DE69719939T2 - Verfahren und Vorrichtung für Immunotest unter Verwendung von fluoreszensinduzierter Oberflächen-plasmonresonanz - Google Patents

Verfahren und Vorrichtung für Immunotest unter Verwendung von fluoreszensinduzierter Oberflächen-plasmonresonanz

Info

Publication number
DE69719939T2
DE69719939T2 DE69719939T DE69719939T DE69719939T2 DE 69719939 T2 DE69719939 T2 DE 69719939T2 DE 69719939 T DE69719939 T DE 69719939T DE 69719939 T DE69719939 T DE 69719939T DE 69719939 T2 DE69719939 T2 DE 69719939T2
Authority
DE
Germany
Prior art keywords
surface plasmon
plasmon resonance
fluorescence
film
induced emission
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69719939T
Other languages
English (en)
Other versions
DE69719939D1 (de
Inventor
Jinn-Nan Lin
Christopher J Wilson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Medical Solutions Diagnostics Inc Canada
Original Assignee
Diagnostic Products Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Diagnostic Products Corp filed Critical Diagnostic Products Corp
Application granted granted Critical
Publication of DE69719939D1 publication Critical patent/DE69719939D1/de
Publication of DE69719939T2 publication Critical patent/DE69719939T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/648—Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/962—Prevention or removal of interfering materials or reactants or other treatment to enhance results, e.g. determining or preventing nonspecific binding
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
DE69719939T 1996-12-30 1997-12-23 Verfahren und Vorrichtung für Immunotest unter Verwendung von fluoreszensinduzierter Oberflächen-plasmonresonanz Expired - Lifetime DE69719939T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/777,406 US5776785A (en) 1996-12-30 1996-12-30 Method and apparatus for immunoassay using fluorescent induced surface plasma emission

Publications (2)

Publication Number Publication Date
DE69719939D1 DE69719939D1 (de) 2003-04-24
DE69719939T2 true DE69719939T2 (de) 2003-11-20

Family

ID=25110171

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69719939T Expired - Lifetime DE69719939T2 (de) 1996-12-30 1997-12-23 Verfahren und Vorrichtung für Immunotest unter Verwendung von fluoreszensinduzierter Oberflächen-plasmonresonanz

Country Status (6)

Country Link
US (1) US5776785A (de)
EP (1) EP0851230B1 (de)
JP (1) JP3100360B2 (de)
AT (1) ATE235055T1 (de)
AU (1) AU698376B2 (de)
DE (1) DE69719939T2 (de)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6353406B1 (en) 1996-10-17 2002-03-05 R.F. Technologies, Inc. Dual mode tracking system
EP0932840A1 (de) 1996-10-17 1999-08-04 Pinpoint Corporation System zum verfolgen von gegenständen
US5955378A (en) * 1997-08-20 1999-09-21 Challener; William A. Near normal incidence optical assaying method and system having wavelength and angle sensitivity
JP2001522047A (ja) * 1997-10-31 2001-11-13 サーノフ コーポレイション 蛍光を増強する方法
DE19810615A1 (de) * 1998-03-12 1999-09-16 Thomas Ruckstuhl Optische Anordnung zum Erfassen von Licht
US5986762A (en) * 1998-06-15 1999-11-16 Imation Corp. Optical sensor having optimized surface profile
US6608671B2 (en) 1998-07-17 2003-08-19 Vertex Pharmaceuticals (San Diego) Llc Detector and screening device for ion channels
US6349160B2 (en) 1998-07-24 2002-02-19 Aurora Biosciences Corporation Detector and screening device for ion channels
US6320991B1 (en) 1998-10-16 2001-11-20 Imation Corp. Optical sensor having dielectric film stack
EP1212458A4 (de) 1999-07-30 2005-01-05 Surromed Inc Instrumente, verfahren und reagenzien, geeignet zur bestimmung mittels oberflächenplasmonresonanz
US7205155B1 (en) * 1999-08-20 2007-04-17 Stiftung Fur Diagnostische Forschung Method for the determination of substances using the evanescence field method
DE10000629C5 (de) * 2000-01-10 2010-06-02 november Aktiengesellschaft, Gesellschaft für Molekulare Medizin Verfahren zur Identifizierung einer auf einen festen Körper aufgebrachten Markierung
JP2001349892A (ja) * 2000-04-03 2001-12-21 Unilever Nv 検査方法及びデバイス
JP4143408B2 (ja) * 2000-11-30 2008-09-03 中外製薬株式会社 化学的安定性に乏しいリガンド結合タンパク質と第一リガンドとの結合活性を測定する方法
JP3525142B2 (ja) * 2001-01-12 2004-05-10 独立行政法人 科学技術振興機構 金属ナノウェルを用いた蛍光分析用素子及びその製造方法
NL1017625C2 (nl) * 2001-03-16 2002-09-24 Ibis Technologies B V Inrichting en werkwijze voor het bepalen van ten minste ÚÚn specifiek soort deeltje in een vloeibaar monster.
EP1422512A1 (de) * 2001-08-28 2004-05-26 Matsushita Electric Industrial Co., Ltd. Vorrichtung zur messung von informationen an einer teilchenkomponente
KR100467315B1 (ko) * 2001-12-26 2005-01-24 한국전자통신연구원 경쟁 결합을 이용하는 바이오센서와 이를 이용한 글루코스 검출 장치 및 방법
NL1020187C2 (nl) * 2002-03-16 2003-09-19 Ibis Technologies B V Inrichting en werkwijze voor het bepalen van deeltjes in een vloeibaar monster.
US7154598B2 (en) * 2002-07-12 2006-12-26 Decision Biomarkers, Inc. Excitation and imaging of fluorescent arrays
US20060127946A1 (en) * 2002-08-16 2006-06-15 Montagu Jean I Reading of fluorescent arrays
US7384742B2 (en) * 2002-08-16 2008-06-10 Decision Biomarkers, Inc. Substrates for isolating reacting and microscopically analyzing materials
US7198901B1 (en) * 2002-09-19 2007-04-03 Biocept, Inc. Reflective substrate and algorithms for 3D biochip
WO2005003743A2 (en) * 2003-05-20 2005-01-13 University Of Maryland Apparatus and methods for surface plasmon-coupled directional emission
DE10324973B4 (de) * 2003-05-27 2006-04-13 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Anordnung und Verfahren zur optischen Detektion von in Proben enthaltenen chemischen, biochemischen Molekülen und/oder Partikeln
WO2005040770A1 (en) * 2003-10-22 2005-05-06 Arizona Board Of Regents, Acting For And On Behalf Of, Arizona State University Chemical sensors featuring dual-sensing motifs
CA2475240A1 (en) * 2004-07-20 2006-01-20 Biophys, Inc. Method and device to measure dynamic internal calibration true dose response curves
CA2475456A1 (en) 2004-07-20 2006-01-20 Biophys, Inc. Method and device to optimize analyte and antibody substrate binding by least energy adsorption
US7805081B2 (en) * 2005-08-11 2010-09-28 Pacific Biosciences Of California, Inc. Methods and systems for monitoring multiple optical signals from a single source
EP2027442A2 (de) * 2006-05-16 2009-02-25 Applied Biosystems, Inc. Systeme, verfahren und vorrichtung für die einzelmolekülsequenzierung
US7949210B2 (en) * 2006-10-09 2011-05-24 Colorado School Of Mines Silicon-compatible surface plasmon optical elements
DE102006048688B4 (de) * 2006-10-14 2022-02-03 Byk Gardner Gmbh Verfahren und Vorrichtung zur Untersuchung von Oberflächen mit Effektpigmenten
JP4921213B2 (ja) * 2007-03-19 2012-04-25 キヤノン株式会社 検出素子、検出素子装置及び検出方法
JP2010043934A (ja) * 2008-08-12 2010-02-25 Fujifilm Corp 検出方法、検出用試料セル、検出用キット及び検出装置
JP5382107B2 (ja) * 2009-03-03 2014-01-08 コニカミノルタ株式会社 表面プラズモン増強蛍光センサおよび表面プラズモン増強蛍光センサに用いられる集光部材
JP2010223802A (ja) * 2009-03-24 2010-10-07 Fujifilm Corp 光信号検出方法
JP5351815B2 (ja) 2010-03-31 2013-11-27 富士フイルム株式会社 光学部材および表面プラズモン共鳴測定装置
WO2011154918A2 (en) * 2010-06-09 2011-12-15 Medisensor Gh, Inc. Diagnostic apparatus for immunoassay and diagnostic method for immunoassay using the same
JP6389868B2 (ja) 2013-03-15 2018-09-12 ジーピービー デット ホールディングス トゥー エルエルシー サンプルの発光及び蛍光測定を行うための装置及び関連する方法
EP3268739B8 (de) * 2015-03-11 2023-10-11 The General Hospital Corporation Plasmonennanopartikel-immuntestverfahren
US9891170B1 (en) * 2017-03-06 2018-02-13 Saudi Arabian Oil Company Stand alone portable sensing system for advanced nanoparticle tracers
JP7104911B2 (ja) * 2018-01-31 2022-07-22 国立研究開発法人産業技術総合研究所 標的物質検出方法及び導波モードセンサ

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE33064E (en) * 1981-09-18 1989-09-19 Prutec Limited Method for the determination of species in solution with an optical wave-guide
US4582809A (en) * 1982-06-14 1986-04-15 Myron J. Block Apparatus including optical fiber for fluorescence immunoassay
CA1261256A (en) * 1984-06-13 1989-09-26 Ian A. Shanks Devices for use in chemical test procedures
GB8423204D0 (en) * 1984-09-14 1984-10-17 Comtech Res Unit Assay technique and equipment
US4775637A (en) * 1984-12-10 1988-10-04 Purtec Limited An immunoassay apparatus having at least two waveguides and method for its use
US4649280A (en) * 1985-05-10 1987-03-10 The University Of Rochester Method and system for the enhancement of fluorescence
GB8620193D0 (en) * 1986-08-19 1986-10-01 Emi Plc Thorn Chemical sensor
IL85137A (en) * 1987-01-21 1992-02-16 Ares Serono Res & Dev Ltd Method of assaying for a ligand using surface plasmon resonance effect
GB8705650D0 (en) * 1987-03-10 1987-04-15 Pa Consulting Services Assay technique
AU604364B2 (en) * 1987-08-13 1990-12-13 Dow Chemical Company, The Sulfur dioxide removal from gas streams using hydroxyalkyl substituted piperazinones
CA1321488C (en) * 1987-08-22 1993-08-24 Martin Francis Finlan Biological sensors
EP0341927B1 (de) * 1988-05-10 1993-07-14 AMERSHAM INTERNATIONAL plc Biosensoren
GB8813307D0 (en) * 1988-06-06 1988-07-13 Amersham Int Plc Biological sensors
GB8817710D0 (en) * 1988-07-25 1988-09-01 Ares Serono Res & Dev Ltd Method of assay
US5478755A (en) * 1988-07-25 1995-12-26 Ares Serono Research & Development Ltd. Long range surface plasma resonance immunoassay
GB8827853D0 (en) * 1988-11-29 1988-12-29 Ares Serono Res & Dev Ltd Sensor for optical assay
US5061857A (en) * 1990-11-09 1991-10-29 The United States Of America As Represented By The Secretary Of The Navy Waveguide-binding sensor for use with assays
US5340715A (en) * 1991-06-07 1994-08-23 Ciba Corning Diagnostics Corp. Multiple surface evanescent wave sensor with a reference
DE69110032T2 (de) * 1991-06-08 1995-12-21 Hewlett Packard Gmbh Verfahren und Gerät zur Feststellung und/oder Konzentrationsbestimmung von Biomolekülen.
EP0575132A1 (de) * 1992-06-17 1993-12-22 Hewlett-Packard Company Optische Messvorrichtung
CA2076709A1 (en) * 1992-08-24 1994-02-25 Ulrich J. Krull Amplified fluorescence emission for chemical transduction

Also Published As

Publication number Publication date
EP0851230A1 (de) 1998-07-01
AU698376B2 (en) 1998-10-29
US5776785A (en) 1998-07-07
ATE235055T1 (de) 2003-04-15
JPH10311831A (ja) 1998-11-24
AU4923297A (en) 1998-07-09
EP0851230B1 (de) 2003-03-19
JP3100360B2 (ja) 2000-10-16
DE69719939D1 (de) 2003-04-24

Similar Documents

Publication Publication Date Title
DE69719939D1 (de) Verfahren und Vorrichtung für Immunotest unter Verwendung von fluoreszensinduzierter Oberflächen-plasmonresonanz
US4368047A (en) Process for conducting fluorescence immunoassays without added labels and employing attenuated internal reflection
US8659755B2 (en) Luminescence reference standards
ATE278944T1 (de) Vorrichtung und verfahren zur durchführung von quantitativen fluoreszenz markierten affinitätstests
NO20023495D0 (no) Fremgangsmåte og apparat for bestemmelse av temperatur- avhengige parametere, slik som assosiasjons-/dissosiasjonsparametere og/eller likevektskonstanten avkomplekser omfattende minst to komponenter
ATE239911T1 (de) Analysegerät
EP2315005A3 (de) Vorrichtung und Verfahren zur Erkennung von Fluoreszenzen in biologischen Proben
DE69738555D1 (de) Gerät unter Verwendung verschiedener optischer Messverfahren
DK0834074T4 (da) Detektering af transmembranpotentialer ved optiske metoder
CA2231186A1 (en) Optical apparatus for performing an immunoassay
WO2003027741A3 (en) Biochemical assay detection in a liquid receptacle using a fiber optic exciter
JP5487150B2 (ja) 光学的測定方法および光学的測定装置
CA2283251A1 (en) Device and method for carrying out fluorescence immunoassays
ATE266856T1 (de) Lichterzeugung, lichtmessung und bestimmung der menge von substanzen in vertiefungen von mikroplatten
JP2001500266A (ja) 物質の検出のための方法および装置
Jett et al. Ultrasensitive flow cytometric analyses
CA2260095A1 (en) Process and device for carrying out quantitative, fluorescence affinity tests
TH55016B (th) ฟลูออโรมิเตอร์แบบกระจก

Legal Events

Date Code Title Description
8364 No opposition during term of opposition