laser
US8208505B2 (en) 2001-01-30 2012-06-26 Board Of Trustees Of Michigan State University Laser system employing harmonic generation
US7609731B2 (en) * 2001-01-30 2009-10-27 Board Of Trustees Operating Michigan State University Laser system using ultra-short laser pulses
US7583710B2 (en) * 2001-01-30 2009-09-01 Board Of Trustees Operating Michigan State University Laser and environmental monitoring system
CA2436503A1 (en) * 2001-02-01 2002-08-08 Huw A. Davies Improved methods for protein identification, characterization and sequencing by tandem mass spectrometry
US20030027135A1 (en) 2001-03-02 2003-02-06 Ecker David J. Method for rapid detection and identification of bioagents
US20040121311A1 (en) 2002-12-06 2004-06-24 Ecker David J. Methods for rapid detection and identification of bioagents in livestock
US20040121310A1 (en) * 2002-12-18 2004-06-24 Ecker David J. Methods for rapid detection and identification of bioagents in forensic studies
US7226739B2 (en) 2001-03-02 2007-06-05 Isis Pharmaceuticals, Inc Methods for rapid detection and identification of bioagents in epidemiological and forensic investigations
US20040121314A1 (en) * 2002-12-06 2004-06-24 Ecker David J. Methods for rapid detection and identification of bioagents in containers
US7666588B2 (en) 2001-03-02 2010-02-23 Ibis Biosciences, Inc. Methods for rapid forensic analysis of mitochondrial DNA and characterization of mitochondrial DNA heteroplasmy
US7718354B2 (en) * 2001-03-02 2010-05-18 Ibis Biosciences, Inc. Methods for rapid identification of pathogens in humans and animals
US20030036057A1 (en) * 2001-03-09 2003-02-20 Andreas Braun Genes and polymorphisms associated with cardiovascular disease and their use
US20020155587A1 (en) 2001-04-20 2002-10-24 Sequenom, Inc. System and method for testing a biological sample
EP1395939A4 (de) * 2001-05-24 2006-06-07 New Objective Inc Verfahren und vorrichtung für elektrospray mit rückkopplungsregelung
US6936224B2 (en) * 2001-06-21 2005-08-30 Perseptive Biosystems, Inc. Apparatus and process for transporting sample plates
US8073627B2 (en) 2001-06-26 2011-12-06 Ibis Biosciences, Inc. System for indentification of pathogens
US7217510B2 (en) * 2001-06-26 2007-05-15 Isis Pharmaceuticals, Inc. Methods for providing bacterial bioagent characterizing information
US6800449B1 (en) 2001-07-13 2004-10-05 Syngenta Participations Ag High throughput functional proteomics
DE10140499B4 (de) * 2001-08-17 2005-02-03 Bruker Daltonik Gmbh Probenträgerplatten für Massenspektrometrie mit Ionisierung durch matrixunterstützte Laserdesorption
US7108975B2 (en) * 2001-09-21 2006-09-19 Regents Of The University Of Michigan Atlastin
US7582425B2 (en) * 2001-09-21 2009-09-01 The Regents Of The University Of Michigan Atlastin
CA2464682A1 (en) * 2001-10-26 2003-05-01 Sequenom, Inc. Method and apparatus for high-throughput sample handling process line
US7255986B2 (en) * 2002-01-31 2007-08-14 The Board Of Trustees Operating Michigan State University Compositions for the diagnosis and treatment of epizootic catarrhal enteritis in ferrets
BR0200690A (pt) * 2002-03-04 2004-03-23 Embrapa Pesquisa Agropecuaria Método para detecção de proteinas de origem em misturas complexas
JP3530942B2 (ja) * 2002-03-05 2004-05-24 独立行政法人通信総合研究所 分子ビーム発生方法及び装置
AU2003220320A1 (en) * 2002-03-21 2003-10-08 Thermo Finnigan Llc Ionization apparatus and method for mass spectrometer system
AUPS177202A0 (en) * 2002-04-16 2002-05-23 Diakyne Pty Ltd Multi-element screening of trace elements
AU2003228809A1 (en) * 2002-05-03 2003-11-17 Sequenom, Inc. Kinase anchor protein muteins, peptides thereof, and related methods
US6680477B2 (en) * 2002-05-31 2004-01-20 Battelle Memorial Institute High spatial resolution matrix assisted laser desorption/ionization (MALDI)
US6624409B1 (en) 2002-07-30 2003-09-23 Agilent Technologies, Inc. Matrix assisted laser desorption substrates for biological and reactive samples
US7214353B2 (en) * 2002-08-30 2007-05-08 Corning Incorporated Peptide or protein-capturing surfaces for high throughput MALDI mass spectrometry
US20030119063A1 (en) * 2002-09-03 2003-06-26 Pham Thang T. High accuracy protein identification
US6707039B1 (en) 2002-09-19 2004-03-16 Agilent Technologies, Inc. AP-MALDI target illumination device and method for using an AP-MALDI target illumination device
US6863731B2 (en) * 2002-10-18 2005-03-08 Controls Corporation Of America System for deposition of inert barrier coating to increase corrosion resistance
JP4241006B2 (ja) * 2002-11-11 2009-03-18 株式会社島津製作所 レーザー脱離イオン化質量分析方法とそれに用いるサンプルプレート
US7105809B2 (en) * 2002-11-18 2006-09-12 3M Innovative Properties Company Microstructured polymeric substrate
AU2003298733B2 (en) * 2002-11-27 2009-06-18 Agena Bioscience, Inc. Fragmentation-based methods and systems for sequence variation detection and discovery
JP2006516193A (ja) 2002-12-06 2006-06-29 アイシス・ファーマシューティカルス・インコーポレーテッド ヒトおよび動物における病原体の迅速な同定方法
US6642516B1 (en) * 2002-12-18 2003-11-04 Agilent Technologies, Inc. Apparatus and method of laser dissociation for mass spectrometry
US6822230B2 (en) * 2002-12-23 2004-11-23 Agilent Technologies, Inc. Matrix-assisted laser desorption/ionization sample holders and methods of using the same
JP2004264043A (ja) * 2003-01-31 2004-09-24 National Institute Of Advanced Industrial & Technology イオン化装置および微小領域分析装置
JP4555820B2 (ja) * 2003-02-10 2010-10-06 ウオーターズ・テクノロジーズ・コーポレイシヨン シリコン上の脱離／イオン化質量分析（ｄｉｏｓ−ｍｓ）を使用した周囲空気の成分の吸着、検出、および同定
US7586091B2 (en) * 2003-03-14 2009-09-08 Nec Corporation Mass spectrometric system and mass spectrometry
US6903334B1 (en) 2003-03-19 2005-06-07 Thermo Finnigan Llc High throughput ion source for MALDI mass spectrometry
US20040185448A1 (en) * 2003-03-20 2004-09-23 Viorica Lopez-Avila Methods and devices for performing matrix assisted laser desorption/lonization protocols
US8046171B2 (en) 2003-04-18 2011-10-25 Ibis Biosciences, Inc. Methods and apparatus for genetic evaluation
CA2523490A1 (en) * 2003-04-25 2004-11-11 Sequenom, Inc. Fragmentation-based methods and systems for de novo sequencing
US8057993B2 (en) 2003-04-26 2011-11-15 Ibis Biosciences, Inc. Methods for identification of coronaviruses
US7964343B2 (en) 2003-05-13 2011-06-21 Ibis Biosciences, Inc. Method for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture
US8158354B2 (en) 2003-05-13 2012-04-17 Ibis Biosciences, Inc. Methods for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture
US7145135B1 (en) 2003-05-30 2006-12-05 Agilent Technologies, Inc. Apparatus and method for MALDI source control with external image capture
GB0313170D0 (en) 2003-06-09 2003-07-16 Qinetiq Ltd Method and apparatus for spore disruption and/or detection
DE112004001121T5 (de) * 2003-06-25 2006-05-04 Waters Investments Ltd., New Castle Vorrichtung zur Verhinderung der Kreuzverunreinigung in einer Plattform und Herstellungsverfahren
DK1660680T3 (da) 2003-07-31 2009-06-22 Sequenom Inc Fremgangsmåde til multipleks-polymerasekædereaktioner på höjt niveau og homogene masseforlængelsesreaktioner til genotypebestemmelse af polymorfismer
US9394565B2 (en) * 2003-09-05 2016-07-19 Agena Bioscience, Inc. Allele-specific sequence variation analysis
US8546082B2 (en) 2003-09-11 2013-10-01 Ibis Biosciences, Inc. Methods for identification of sepsis-causing bacteria
US8097416B2 (en) 2003-09-11 2012-01-17 Ibis Biosciences, Inc. Methods for identification of sepsis-causing bacteria
US20120122101A1 (en) 2003-09-11 2012-05-17 Rangarajan Sampath Compositions for use in identification of bacteria
US20100129811A1 (en) * 2003-09-11 2010-05-27 Ibis Biosciences, Inc. Compositions for use in identification of pseudomonas aeruginosa
CA2539074C (en) 2003-09-19 2017-11-07 Epitopix, Llc Campylobacter polypeptides and methods of use
US6825478B1 (en) * 2003-10-10 2004-11-30 Perseptive Biosystems, Inc. MALDI plate with removable magnetic insert
US6953928B2 (en) * 2003-10-31 2005-10-11 Applera Corporation Ion source and methods for MALDI mass spectrometry
US8163895B2 (en) 2003-12-05 2012-04-24 Ibis Biosciences, Inc. Compositions for use in identification of orthopoxviruses
US20050128754A1 (en) * 2003-12-12 2005-06-16 Redden Myron K. Ceramic foam light diffuser
US7030373B2 (en) * 2003-12-19 2006-04-18 Applera Corporation MALDI plate construction with grid
US7438859B2 (en) * 2003-12-31 2008-10-21 Protedyne Corporation Method and apparatus for laser impulse sample deposition
EP1574849B1 (de) * 2004-01-22 2012-09-26 Thermo Finnigan Llc Verfahren und Gerät für FAIMS mit laserbasierter Ionisationsquelle
US7432057B2 (en) * 2004-01-30 2008-10-07 Michigan State University Genetic test for PSE-susceptible turkeys
US7666592B2 (en) 2004-02-18 2010-02-23 Ibis Biosciences, Inc. Methods for concurrent identification and quantification of an unknown bioagent
US8119336B2 (en) 2004-03-03 2012-02-21 Ibis Biosciences, Inc. Compositions for use in identification of alphaviruses
WO2005115737A2 (en) * 2004-03-22 2005-12-08 Quantaspec Inc. System and method for detecting and identifying an analyte
CN101233240A (zh) * 2004-03-26 2008-07-30 斯昆诺有限公司 与质量分析结合的甲基化特异性扩增产物的碱基特异性切割
US7608394B2 (en) 2004-03-26 2009-10-27 Sequenom, Inc. Methods and compositions for phenotype identification based on nucleic acid methylation
EP1734560B1 (de) * 2004-03-30 2013-04-10 University of Yamanashi Ionisierungsverfahren und -einrichtung für die massenanalyse
JP4810533B2 (ja) 2004-05-24 2011-11-09 アイビス バイオサイエンシズ インコーポレイティッド ディジタルスレショルド化による選択的イオン濾過作用を用いた質量分光測定法
US20050266411A1 (en) 2004-05-25 2005-12-01 Hofstadler Steven A Methods for rapid forensic analysis of mitochondrial DNA
US7785843B2 (en) * 2004-06-23 2010-08-31 Sequenom, Inc. Target-specific compomers and methods of use
US7811753B2 (en) 2004-07-14 2010-10-12 Ibis Biosciences, Inc. Methods for repairing degraded DNA
JP2008512129A (ja) * 2004-09-10 2008-04-24 セクエノム，インコーポレイティド 核酸の広範囲配列分析法
EP1804958A4 (de) * 2004-09-17 2010-11-17 Nanosys Inc Nanostrukturierte dünnfilme und ihre verwendung
US8633437B2 (en) 2005-02-14 2014-01-21 Board Of Trustees Of Michigan State University Ultra-fast laser system
US8084207B2 (en) 2005-03-03 2011-12-27 Ibis Bioscience, Inc. Compositions for use in identification of papillomavirus
CA2600184A1 (en) 2005-03-03 2006-09-08 Isis Pharmaceuticals, Inc. Compositions for use in identification of adventitious viruses
US7265368B2 (en) * 2005-05-13 2007-09-04 Applera Corporation Ion optical mounting assemblies
US20060266941A1 (en) * 2005-05-26 2006-11-30 Vestal Marvin L Method and apparatus for interfacing separations techniques to MALDI-TOF mass spectrometry
US7435951B2 (en) * 2005-06-08 2008-10-14 Agilent Technologies, Inc. Ion source sample plate illumination system
US8026084B2 (en) 2005-07-21 2011-09-27 Ibis Biosciences, Inc. Methods for rapid identification and quantitation of nucleic acid variants
US7495231B2 (en) * 2005-09-08 2009-02-24 Agilent Technologies, Inc. MALDI sample plate imaging workstation
US7919279B2 (en) * 2005-09-29 2011-04-05 Children's Hospital & Research Center At Oakland Methods and compositions for KIR genotyping
US7180058B1 (en) 2005-10-05 2007-02-20 Thermo Finnigan Llc LDI/MALDI source for enhanced spatial resolution
WO2007046162A1 (ja) * 2005-10-20 2007-04-26 Japan Science And Technology Agency 質量分析法に用いられる試料ターゲットおよびその製造方法、並びに当該試料ターゲットを用いた質量分析装置
US7423260B2 (en) * 2005-11-04 2008-09-09 Agilent Technologies, Inc. Apparatus for combined laser focusing and spot imaging for MALDI
US20070207455A1 (en) * 2005-11-17 2007-09-06 Third Wave Technologies, Inc. Compositions and methods for detecting an HCV-1 subtype
EP2468901B1 (de) 2005-11-29 2017-04-05 Cambridge Enterprise Limited Marker für Brustkrebs
EP1957959A2 (de) 2005-11-30 2008-08-20 Board of Trustees of Michigan State University Identifizierung molekularer eigenschaften auf laserbasis
US7781730B2 (en) * 2006-02-14 2010-08-24 Los Alamos National Security, Llc Linear electronic field time-of-flight ion mass spectrometers
KR20080114773A (ko) * 2006-03-01 2008-12-31 펄리건 사이언시스, 인코퍼레이티드 중독에 대한 마커
US20110143344A1 (en) * 2006-03-01 2011-06-16 The Washington University Genetic polymorphisms and substance dependence
US8026477B2 (en) 2006-03-03 2011-09-27 Ionsense, Inc. Sampling system for use with surface ionization spectroscopy
US7700913B2 (en) 2006-03-03 2010-04-20 Ionsense, Inc. Sampling system for use with surface ionization spectroscopy
WO2007118222A2 (en) 2006-04-06 2007-10-18 Ibis Biosciences, INC Compositions for the use in identification of fungi
WO2007145702A2 (en) 2006-04-10 2007-12-21 Board Of Trustees Of Michigan State University Laser material processing systems and methods with, in particular, use of a hollow waveguide for broadening the bandwidth of the pulse above 20 nm
DE102006023061B4 (de) * 2006-05-17 2008-08-14 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Gasdetektor mit akustischer Messzelle und selektiv adsorbierender Oberfläche
EP2035122A4 (de) * 2006-05-26 2010-05-05 Ionsense Inc Biegsames probennahmesystem mit offener röhre zur verwendung mit oberflächenionisierungstechnik
CA2663029C (en) 2006-09-14 2016-07-19 Ibis Biosciences, Inc. Targeted whole genome amplification method for identification of pathogens
US8440965B2 (en) 2006-10-13 2013-05-14 Ionsense, Inc. Sampling system for use with surface ionization spectroscopy
US7642806B2 (en) * 2006-10-13 2010-01-05 General Atomics Test apparatus, system, and method with a magnetic feature
WO2008046111A2 (en) 2006-10-13 2008-04-17 Ionsense, Inc. A sampling system for containment and transfer of ions into a spectroscopy system
AU2008210421B2 (en) 2007-01-30 2014-03-13 Pharmacyclics Llc Methods for determining cancer resistance to histone deacetylase inhibitors
JP5680304B2 (ja) 2007-02-23 2015-03-04 アイビス バイオサイエンシズ インコーポレイティッド 迅速な法医学的ｄｎａ分析法
WO2009023358A2 (en) * 2007-05-25 2009-02-19 Ibis Biosciences, Inc. Compositions for use in identification of strains of hepatitis c virus
WO2008151023A2 (en) 2007-06-01 2008-12-11 Ibis Biosciences, Inc. Methods and compositions for multiple displacement amplification of nucleic acids
US20110045456A1 (en) * 2007-06-14 2011-02-24 Ibis Biosciences, Inc. Compositions for use in identification of adventitious contaminant viruses
GB2453407B (en) * 2007-07-31 2012-07-18 Bruker Daltonik Gmbh Matrix-assisted laser desorption with high ionization yield
DE102007043456B4 (de) * 2007-07-31 2012-02-09 Bruker Daltonik Gmbh Matrixunterstützte Laserdesorption hoher Ionisierungsausbeute
US20090180931A1 (en) 2007-09-17 2009-07-16 Sequenom, Inc. Integrated robotic sample transfer device
US8311069B2 (en) 2007-12-21 2012-11-13 Board Of Trustees Of Michigan State University Direct ultrashort laser system
US8044346B2 (en) * 2007-12-21 2011-10-25 Licentia Oy Method and system for desorbing and ionizing chemical compounds from surfaces
US20110097704A1 (en) * 2008-01-29 2011-04-28 Ibis Biosciences, Inc. Compositions for use in identification of picornaviruses
WO2009155103A2 (en) * 2008-05-30 2009-12-23 Ibis Biosciences, Inc. Compositions for use in identification of tick-borne pathogens
WO2009151982A1 (en) * 2008-05-30 2009-12-17 Ibis Biosciences, Inc. Compositions for use in identification of francisella
US20110151437A1 (en) * 2008-06-02 2011-06-23 Ibis Biosciences, Inc. Compositions for use in identification of adventitious viruses
US8550694B2 (en) 2008-09-16 2013-10-08 Ibis Biosciences, Inc. Mixing cartridges, mixing stations, and related kits, systems, and methods
WO2010033627A2 (en) 2008-09-16 2010-03-25 Ibis Biosciences, Inc. Sample processing units, systems, and related methods
WO2010033625A1 (en) 2008-09-16 2010-03-25 Ibis Biosciences, Inc. Microplate handling systems and related computer program products and methods
WO2010039696A1 (en) * 2008-10-02 2010-04-08 Ibis Biosciences, Inc. Compositions for use in identification of herpesviruses
US20110189687A1 (en) * 2008-10-02 2011-08-04 Ibis Bioscience, Inc. Compositions for use in identification of members of the bacterial genus mycoplasma
US20110183343A1 (en) * 2008-10-03 2011-07-28 Rangarajan Sampath Compositions for use in identification of members of the bacterial class alphaproteobacter
WO2010039763A2 (en) * 2008-10-03 2010-04-08 Ibis Biosciences, Inc. Compositions for use in identification of antibiotic-resistant bacteria
WO2010039870A1 (en) * 2008-10-03 2010-04-08 Ibis Biosciences, Inc. Compositions for use in identification of neisseria, chlamydia, and/or chlamydophila bacteria
WO2010039787A1 (en) * 2008-10-03 2010-04-08 Ibis Biosciences, Inc. Compositions for use in identification of clostridium difficile
US20110183345A1 (en) * 2008-10-03 2011-07-28 Ibis Biosciences, Inc. Compositions for use in identification of streptococcus pneumoniae
US9202678B2 (en) * 2008-11-14 2015-12-01 Board Of Trustees Of Michigan State University Ultrafast laser system for biological mass spectrometry
EP2211430A3 (de) 2009-01-23 2015-05-27 Board of Trustees of Michigan State University Laserautokorrelationssystem
US8158936B2 (en) 2009-02-12 2012-04-17 Ibis Biosciences, Inc. Ionization probe assemblies
DE202009002192U1 (de) * 2009-02-16 2009-04-23 Thermo Fisher Scientific (Bremen) Gmbh Elektrode zur Beeinflussung der Ionenbewegung in Massenspektrometern
WO2010141128A2 (en) 2009-03-05 2010-12-09 Board Of Trustees Of Michigan State University Laser amplification system
US9719083B2 (en) 2009-03-08 2017-08-01 Ibis Biosciences, Inc. Bioagent detection methods
US9393564B2 (en) 2009-03-30 2016-07-19 Ibis Biosciences, Inc. Bioagent detection systems, devices, and methods
WO2010124257A2 (en) * 2009-04-24 2010-10-28 Colby Pharmaceutical Company Methods and kits for determining oxygen free radical (ofr) levels in animal and human tissues as a prognostic marker for cancer and other pathophysiologies
US8207497B2 (en) 2009-05-08 2012-06-26 Ionsense, Inc. Sampling of confined spaces
WO2011008971A1 (en) 2009-07-17 2011-01-20 Ibis Biosciences, Inc. Lift and mount apparatus
US9194877B2 (en) 2009-07-17 2015-11-24 Ibis Biosciences, Inc. Systems for bioagent indentification
WO2011014811A1 (en) 2009-07-31 2011-02-03 Ibis Biosciences, Inc. Capture primers and capture sequence linked solid supports for molecular diagnostic tests
US9080209B2 (en) 2009-08-06 2015-07-14 Ibis Biosciences, Inc. Non-mass determined base compositions for nucleic acid detection
US20110065111A1 (en) * 2009-08-31 2011-03-17 Ibis Biosciences, Inc. Compositions For Use In Genotyping Of Klebsiella Pneumoniae
ES2628739T3 (es) 2009-10-15 2017-08-03 Ibis Biosciences, Inc. Amplificación por desplazamiento múltiple
US8630322B2 (en) 2010-03-01 2014-01-14 Board Of Trustees Of Michigan State University Laser system for output manipulation
US8774488B2 (en) 2010-03-11 2014-07-08 Cellscape Corporation Method and device for identification of nucleated red blood cells from a maternal blood sample
US9758840B2 (en) * 2010-03-14 2017-09-12 Ibis Biosciences, Inc. Parasite detection via endosymbiont detection
US9492887B2 (en) 2010-04-01 2016-11-15 Electro Scientific Industries, Inc. Touch screen interface for laser processing
US8519330B2 (en) 2010-10-01 2013-08-27 Ut-Battelle, Llc Systems and methods for laser assisted sample transfer to solution for chemical analysis
US8637813B2 (en) * 2010-10-01 2014-01-28 Ut-Battelle, Llc System and method for laser assisted sample transfer to solution for chemical analysis
US8822949B2 (en) 2011-02-05 2014-09-02 Ionsense Inc. Apparatus and method for thermal assisted desorption ionization systems
US8901488B1 (en) 2011-04-18 2014-12-02 Ionsense, Inc. Robust, rapid, secure sample manipulation before during and after ionization for a spectroscopy system
US8829426B2 (en) 2011-07-14 2014-09-09 The George Washington University Plume collimation for laser ablation electrospray ionization mass spectrometry
GB2493179B (en) * 2011-07-26 2018-09-05 Kratos Analytical Ltd MALDI sample preparation methods and targets
US9209003B2 (en) * 2011-10-26 2015-12-08 Dh Technologies Development Pte. Ltd. Quantification of an analyte in serum and other biological matrices
GB201122309D0 (en) * 2011-12-23 2012-02-01 Micromass Ltd An imaging mass spectrometer and a method of mass spectrometry
US9222115B2 (en) 2011-12-30 2015-12-29 Abbott Molecular, Inc. Channels with cross-sectional thermal gradients
SG193046A1 (en) * 2012-02-23 2013-09-30 Histoindex Pte Ltd A digital imaging system for biopsy inspection
CN104379563B (zh) 2012-04-10 2018-12-21 加利福尼亚大学董事会 用于治疗癌症的组合物和方法
JP5875483B2 (ja) * 2012-08-14 2016-03-02 富士フイルム株式会社 質量分析装置
US9227978B2 (en) 2013-03-15 2016-01-05 Araxes Pharma Llc Covalent inhibitors of Kras G12C
EP2792471B1 (de) 2013-04-16 2018-01-31 Stratec Consumables GmbH Polymerteile
CA2895360C (en) 2013-04-17 2023-05-02 Fluidigm Canada Inc. Sample analysis for mass cytometry
JO3805B1 (ar) 2013-10-10 2021-01-31 Araxes Pharma Llc مثبطات كراس جي12سي
US9337007B2 (en) 2014-06-15 2016-05-10 Ionsense, Inc. Apparatus and method for generating chemical signatures using differential desorption
BR112016030008A2 (pt) 2014-06-27 2017-10-24 Abbott Lab método para a detecção de infecção por pegivirus humano 2 em um indivíduo, para a detecção de ácido nucleico de pegivirus humano 2 e para a detecção de pegivirus humano 2 em uma amostra, e, composição
JO3556B1 (ar) 2014-09-18 2020-07-05 Araxes Pharma Llc علاجات مدمجة لمعالجة السرطان
WO2016049568A1 (en) 2014-09-25 2016-03-31 Araxes Pharma Llc Methods and compositions for inhibition of ras
EP3197870B1 (de) 2014-09-25 2020-08-19 Araxes Pharma LLC Inhibitoren von g12c mutierten kras proteinen
WO2016061432A1 (en) * 2014-10-17 2016-04-21 Porex Corporation Disposable porous cleaning devices and methods
US9850479B2 (en) * 2015-03-03 2017-12-26 The Board Of Regents Of The University Of Oklahoma Method and apparatus for sampling macromolecules from a biological specimen
US10246424B2 (en) 2015-04-10 2019-04-02 Araxes Pharma Llc Substituted quinazoline compounds and methods of use thereof
ES2856880T3 (es) 2015-04-15 2021-09-28 Araxes Pharma Llc Inhibidores tricíclicos condensados de KRAS y métodos de uso de los mismos
US10144724B2 (en) 2015-07-22 2018-12-04 Araxes Pharma Llc Substituted quinazoline compounds and methods of use thereof
CN108371711A (zh) 2015-08-17 2018-08-07 库拉肿瘤学公司 使用法尼基转移酶抑制剂治疗癌症患者的方法
EP3356353A1 (de) 2015-09-28 2018-08-08 Araxes Pharma LLC Inhibitoren von kras-g12c-mutanten proteinen
EP3356347A1 (de) 2015-09-28 2018-08-08 Araxes Pharma LLC Inhibitoren von kras-g12c-mutanten proteinen
WO2017058805A1 (en) 2015-09-28 2017-04-06 Araxes Pharma Llc Inhibitors of kras g12c mutant proteins
EP3356349A1 (de) 2015-09-28 2018-08-08 Araxes Pharma LLC Inhibitoren von kras-g12c-mutanten proteinen
WO2017058768A1 (en) 2015-09-28 2017-04-06 Araxes Pharma Llc Inhibitors of kras g12c mutant proteins
WO2017058902A1 (en) 2015-09-28 2017-04-06 Araxes Pharma Llc Inhibitors of kras g12c mutant proteins
US10882847B2 (en) 2015-09-28 2021-01-05 Araxes Pharma Llc Inhibitors of KRAS G12C mutant proteins
WO2017070256A2 (en) 2015-10-19 2017-04-27 Araxes Pharma Llc Method for screening inhibitors of ras
TW201726656A (zh) 2015-11-16 2017-08-01 亞瑞克西斯製藥公司 包含經取代雜環基團之２－經取代喹唑啉化合物及其使用方法
US9988357B2 (en) 2015-12-09 2018-06-05 Araxes Pharma Llc Methods for preparation of quinazoline derivatives
US10822312B2 (en) 2016-03-30 2020-11-03 Araxes Pharma Llc Substituted quinazoline compounds and methods of use
US10646488B2 (en) 2016-07-13 2020-05-12 Araxes Pharma Llc Conjugates of cereblon binding compounds and G12C mutant KRAS, HRAS or NRAS protein modulating compounds and methods of use thereof
WO2018064510A1 (en) 2016-09-29 2018-04-05 Araxes Pharma Llc Inhibitors of kras g12c mutant proteins
JP2019534260A (ja) 2016-10-07 2019-11-28 アラクセス ファーマ エルエルシー Ｒａｓの阻害剤としての複素環式化合物およびその使用方法
JP7191828B2 (ja) 2016-12-15 2022-12-19 ザ・リージエンツ・オブ・ザ・ユニバーシテイー・オブ・カリフオルニア がん治療のための組成物および方法
US11136308B2 (en) 2017-01-26 2021-10-05 Araxes Pharma Llc Substituted quinazoline and quinazolinone compounds and methods of use thereof
WO2018140600A1 (en) 2017-01-26 2018-08-02 Araxes Pharma Llc Fused hetero-hetero bicyclic compounds and methods of use thereof
WO2018140513A1 (en) 2017-01-26 2018-08-02 Araxes Pharma Llc 1-(3-(6-(3-hydroxynaphthalen-1-yl)benzofuran-2-yl)azetidin-1yl)prop-2-en-1-one derivatives and similar compounds as kras g12c modulators for treating cancer
US11274093B2 (en) 2017-01-26 2022-03-15 Araxes Pharma Llc Fused bicyclic benzoheteroaromatic compounds and methods of use thereof
US11358959B2 (en) 2017-01-26 2022-06-14 Araxes Pharma Llc Benzothiophene and benzothiazole compounds and methods of use thereof
WO2018218069A1 (en) 2017-05-25 2018-11-29 Araxes Pharma Llc Quinazoline derivatives as modulators of mutant kras, hras or nras
AU2018271990A1 (en) 2017-05-25 2019-12-12 Araxes Pharma Llc Covalent inhibitors of KRAS
US10736897B2 (en) 2017-05-25 2020-08-11 Araxes Pharma Llc Compounds and methods of use thereof for treatment of cancer
WO2020046892A1 (en) * 2018-08-28 2020-03-05 Virgin Instruments Corporation Molecular imaging of biological samples with sub-cellular spatial resolution and high sensitivity

Family Cites Families (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2141387C3 (de) * 1971-08-18 1975-12-11 Ernst Dr. 8000 Muenchen Remy Verfahren zur auf Mikrobereiche beschränkten Verdampfung, Zerstörung, Anregung und/oder Ionisierung von Probenmaterial sowie Anordnung zur Durchführung des Verfahrens
DE2739829C2 (de) * 1977-09-03 1986-04-10 Gesellschaft für Strahlen- und Umweltforschung mbH, 8000 München Anordnung zur Analyse einer Probenschicht durch Beschuß mit elektromagnetischer Strahlung
DE2739828C2 (de) * 1977-09-03 1986-07-03 Gesellschaft für Strahlen- und Umweltforschung mbH, 8000 München Einrichtung zur Analyse von Proben
DE2819711C2 (de) 1978-05-05 1984-02-16 Gesellschaft für Strahlen- und Umweltforschung mbH, 8000 München Verfahren und Vorrichtung zur Analyse einer Probe mit Hilfe gepulster Laserstrahlung
US4442354A (en) 1982-01-22 1984-04-10 Atom Sciences, Inc. Sputter initiated resonance ionization spectrometry
DE3221681A1 (de) * 1982-06-08 1983-12-08 Bayer Ag, 5090 Leverkusen Massenspektrometer mit externer probenhalterung
DE3329892A1 (de) * 1983-08-18 1985-03-07 Köster, Hubert, Prof. Dr., 2000 Hamburg Verfahren zur herstellung von oligonucleotiden
US5118605A (en) * 1984-10-16 1992-06-02 Chiron Corporation Polynucleotide determination with selectable cleavage sites
GB2177507B (en) * 1985-06-13 1989-02-15 Mitsubishi Electric Corp Laser mass spectroscopic analyzer
FR2597260B1 (fr) * 1986-04-10 1988-07-15 Univ Pasteur Procede d'introduction directe automatique d'echantillons dans un spectrometre de masse, et dispositif pour la mise en oeuvre de ce procede
GB8626075D0 (en) 1986-10-31 1986-12-03 Vg Instr Group Time-of-flight mass spectrometer
DE3809504C1 (de) 1988-03-22 1989-09-21 Bruker - Franzen Analytik Gmbh, 2800 Bremen, De
US4920264A (en) 1989-01-17 1990-04-24 Sri International Method for preparing samples for mass analysis by desorption from a frozen solution
EP0434792A4 (en) 1989-05-19 1992-05-20 John B. Fenn Multiply charged ions and a method for determining the molecular weight of large molecules
GB2236186B (en) * 1989-08-22 1994-01-05 Finnigan Mat Gmbh Process and device for laser desorption of analyte molecular ions, especially of biomolecules
US5045694A (en) 1989-09-27 1991-09-03 The Rockefeller University Instrument and method for the laser desorption of ions in mass spectrometry
US5288644A (en) * 1990-04-04 1994-02-22 The Rockefeller University Instrument and method for the sequencing of genome
US5135870A (en) 1990-06-01 1992-08-04 Arizona Board Of Regents Laser ablation/ionizaton and mass spectrometric analysis of massive polymers
DE4019005C2 (de) 1990-06-13 2000-03-09 Finnigan Mat Gmbh Vorrichtungen zur Analyse von Ionen hoher Masse
US5210412A (en) 1991-01-31 1993-05-11 Wayne State University Method for analyzing an organic sample
WO1992013629A1 (en) 1991-01-31 1992-08-20 Wayne State University A method for analyzing an organic sample
US5300774A (en) * 1991-04-25 1994-04-05 Applied Biosystems, Inc. Time-of-flight mass spectrometer with an aperture enabling tradeoff of transmission efficiency and resolution
DE4202123C2 (de) * 1992-01-27 1995-04-06 Bruker Franzen Analytik Gmbh Vorrichtung für die massenspektrometrische Untersuchung schneller organischer Ionen
US5382793A (en) * 1992-03-06 1995-01-17 Hewlett-Packard Company Laser desorption ionization mass monitor (LDIM)
US5795714A (en) * 1992-11-06 1998-08-18 Trustees Of Boston University Method for replicating an array of nucleic acid probes
US5503980A (en) * 1992-11-06 1996-04-02 Trustees Of Boston University Positional sequencing by hybridization
EP1262564A3 (de) * 1993-01-07 2004-03-31 Sequenom, Inc. Dns-Sequenzierung durch Massenspektrometrie
US5605798A (en) * 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
CA2158642A1 (en) * 1993-03-19 1994-09-29 Hubert Koster Dna sequencing by mass spectrometry via exonuclease degradation
US5381008A (en) * 1993-05-11 1995-01-10 Mds Health Group Ltd. Method of plasma mass analysis with reduced space charge effects
US5376788A (en) * 1993-05-26 1994-12-27 University Of Manitoba Apparatus and method for matrix-assisted laser desorption mass spectrometry
GB9315847D0 (en) * 1993-07-30 1993-09-15 Isis Innovation Tag reagent and assay method
FR2709761B1 (fr) 1993-09-10 1995-11-24 Pasteur Institut Procédé de détection de molécules contenant des mésappariements nucléotidiques et de localisation de ces mésappariements, et application à la détection de substitutions ou de délétions de bases .
US5807522A (en) * 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US5498545A (en) * 1994-07-21 1996-03-12 Vestal; Marvin L. Mass spectrometer system and method for matrix-assisted laser desorption measurements
US5504326A (en) * 1994-10-24 1996-04-02 Indiana University Foundation Spatial-velocity correlation focusing in time-of-flight mass spectrometry
WO1996032504A2 (en) * 1995-04-11 1996-10-17 Trustees Of Boston University Solid phase sequencing of biopolymers
US5591969A (en) * 1995-04-12 1997-01-07 The United States Of America As Represented By The Secretary Of The Navy Inductive detector for time-of-flight mass spectrometers
WO1996036986A1 (en) 1995-05-19 1996-11-21 Perseptive Biosystems, Inc. Methods and apparatus for sequencing polymers with a statistical certainty using mass spectrometry
US5753439A (en) * 1995-05-19 1998-05-19 Trustees Of Boston University Nucleic acid detection methods
US5625184A (en) 1995-05-19 1997-04-29 Perseptive Biosystems, Inc. Time-of-flight mass spectrometry analysis of biomolecules
US5830655A (en) 1995-05-22 1998-11-03 Sri International Oligonucleotide sizing using cleavable primers
US5700642A (en) 1995-05-22 1997-12-23 Sri International Oligonucleotide sizing using immobilized cleavable primers
US6146854A (en) * 1995-08-31 2000-11-14 Sequenom, Inc. Filtration processes, kits and devices for isolating plasmids
US5869242A (en) 1995-09-18 1999-02-09 Myriad Genetics, Inc. Mass spectrometry to assess DNA sequence polymorphisms
US5654545A (en) 1995-09-19 1997-08-05 Bruker-Franzen Analytik Gmbh Mass resolution in time-of-flight mass spectrometers with reflectors
WO1997016699A1 (en) * 1995-10-30 1997-05-09 Trustees Of Boston University Piezoelectric force sensing apparatus and methods for biopolymer sequencing
US5716825A (en) * 1995-11-01 1998-02-10 Hewlett Packard Company Integrated nucleic acid analysis system for MALDI-TOF MS
US5742049A (en) 1995-12-21 1998-04-21 Bruker-Franzen Analytik Gmbh Method of improving mass resolution in time-of-flight mass spectrometry
US5641959A (en) 1995-12-21 1997-06-24 Bruker-Franzen Analytik Gmbh Method for improved mass resolution with a TOF-LD source
WO1997037041A2 (en) * 1996-03-18 1997-10-09 Sequenom, Inc. Dna sequencing by mass spectrometry
US5777325A (en) 1996-05-06 1998-07-07 Hewlett-Packard Company Device for time lag focusing time-of-flight mass spectrometry
US5928906A (en) * 1996-05-09 1999-07-27 Sequenom, Inc. Process for direct sequencing during template amplification
US6022688A (en) * 1996-05-13 2000-02-08 Sequenom, Inc. Method for dissociating biotin complexes
DE19628178C1 (de) * 1996-07-12 1997-09-18 Bruker Franzen Analytik Gmbh Verfahren zum Beladen von Probenträgern für Massenspektrometer
US5777324A (en) * 1996-09-19 1998-07-07 Sequenom, Inc. Method and apparatus for maldi analysis
US5864137A (en) * 1996-10-01 1999-01-26 Genetrace Systems, Inc. Mass spectrometer
US5885775A (en) 1996-10-04 1999-03-23 Perseptive Biosystems, Inc. Methods for determining sequences information in polynucleotides using mass spectrometry
CA2268740C (en) 1996-11-06 2010-07-20 Sequenom, Inc. High density immobilization of nucleic acids
US5900481A (en) 1996-11-06 1999-05-04 Sequenom, Inc. Bead linkers for immobilizing nucleic acids to solid supports
ATE204290T1 (de) 1996-11-06 2001-09-15 Sequenom Inc Zusammensetzungen und verfahren zur immobilisierung von nukleinsäure auf festträgern
EP0954612A2 (de) * 1996-11-06 1999-11-10 Sequenom, Inc. Dna-diagnostik mittels massenspektrometrie
US6248101B1 (en) 1997-01-22 2001-06-19 Barzell Whitmore Maroon Bells, Inc. Omni-directional precision instrument platform
US6207370B1 (en) 1997-09-02 2001-03-27 Sequenom, Inc. Diagnostics based on mass spectrometric detection of translated target polypeptides
US6723564B2 (en) 1998-05-07 2004-04-20 Sequenom, Inc. IR MALDI mass spectrometry of nucleic acids using liquid matrices

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102021105327B3 (de) 2021-03-05 2022-05-12 Bruker Daltonics GmbH & Co. KG Desorptions-Ionenquelle mit Postdesorptions-Ionisierung in Transmissionsgeometrie

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