DE69737814D1 - Gekürzte lösliche typ-i-rezeptoren für tumor-nekrose-faktor - Google Patents

Gekürzte lösliche typ-i-rezeptoren für tumor-nekrose-faktor

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Publication number
DE69737814D1
DE69737814D1 DE69737814T DE69737814T DE69737814D1 DE 69737814 D1 DE69737814 D1 DE 69737814D1 DE 69737814 T DE69737814 T DE 69737814T DE 69737814 T DE69737814 T DE 69737814T DE 69737814 D1 DE69737814 D1 DE 69737814D1
Authority
DE
Germany
Prior art keywords
factor
recipes
shorten
soluble type
tumor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69737814T
Other languages
English (en)
Other versions
DE69737814T2 (de
Inventor
Eric F Fisher
Carl K Edwards
Gary L Kieft
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amgen Inc
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Application granted granted Critical
Publication of DE69737814D1 publication Critical patent/DE69737814D1/de
Publication of DE69737814T2 publication Critical patent/DE69737814T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/525—Tumour necrosis factor [TNF]
    • A—HUMAN NECESSITIES
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    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0306—Animal model for genetic diseases
    • A01K2267/0325—Animal model for autoimmune diseases
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
    • Y10S530/815—Carrier is a synthetic polymer
DE69737814T 1996-07-09 1997-07-09 Gekürzte lösliche typ-i-rezeptoren für tumor-nekrose-faktor Expired - Lifetime DE69737814T2 (de)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US2144396P 1996-07-09 1996-07-09
US21443P 1996-07-09
US3253496P 1996-12-06 1996-12-06
US32534P 1996-12-06
US3773797P 1997-01-23 1997-01-23
US37737P 1997-01-23
US3931497P 1997-02-07 1997-02-07
US39314P 1997-02-07
US3979297P 1997-03-04 1997-03-04
US39792P 1997-03-04
PCT/US1997/012244 WO1998001555A2 (en) 1996-07-09 1997-07-09 Truncated soluble tumor necrosis factor type-i and type-ii receptors

Publications (2)

Publication Number Publication Date
DE69737814D1 true DE69737814D1 (de) 2007-07-26
DE69737814T2 DE69737814T2 (de) 2008-03-06

Family

ID=27533913

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69737814T Expired - Lifetime DE69737814T2 (de) 1996-07-09 1997-07-09 Gekürzte lösliche typ-i-rezeptoren für tumor-nekrose-faktor

Country Status (22)

Country Link
US (2) US6989147B2 (de)
EP (1) EP0914431B1 (de)
JP (2) JP2002514048A (de)
KR (1) KR20000023695A (de)
AT (1) ATE364695T1 (de)
AU (2) AU3601397A (de)
BG (1) BG64910B1 (de)
BR (1) BR9710350A (de)
CA (1) CA2259156C (de)
CZ (1) CZ296835B6 (de)
DE (1) DE69737814T2 (de)
EA (1) EA003900B1 (de)
ES (1) ES2288304T3 (de)
IL (1) IL127874A0 (de)
NO (1) NO990086L (de)
NZ (1) NZ333647A (de)
PL (1) PL189309B1 (de)
SK (1) SK1599A3 (de)
TR (1) TR199700610A2 (de)
TW (1) TW555765B (de)
WO (1) WO1998001555A2 (de)
YU (1) YU299A (de)

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US6316408B1 (en) 1997-04-16 2001-11-13 Amgen Inc. Methods of use for osetoprotegerin binding protein receptors
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DE60024636T2 (de) * 1999-06-21 2006-08-17 Santen Pharmaceutical Co., Ltd Arzneimittel für die rheumatoide arthritis
CA2399388A1 (en) * 2000-02-11 2001-08-16 Michael J. Lenardo Identification of a domain in the tumor necrosis factor receptor family that mediates pre-ligand receptor assembly and function
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US7087224B2 (en) * 2000-10-31 2006-08-08 Amgen Inc. Method of treating anemia by administering IL-1ra
HUP0302738A3 (en) * 2000-12-06 2010-01-28 Serono Lab Use of sarp-1 for the treatment and/or prevention of scleroderma
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US7718776B2 (en) 2002-04-05 2010-05-18 Amgen Inc. Human anti-OPGL neutralizing antibodies as selective OPGL pathway inhibitors
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JP2007523117A (ja) * 2004-02-20 2007-08-16 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 抗コリン作用薬及びｐｅｇｓｕｎｅｒｃｅｐｔを基にした新規な医薬組成物
EP1786837B1 (de) 2004-08-04 2013-05-01 Amgen Inc., Antikörper zu dkk-1
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WO2009009186A2 (en) * 2007-04-13 2009-01-15 The Regents Of The University Of California Receptors useful for gas phase chemical sensing
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CN103370334B (zh) * 2010-12-23 2016-06-22 韩诺生物制药株式会社 修饰的人肿瘤坏死因子受体-i多肽或其片段及其制备方法
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