DE69737070D1 - Systeme zur präsentation von mhc-antigenen der klasse ii und verfahren zur aktivierung von cd4?+-t-lymphozyten - Google Patents
Systeme zur präsentation von mhc-antigenen der klasse ii und verfahren zur aktivierung von cd4?+-t-lymphozytenInfo
- Publication number
- DE69737070D1 DE69737070D1 DE69737070T DE69737070T DE69737070D1 DE 69737070 D1 DE69737070 D1 DE 69737070D1 DE 69737070 T DE69737070 T DE 69737070T DE 69737070 T DE69737070 T DE 69737070T DE 69737070 D1 DE69737070 D1 DE 69737070D1
- Authority
- DE
- Germany
- Prior art keywords
- antigenes
- mhc
- lymphocytes
- presentation
- activation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 210000001744 T-lymphocyte Anatomy 0.000 title abstract 2
- 230000004913 activation Effects 0.000 title 1
- 210000000447 Th1 cell Anatomy 0.000 abstract 1
- 210000004241 Th2 cell Anatomy 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 239000011159 matrix material Substances 0.000 abstract 1
- 230000009210 ongoing activation Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0601—Invertebrate cells or tissues, e.g. insect cells; Culture media therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5154—Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5156—Animal cells expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/81—Drug, bio-affecting and body treating compositions involving autoimmunity, allergy, immediate hypersensitivity, delayed hypersensitivity, immunosuppression, immunotolerance, or anergy
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1817596P | 1996-05-23 | 1996-05-23 | |
US18175P | 1996-05-23 | ||
PCT/US1997/008697 WO1997046256A1 (en) | 1996-05-23 | 1997-05-22 | Mhc class ii antigen-presenting systems and methods for activating cd4+ t cells |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69737070D1 true DE69737070D1 (de) | 2007-01-18 |
DE69737070T2 DE69737070T2 (de) | 2007-06-21 |
Family
ID=21786645
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69737070T Expired - Lifetime DE69737070T2 (de) | 1996-05-23 | 1997-05-22 | Systeme zur präsentation von mhc-antigenen der klasse ii und verfahren zur aktivierung von cd4?+-t-lymphozyten |
Country Status (12)
Country | Link |
---|---|
US (4) | US6355479B1 (de) |
EP (1) | EP0969865B1 (de) |
JP (2) | JP5006998B2 (de) |
AT (1) | ATE347588T1 (de) |
AU (1) | AU723355B2 (de) |
CA (1) | CA2254975C (de) |
DE (1) | DE69737070T2 (de) |
DK (1) | DK0969865T3 (de) |
ES (1) | ES2278390T3 (de) |
IL (1) | IL126843A (de) |
PT (1) | PT969865E (de) |
WO (1) | WO1997046256A1 (de) |
Families Citing this family (74)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69737070T2 (de) * | 1996-05-23 | 2007-06-21 | The Scripps Research Institute, La Jolla | Systeme zur präsentation von mhc-antigenen der klasse ii und verfahren zur aktivierung von cd4?+-t-lymphozyten |
US6291430B1 (en) * | 1997-09-12 | 2001-09-18 | Ludwig Institute For Cancer Research | Mage-3 peptides presented by HLA class II molecules |
WO1999058977A1 (en) | 1998-05-11 | 1999-11-18 | Miltenyi Biotec Gmbh | Method of direct selection of antigen-specific t cells |
US6230662B1 (en) | 1998-06-22 | 2001-05-15 | Theresa Miale | Animal lift and transport apparatus and method for using the same |
WO2000009665A1 (en) * | 1998-08-10 | 2000-02-24 | Chiron Corporation | Engineered antigen-presenting cells expressing an array of antigens and uses thereof |
US7807377B2 (en) | 1998-10-20 | 2010-10-05 | Salvatore Albani | Method of isolating antigen-specific T cells employing artificial antigen presenting cells |
DK1123086T3 (da) * | 1998-10-20 | 2010-06-14 | Androclus Technologies S R L I | Kunstige antigen-specifikke celler og tilhørende fremgangsmåder |
US6225443B1 (en) * | 1999-05-19 | 2001-05-01 | Wisconsin Alumni Research Foundation | Cytotoxic T lymphocyte epitopes of the major outer membrane protein of chlamydia trachomatis |
US7521202B2 (en) | 1999-12-17 | 2009-04-21 | The Board Of Regents Of The University Of Oklahoma | Method and apparatus for the production of soluble MHC antigens and uses thereof |
DE10009341A1 (de) * | 2000-02-22 | 2001-09-06 | Florian Kern | Verfahren zur antigen-spezifischen Stimulation von T-Lymphozyten |
US7541184B2 (en) * | 2000-02-24 | 2009-06-02 | Invitrogen Corporation | Activation and expansion of cells |
AU2000243137A1 (en) * | 2000-04-20 | 2001-11-07 | Salvatore Albani | Methods for isolation, quantification, characterization and modulation of antigen-specific t cells |
ATE433107T1 (de) | 2000-10-10 | 2009-06-15 | Univ Oklahoma | Vergleichende ligandenabbildung aus mhc-positiven zellen |
US20070026433A1 (en) | 2001-03-09 | 2007-02-01 | Hildebrand William H | Epitope testing using soluble HLA |
WO2002056908A2 (en) * | 2001-01-16 | 2002-07-25 | Hildebrand William H | Artificial antigen-presenting cells |
AU2002255532A1 (en) * | 2001-02-13 | 2002-10-15 | Joseph D. Mosca | Biological carriers for induction of immune responses |
ES2643582T3 (es) * | 2001-02-20 | 2017-11-23 | Janssen Pharmaceuticals, Inc. | Antígeno de Drosophila artificial que presenta célula para preparar suspensión de células CD8 para su uso en el tratamiento del cáncer |
US20040071671A1 (en) * | 2001-02-20 | 2004-04-15 | Leturcq Didier J. | Cell therapy method for the treatment of tumors |
FR2824567B1 (fr) * | 2001-05-11 | 2003-08-08 | Inst Nat Sante Rech Med | Procede d'obtention de lymphocytes tr1 regulateurs specifiques d'antigene |
US7638326B2 (en) | 2002-01-03 | 2009-12-29 | The Trustees Of The University Of Pennsylvania | Activation and expansion of T-cells using an engineered multivalent signaling platform |
WO2003057171A2 (en) * | 2002-01-03 | 2003-07-17 | The Trustees Of The University Of Pennsylvania | Activation and expansion of t-cells using an engineered multivalent signaling platform |
US7745140B2 (en) | 2002-01-03 | 2010-06-29 | The Trustees Of The University Of Pennsylvania | Activation and expansion of T-cells using an engineered multivalent signaling platform as a research tool |
EP1808200A3 (de) | 2002-10-11 | 2007-09-19 | Sentoclone AB | Krebsimmuntherapie |
US20040072262A1 (en) * | 2002-10-11 | 2004-04-15 | Montero-Julian Felix A. | Methods and systems for detecting MHC class I binding peptides |
US7435592B2 (en) | 2003-05-13 | 2008-10-14 | Immunovative Therapies, Ltd. | Compositions for allogeneic cell therapy |
EP1692504A4 (de) * | 2003-11-03 | 2007-06-27 | Beckman Coulter Inc | Verfahren auf lösungsbasis zum nachweis von mhc-bindungsproteinen |
US7592431B2 (en) | 2004-02-26 | 2009-09-22 | Immunovative Therapies, Ltd. | Biodegradable T-cell Activation device |
WO2005081982A2 (en) | 2004-02-26 | 2005-09-09 | Immunovative Therapies, Ltd. | Methods for preparing t-cells for cell therapy |
EP1766393A4 (de) * | 2004-05-07 | 2008-06-18 | Beckman Coulter Inc | Mhc-brückensystem zum nachweis der ctl-vermittelten lyse antigenpräsentierender zellen |
EP3363907A1 (de) | 2004-05-27 | 2018-08-22 | The Trustees of the University of Pennsylvania | Neue künstliches antigen präsentierende zellen und verwendungen dafür |
WO2006009838A2 (en) * | 2004-06-17 | 2006-01-26 | Beckman Coulter, Inc. | Mycobacterium tuberculosis epitopes and methods of use thereof |
EP1712615A1 (de) * | 2005-04-15 | 2006-10-18 | Txcell | In vitro Herstellung einer Zellpopulation mittels Nährzellen |
NZ593388A (en) | 2005-06-08 | 2012-08-31 | Dana Farber Cancer Inst Inc | Methods and compositions for the treatment of persistent infections and cancer by inhibiting the programmed cell death 1 (pd-1) pathway |
US20100080792A1 (en) * | 2005-06-16 | 2010-04-01 | Dorothee Herlyn | Method for Identifying a MHC Class II-Dependent Tumor-Associated T Helper Cell Antigen |
WO2007071410A1 (en) | 2005-12-21 | 2007-06-28 | Sentoclone Ab | Method for treating urinary bladder cancer |
EP1966369B1 (de) | 2005-12-21 | 2010-10-06 | Sentoclone AB | Verfahren zur expansion tumorreaktiver t-lymphozyten zur immuntherapie von patienten mit krebs |
WO2007071390A1 (en) | 2005-12-21 | 2007-06-28 | Sentoclone Ab | Method for treating malignant melanoma |
US8211425B2 (en) | 2005-12-21 | 2012-07-03 | Sentoclone International Ab | Method for treating disseminated cancer |
WO2007103009A2 (en) | 2006-03-01 | 2007-09-13 | Janssen Pharmaceutica N.V. | CANCER TREATMENT COMBINING LYMPHODEPLETING AGENT WITH CTLs AND CYTOKINES |
BRPI0720342A2 (pt) * | 2006-10-04 | 2018-09-18 | Janssen Pharmaceutica N.V. | preparado de células apresentadoras de antígenos artificiais e seu uso em terapias celulares. |
NZ619576A (en) * | 2006-12-27 | 2014-07-25 | Harvard College | Compositions and methods for the treatment of infections and tumors |
US20120034156A1 (en) * | 2010-08-03 | 2012-02-09 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Artificial cells |
US9598491B2 (en) | 2008-11-28 | 2017-03-21 | Emory University | Methods for the treatment of infections and tumors |
US8075895B2 (en) | 2009-09-22 | 2011-12-13 | Janssen Pharmaceutica N.V. | Identification of antigenic peptides from multiple myeloma cells |
EP2404618A1 (de) | 2010-07-07 | 2012-01-11 | Stichting Katholieke Universiteit meer in het bijzonder Radboud Universiteit Nijmegen | Immunomodulatorische Protein-Konstrukte mit einem helikalen Polymer-Rückgrat |
CA2799516C (en) * | 2010-08-06 | 2016-01-05 | Canine-Lab.Inc. | Immunological function enhancing agent |
ES2648136T3 (es) | 2011-05-03 | 2017-12-28 | Immunovative Therapies, Ltd. | Métodos para el manejo de drogas biológicas que contengan células vivientes |
CN103687602A (zh) | 2011-05-03 | 2014-03-26 | 免疫创新治疗有限公司 | 利用免疫疗法诱导il-12 |
JP6339998B2 (ja) | 2012-04-24 | 2018-06-06 | ダン エス. カウフマン, | 幹細胞よりナチュラルキラー細胞を発生させる方法 |
WO2014186469A2 (en) | 2013-05-14 | 2014-11-20 | Board Of Regents, The University Of Texas System | Human application of engineered chimeric antigen receptor (car) t-cells |
JP6861516B2 (ja) | 2013-12-16 | 2021-04-21 | ザ ユナイテッド ステイツ オブ アメリカ, アズ リプレゼンテッド バイ ザ セクレタリー, デパートメント オブ ヘルス アンド ヒューマン サービシーズ | Vlp−レプリコンを用いたクラスii mhc抗原の送達による癌免疫療法 |
CN106414748B (zh) | 2014-02-14 | 2021-05-28 | 得克萨斯州大学系统董事会 | 嵌合抗原受体及制备方法 |
US10857219B2 (en) | 2014-03-28 | 2020-12-08 | The Board Of Regents Of The University Of Oklahoma | Compositions comprising soluble HLA/M. tuberculosis-specific ligand complexes and methods of production and use thereof |
US20170158749A1 (en) | 2014-04-23 | 2017-06-08 | Board Of Regents, The University Of Texas System | Chimeric antigen receptors (car) and methods for making and using the same |
WO2015164740A1 (en) | 2014-04-24 | 2015-10-29 | Board Of Regents, The University Of Texas System | Application of induced pluripotent stem cells to generate adoptive cell therapy products |
EP3215534B1 (de) | 2014-11-05 | 2020-04-15 | Board of Regents, The University of Texas System | Chimäre antigenrezeptoren (car) zur selektiven abzielung auf proteinkomplexe |
AU2015343013B2 (en) | 2014-11-05 | 2020-07-16 | Board Of Regents, The University Of Texas System | Gene modified immune effector cells and engineered cells for expansion of immune effector cells |
FR3031519B1 (fr) | 2015-01-14 | 2016-12-30 | Arkema France | Composition a base de terpolymere electroactif |
CA2979493A1 (en) * | 2015-03-16 | 2016-09-22 | Max-Delbruck-Centrum Fur Molekulare Medizin In Der Helmholtz-Gemeinschaft | Method of detecting new immunogenic t cell epitopes and isolating new antigen-specific t cell receptors by means of an mhc cell library |
WO2017075147A1 (en) | 2015-10-27 | 2017-05-04 | Board Of Regents, The University Of Texas System | Chimeric antigen receptor molecules and uses thereof |
US11787848B2 (en) | 2016-06-08 | 2023-10-17 | Precigen, Inc. | CD33 specific chimeric antigen receptors |
KR102553195B1 (ko) | 2016-07-29 | 2023-07-07 | 주노 쎄러퓨티크스 인코퍼레이티드 | 항-cd19 항체에 대한 항-이디오타입 항체 |
EP3538112A4 (de) | 2016-11-09 | 2020-09-02 | Musc Foundation for Research Development | Cd38-nad+-regulierte stoffwechselachse in der antitumorimmuntherapie |
JP7288401B2 (ja) | 2017-01-10 | 2023-06-07 | プレシゲン,インコーポレイテッド | 新規の遺伝子スイッチ発現系を介したポリペプチドの発現のモジュレーション |
US11285196B2 (en) | 2017-03-13 | 2022-03-29 | Eslam Abbas Baseuny | Multivalent biologic constructs for inducing a therapeutic modulation of cellular response and uses thereof |
AU2018254442B2 (en) | 2017-04-18 | 2024-03-28 | FUJIFILM Cellular Dynamics, Inc. | Antigen-specific immune effector cells |
IL270990B2 (en) | 2017-06-07 | 2024-02-01 | Precigen Inc | Expression of new cell markers |
US20220031749A1 (en) | 2018-11-28 | 2022-02-03 | Board Of Regents, The University Of Texas System | Multiplex genome editing of immune cells to enhance functionality and resistance to suppressive environment |
CA3121210A1 (en) | 2018-11-29 | 2020-06-04 | Board Of Regents, The University Of Texas System | Methods for ex vivo expansion of natural killer cells and use thereof |
WO2021092333A1 (en) | 2019-11-06 | 2021-05-14 | Baylor College Of Medicine | Method for producing cytotoxic effector memory t cells for t-cell treatment of cancer |
WO2021163191A1 (en) | 2020-02-10 | 2021-08-19 | Board Of Regents, The University Of Texas System | Methods for rapid cloning and expression of hla class i cells |
CN115715295A (zh) | 2020-05-27 | 2023-02-24 | 安逊生物科学股份有限公司 | 将car t细胞重新定向到感兴趣的抗原的衔接分子 |
EP4267605A2 (de) | 2020-12-23 | 2023-11-01 | Janssen Biotech, Inc. | Neoantigen-peptid-mimetika |
WO2023211972A1 (en) | 2022-04-28 | 2023-11-02 | Medical University Of South Carolina | Chimeric antigen receptor modified regulatory t cells for treating cancer |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5242687A (en) * | 1989-03-15 | 1993-09-07 | Tkb Associates Limited Partnership | Method of reducing cellular immune response involving T-cells using CD8-bearing antigen presenting cells |
US5395760A (en) | 1989-09-05 | 1995-03-07 | Immunex Corporation | DNA encoding tumor necrosis factor-α and -β receptors |
JP2683461B2 (ja) * | 1991-07-05 | 1997-11-26 | 住友電気工業株式会社 | 光ファイバケーブルの製造方法 |
US5583031A (en) * | 1992-02-06 | 1996-12-10 | President And Fellows Of Harvard College | Empty major histocompatibility class II heterodimers |
US5314813A (en) | 1992-02-19 | 1994-05-24 | Scripps Research Institute | Drosophila cell lines expressing genes encoding MHC class I antigens and B2-microglobulin and capable of assembling empty complexes and methods of making said cell lines |
WO1996012009A2 (en) * | 1994-10-14 | 1996-04-25 | Tykocinski Mark L | Methods for engineering antigen-presenting cells |
DE69737070T2 (de) * | 1996-05-23 | 2007-06-21 | The Scripps Research Institute, La Jolla | Systeme zur präsentation von mhc-antigenen der klasse ii und verfahren zur aktivierung von cd4?+-t-lymphozyten |
-
1997
- 1997-05-22 DE DE69737070T patent/DE69737070T2/de not_active Expired - Lifetime
- 1997-05-22 AU AU32103/97A patent/AU723355B2/en not_active Expired
- 1997-05-22 AT AT97927709T patent/ATE347588T1/de active
- 1997-05-22 CA CA002254975A patent/CA2254975C/en not_active Expired - Lifetime
- 1997-05-22 ES ES97927709T patent/ES2278390T3/es not_active Expired - Lifetime
- 1997-05-22 IL IL126843A patent/IL126843A/en not_active IP Right Cessation
- 1997-05-22 JP JP50061698A patent/JP5006998B2/ja not_active Expired - Lifetime
- 1997-05-22 WO PCT/US1997/008697 patent/WO1997046256A1/en active IP Right Grant
- 1997-05-22 DK DK97927709T patent/DK0969865T3/da active
- 1997-05-22 EP EP97927709A patent/EP0969865B1/de not_active Expired - Lifetime
- 1997-05-22 US US09/194,285 patent/US6355479B1/en not_active Expired - Lifetime
- 1997-05-22 PT PT97927709T patent/PT969865E/pt unknown
-
2000
- 2000-11-17 US US09/715,891 patent/US7074617B1/en not_active Expired - Fee Related
-
2004
- 2004-04-08 US US10/822,173 patent/US7439335B2/en not_active Expired - Fee Related
- 2004-07-29 US US10/903,213 patent/US7402430B2/en not_active Expired - Fee Related
-
2012
- 2012-03-29 JP JP2012077703A patent/JP2012143245A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
AU3210397A (en) | 1998-01-05 |
PT969865E (pt) | 2007-02-28 |
ES2278390T3 (es) | 2007-08-01 |
IL126843A0 (en) | 1999-09-22 |
JP2000511898A (ja) | 2000-09-12 |
JP2012143245A (ja) | 2012-08-02 |
CA2254975C (en) | 2008-12-16 |
AU723355B2 (en) | 2000-08-24 |
DE69737070T2 (de) | 2007-06-21 |
US20050059144A1 (en) | 2005-03-17 |
JP5006998B2 (ja) | 2012-08-22 |
ATE347588T1 (de) | 2006-12-15 |
US20050054090A1 (en) | 2005-03-10 |
IL126843A (en) | 2007-06-17 |
DK0969865T3 (da) | 2007-03-19 |
WO1997046256A1 (en) | 1997-12-11 |
EP0969865A1 (de) | 2000-01-12 |
EP0969865B1 (de) | 2006-12-06 |
EP0969865A4 (de) | 2001-07-11 |
US7074617B1 (en) | 2006-07-11 |
CA2254975A1 (en) | 1997-12-11 |
US6355479B1 (en) | 2002-03-12 |
US7439335B2 (en) | 2008-10-21 |
US7402430B2 (en) | 2008-07-22 |
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