DE69719057D1 - Verfahren zur signalverstärkung - Google Patents
Verfahren zur signalverstärkungInfo
- Publication number
- DE69719057D1 DE69719057D1 DE69719057T DE69719057T DE69719057D1 DE 69719057 D1 DE69719057 D1 DE 69719057D1 DE 69719057 T DE69719057 T DE 69719057T DE 69719057 T DE69719057 T DE 69719057T DE 69719057 D1 DE69719057 D1 DE 69719057D1
- Authority
- DE
- Germany
- Prior art keywords
- gaining
- signals
- gaining signals
- disclosed
- methods
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6804—Nucleic acid analysis using immunogens
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/682—Signal amplification
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2458/00—Labels used in chemical analysis of biological material
- G01N2458/10—Oligonucleotides as tagging agents for labelling antibodies
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2271896P | 1996-07-12 | 1996-07-12 | |
PCT/US1997/012118 WO1998002580A2 (en) | 1996-07-12 | 1997-07-11 | Signal amplification method |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69719057D1 true DE69719057D1 (de) | 2003-03-20 |
DE69719057T2 DE69719057T2 (de) | 2003-12-04 |
Family
ID=21811080
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69719057T Expired - Lifetime DE69719057T2 (de) | 1996-07-12 | 1997-07-11 | Verfahren zur signalverstärkung |
Country Status (8)
Country | Link |
---|---|
US (3) | US5902724A (de) |
EP (1) | EP0938588B1 (de) |
JP (1) | JP2000515367A (de) |
AT (1) | ATE232559T1 (de) |
AU (1) | AU4040097A (de) |
CA (1) | CA2259918A1 (de) |
DE (1) | DE69719057T2 (de) |
WO (1) | WO1998002580A2 (de) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9805935D0 (en) * | 1998-03-19 | 1998-05-13 | Ciba Geigy Ag | Organic compounds |
GB9905580D0 (en) | 1999-03-12 | 1999-05-05 | Tepnel Medical Ltd | Enyzymatically catalysed signal amplification |
US6472153B1 (en) * | 1999-10-26 | 2002-10-29 | Epoch Biosciences, Inc. | Hybridization-triggered fluorescent detection of nucleic acids |
AU2001247328C1 (en) * | 2000-03-08 | 2006-10-26 | Datascope Investment Corp. | Methods for assay and detection on a microarray |
US6803196B1 (en) | 2000-10-13 | 2004-10-12 | Affymetrix, Inc. | Methods and compositions for detecting signals in binding assays using microparticles |
US20030109067A1 (en) * | 2001-12-06 | 2003-06-12 | Immunetech, Inc. | Homogeneous immunoassays for multiple allergens |
US20040002095A1 (en) * | 2002-03-22 | 2004-01-01 | Bio-Rad Laboratories, Inc. | Universal signal amplification tail |
CN101410530B (zh) | 2003-04-18 | 2013-03-27 | 贝克顿·迪金森公司 | 免疫-扩增 |
US9017992B2 (en) * | 2005-07-01 | 2015-04-28 | Dako Denmark A/S | In situ hybridization detection method |
US20100143905A1 (en) * | 2007-03-29 | 2010-06-10 | Lane Michael J | Methods and compositions for multivalent binding and methods for manufacture of rapid diagnostic tests |
WO2008154085A1 (en) * | 2007-06-06 | 2008-12-18 | Bio-Rad Laboratories, Inc. | Signal amplification using circular hairpin probes |
US20090298805A1 (en) | 2008-06-03 | 2009-12-03 | Polson George A | Topical pyrithione compositions and methods for treatment of nail fungus |
JP2010048566A (ja) * | 2008-08-19 | 2010-03-04 | Sumitomo Chemical Co Ltd | Dnaを定量又は検出する方法 |
US8900850B2 (en) * | 2009-09-17 | 2014-12-02 | Michael J. Lane | Lateral flow based methods and assays for rapid and inexpensive diagnostic tests |
JP5726917B2 (ja) * | 2010-02-26 | 2015-06-03 | ヴェンタナ メディカル システムズ, インク. | ポリタグプローブ |
US20130184184A1 (en) * | 2010-11-22 | 2013-07-18 | The University Of Chicago | Methods and/or Use of Oligonucleotide Conjugates Having Varied Degrees of Labeling for Assays and Detections |
WO2013067489A1 (en) * | 2011-11-05 | 2013-05-10 | President And Fellows Of Harvard College | Nucleic acid-based linkers for detecting and measuring interactions |
WO2013177046A1 (en) | 2012-05-21 | 2013-11-28 | Solulink, Inc. | Methods and/or use of oligonucleotide conjugates for suppressing background due to cross-hybridization |
JP6585046B2 (ja) * | 2013-08-22 | 2019-10-02 | アプトン バイオシステムズ インコーポレイテッド | 電気的方法を用いた分子分析物のデジタル分析の方法 |
US11198900B2 (en) | 2014-12-06 | 2021-12-14 | Children's Medical Center Corporation | Nucleic acid-based linkers for detecting and measuring interactions |
US10036066B2 (en) | 2015-03-17 | 2018-07-31 | Dako Denmark A/S | In situ hybridization detection method |
US11396650B2 (en) | 2015-06-02 | 2022-07-26 | Children's Medical Center Corporation | Nucleic acid complexes for screening barcoded compounds |
WO2017139409A1 (en) | 2016-02-09 | 2017-08-17 | Children's Medical Center Corporation | Method for detection of analytes via polymer complexes |
US10919037B2 (en) | 2016-03-23 | 2021-02-16 | Children's Medical Center Corporation | Systems and apparatus for detecting compounds in human biological samples |
AU2017291727B2 (en) | 2016-07-05 | 2021-07-08 | California Institute Of Technology | Fractional initiator hybridization chain reaction |
US11591636B2 (en) | 2017-11-20 | 2023-02-28 | Children's Medical Center Corporation | Force-controlled nanoswitch assays for single-molecule detection in complex biological fluids |
WO2019200326A1 (en) | 2018-04-13 | 2019-10-17 | Rarecyte, Inc. | Kits for labeling of biomarkers and methods of using the same |
EP4284925A1 (de) | 2021-01-26 | 2023-12-06 | California Institute of Technology | Allosterische bedingte guide-rnas zur zellselektiven regulierung von crispr/cas |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4994373A (en) * | 1983-01-27 | 1991-02-19 | Enzo Biochem, Inc. | Method and structures employing chemically-labelled polynucleotide probes |
GB8306426D0 (en) * | 1983-03-09 | 1983-04-13 | Malcolm A D B | Detecting polynucleotide sequence |
CA1228811A (en) * | 1983-05-05 | 1987-11-03 | Robert G. Pergolizzi | Assay method utilizing polynucleotide sequences |
GB8405437D0 (en) * | 1984-03-01 | 1984-04-04 | Amersham Int Plc | Detecting polynucleotide sequences |
ATE65092T1 (de) * | 1985-05-31 | 1991-07-15 | Amoco Corp | Verstaerkung von hybridisierungssignalen durch verwendung von komplementarischen dns-straengen. |
US4882269A (en) * | 1985-12-13 | 1989-11-21 | Princeton University | Amplified hybridization assay |
US5124246A (en) * | 1987-10-15 | 1992-06-23 | Chiron Corporation | Nucleic acid multimers and amplified nucleic acid hybridization assays using same |
CA2039517C (en) * | 1990-04-03 | 2006-11-07 | David Segev | Dna probe signal amplification |
WO1992015708A1 (en) * | 1991-02-27 | 1992-09-17 | Amoco Corporation | Methods for improving the sensitivity of hybridization assays |
US5567591A (en) * | 1991-06-24 | 1996-10-22 | Becton Dickinson And Company | Amplified assay for analyte |
US5681697A (en) * | 1993-12-08 | 1997-10-28 | Chiron Corporation | Solution phase nucleic acid sandwich assays having reduced background noise and kits therefor |
CA2126952C (en) * | 1994-06-28 | 2010-12-14 | Sithian Pandian | Probe, kit, and method of amplification for increasing the sensitivity of nucleic acid hybridization assays |
US5681702A (en) * | 1994-08-30 | 1997-10-28 | Chiron Corporation | Reduction of nonspecific hybridization by using novel base-pairing schemes |
US5770365A (en) * | 1995-08-25 | 1998-06-23 | Tm Technologies, Inc. | Nucleic acid capture moieties |
-
1997
- 1997-07-11 WO PCT/US1997/012118 patent/WO1998002580A2/en active IP Right Grant
- 1997-07-11 AU AU40400/97A patent/AU4040097A/en not_active Abandoned
- 1997-07-11 AT AT97937967T patent/ATE232559T1/de not_active IP Right Cessation
- 1997-07-11 CA CA002259918A patent/CA2259918A1/en not_active Abandoned
- 1997-07-11 JP JP10504560A patent/JP2000515367A/ja not_active Ceased
- 1997-07-11 US US08/893,535 patent/US5902724A/en not_active Expired - Lifetime
- 1997-07-11 DE DE69719057T patent/DE69719057T2/de not_active Expired - Lifetime
- 1997-07-11 EP EP97937967A patent/EP0938588B1/de not_active Expired - Lifetime
-
1999
- 1999-04-16 US US09/293,362 patent/US6245513B1/en not_active Expired - Lifetime
-
2001
- 2001-02-27 US US09/796,725 patent/US20040005552A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US5902724A (en) | 1999-05-11 |
WO1998002580A3 (en) | 1998-05-14 |
AU4040097A (en) | 1998-02-09 |
CA2259918A1 (en) | 1998-01-22 |
ATE232559T1 (de) | 2003-02-15 |
EP0938588A2 (de) | 1999-09-01 |
WO1998002580A2 (en) | 1998-01-22 |
EP0938588B1 (de) | 2003-02-12 |
JP2000515367A (ja) | 2000-11-21 |
US6245513B1 (en) | 2001-06-12 |
DE69719057T2 (de) | 2003-12-04 |
US20040005552A1 (en) | 2004-01-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |