DE69738223D1 - Verbesserte methoden zur diagnostischen bilderzeugung unter verwendung eines kontrastmittels und eines koronaren vasodilators - Google Patents

Verbesserte methoden zur diagnostischen bilderzeugung unter verwendung eines kontrastmittels und eines koronaren vasodilators

Info

Publication number
DE69738223D1
DE69738223D1 DE69738223T DE69738223T DE69738223D1 DE 69738223 D1 DE69738223 D1 DE 69738223D1 DE 69738223 T DE69738223 T DE 69738223T DE 69738223 T DE69738223 T DE 69738223T DE 69738223 D1 DE69738223 D1 DE 69738223D1
Authority
DE
Germany
Prior art keywords
contrastant
improved methods
picture generation
coronary vasodilator
diagnostic picture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69738223T
Other languages
English (en)
Other versions
DE69738223T3 (de
DE69738223T2 (de
Inventor
Evan C Unger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lantheus Medical Imaging Inc
Original Assignee
ImaRx Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24861044&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69738223(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by ImaRx Pharmaceutical Corp filed Critical ImaRx Pharmaceutical Corp
Publication of DE69738223D1 publication Critical patent/DE69738223D1/de
Application granted granted Critical
Publication of DE69738223T2 publication Critical patent/DE69738223T2/de
Publication of DE69738223T3 publication Critical patent/DE69738223T3/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/411—Detecting or monitoring allergy or intolerance reactions to an allergenic agent or substance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/227—Liposomes, lipoprotein vesicles, e.g. LDL or HDL lipoproteins, micelles, e.g. phospholipidic or polymeric
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/20—Measuring for diagnostic purposes; Identification of persons for measuring urological functions restricted to the evaluation of the urinary system
    • A61B5/201—Assessing renal or kidney functions
DE69738223T 1996-09-11 1997-08-26 Verbesserte verfahren zur diagnostischen bilderzeugung unter verwendung eines kontrastmittels und eines koronaren vasodilatators Expired - Lifetime DE69738223T3 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US71217396A 1996-09-11 1996-09-11
US712173 1996-09-11
PCT/US1997/014986 WO1998010799A1 (en) 1996-09-11 1997-08-26 Improved methods for diagnostic imaging involving the use of a contrast agent and a coronary vasodilator
EP97938609A EP1017425B2 (de) 1996-09-11 1997-08-26 Verbesserte methoden zur diagnostischen bilderzeugung unter verwendung eines kontrastmittels und eines koronaren vasodilators

Publications (3)

Publication Number Publication Date
DE69738223D1 true DE69738223D1 (de) 2007-11-29
DE69738223T2 DE69738223T2 (de) 2008-07-24
DE69738223T3 DE69738223T3 (de) 2011-07-07

Family

ID=24861044

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69738223T Expired - Lifetime DE69738223T3 (de) 1996-09-11 1997-08-26 Verbesserte verfahren zur diagnostischen bilderzeugung unter verwendung eines kontrastmittels und eines koronaren vasodilatators

Country Status (7)

Country Link
US (2) US5846517A (de)
EP (2) EP1323434B1 (de)
AU (1) AU732813B2 (de)
CA (1) CA2263924C (de)
DE (1) DE69738223T3 (de)
PT (1) PT1323434E (de)
WO (1) WO1998010799A1 (de)

Families Citing this family (157)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6088613A (en) 1989-12-22 2000-07-11 Imarx Pharmaceutical Corp. Method of magnetic resonance focused surgical and therapeutic ultrasound
US5585112A (en) 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
US6113570A (en) * 1994-09-09 2000-09-05 Coraje, Inc. Method of removing thrombosis in fistulae
US6397098B1 (en) 1994-09-21 2002-05-28 Medrad, Inc. Data communication and control for medical imaging systems
US6743779B1 (en) * 1994-11-29 2004-06-01 Imarx Pharmaceutical Corp. Methods for delivering compounds into a cell
US6033645A (en) * 1996-06-19 2000-03-07 Unger; Evan C. Methods for diagnostic imaging by regulating the administration rate of a contrast agent
US6521211B1 (en) 1995-06-07 2003-02-18 Bristol-Myers Squibb Medical Imaging, Inc. Methods of imaging and treatment with targeted compositions
US5648098A (en) * 1995-10-17 1997-07-15 The Board Of Regents Of The University Of Nebraska Thrombolytic agents and methods of treatment for thrombosis
AP890A (en) * 1996-02-19 2000-11-13 Nycomed Imaging As "Gas-containing contrast agents of use in diagnostic imaging.
BR9711082A (pt) 1996-03-29 2000-01-11 Lawrence Berkeley National Lab Realce de rmn emri na presença de gases mopbres hiperpolarizados.
WO1997040679A1 (en) 1996-05-01 1997-11-06 Imarx Pharmaceutical Corp. Methods for delivering compounds into a cell
JP2001502349A (ja) * 1996-10-21 2001-02-20 ニユコメド・イメージング・アクシエセルカペト 造影剤におけるまたはこれに関する改良
US20070036722A1 (en) * 1996-10-28 2007-02-15 Pal Rongved Separation processes
US6261537B1 (en) 1996-10-28 2001-07-17 Nycomed Imaging As Diagnostic/therapeutic agents having microbubbles coupled to one or more vectors
US6331289B1 (en) 1996-10-28 2001-12-18 Nycomed Imaging As Targeted diagnostic/therapeutic agents having more than one different vectors
CA2270120A1 (en) 1996-10-28 1998-05-07 Pal Rongved Improvements in or relating to diagnostic/therapeutic agents
US6120751A (en) 1997-03-21 2000-09-19 Imarx Pharmaceutical Corp. Charged lipids and uses for the same
US6090800A (en) 1997-05-06 2000-07-18 Imarx Pharmaceutical Corp. Lipid soluble steroid prodrugs
EP0979071B1 (de) * 1997-04-30 2007-11-07 Point Biomedical Corporation Mikropartikel, geeignet als kontrastmittel im ultraschall und zur wirkstoffgabe in den blutkreislauf
US6416740B1 (en) 1997-05-13 2002-07-09 Bristol-Myers Squibb Medical Imaging, Inc. Acoustically active drug delivery systems
US6548047B1 (en) 1997-09-15 2003-04-15 Bristol-Myers Squibb Medical Imaging, Inc. Thermal preactivation of gaseous precursor filled compositions
EP1024837A1 (de) * 1997-10-21 2000-08-09 Nycomed Imaging As Ultraschall-abbildung mittels zielgerichten kontrastmittel und vasodilatierende wirkstoff
US6607829B1 (en) * 1997-11-13 2003-08-19 Massachusetts Institute Of Technology Tellurium-containing nanocrystalline materials
US6207392B1 (en) 1997-11-25 2001-03-27 The Regents Of The University Of California Semiconductor nanocrystal probes for biological applications and process for making and using such probes
US6123923A (en) * 1997-12-18 2000-09-26 Imarx Pharmaceutical Corp. Optoacoustic contrast agents and methods for their use
US7273458B2 (en) 1998-01-12 2007-09-25 Georgia Tech Research Corporation Method of applying acoustic energy effective to alter transport or cell viability
US20010003580A1 (en) 1998-01-14 2001-06-14 Poh K. Hui Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
GB9808582D0 (en) * 1998-04-22 1998-06-24 Nycomed Imaging As Improvements in or relating to contrast agents
US20040170564A1 (en) * 1998-04-22 2004-09-02 Roald Skurtveit Ultrasound contrast agent dispersions comprising gas and destabilising agent
GB9808599D0 (en) * 1998-04-22 1998-06-24 Nycomed Imaging As Improvements in or realting to contrast agents
US6186951B1 (en) * 1998-05-26 2001-02-13 Riverside Research Institute Ultrasonic systems and methods for fluid perfusion and flow rate measurement
GB9813568D0 (en) * 1998-06-23 1998-08-19 Nycomed Imaging As Improvements in or relating to cardiac imaging
DE19840536A1 (de) 1998-08-28 2000-03-09 Schering Ag Mit Ultraschallkontrastmittel gefüllte Spritze mit einer magnetischen Bewegungsvorrichtung
DE19840532A1 (de) 1998-08-28 2000-03-09 Schering Ag Mit Ultraschallkonstrastmittel gefüllte Spritze mit einer mechanischen Bewegungsvorrichtung
US7686763B2 (en) * 1998-09-18 2010-03-30 University Of Washington Use of contrast agents to increase the effectiveness of high intensity focused ultrasound therapy
US7211054B1 (en) * 1998-11-06 2007-05-01 University Of Rochester Method of treating a patient with a neurodegenerative disease using ultrasound
US6444192B1 (en) 1999-02-05 2002-09-03 The Regents Of The University Of California Diagnostic imaging of lymph structures
US6317623B1 (en) 1999-03-12 2001-11-13 Medrad, Inc. Apparatus and method for controlling contrast enhanced imaging procedures
US6575930B1 (en) 1999-03-12 2003-06-10 Medrad, Inc. Agitation devices and dispensing systems incorporating such agitation devices
US7510536B2 (en) 1999-09-17 2009-03-31 University Of Washington Ultrasound guided high intensity focused ultrasound treatment of nerves
US7520856B2 (en) * 1999-09-17 2009-04-21 University Of Washington Image guided high intensity focused ultrasound device for therapy in obstetrics and gynecology
US7045049B1 (en) * 1999-10-01 2006-05-16 Nanoplex Technologies, Inc. Method of manufacture of colloidal rod particles as nanobar codes
US20040209376A1 (en) * 1999-10-01 2004-10-21 Surromed, Inc. Assemblies of differentiable segmented particles
US20040178076A1 (en) * 1999-10-01 2004-09-16 Stonas Walter J. Method of manufacture of colloidal rod particles as nanobarcodes
US6919009B2 (en) * 1999-10-01 2005-07-19 Nanoplex Technologies, Inc. Method of manufacture of colloidal rod particles as nanobarcodes
US7225082B1 (en) * 1999-10-01 2007-05-29 Oxonica, Inc. Colloidal rod particles as nanobar codes
US20050032226A1 (en) * 1999-10-01 2005-02-10 Natan Michael J. Encoded nanoparticles in paper manufacture
CA2387127A1 (en) 1999-10-25 2001-05-17 Therus Corporation Use of focused ultrasound for vascular sealing
US6626855B1 (en) 1999-11-26 2003-09-30 Therus Corpoation Controlled high efficiency lesion formation using high intensity ultrasound
GB2360892A (en) * 2000-02-11 2001-10-03 David John Watmough Imaging apparatus incorporating light and ultrasound applying means within the same applicator
US6445945B1 (en) 2000-06-26 2002-09-03 André Arsenault Non-invasive detection of endothelial dysfunction by blood flow measurement in opposed limbs using tracer injection
US6652833B2 (en) * 2000-07-13 2003-11-25 The Regents Of The University Of California Functionalized active-nucleus complex sensor
US7061237B2 (en) * 2000-07-13 2006-06-13 The Regents Of The University Of California Remote NMR/MRI detection of laser polarized gases
US20030165431A1 (en) * 2000-07-13 2003-09-04 The Regents Of The University Of California Method for detecting macromolecular conformational change and binding information
US7335169B2 (en) * 2000-08-24 2008-02-26 Timi 3 Systems, Inc. Systems and methods for delivering ultrasound energy at an output power level that remains essentially constant despite variations in transducer impedance
US7104958B2 (en) 2001-10-01 2006-09-12 New Health Sciences, Inc. Systems and methods for investigating intracranial pressure
KR20040015011A (ko) * 2000-09-29 2004-02-18 뉴 헬스 사이언시즈 인코포레이티드 혈관 건강 분석평가 시스템 및 방법
EP1216709A1 (de) * 2000-12-21 2002-06-26 Boehringer Ingelheim Pharma KG Verwendung von aktiviertem Gerinnungsfaktor VII zur Behandlung von durch thrombolytische Therapie-induzierten wichtigen Blutungen
WO2002080647A2 (en) * 2001-04-03 2002-10-17 Surromed, Inc. Methods and reagents for multiplexed analyte capture, surface array self-assembly, and analysis of complex biological samples
AUPR576901A0 (en) * 2001-06-19 2001-07-12 University Of Tasmania Improved method of measuring changes in microvascular capillary blood flow
AU2002311087B2 (en) * 2001-06-19 2006-12-21 University Of Tasmania Improved method of measuring changes in microvascular capillary blood flow
KR20030014548A (ko) * 2001-08-11 2003-02-19 한승무 한약물을 이용한 초음파 물리치료기
US7344702B2 (en) * 2004-02-13 2008-03-18 Bristol-Myers Squibb Pharma Company Contrast agents for myocardial perfusion imaging
AU2002359576A1 (en) 2001-12-03 2003-06-17 Ekos Corporation Catheter with multiple ultrasound radiating members
US7700074B2 (en) * 2002-02-07 2010-04-20 Pettegrew Jay W Method and system for diagnosis of neuropsychiatric disorders including chronic alcoholism
US7407778B2 (en) 2002-02-07 2008-08-05 Pettegrew Jay W Compounds, compositions and methods for treating neuropsychiatric disorders
US7939170B2 (en) * 2002-08-15 2011-05-10 The Rockefeller University Water soluble metal and semiconductor nanoparticle complexes
US7367947B2 (en) * 2002-11-08 2008-05-06 Koninklijke Philips Electronics N.V. Elevation beamwidth control for control for contrast imaging
US7376455B2 (en) * 2003-05-22 2008-05-20 Scimed Life Systems, Inc. Systems and methods for dynamic optical imaging
WO2004110963A2 (en) * 2003-05-29 2004-12-23 Pettegrew Jay W Glycerophosphocholine and its derivatives for medical imaging neuropsychiatric disorders
US20060257842A1 (en) * 2003-05-29 2006-11-16 Pettegrew Jay W Cryopreservation media and molecules
US20050019556A1 (en) * 2003-06-17 2005-01-27 Surromed, Inc. Labeling and authentication of metal objects
DE10327839A1 (de) * 2003-06-20 2005-01-05 Arvinmeritor Gmbh Fahrzeugdachmodul
WO2005020890A2 (en) * 2003-07-11 2005-03-10 Surromed, Inc. Multiplexed molecular beacon assay for detection of pathogens
WO2005013801A2 (en) * 2003-07-18 2005-02-17 Munn Charles S Enhanced cardiac radionuclide imaging techniques
JP4473543B2 (ja) * 2003-09-05 2010-06-02 株式会社東芝 超音波診断装置
US7894880B2 (en) * 2003-10-23 2011-02-22 The Board Of Trustees Of The Leland Stanford Junior University Measurement of renal extraction fraction using contrast enhanced computed tomography
US20050106101A1 (en) * 2003-10-31 2005-05-19 Ajay Purohit Novel chemical agents comprising an adenosine moiety or an adenosine analog moiety and an imaging moiety and methods of their use
DE10357334A1 (de) * 2003-12-05 2005-07-07 Grönemeyer, Dietrich H. W., Prof. Dr.med. MR-kompatibles medizinisches Implantat
US20110040171A1 (en) 2003-12-16 2011-02-17 University Of Washington Image guided high intensity focused ultrasound treatment of nerves
US7878978B2 (en) * 2004-03-18 2011-02-01 University Of Pittsburgh- Of The Commonwealth System Of Higher Education Use of relaxin to increase arterial compliance
US7713517B2 (en) 2004-04-21 2010-05-11 Marval Biosciences, Inc. Compositions and methods for enhancing contrast in imaging
US8357351B2 (en) * 2004-04-21 2013-01-22 Ananth Annapragada Nano-scale contrast agents and methods of use
US7485283B2 (en) 2004-04-28 2009-02-03 Lantheus Medical Imaging Contrast agents for myocardial perfusion imaging
EP1750575B1 (de) * 2004-05-10 2013-06-05 Highland Innovation Centre Limited Gerät zur untersuchung eines körpers mit lebendem gewebe
US9066679B2 (en) 2004-08-31 2015-06-30 University Of Washington Ultrasonic technique for assessing wall vibrations in stenosed blood vessels
WO2006028959A2 (en) * 2004-09-03 2006-03-16 Imarx Therapeutics, Inc. Apparatus and method to prepare a microsphere-forming composition
CA2575687A1 (en) * 2004-09-16 2006-03-23 University Of Washington Acoustic coupler using an independent water pillow with circulation for cooling a transducer
US20060083681A1 (en) * 2004-10-18 2006-04-20 Ajay Purohit Compounds for myocardial perfusion imaging
WO2006055813A2 (en) 2004-11-16 2006-05-26 Medrad, Inc. Modeling of pharmaceutical propagation
EP2990073B1 (de) 2004-11-24 2018-05-02 Bayer Healthcare LLC Vorrichtungen und systeme zur flüssigkeitsabgabe
CN100574809C (zh) * 2005-01-10 2009-12-30 重庆海扶(Hifu)技术有限公司 一种高强度聚焦超声治疗用氟碳乳剂类助剂及其应用
US8435558B1 (en) 2005-06-28 2013-05-07 University Of South Florida Ultrasound enhancement of drug release across non-ionic surfactant membranes
US7981442B2 (en) * 2005-06-28 2011-07-19 University Of South Florida Ultrasound enhancement of drug release across non-ionic surfactant membranes
US7824659B2 (en) 2005-08-10 2010-11-02 Lantheus Medical Imaging, Inc. Methods of making radiolabeled tracers and precursors thereof
US20090028798A1 (en) * 2005-08-11 2009-01-29 Government Of The Usa, Represented By The Secretary, Dept.Of Health And Human Services Method for determining redox status of a tissue
EP1921976A2 (de) 2005-08-12 2008-05-21 University of Washington Verfahren und gerät zur vorbereitung von organen und geweben für eine laparoskopische operation
US20070059247A1 (en) * 2005-08-30 2007-03-15 Lindner Jonathan R Deposit contrast agents and related methods thereof
US8414494B2 (en) 2005-09-16 2013-04-09 University Of Washington Thin-profile therapeutic ultrasound applicators
US8016757B2 (en) 2005-09-30 2011-09-13 University Of Washington Non-invasive temperature estimation technique for HIFU therapy monitoring using backscattered ultrasound
US20070233185A1 (en) 2005-10-20 2007-10-04 Thomas Anderson Systems and methods for sealing a vascular opening
WO2008048271A2 (en) * 2005-10-24 2008-04-24 Magsense Life Sciences, Inc. Polymer coated microparticles
CN101360505B (zh) * 2005-11-14 2015-09-09 瓦洛里塞森-勒谢什有限合伙公司 包含含有不可水解共价键的聚合物结合剂的药物组合物及其在治疗乳糜泻中的用途
KR100851933B1 (ko) * 2005-12-02 2008-08-12 연세대학교 산학협력단 망간 산화물 나노입자를 포함하는 자기공명 영상제
WO2007070827A2 (en) * 2005-12-15 2007-06-21 Bristol-Myers Squibb Pharma Company Contrast agents for myocardium perfusion imaging
WO2007127176A2 (en) 2006-04-24 2007-11-08 Ekos Corporation Ultrasound therapy system
WO2007149454A2 (en) * 2006-06-19 2007-12-27 Beth Isreal Deaconess Medical Center, Inc. Imaging agents for use in magnetic resonance blood flow/perfusion imaging
US20080019921A1 (en) * 2006-06-30 2008-01-24 Invitrogen Corporation Uniform fluorescent microsphere with hydrophobic surfaces
WO2008085421A2 (en) 2006-12-29 2008-07-17 Medrad, Inc. Patient-based parameter generation systems for medical injection procedures
US10182833B2 (en) 2007-01-08 2019-01-22 Ekos Corporation Power parameters for ultrasonic catheter
JP5449651B2 (ja) 2007-03-09 2014-03-19 株式会社東芝 Ｘ線ｃｔ装置および心筋パーフュージョン情報生成システム
AU2008226462A1 (en) * 2007-03-09 2008-09-18 Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Nitroxide radical as a treatment for neurodegeneration
US9044568B2 (en) 2007-06-22 2015-06-02 Ekos Corporation Method and apparatus for treatment of intracranial hemorrhages
CN103976736B (zh) 2007-07-17 2017-01-11 拜耳医药保健有限责任公司 确定心肺功能评估和输液过程的参数的设备和系统
US8337813B2 (en) * 2007-09-14 2012-12-25 Northwestern University Contrast agents
EP2217146A4 (de) * 2007-12-05 2015-10-14 Marval Biosciences Inc Kontrastmittel in nanogrösse und verfahren zu ihrer verwendung
US20090208421A1 (en) 2008-02-19 2009-08-20 Dominique Meyer Process for preparing a pharmaceutical formulation of contrast agents
CA2967254C (en) 2008-02-29 2019-03-26 Lantheus Medical Imaging, Inc. Contrast agents for applications including imaging cancer
CN102026625A (zh) * 2008-03-17 2011-04-20 犹他州大学研究基金会 二硫代氨基甲酸金属螯合物及其制备和应用的方法
US20090311191A1 (en) * 2008-06-13 2009-12-17 Ananth Annapragada Imaging of atherosclerotic plaques using liposomal imaging agents
GB0811856D0 (en) * 2008-06-27 2008-07-30 Ucl Business Plc Magnetic microbubbles, methods of preparing them and their uses
US9421330B2 (en) 2008-11-03 2016-08-23 Bayer Healthcare Llc Mitigation of contrast-induced nephropathy
CN102458396B (zh) 2009-04-15 2017-05-10 兰休斯医疗成像公司 使用抗坏血酸稳定化放射性药物组合物
US20110042121A1 (en) * 2009-08-21 2011-02-24 Rogers Bernard I Electrical cable protection block
US9119951B2 (en) 2009-10-12 2015-09-01 Kona Medical, Inc. Energetic modulation of nerves
US20110118600A1 (en) 2009-11-16 2011-05-19 Michael Gertner External Autonomic Modulation
US8986211B2 (en) 2009-10-12 2015-03-24 Kona Medical, Inc. Energetic modulation of nerves
US8469904B2 (en) 2009-10-12 2013-06-25 Kona Medical, Inc. Energetic modulation of nerves
US8986231B2 (en) 2009-10-12 2015-03-24 Kona Medical, Inc. Energetic modulation of nerves
US20160059044A1 (en) 2009-10-12 2016-03-03 Kona Medical, Inc. Energy delivery to intraparenchymal regions of the kidney to treat hypertension
US8517962B2 (en) 2009-10-12 2013-08-27 Kona Medical, Inc. Energetic modulation of nerves
US20110092880A1 (en) 2009-10-12 2011-04-21 Michael Gertner Energetic modulation of nerves
US8295912B2 (en) 2009-10-12 2012-10-23 Kona Medical, Inc. Method and system to inhibit a function of a nerve traveling with an artery
US9174065B2 (en) 2009-10-12 2015-11-03 Kona Medical, Inc. Energetic modulation of nerves
CN109200296B (zh) 2010-02-08 2021-12-14 兰休斯医疗成像公司 用于合成显像剂和其中间体的方法和装置
US8740835B2 (en) * 2010-02-17 2014-06-03 Ekos Corporation Treatment of vascular occlusions using ultrasonic energy and microbubbles
CA2803169C (en) 2010-06-24 2020-09-22 Medrad, Inc. Modeling of pharmaceutical propagation and parameter generation for injection protocols
ES2880291T3 (es) 2011-06-02 2021-11-24 Univ Louisville Res Found Inc Nanopartículas conjugadas a un agente antinucleolina
HUE056182T2 (hu) 2012-05-14 2022-01-28 Bayer Healthcare Llc Összeállítások és eljárások gyógyászati fluidum befecskendezési protokollok röntgencsõ-feszültség alapján történõ meghatározására
AU2013203000B9 (en) 2012-08-10 2017-02-02 Lantheus Medical Imaging, Inc. Compositions, methods, and systems for the synthesis and use of imaging agents
US9555379B2 (en) 2013-03-13 2017-01-31 Bayer Healthcare Llc Fluid path set with turbulent mixing chamber, backflow compensator
CA2951922C (en) * 2014-06-12 2023-02-28 Evan C. Unger Phospholipid composition and microbubbles and emulsions formed using same
US10925579B2 (en) 2014-11-05 2021-02-23 Otsuka Medical Devices Co., Ltd. Systems and methods for real-time tracking of a target tissue using imaging before and during therapy delivery
US10500227B2 (en) * 2014-12-03 2019-12-10 University Of Cincinnati Bioactive gas-encapsulated echogenic liposomes and methods for treating cardiovascular disease
EA201791437A1 (ru) * 2014-12-31 2017-12-29 Лантеус Медикал Имэджинг, Инк. Композиции микросфер c инкапсулированным в липиде газом и соответствующие способы
EP3307388B1 (de) 2015-06-10 2022-06-22 Ekos Corporation Ultraschallkatheter
US11304899B2 (en) * 2015-12-21 2022-04-19 Nuvox Pharma Llc Compositions of fluorocarbon nanoemulsion, and methods of preparation and use thereof
WO2017152036A1 (en) 2016-03-03 2017-09-08 Bayer Healthcare Llc System and method for improved fluid delivery in multi-fluid injector systems
JP2019515936A (ja) 2016-05-04 2019-06-13 ランセウス メディカル イメージング， インコーポレイテッド 超音波造影剤を調製するための方法およびデバイス
US9789210B1 (en) 2016-07-06 2017-10-17 Lantheus Medical Imaging, Inc. Methods for making ultrasound contrast agents
EP3493852A1 (de) * 2016-08-02 2019-06-12 University of Louisville Research Foundation, Inc. Gezielte nanotröpfchenemulsionen zur behandlung von krebs
IL265763B2 (en) * 2016-10-04 2023-04-01 Univ California Multi-frequency harmonic acoustics for target identification and boundary detection
AU2018326485B2 (en) 2017-08-31 2024-01-04 Bayer Healthcare Llc Injector pressure calibration system and method
US11779702B2 (en) 2017-08-31 2023-10-10 Bayer Healthcare Llc Method for dynamic pressure control in a fluid injector system
US11141535B2 (en) 2017-08-31 2021-10-12 Bayer Healthcare Llc Fluid path impedance assessment for improving fluid delivery performance
EP3675930B1 (de) 2017-08-31 2024-01-17 Bayer Healthcare LLC Verfahren zur mechanischen kalibrierung der antriebselementposition und eines fluidinjektorsystems
CN110809482B (zh) 2017-08-31 2023-03-07 拜耳医药保健有限公司 流体注入器系统体积补偿系统和方法

Family Cites Families (203)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3015128A (en) * 1960-08-18 1962-01-02 Southwest Res Inst Encapsulating apparatus
NL302030A (de) 1962-12-21 1900-01-01
US3291843A (en) 1963-10-08 1966-12-13 Du Pont Fluorinated vinyl ethers and their preparation
BE661981A (de) * 1964-04-03
US3594326A (en) * 1964-12-03 1971-07-20 Ncr Co Method of making microscopic capsules
US3968203A (en) * 1965-10-01 1976-07-06 Jerome G. Spitzer Aerosol astringent composition
US3488714A (en) * 1966-09-19 1970-01-06 Dow Chemical Co Formed laminate structure and method of preparation
US3615972A (en) * 1967-04-28 1971-10-26 Dow Chemical Co Expansible thermoplastic polymer particles containing volatile fluid foaming agent and method of foaming the same
US3532500A (en) * 1967-07-25 1970-10-06 Eastman Kodak Co Light sensitive vesicular composition comprising an azido-s-triazine compound
US3557294A (en) 1967-10-12 1971-01-19 Allied Chem Fluorinated ethers as inhalation convulsants
US3479811A (en) * 1967-11-29 1969-11-25 Dow Chemical Co Yarn and method of making the same
US3732172A (en) * 1968-02-28 1973-05-08 Ncr Co Process for making minute capsules and prefabricated system useful therein
US3650831A (en) * 1969-03-10 1972-03-21 Armour Dial Inc Method of cleaning surfaces
US4027007A (en) * 1970-12-09 1977-05-31 Colgate-Palmolive Company Antiperspirants formulated with borax
US3873564A (en) * 1971-03-03 1975-03-25 Synvar Ass 2-Imidazolinyl-3-oxide-1-oxypropionic acid
US4108806A (en) * 1971-12-06 1978-08-22 The Dow Chemical Company Thermoplastic expandable microsphere process and product
US4179546A (en) * 1972-08-28 1979-12-18 The Dow Chemical Company Method for expanding microspheres and expandable composition
US3960583A (en) * 1974-05-02 1976-06-01 Philadelphia Quartz Company Method of preparing modified hollow, largely spherical particles by spray drying
CH588887A5 (de) * 1974-07-19 1977-06-15 Battelle Memorial Institute
US3945956A (en) * 1975-06-23 1976-03-23 The Dow Chemical Company Polymerization of styrene acrylonitrile expandable microspheres
US4138383A (en) * 1975-11-24 1979-02-06 California Institute Of Technology Preparation of small bio-compatible microspheres
GB1523965A (en) 1976-03-19 1978-09-06 Ici Ltd Pharmaceutical compositions containing steroids
US4162282A (en) * 1976-04-22 1979-07-24 Coulter Electronics, Inc. Method for producing uniform particles
GB1599881A (en) * 1977-02-02 1981-10-07 Millington A R Preparation for diagnostic radiology
CH624011A5 (de) * 1977-08-05 1981-07-15 Battelle Memorial Institute
CH621479A5 (de) * 1977-08-05 1981-02-13 Battelle Memorial Institute
US4192859A (en) * 1978-09-29 1980-03-11 E. R. Squibb & Sons, Inc. Contrast media containing liposomes as carriers
US4310506A (en) * 1979-02-22 1982-01-12 California Institute Of Technology Means of preparation and applications of liposomes containing high concentrations of entrapped ionic species
US4276885A (en) * 1979-05-04 1981-07-07 Rasor Associates, Inc Ultrasonic image enhancement
US4265251A (en) * 1979-06-28 1981-05-05 Rasor Associates, Inc. Method of determining pressure within liquid containing vessel
US4310505A (en) * 1979-11-08 1982-01-12 California Institute Of Technology Lipid vesicles bearing carbohydrate surfaces as lymphatic directed vehicles for therapeutic and diagnostic substances
US4342826A (en) * 1980-02-04 1982-08-03 Collaborative Research, Inc. Immunoassay products and methods
US4421562A (en) * 1980-04-13 1983-12-20 Pq Corporation Manufacturing process for hollow microspheres
US4344929A (en) * 1980-04-25 1982-08-17 Alza Corporation Method of delivering drug with aid of effervescent activity generated in environment of use
US4315514A (en) * 1980-05-08 1982-02-16 William Drewes Method and apparatus for selective cell destruction
US4331654A (en) * 1980-06-13 1982-05-25 Eli Lilly And Company Magnetically-localizable, biodegradable lipid microspheres
US4681119A (en) * 1980-11-17 1987-07-21 Schering Aktiengesellschaft Method of production and use of microbubble precursors
US4657756A (en) * 1980-11-17 1987-04-14 Schering Aktiengesellschaft Microbubble precursors and apparatus for their production and use
US4442843A (en) * 1980-11-17 1984-04-17 Schering, Ag Microbubble precursors and methods for their production and use
US4420442A (en) * 1981-04-13 1983-12-13 Pq Corporation Manufacturing process for hollow microspheres
US4533254A (en) * 1981-04-17 1985-08-06 Biotechnology Development Corporation Apparatus for forming emulsions
EP0068961A3 (de) * 1981-06-26 1983-02-02 Thomson-Csf Vorrichtung zur lokalen Erwärmung von biologischen Gewebe
US4426330A (en) * 1981-07-20 1984-01-17 Lipid Specialties, Inc. Synthetic phospholipid compounds
US4534899A (en) * 1981-07-20 1985-08-13 Lipid Specialties, Inc. Synthetic phospholipid compounds
US4569836A (en) * 1981-08-27 1986-02-11 Gordon Robert T Cancer treatment by intracellular hyperthermia
EP0088773B1 (de) * 1981-09-23 1987-09-09 M.B. Fillers Pty. Ltd. Zweischichtige silikat-mikrohohlkugel
DE3141641A1 (de) * 1981-10-16 1983-04-28 Schering Ag, 1000 Berlin Und 4619 Bergkamen Ultraschall-kontrastmittel und dessen herstellung
BR8107560A (pt) 1981-11-19 1983-07-05 Luiz Romariz Duarte Estimulacao ultra-sonica da consolidacao de fraturas osseas
US4540629A (en) * 1982-04-08 1985-09-10 Pq Corporation Hollow microspheres with organosilicon-silicate walls
DE3225848A1 (de) 1982-07-07 1984-01-19 Schering AG, 1000 Berlin und 4709 Bergkamen Kortikoidhaltige zubereitung zur topischen applikation
FR2534487B1 (fr) 1982-10-15 1988-06-10 Dior Christian Parfums Procede d'homogeneisation de dispersions de phases lamellaires lipidiques hydratees, et suspensions obtenues par ce procede
EP0111386B1 (de) * 1982-10-26 1987-11-19 University Of Aberdeen Ultraschallanlage zur Hyperthermie
US4603044A (en) * 1983-01-06 1986-07-29 Technology Unlimited, Inc. Hepatocyte Directed Vesicle delivery system
US4731239A (en) * 1983-01-10 1988-03-15 Gordon Robert T Method for enhancing NMR imaging; and diagnostic use
US4572203A (en) * 1983-01-27 1986-02-25 Feinstein Steven B Contact agents for ultrasonic imaging
US4718433A (en) * 1983-01-27 1988-01-12 Feinstein Steven B Contrast agents for ultrasonic imaging
US4775522A (en) * 1983-03-04 1988-10-04 Children's Hospital Research Foundation, A Division Of Children's Hospital Medical Center NMR compositions for indirectly detecting a dissolved gas in an animal
US4981692A (en) * 1983-03-24 1991-01-01 The Liposome Company, Inc. Therapeutic treatment by intramammary infusion
US5141738A (en) * 1983-04-15 1992-08-25 Schering Aktiengesellschaft Ultrasonic contrast medium comprising gas bubbles and solid lipophilic surfactant-containing microparticles and use thereof
US4485193A (en) 1983-05-10 1984-11-27 The Dow Chemical Company Expandable synthetic resinous thermoplastic particles, method for the preparation thereof and the application therefor
US4900540A (en) * 1983-06-20 1990-02-13 Trustees Of The University Of Massachusetts Lipisomes containing gas for ultrasound detection
US4544545A (en) * 1983-06-20 1985-10-01 Trustees University Of Massachusetts Liposomes containing modified cholesterol for organ targeting
US4615879A (en) * 1983-11-14 1986-10-07 Vanderbilt University Particulate NMR contrast agents for gastrointestinal application
FR2563725B1 (fr) * 1984-05-03 1988-07-15 Dory Jacques Appareil d'examen et de localisation de tumeurs par ultrasons muni d'un dispositif de traitement localise par hyperthermie
JPH0753661B2 (ja) * 1984-03-08 1995-06-07 フアレス フアーマスーチカル リサーチ エヌブイ プロ―リポソーム組成物及びリポソームの水性分散物を作る方法
GB8407557D0 (en) * 1984-03-23 1984-05-02 Hayward J A Polymeric lipsomes
US4728575A (en) * 1984-04-27 1988-03-01 Vestar, Inc. Contrast agents for NMR imaging
US5008050A (en) * 1984-06-20 1991-04-16 The Liposome Company, Inc. Extrusion technique for producing unilamellar vesicles
US4620546A (en) * 1984-06-30 1986-11-04 Kabushiki Kaisha Toshiba Ultrasound hyperthermia apparatus
SE8403905D0 (sv) 1984-07-30 1984-07-30 Draco Ab Liposomes and steroid esters
US4767610A (en) 1984-10-19 1988-08-30 The Regents Of The University Of California Method for detecting abnormal cell masses in animals
US4789501A (en) * 1984-11-19 1988-12-06 The Curators Of The University Of Missouri Glass microspheres
US4921706A (en) * 1984-11-20 1990-05-01 Massachusetts Institute Of Technology Unilamellar lipid vesicles and method for their formation
US4830858A (en) * 1985-02-11 1989-05-16 E. R. Squibb & Sons, Inc. Spray-drying method for preparing liposomes and products produced thereby
US4689986A (en) * 1985-03-13 1987-09-01 The University Of Michigan Variable frequency gas-bubble-manipulating apparatus and method
US5186922A (en) 1985-03-15 1993-02-16 See/Shell Biotechnology, Inc. Use of biodegradable microspheres labeled with imaging energy constrast materials
US4663161A (en) 1985-04-22 1987-05-05 Mannino Raphael J Liposome methods and compositions
WO1986006959A1 (en) * 1985-05-22 1986-12-04 Liposome Technology, Inc. Liposome inhalation method and system
EP0216730B1 (de) 1985-08-12 1991-01-23 Battelle Memorial Institute Poröse Filtrierungsglaskugeln und Methode zu deren Herstellung
US4684479A (en) * 1985-08-14 1987-08-04 Arrigo Joseph S D Surfactant mixtures, stable gas-in-liquid emulsions, and methods for the production of such emulsions from said mixtures
US4938947A (en) * 1985-11-01 1990-07-03 Centre National De La Recherche Scientifique (Cnrs) Aerosol composition for in vivo imaging
US4927623A (en) * 1986-01-14 1990-05-22 Alliance Pharmaceutical Corp. Dissolution of gas in a fluorocarbon liquid
US4987154A (en) * 1986-01-14 1991-01-22 Alliance Pharmaceutical Corp. Biocompatible, stable and concentrated fluorocarbon emulsions for contrast enhancement and oxygen transport in internal animal use
US4865836A (en) * 1986-01-14 1989-09-12 Fluoromed Pharmaceutical, Inc. Brominated perfluorocarbon emulsions for internal animal use for contrast enhancement and oxygen transport
EP0231091B1 (de) 1986-01-24 1993-03-31 Children's Hospital Medical Center Stabile Emulsionen von stark fluorierten, organischen Verbindungen
US4737323A (en) * 1986-02-13 1988-04-12 Liposome Technology, Inc. Liposome extrusion method
US4834964A (en) 1986-03-07 1989-05-30 M.R.I., Inc. Use of charged nitroxides as NMR image enhancing agents for CSF
JPH0751496B2 (ja) * 1986-04-02 1995-06-05 武田薬品工業株式会社 リポソ−ムの製造法
DE3614657A1 (de) 1986-04-30 1987-11-05 Dornier Medizintechnik Pharmaka enthaltende lipidvesikel, verfahren zu ihrer herstellung und einbringung in den koerper eines lebewesens und freisetzung der in den lipidvesikeln enthaltende pharmaka
IL79559A0 (en) 1986-07-29 1986-10-31 Univ Ramot Contrast agents for nmr medical imaging
FR2602774B1 (fr) * 1986-07-29 1990-10-19 Atta Nouvelles molecules amphiphiles polyhydroxylees et perfluoroalkylees ayant des proprietes tensioactives
US4728578A (en) * 1986-08-13 1988-03-01 The Lubrizol Corporation Compositions containing basic metal salts and/or non-Newtonian colloidal disperse systems and vinyl aromatic containing polymers
US4776991A (en) * 1986-08-29 1988-10-11 The United States Of America As Represented By The Secretary Of The Navy Scaled-up production of liposome-encapsulated hemoglobin
US4781871A (en) * 1986-09-18 1988-11-01 Liposome Technology, Inc. High-concentration liposome processing method
US4769241A (en) 1986-09-23 1988-09-06 Alpha Therapeutic Corporation Apparatus and process for oxygenation of liquid state dissolved oxygen-carrying formulation
ZW11287A1 (en) * 1986-11-04 1989-01-25 Aeci Ltd Process for the production of an explosive
DE3637926C1 (de) 1986-11-05 1987-11-26 Schering Ag Ultraschall-Manometrieverfahren in einer Fluessigkeit mittels Mikroblaeschen
US5049388A (en) * 1986-11-06 1991-09-17 Research Development Foundation Small particle aerosol liposome and liposome-drug combinations for medical use
US4863717A (en) * 1986-11-10 1989-09-05 The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon Methods for circumventing the problem of free radial reduction associated with the use of stable nitroxide free radicals as contrast agents for magnetic reasonance imaging
US4933121A (en) * 1986-12-10 1990-06-12 Ciba Corning Diagnostics Corp. Process for forming liposomes
DK175531B1 (da) 1986-12-15 2004-11-22 Nexstar Pharmaceuticals Inc Leveringsvehikel med amphiphil-associeret aktiv bestanddel
CA1321048C (en) * 1987-03-05 1993-08-10 Robert W. J. Lencki Microspheres and method of producing same
US5219538A (en) 1987-03-13 1993-06-15 Micro-Pak, Inc. Gas and oxygen carrying lipid vesicles
US5000960A (en) * 1987-03-13 1991-03-19 Micro-Pak, Inc. Protein coupling to lipid vesicles
US4895876A (en) 1987-03-20 1990-01-23 Air Products And Chemicals, Inc. Concentrated stable fluorochemical aqueous emulsions containing triglycerides
US4866096A (en) 1987-03-20 1989-09-12 Air Products And Chemicals, Inc. Stable fluorochemical aqueous emulsions
ES2058714T3 (es) 1987-06-23 1994-11-01 Nycomed Innovation Ab Mejoras introducidas en formacion de imagenes por resonancia magnetica.
US5354549A (en) 1987-07-24 1994-10-11 Nycomed Imaging As Iodinated esters
IE61591B1 (en) 1987-12-29 1994-11-16 Molecular Biosystems Inc Concentrated stabilized microbubble-type ultrasonic imaging agent and method of production
US4844882A (en) * 1987-12-29 1989-07-04 Molecular Biosystems, Inc. Concentrated stabilized microbubble-type ultrasonic imaging agent
IE66912B1 (en) 1988-02-05 1996-02-07 Schering Ag Ultrasonic contrast agents process for their preparation and their use as diagnostic and therapeutic agents
US5425366A (en) 1988-02-05 1995-06-20 Schering Aktiengesellschaft Ultrasonic contrast agents for color Doppler imaging
US4898734A (en) * 1988-02-29 1990-02-06 Massachusetts Institute Of Technology Polymer composite for controlled release or membrane formation
DE3812816A1 (de) 1988-04-16 1989-11-02 Lawaczeck Ruediger Dipl Phys P Verfahren zur solubilisierung von liposomen und/oder biologischer membranen sowie deren verwendung
US5171755A (en) 1988-04-29 1992-12-15 Hemagen/Pfc Emulsions of highly fluorinated organic compounds
US4893624A (en) * 1988-06-21 1990-01-16 Massachusetts Institute Of Technology Diffuse focus ultrasound hyperthermia system
US4993415A (en) * 1988-08-19 1991-02-19 Alliance Pharmaceutical Corp. Magnetic resonance imaging with perfluorocarbon hydrides
US4996041A (en) * 1988-08-19 1991-02-26 Toshiyuki Arai Method for introducing oxygen-17 into tissue for imaging in a magnetic resonance imaging system
DE3828905A1 (de) 1988-08-23 1990-03-15 Schering Ag Mittel bestehend aus cavitate oder clathrate bildenden wirt/gast-komplexen als kontrastmittel
US5045304A (en) * 1988-08-31 1991-09-03 Wayne State University Contras agent having an imaging agent coupled to viable granulocytes for use in magnetic resonance imaging of abscess and a method of preparing and using same
US5410516A (en) 1988-09-01 1995-04-25 Schering Aktiengesellschaft Ultrasonic processes and circuits for performing them
US4957656A (en) * 1988-09-14 1990-09-18 Molecular Biosystems, Inc. Continuous sonication method for preparing protein encapsulated microbubbles
IL91664A (en) 1988-09-28 1993-05-13 Yissum Res Dev Co Ammonium transmembrane gradient system for efficient loading of liposomes with amphipathic drugs and their controlled release
FR2637182B1 (fr) 1988-10-03 1992-11-06 Lvmh Rech Compositions a base de phases lamellaires lipidiques hydratees ou de liposomes contenant un ecdysteroide, de preference l'ecdysterone, ou l'un de ses derives; et compositions cosmetiques, pharmaceutiques, notamment dermatologiques, de sericulture ou phytosanitaires l'incorporant
US5114703A (en) * 1989-05-30 1992-05-19 Alliance Pharmaceutical Corp. Percutaneous lymphography using particulate fluorocarbon emulsions
DE69002767T2 (de) 1989-06-22 1994-03-17 Atta Fluor- und phosphorhaltige amphiphilische moleküle mit oberflächenaktiven eigenschaften.
US5019370A (en) * 1989-07-10 1991-05-28 University Of Kentucky Research Foundation Biodegradable, low biological toxicity radiographic contrast medium and method of x-ray imaging
US5194266A (en) 1989-08-08 1993-03-16 Liposome Technology, Inc. Amphotericin B/cholesterol sulfate composition and method
US5013556A (en) * 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
US5620689A (en) 1989-10-20 1997-04-15 Sequus Pharmaceuuticals, Inc. Liposomes for treatment of B-cell and T-cell disorders
US5149319A (en) 1990-09-11 1992-09-22 Unger Evan C Methods for providing localized therapeutic heat to biological tissues and fluids
US5209720A (en) 1989-12-22 1993-05-11 Unger Evan C Methods for providing localized therapeutic heat to biological tissues and fluids using gas filled liposomes
US5585112A (en) 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
US5088499A (en) * 1989-12-22 1992-02-18 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
US5542935A (en) 1989-12-22 1996-08-06 Imarx Pharmaceutical Corp. Therapeutic delivery systems related applications
US5230882A (en) 1989-12-22 1993-07-27 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
US5228446A (en) 1989-12-22 1993-07-20 Unger Evan C Gas filled liposomes and their use as ultrasonic contrast agents
US5305757A (en) 1989-12-22 1994-04-26 Unger Evan C Gas filled liposomes and their use as ultrasonic contrast agents
US5334381A (en) 1989-12-22 1994-08-02 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
US5352435A (en) 1989-12-22 1994-10-04 Unger Evan C Ionophore containing liposomes for ultrasound imaging
US5123414A (en) * 1989-12-22 1992-06-23 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
US5469854A (en) 1989-12-22 1995-11-28 Imarx Pharmaceutical Corp. Methods of preparing gas-filled liposomes
DE4004430A1 (de) 1990-02-09 1991-08-14 Schering Ag Aus polyaldehyden aufgebaute kontrastmittel
US5578292A (en) 1991-11-20 1996-11-26 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
IN172208B (de) 1990-04-02 1993-05-01 Sint Sa
US5445813A (en) 1992-11-02 1995-08-29 Bracco International B.V. Stable microbubble suspensions as enhancement agents for ultrasound echography
US5556610A (en) 1992-01-24 1996-09-17 Bracco Research S.A. Gas mixtures useful as ultrasound contrast media, contrast agents containing the media and method
US5672585A (en) 1990-04-06 1997-09-30 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5358702A (en) 1990-04-10 1994-10-25 Unger Evan C Methoxylated gel particle contrast media for improved diagnostic imaging
US5078994A (en) * 1990-04-12 1992-01-07 Eastman Kodak Company Microgel drug delivery system
US5137928A (en) * 1990-04-26 1992-08-11 Hoechst Aktiengesellschaft Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents
US5190982A (en) 1990-04-26 1993-03-02 Hoechst Aktiengesellschaft Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents
US5205287A (en) 1990-04-26 1993-04-27 Hoechst Aktiengesellschaft Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents
AU636481B2 (en) † 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
US5315997A (en) 1990-06-19 1994-05-31 Molecular Biosystems, Inc. Method of magnetic resonance imaging using diamagnetic contrast
US5215680A (en) 1990-07-10 1993-06-01 Cavitation-Control Technology, Inc. Method for the production of medical-grade lipid-coated microbubbles, paramagnetic labeling of such microbubbles and therapeutic uses of microbubbles
IL95743A (en) * 1990-09-19 1993-02-21 Univ Ramot Method of measuring blood flow
US5487390A (en) 1990-10-05 1996-01-30 Massachusetts Institute Of Technology Gas-filled polymeric microbubbles for ultrasound imaging
EP0504340B1 (de) 1990-10-05 1995-06-21 BRACCO International B.V. Verfahren zur herstellung von stabilen suspensionen von hohlen mit gasgefüllten mikrosphären zur verwendung in ultraschallechographie
DE69215722T3 (de) 1991-03-22 2001-03-08 Katsuro Tachibana Verstärker zur Ultraschalltherapie von Erkrankungen sowie diesen enthaltende flüssige Arzneimittelzusammensetzungen
GB9106686D0 (en) 1991-03-28 1991-05-15 Hafslund Nycomed As Improvements in or relating to contrast agents
GB9106673D0 (en) 1991-03-28 1991-05-15 Hafslund Nycomed As Improvements in or relating to contrast agents
US5205290A (en) 1991-04-05 1993-04-27 Unger Evan C Low density microspheres and their use as contrast agents for computed tomography
US5496535A (en) 1991-04-12 1996-03-05 Alliance Pharmaceutical Corp. Fluorocarbon contrast media for use with MRI and radiographic imaging
US5147631A (en) * 1991-04-30 1992-09-15 Du Pont Merck Pharmaceutical Company Porous inorganic ultrasound contrast agents
WO1992021382A1 (en) 1991-06-03 1992-12-10 Holmes, Michael, John Improvements in or relating to contrast agents
US5409688A (en) 1991-09-17 1995-04-25 Sonus Pharmaceuticals, Inc. Gaseous ultrasound contrast media
ES2145011T5 (es) * 1991-09-17 2008-02-01 Ge Healthcare As Medios de contraste gaseoso para ecografias.
US5264220A (en) * 1991-11-12 1993-11-23 Long David M Jr Method of extending the vascular dwell-time of particulate therapeutic and particulate diagnostic agents
US5196183A (en) 1991-12-04 1993-03-23 Sterling Winthrop Inc. Contrast agents for ultrasound imaging
GB9200388D0 (en) 1992-01-09 1992-02-26 Nycomed As Improvements in or relating to contrast agents
GB9200387D0 (en) 1992-01-09 1992-02-26 Nycomed As Improvements in or relating to contrast agents
IL104084A (en) 1992-01-24 1996-09-12 Bracco Int Bv Sustainable aqueous suspensions of pressure-resistant and gas-filled blisters, their preparation, and contrast agents containing them
WO1993015722A1 (en) 1992-02-07 1993-08-19 Syntex (Usa) Inc. Controlled delivery of pharmaceuticals from preformed porous microparticles
US5247935A (en) 1992-03-19 1993-09-28 General Electric Company Magnetic resonance guided focussed ultrasound surgery
HUT72323A (en) 1993-01-25 1996-04-29 Sonus Pharma Inc Phase shift colloids as ultrasound contrast agents
US5558855A (en) 1993-01-25 1996-09-24 Sonus Pharmaceuticals Phase shift colloids as ultrasound contrast agents
US5362478A (en) 1993-03-26 1994-11-08 Vivorx Pharmaceuticals, Inc. Magnetic resonance imaging with fluorocarbons encapsulated in a cross-linked polymeric shell
DE69433723T3 (de) 1993-02-22 2008-10-30 Abraxis Bioscience, Inc., Los Angeles Verfahren für die in-vivo-verabreichung von biologischen substanzen und hierfür verwendbare zusammensetzungen
US5716597A (en) 1993-06-04 1998-02-10 Molecular Biosystems, Inc. Emulsions as contrast agents and method of use
AU683485B2 (en) 1993-07-02 1997-11-13 Molecular Biosystems, Inc. Method for making encapsulated gas microspheres from heat denatured protein in the absence of oxygen gas
DE69434119T3 (de) 1993-07-30 2011-05-05 Imcor Pharmaceutical Co., San Diego Stabilisierte mikrogasbläschen-zusammensetzungen für echographie
US5433204A (en) 1993-11-16 1995-07-18 Camilla Olson Method of assessing placentation
AU679295B2 (en) † 1993-12-15 1997-06-26 Bracco Suisse S.A. Gas mixtures useful as ultrasound contrast media
CA2185810A1 (en) 1994-03-28 1995-10-05 Jo Klaveness Liposomes
US5502094A (en) 1994-05-20 1996-03-26 Minnesota Mining And Manufacturing Company Physiologically acceptable emulsions containing perfluorocarbon ether hydrides and methods for use
US5965109A (en) * 1994-08-02 1999-10-12 Molecular Biosystems, Inc. Process for making insoluble gas-filled microspheres containing a liquid hydrophobic barrier
US5562893A (en) 1994-08-02 1996-10-08 Molecular Biosystems, Inc. Gas-filled microspheres with fluorine-containing shells
US5540909A (en) 1994-09-28 1996-07-30 Alliance Pharmaceutical Corp. Harmonic ultrasound imaging with microbubbles
US5560364A (en) 1995-05-12 1996-10-01 The Board Of Regents Of The University Of Nebraska Suspended ultra-sound induced microbubble cavitation imaging
US5558092A (en) 1995-06-06 1996-09-24 Imarx Pharmaceutical Corp. Methods and apparatus for performing diagnostic and therapeutic ultrasound simultaneously
US5606973A (en) 1995-06-07 1997-03-04 Molecular Biosystems, Inc. Liquid core microdroplets for ultrasound imaging
CA2263568C (en) * 1996-09-11 2008-12-02 Imarx Pharmaceutical Corp. Methods for diagnostic imaging using a contrast agent and a renal vasodilator
JP2001502349A (ja) * 1996-10-21 2001-02-20 ニユコメド・イメージング・アクシエセルカペト 造影剤におけるまたはこれに関する改良
EP0991427A2 (de) * 1996-10-28 2000-04-12 Marsden, John Christopher Verbesserungen an oder in verbindung mit diagnostischen/therapeutischen mitteln
NZ335799A (en) * 1996-10-28 2000-11-24 Nycomed Imaging As Improvements in or relating to diagnostic/therapeutic agents
WO1998018501A2 (en) * 1996-10-28 1998-05-07 Marsden, John, Christopher Improvements in or relating to diagnostic/therapeutic agents
WO1998018498A2 (en) * 1996-10-28 1998-05-07 Marsden, John, Christopher Improvements in or relating to diagnostic/therapeutic agents
GB9717588D0 (en) * 1997-08-19 1997-10-22 Nycomed Imaging As Improvements in or relating to contrast agents
US6123923A (en) * 1997-12-18 2000-09-26 Imarx Pharmaceutical Corp. Optoacoustic contrast agents and methods for their use
US7625093B2 (en) 2005-03-29 2009-12-01 Seiko Epson Corporation Image display device having a plurality of basic-color projection units
US8501161B2 (en) 2006-05-09 2013-08-06 Colgate-Palmolive Company Oral care regimen
US20130247924A1 (en) 2012-03-23 2013-09-26 Mark Scatterday Electronic cigarette having a flexible and soft configuration

Also Published As

Publication number Publication date
CA2263924A1 (en) 1998-03-19
EP1017425B2 (de) 2010-12-15
EP1323434B1 (de) 2007-07-11
EP1017425A4 (de) 2002-03-06
EP1323434A2 (de) 2003-07-02
AU4089897A (en) 1998-04-02
EP1323434A3 (de) 2004-03-24
EP1017425A1 (de) 2000-07-12
EP1017425B1 (de) 2007-10-17
DE69738223T3 (de) 2011-07-07
US5846517A (en) 1998-12-08
PT1323434E (pt) 2007-08-24
US6884407B1 (en) 2005-04-26
CA2263924C (en) 2008-11-18
AU732813B2 (en) 2001-05-03
WO1998010799A1 (en) 1998-03-19
DE69738223T2 (de) 2008-07-24

Similar Documents

Publication Publication Date Title
DE69738223D1 (de) Verbesserte methoden zur diagnostischen bilderzeugung unter verwendung eines kontrastmittels und eines koronaren vasodilators
DE69530685D1 (de) Verfahren zur herstellung eines lautsprecherdämpfers
DE69704302T2 (de) Verfahren und vorrichtung zur herstellung eines kompositmaterials
DE69513994D1 (de) Verfahren zur herstellung eines minidimensionierten massenspektrometers
DE69422072D1 (de) System und Verfahren zur schnellen Verschlüsselung unter Verwendung eines Vielfachschlüsselgenerators
DE69720019T2 (de) Verfahren zur herstellung eines elastichen eingeschnürt gebundenen materials
DE69838709D1 (de) Verfahren zur herstellung eines beschleunigungsaufnehmers
DE69921152D1 (de) Verfahren und vorrichtung zur herstellung einer papiermaschinenbespannung
DE69634721D1 (de) Anordnung und Verfahren zum Erzeugen einer Hintergrund-Textur
DE59704275D1 (de) Rostplatte sowie Verfahren zur Herstellung einer Rostplatte
DE59814443D1 (de) Verfahren zur regelung eines generators
DE69515447T2 (de) Verfahren und Vorrichtung zur Herstellung eines Flächenhaftverschluss
DE69614562D1 (de) Verfahren zur herstellung von voluminösen vliesstoffen
DE69834916D1 (de) Im-ohr-hilfegerät mit vermindertem verstopfungseffekt und verfahren zur herstellung und benutzeranpassung eines solchen hörhilfegerät
DE19782013T1 (de) Verfahren zur Herstellung eines Strukturgliedes
DE69736005D1 (de) Schnelle verfahrung zur herstellung eines stoffes
DE69324236D1 (de) Ein optisches gitter und ein verfahren zur herstellung eines optischen gitters
DE69709716D1 (de) Verfahren zur herstellung eines kohlenstoff/kohlenstoff wärmetauschers
DE69513360T2 (de) Verfahren zur Herstellung eines hohlen Strukturelements und hohles Strukturelement
DE59702129D1 (de) Verfahren zur Herstellung eines Zierteiles und Zierteil
DE69734980D1 (de) Verfahren und vorrichtung zur herstellung von weichem tissuepapier
DE69610710T2 (de) Verfahren zur herstellung eines mesoporösen kristallinen materials
DE69520361T2 (de) Vorrichtung und kontinuierliches verfahren zur herstellung einer gerinnungstesteinrichtung
DE69526427T2 (de) Reinigungssystem und Verfahren zu dessen Herstellung unter Verwendung eines Reinigungstuchs mit beschränktem Luftvolumen
ATE192628T1 (de) Verfahren zur herstellung eines einbügelbaren einlagestoffs

Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: BRISTOL-MYERS SQUIBB MEDICAL IMAGING, INC., PR, US

8363 Opposition against the patent
8366 Restricted maintained after opposition proceedings