DE69720551D1 - Makrozyklische derivate von erythromycin a und b mit 13 ringatomen - Google Patents

Makrozyklische derivate von erythromycin a und b mit 13 ringatomen

Info

Publication number
DE69720551D1
DE69720551D1 DE69720551T DE69720551T DE69720551D1 DE 69720551 D1 DE69720551 D1 DE 69720551D1 DE 69720551 T DE69720551 T DE 69720551T DE 69720551 T DE69720551 T DE 69720551T DE 69720551 D1 DE69720551 D1 DE 69720551D1
Authority
DE
Germany
Prior art keywords
ringatomas
erythromycin
hypermotilinemia
pharmaceutical compositions
macrocyclic derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69720551T
Other languages
English (en)
Other versions
DE69720551T2 (de
Inventor
A Lartey
Brunell Curty
Ramin Faghih
Nerby Nellans
Christian Petersen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Application granted granted Critical
Publication of DE69720551D1 publication Critical patent/DE69720551D1/de
Publication of DE69720551T2 publication Critical patent/DE69720551T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
DE69720551T 1996-06-18 1997-04-25 Makrozyklische derivate von erythromycin a und b mit 13 ringatomen Expired - Fee Related DE69720551T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US668050 1996-06-18
US08/668,050 US5712253A (en) 1996-06-18 1996-06-18 Macrocyclic 13-membered ring derivatives of erythromycins A and B
PCT/US1997/007015 WO1997048713A1 (en) 1996-06-18 1997-04-25 Macrocyclic 13-membered ring derivatives of erythromycins a and b

Publications (2)

Publication Number Publication Date
DE69720551D1 true DE69720551D1 (de) 2003-05-08
DE69720551T2 DE69720551T2 (de) 2004-02-26

Family

ID=24680797

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69720551T Expired - Fee Related DE69720551T2 (de) 1996-06-18 1997-04-25 Makrozyklische derivate von erythromycin a und b mit 13 ringatomen

Country Status (10)

Country Link
US (1) US5712253A (de)
EP (1) EP1021456B1 (de)
JP (1) JP2000512653A (de)
AT (1) ATE236185T1 (de)
CA (1) CA2257361A1 (de)
DE (1) DE69720551T2 (de)
DK (1) DK1021456T3 (de)
ES (1) ES2196331T3 (de)
PT (1) PT1021456E (de)
WO (1) WO1997048713A1 (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998023629A1 (fr) * 1996-11-26 1998-06-04 Chugai Seiyaku Kabushiki Kaisha Composes de macrolides comportant une chaine a 13 elements, medicament les contenant et leur procede de preparation
TW460478B (en) 1997-08-15 2001-10-21 Chugai Pharmaceutical Co Ltd Phenethylamine derivatives
US5780605A (en) * 1997-09-08 1998-07-14 Abbott Laboratories 6,9-bridged erythromycin derivatives
DE19805822B4 (de) * 1998-02-13 2009-02-05 Solvay Pharmaceuticals Gmbh 11-Acetyl-12,13-dioxabicyclo[8.2.1]tridecenon-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
US6165985A (en) * 1998-02-13 2000-12-26 Solvay Pharmaceuticals Gmbh 11-acetyl-12,13-dioxabicyclo[8.2.1]-tridecenone derivatives, processes for their preparation and pharmaceutical compositions comprising them
ATE354582T1 (de) * 1998-06-12 2007-03-15 Merck & Co Inc Klonierung und identifizierung des motilin- rezeptors
TW509699B (en) 1998-09-24 2002-11-11 Chugau Pharmaceutical Co Ltd Ethylamine derivatives
US7553969B1 (en) 1999-01-28 2009-06-30 Chugai Seiyaku Kabushiki Kaisha Substituted phenethylamine derivatives
US7179886B1 (en) 1999-06-08 2007-02-20 Merck & Co., Inc. Cloning and identification of the motilin receptor
JP2003523347A (ja) 2000-02-18 2003-08-05 コーサン バイオサイエンシーズ， インコーポレイテッド モチライド化合物
WO2002057791A2 (en) * 2000-11-29 2002-07-25 Lifespan Biosciences, Inc. Diagnostic and therapeutic compositions and methods related to grp 38
US20030186336A1 (en) * 2001-11-29 2003-10-02 Burmer Glenna C. Diagnostic and therapeutic compositions and methods related to GPCR 38, a G protein-coupled receptor (GPCR)
JP4796300B2 (ja) * 2002-08-29 2011-10-19 ファイザー インコーポレイテッド モチライド化合物
AR043050A1 (es) 2002-09-26 2005-07-13 Rib X Pharmaceuticals Inc Compuestos heterociclicos bifuncionales y metodos para preparar y usar los mismos
JP4928261B2 (ja) 2003-06-18 2012-05-09 トランザイム・ファーマ・インコーポレイテッド モチリン受容体の大環状拮抗薬
PT1648922E (pt) * 2003-07-31 2011-01-04 Tranzyme Pharma Inc Compostos macrocíclicos espacialmente definidos úteis para descoberta de fármacos
JP4928263B2 (ja) * 2003-07-31 2012-05-09 トランザイム・ファーマ ペプチド結合サロゲートを組み入れた空間的に規定された大環状分子
US20050113319A1 (en) * 2003-08-26 2005-05-26 Christopher Carreras 11-Deoxy-6,9-ether erythromycin compounds
US7407941B2 (en) * 2003-08-26 2008-08-05 Pfizer, Inc. N-desmethyl-N-substituted-11-deoxyerythromycin compounds
US7211568B2 (en) * 2003-12-18 2007-05-01 Kosan Biosciences Incorporated 9-Desoxoerythromycin compounds as prokinetic agents
US8202843B2 (en) 2004-02-27 2012-06-19 Rib-X Pharmaceuticals, Inc. Macrocyclic compounds and methods of making and using the same
US20080249034A1 (en) * 2005-03-21 2008-10-09 Zambon S.P.A. Use of Macrolides for Treating Intestinal Inflammation
EP1861490A4 (de) * 2005-03-23 2010-11-17 Univ St Louis Verwendung von archaea zur modulierung der nährstoffaufnahmefunktionen der gastrointestinalen biozönose
US7582611B2 (en) * 2005-05-24 2009-09-01 Pfizer Inc. Motilide compounds
US20070135362A1 (en) * 2005-12-08 2007-06-14 Yaoquan Liu Method for demethylating the 3'-dimethylamino group of erythromycin compounds
US8088733B2 (en) 2006-07-06 2012-01-03 Tranzyme Pharma Inc. Methods of using macrocyclic agonists of the ghrelin receptor for treatment of gastrointestinal motility disorders
CA2662897C (en) 2006-09-11 2017-11-07 Tranzyme Pharma, Inc. Macrocyclic antagonists of the motilin receptor for treatment of gastrointestinal dysmotility disorders
CA2670482C (en) * 2006-12-05 2011-10-11 Pfizer Inc. Motilide polymorphs
US20080287371A1 (en) * 2007-05-17 2008-11-20 Tranzyme Pharma Inc. Macrocyclic antagonists of the motilin receptor for modulation of the migrating motor complex

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3878192A (en) * 1972-06-05 1975-04-15 Blasina Lab Chim Farm Sweet and palatable water soluble derivatives of erythromycin
JPS6187625A (ja) * 1984-10-05 1986-05-06 Satoshi Omura 消化管収縮運動促進剤
US5008249A (en) * 1985-08-31 1991-04-16 Kitasato Kenkyusho Therapeutic method of stimulating digestive tract contractile motion in mammals
EP0215355B1 (de) * 1985-08-31 1994-04-06 Kitasato Kenkyusho Erythromycinderivat und Verfahren zu dessen Herstellung
US4640910A (en) * 1985-11-12 1987-02-03 Abbott Laboratories Erythromycin A silylated compounds and method of use
US4681872A (en) * 1985-11-12 1987-07-21 Abbott Laboratories Erythromycin A 11,12-carbonate and method of use
JPS63107994A (ja) * 1986-05-02 1988-05-12 Taisho Pharmaceut Co Ltd エリスロマイシン誘導体
MY103197A (en) * 1987-02-20 1993-05-29 Kitasato Inst A growth promoting composition and production thereof
US4920102A (en) * 1988-04-18 1990-04-24 Eli Lilly And Company Method for treating gastrointestinal disorders

Also Published As

Publication number Publication date
PT1021456E (pt) 2003-08-29
WO1997048713A1 (en) 1997-12-24
DE69720551T2 (de) 2004-02-26
ES2196331T3 (es) 2003-12-16
DK1021456T3 (da) 2003-08-18
ATE236185T1 (de) 2003-04-15
US5712253A (en) 1998-01-27
JP2000512653A (ja) 2000-09-26
CA2257361A1 (en) 1997-12-24
EP1021456A1 (de) 2000-07-26
EP1021456B1 (de) 2003-04-02

Similar Documents

Publication Publication Date Title
DE69720551D1 (de) Makrozyklische derivate von erythromycin a und b mit 13 ringatomen
AP9801378A0 (en) 9-amino-3- keto erythromycin derivatives.
CA2216796A1 (en) Quinazoline derivatives
CA2258548A1 (en) Phenylamino-substituted tricyclic derivatives for treatment of hyperproliferative diseases
DE69713152D1 (de) Cyclosporinderivate, deren herstellung und pharmazeutische zusammensetzungen
NO996108L (no) 9-oksinerytromycinderivater
AU697679B2 (en) Treatment of tinnitis using neuroprotective agents
GB9322643D0 (en) Lactam derivatives
TR200103395T2 (tr) 13-metil eritromisin türevleri.
DK0876388T3 (da) Tricykliske erythromycinderivater
DK0734383T3 (da) Cykliske amidderivater som neurokinin-A-antagonister
ES2115760T3 (es) Derivados de 4''-desoxieritromicina.
CA2286511A1 (en) Novel macrolide derivatives
GB9502644D0 (en) Heterocyclic derivatives
AP9801377A0 (en) Tricyclic erythromycin derivatives.
CA2282279A1 (en) Atropisomers of 3-heteroaryl-4(3h)-quinazolinones for the treatment of neurodegenerative and cns-trauma related conditions
DE69330601D1 (de) Serotoninergische ergolin derivate
DE69626040D1 (de) 3-deoxy-3-descladinosederivate von erythromycin a und b

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee