DE69808258D1 - Molekül-agonisten für den insulinähnlichen wachstumfaktor - Google Patents
Molekül-agonisten für den insulinähnlichen wachstumfaktorInfo
- Publication number
- DE69808258D1 DE69808258D1 DE69808258T DE69808258T DE69808258D1 DE 69808258 D1 DE69808258 D1 DE 69808258D1 DE 69808258 T DE69808258 T DE 69808258T DE 69808258 T DE69808258 T DE 69808258T DE 69808258 D1 DE69808258 D1 DE 69808258D1
- Authority
- DE
- Germany
- Prior art keywords
- insulin
- growth factor
- molecule agonists
- igf
- growth
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/30—Insulin-like growth factors (Somatomedins), e.g. IGF-1, IGF-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4743—Insulin-like growth factor binding protein
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/12—Growth hormone, growth factor other than t-cell or b-cell growth factor, and growth hormone releasing factor; related peptides
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/825,852 US6121416A (en) | 1997-04-04 | 1997-04-04 | Insulin-like growth factor agonist molecules |
PCT/US1998/006514 WO1998045427A2 (en) | 1997-04-04 | 1998-03-31 | Insulin-like growth factor agonist peptides |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69808258D1 true DE69808258D1 (de) | 2002-10-31 |
DE69808258T2 DE69808258T2 (de) | 2003-09-18 |
Family
ID=25245064
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69808258T Expired - Lifetime DE69808258T2 (de) | 1997-04-04 | 1998-03-31 | Molekül-agonisten für den insulinähnlichen wachstumfaktor |
Country Status (13)
Country | Link |
---|---|
US (16) | US6121416A (de) |
EP (2) | EP1251137A3 (de) |
JP (1) | JP4562814B2 (de) |
AT (1) | ATE224951T1 (de) |
AU (1) | AU732989B2 (de) |
CA (1) | CA2286264A1 (de) |
DE (1) | DE69808258T2 (de) |
DK (1) | DK0972020T3 (de) |
ES (1) | ES2183344T3 (de) |
HK (1) | HK1047755A1 (de) |
IL (1) | IL131925A0 (de) |
PT (1) | PT972020E (de) |
WO (1) | WO1998045427A2 (de) |
Families Citing this family (62)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6420518B1 (en) | 1997-04-04 | 2002-07-16 | Genetech, Inc. | Insulin-like growth factor agonist molecules |
ES2329220T3 (es) | 1999-01-06 | 2009-11-24 | Genentech, Inc. | Variantes mutantes del factor de crecimiento similar a insulina (igf) i. |
WO2000040613A1 (en) | 1999-01-06 | 2000-07-13 | Genentech, Inc. | Insulin-like growth factor (igf) i mutant variants |
US20030224017A1 (en) * | 2002-03-06 | 2003-12-04 | Samal Siba K. | Recombinant Newcastle disease viruses useful as vaccines or vaccine vectors |
CA2389575A1 (en) * | 1999-10-29 | 2001-05-10 | Oregon Health Sciences University | Modulation of neuroendocrine differentiation by protein 25.1 |
EP1265630B1 (de) | 2000-03-24 | 2006-06-07 | Genentech, Inc. | Verwendung von insulin zur behandlung von knorpelkrankheiten |
EP1282437B1 (de) | 2000-05-16 | 2008-03-19 | Genentech, Inc. | Behandlung von knorpelerkrankungen |
FR2810675B1 (fr) * | 2000-06-22 | 2002-09-27 | Pf Medicament | Construction modifiee en aval du codon d'initiation pour la surexpression de proteines recombinantes |
AU3956002A (en) * | 2000-11-28 | 2002-06-11 | Childrens Medical Center | Determination of risk and treatment of complications of prematurity |
US7611711B2 (en) * | 2001-01-17 | 2009-11-03 | Vegenics Limited | VEGFR-3 inhibitor materials and methods |
DE60233359D1 (de) * | 2001-02-09 | 2009-09-24 | Genentech Inc | Verfahren zur Identifizierung von indirekten IGF-1-Agonisten |
US6555581B1 (en) | 2001-02-15 | 2003-04-29 | Jones Pharma, Inc. | Levothyroxine compositions and methods |
US6790672B2 (en) * | 2001-02-19 | 2004-09-14 | Board Of Regents The University Of Texas System | Encoded molecular sieve particle-based sensors |
CA2702192A1 (en) | 2001-03-14 | 2002-09-19 | Genentech, Inc. | Igf antagonist peptides |
US6841386B2 (en) | 2001-04-10 | 2005-01-11 | Viacell, Inc. | Modulation of primary stem cell differentiation using an insulin-like growth factor binding protein |
US7232798B2 (en) | 2001-11-13 | 2007-06-19 | Tran Loi H | Neuroprotection and neuroegenisis by administering cyclic prolyl glycine |
US20100247483A1 (en) * | 2001-11-13 | 2010-09-30 | Tran Loi H | Therapeutic agent composition and method of use |
WO2003041655A2 (en) * | 2001-11-13 | 2003-05-22 | Loi Tran | Therapeutic agent composition and method of use |
JP4563171B2 (ja) | 2002-05-24 | 2010-10-13 | シェーリング コーポレイション | 中和ヒト抗igfr抗体 |
AU2003273615B2 (en) * | 2002-06-11 | 2010-07-29 | Brigham And Women's Hospital | Neuroprotective synergy of erythropoietin and insulin-like growth factor |
US7118877B2 (en) * | 2002-07-08 | 2006-10-10 | Wyeth | Caspase 9 activation and uses therefor |
WO2004022083A1 (en) * | 2002-09-04 | 2004-03-18 | Dsm Ip Assets B.V. | A nutritional and therapeutic composition of an insulin sensitizer and a peptide fraction |
WO2004023647A1 (en) * | 2002-09-06 | 2004-03-18 | Telefonaktiebolaget Lm Ericsson | Composite power amplifier |
US20040121407A1 (en) * | 2002-09-06 | 2004-06-24 | Elixir Pharmaceuticals, Inc. | Regulation of the growth hormone/IGF-1 axis |
RU2005111253A (ru) * | 2002-09-18 | 2005-11-20 | Сантр Оспиталье Де Л` Юниверсите Де Монреаль (Схюм) (Ca) | Аналоги ghrh |
CA2504607A1 (en) * | 2002-11-14 | 2004-05-27 | Wyeth | Methods and compositions for treating neurological disorders |
US7273788B2 (en) * | 2003-05-21 | 2007-09-25 | Micron Technology, Inc. | Ultra-thin semiconductors bonded on glass substrates |
WO2005001486A1 (en) | 2003-06-06 | 2005-01-06 | Genentech, Inc. | Modulating the interaction between hgf beta chain and c-met |
US7920906B2 (en) | 2005-03-10 | 2011-04-05 | Dexcom, Inc. | System and methods for processing analyte sensor data for sensor calibration |
ATE536186T1 (de) | 2003-09-12 | 2011-12-15 | Tercica Inc | Verfahren zur behandlung von igf-1 (insulin-like growth factor 1)-mangel |
EP1670822A2 (de) * | 2003-10-03 | 2006-06-21 | Genentech, Inc. | Igf-bindende proteine |
CN1938428A (zh) | 2003-11-12 | 2007-03-28 | 先灵公司 | 多基因表达的质粒系统 |
US9247900B2 (en) | 2004-07-13 | 2016-02-02 | Dexcom, Inc. | Analyte sensor |
TW200526684A (en) | 2003-11-21 | 2005-08-16 | Schering Corp | Anti-IGFR1 antibody therapeutic combinations |
CA2548282A1 (en) | 2003-12-11 | 2005-06-30 | Genentech, Inc. | Methods and compositions for inhibiting c-met dimerization and activation |
AU2005224942B2 (en) * | 2004-03-19 | 2011-08-11 | Merck Patent Gmbh | Modified bouganin proteins, cytotoxins and methods and uses thereof |
US7946984B2 (en) | 2004-07-13 | 2011-05-24 | Dexcom, Inc. | Transcutaneous analyte sensor |
WO2006127694A2 (en) | 2004-07-13 | 2006-11-30 | Dexcom, Inc. | Analyte sensor |
DE602005025685D1 (de) | 2004-12-03 | 2011-02-10 | Schering Corp | Biologische marker zur vorauswahl von patienten für die anti-igf1r-therapie |
US7833513B2 (en) | 2004-12-03 | 2010-11-16 | Rhode Island Hospital | Treatment of Alzheimer's Disease |
CA2604393A1 (en) * | 2005-04-15 | 2006-10-26 | Schering Corporation | Methods and compositions for treating or preventing cancer |
AU2006259536A1 (en) * | 2005-06-15 | 2006-12-28 | Schering Corporation | Anti-IGF1R antibody formulations |
EP2343551B1 (de) | 2006-04-10 | 2014-05-28 | Genentech, Inc. | Dishevelled PDZ-Modulatoren |
US8518877B2 (en) * | 2007-04-18 | 2013-08-27 | Premacure Ab | Method and product for treatment and/or prevention of complications of prematurity |
JP2010536880A (ja) | 2007-08-22 | 2010-12-02 | ギリード・コロラド・インコーポレーテッド | 糖尿病の合併症のための療法 |
WO2009105709A1 (en) | 2008-02-21 | 2009-08-27 | Dexcom, Inc. | Systems and methods for processing, transmitting and displaying sensor data |
US8682408B2 (en) | 2008-03-28 | 2014-03-25 | Dexcom, Inc. | Polymer membranes for continuous analyte sensors |
US8583204B2 (en) | 2008-03-28 | 2013-11-12 | Dexcom, Inc. | Polymer membranes for continuous analyte sensors |
US11730407B2 (en) | 2008-03-28 | 2023-08-22 | Dexcom, Inc. | Polymer membranes for continuous analyte sensors |
EP2571992B1 (de) | 2010-05-21 | 2018-04-25 | Merrimack Pharmaceuticals, Inc. | Bispezifische fusionsproteine |
CA2812785A1 (en) | 2010-10-20 | 2012-04-26 | Genentech, Inc. | Methods and compositions for modulating the wnt pathway |
JP6190813B2 (ja) | 2011-10-14 | 2017-08-30 | ジェネンテック, インコーポレイテッド | チモーゲン活性化因子 |
WO2013056054A2 (en) | 2011-10-14 | 2013-04-18 | Genentech, Inc | Peptide inhibitors of bace1 |
CN108367048B (zh) | 2015-10-02 | 2022-08-12 | 银溪制药股份有限公司 | 用于组织修复的双特异性治疗性蛋白质 |
EP3681602A1 (de) | 2017-09-11 | 2020-07-22 | Shire Human Genetic Therapies, Inc. | Verfahren und zusammensetzungen zur behandlung chronischer lungenerkrankungen |
JP2021524864A (ja) | 2018-05-15 | 2021-09-16 | ロイド ハン ロイ トランLloyd Hung Loi Tran | 軽度の認知障害、抑うつ、および精神障害の治療のための治療薬組成物およびその使用方法 |
US20210008172A1 (en) | 2019-07-11 | 2021-01-14 | Opko Biologics Ltd. | Long-acting igf-1 or igf-1 variants and methods of producing same |
GB201913196D0 (en) | 2019-09-12 | 2019-10-30 | Univ Newcastle | Culture method |
US20230381285A1 (en) | 2020-10-19 | 2023-11-30 | Oak Hill Bio Ltd | Compositions suitable for use in neonates |
DE102021122096A1 (de) | 2021-08-26 | 2023-03-02 | Forschungsinstitut für Nutztierbiologie | IGF-1, IGFBP-2 und Insulin umfassende Zusammensetzungen und ihre Verwendung |
WO2023139115A1 (en) | 2022-01-19 | 2023-07-27 | Oak Hill Bio Limited | Compositions and methods for reducing oxidation of igf‐1/igfbp |
CN117347626B (zh) * | 2023-12-06 | 2024-03-12 | 安徽惠邦生物工程有限公司 | 人胰岛素样生长因子结合蛋白-1化学发光免疫分析试剂盒及其制备方法 |
Family Cites Families (62)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4411890A (en) * | 1981-04-14 | 1983-10-25 | Beckman Instruments, Inc. | Synthetic peptides having pituitary growth hormone releasing activity |
US3721252A (en) * | 1971-04-01 | 1973-03-20 | Catheter And Instr Corp | Spring guide washer |
US4511503A (en) * | 1982-12-22 | 1985-04-16 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
IL71991A (en) * | 1983-06-06 | 1994-05-30 | Genentech Inc | Preparation of human FGI and FGE in their processed form through recombinant AND tranology in prokaryotes |
PH23185A (en) | 1983-06-13 | 1989-05-29 | Scheindel Ass Inc | Pressure operated dispensing container |
WO1985000831A1 (en) * | 1983-08-10 | 1985-02-28 | Amgen | Microbial expression of insulin-like growth factor |
DE3463991D1 (en) | 1983-08-15 | 1987-07-02 | Amp Inc | An improved compliant section for circuit board contact elements |
WO1987001038A1 (en) * | 1985-08-22 | 1987-02-26 | Commonwealth Scientific And Industrial Research Or | Peptide analogues of mammalian insulin-like growth factor-1 |
SE8505922D0 (sv) * | 1985-12-13 | 1985-12-13 | Kabigen Ab | Construction of an igg binding protein to facilitate downstream processing using protein engineering |
ATE90690T1 (de) * | 1987-04-06 | 1993-07-15 | Celtrix Pharma | Menschliche somatomedin-traeger-proteinuntereinheiten und verfahren zu ihrer herstellung. |
CA1314507C (en) * | 1987-04-23 | 1993-03-16 | Edith Yee-Tak Wong | Secretion of insulin-like growth factor-i in e. coli |
SE8703625D0 (sv) * | 1987-09-18 | 1987-09-18 | Kabivitrum Ab | New medical use |
US4876242A (en) * | 1987-09-21 | 1989-10-24 | Merck & Co., Inc. | Human insulin-like growth factor analoges with reduced binding to serum carrier proteins and their production in yeast |
US5470828A (en) * | 1987-12-24 | 1995-11-28 | Gropep Pty. Ltd. | Peptide analogs of insulin-like growth factor II |
WO1989005822A1 (en) * | 1987-12-24 | 1989-06-29 | Gropep Pty. Ltd. | Peptide analogues of insulin-like growth factor 1 (igf-1) or factor 2 (igf-2) |
US4988675A (en) * | 1988-02-05 | 1991-01-29 | Ciba-Geigy Corporation | Method for preventing secondary effects |
EP0327503B1 (de) * | 1988-02-05 | 1993-03-10 | Ciba-Geigy Ag | Verwendung von IGF I zur Herstellung eines Präparates für die Behandlung von Nierenkrankheiten |
DK131988A (da) * | 1988-03-11 | 1989-09-12 | Erasmus University | Igf-bindingsprotein, dna-struktur, der koder for igf-bindingsproteinet og vektor indeholdende denne dna-struktur |
US5258287A (en) * | 1988-03-22 | 1993-11-02 | Genentech, Inc. | DNA encoding and methods of production of insulin-like growth factor binding protein BP53 |
WO1989009792A1 (en) * | 1988-04-12 | 1989-10-19 | Synergen, Inc. | Method for potentiating and inhibiting insulin-like growth factor activity |
US5223409A (en) * | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
US5534617A (en) * | 1988-10-28 | 1996-07-09 | Genentech, Inc. | Human growth hormone variants having greater affinity for human growth hormone receptor at site 1 |
GB8826451D0 (en) * | 1988-11-11 | 1988-12-14 | Sandoz Ltd | Improvements in/relating to organic compounds |
IL92816A0 (en) * | 1988-12-22 | 1990-09-17 | Biogrowth Inc | Recombinant dna molecules,hosts,processes and human somatomedin carrier protein-like polypeptides |
EP0379338A3 (de) * | 1989-01-17 | 1991-07-24 | Merck & Co. Inc. | Menschlicher insulinähnlicher Wachstumsfaktor und seine Herstellung in Hefe |
US5652214A (en) * | 1989-06-05 | 1997-07-29 | Cephalon, Inc. | Treating disorders by application of insulin-like growth factors and analogs |
US5093317A (en) * | 1989-06-05 | 1992-03-03 | Cephalon, Inc. | Treating disorders by application of insulin-like growth factor |
GB8920381D0 (en) * | 1989-09-08 | 1989-10-25 | Greater Glasgow Health Board | Treatment of insulin-resistant diabetes |
US5126324A (en) * | 1990-06-07 | 1992-06-30 | Genentech, Inc. | Method of enhancing growth in patients using combination therapy |
US5374620A (en) * | 1990-06-07 | 1994-12-20 | Genentech, Inc. | Growth-promoting composition and its use |
US5210017A (en) * | 1990-11-19 | 1993-05-11 | Genentech, Inc. | Ligand-mediated immunofunctional hormone binding protein assay method |
US5593844A (en) * | 1990-11-19 | 1997-01-14 | Genentech, Inc. | Ligand-mediated immunofunctional hormone binding protein assay method |
SE9100099D0 (sv) * | 1991-01-11 | 1991-01-11 | Kabi Pharmacia Ab | Use of growth factor |
US5187151A (en) * | 1991-02-12 | 1993-02-16 | Genentech, Inc. | Use of binding protein with igf-i as an anabolic growth promoting agent |
CA2105300C (en) * | 1991-03-01 | 2008-12-23 | Robert C. Ladner | Process for the development of binding mini-proteins |
US5206235A (en) * | 1991-03-20 | 1993-04-27 | Merck & Co., Inc. | Benzo-fused lactams that promote the release of growth hormone |
US5202119A (en) * | 1991-06-28 | 1993-04-13 | Genentech, Inc. | Method of stimulating immune response |
DE69218948T2 (de) * | 1991-08-01 | 1997-07-31 | Genentech Inc | IGF-I zur Verbesserung der neuronale Lage |
US6310040B1 (en) * | 1991-11-08 | 2001-10-30 | Cephalon, Inc. | Treating retinal neuronal disorders by the application of insulin-like growth factors and analogs |
SE9201573D0 (sv) * | 1992-05-19 | 1992-05-19 | Kabi Pharmacia Ab | Use of igf-1 |
WO1993025219A1 (en) * | 1992-06-12 | 1993-12-23 | Cephalon, Inc. | Prevention and treatment of peripheral neuropathy |
GB9217696D0 (en) * | 1992-08-20 | 1992-09-30 | Agricultural & Food Res | Use of specific binding molecules |
US5273961A (en) * | 1992-09-22 | 1993-12-28 | Genentech, Inc. | Method of prophylaxis of acute renal failure |
WO1994016722A1 (en) * | 1993-01-25 | 1994-08-04 | The Beth Israel Hospital Association | Method for modifying, diagnosing, and screening for igf-i sensitive cell barrier properties |
CA2154078A1 (en) * | 1993-01-29 | 1994-08-04 | George N. Cox | Wound healing composition |
US5457109A (en) * | 1993-09-15 | 1995-10-10 | Warner-Lambert Company | Use of thiazolidinedione derivatives and related antihyperglycemic agents in the treatment of disease states at risk for progressing to noninsulin-dependent diabetes mellitus |
DE69427650T2 (de) * | 1993-12-23 | 2001-11-22 | Novo Nordisk As | Verbindungen mit wachstumshormon-freisetzenden eigenschaften |
JP3181918B2 (ja) * | 1993-12-23 | 2001-07-03 | ノボ ノルディスク アクティーゼルスカブ | 成長ホルモン放出特性を持つ化合物 |
SE9402370D0 (sv) * | 1994-07-04 | 1994-07-04 | Pharmacia Ab | Use of IGF-I |
US5798337A (en) * | 1994-11-16 | 1998-08-25 | Genentech, Inc. | Low molecular weight peptidomimetic growth hormone secretagogues |
SE9501472D0 (sv) * | 1995-04-21 | 1995-04-21 | Pharmacia Ab | Truncated IGF-I |
US5622932A (en) * | 1995-05-05 | 1997-04-22 | Eli Lilly And Company | IGF-1 superagonists |
DK0828758T3 (da) * | 1995-05-26 | 2002-01-07 | Theratechnologies Inc | Kimæriske fedtlegeme-pro-GRF-analoger med forøget biologisk potensering |
AU6046696A (en) * | 1995-06-07 | 1996-12-30 | Glaxo Group Limited | Peptides and compounds that bind to a receptor |
ZA964814B (en) * | 1995-06-07 | 1998-02-09 | Glaxo Group Ltd | Peptides and compounds that bind to a receptor. |
CZ391097A3 (cs) * | 1995-06-07 | 1998-07-15 | Ortho Pharmaceutical Corporation | Látky a peptidy vážící se na erythropoietinový receptor |
US5958872A (en) * | 1996-04-01 | 1999-09-28 | Apoptosis Technology, Inc. | Active survival domains of IGF-IR and methods of use |
JPH11508608A (ja) * | 1996-04-17 | 1999-07-27 | ニューロクライン バイオサイエンシーズ,インコーポレイテッド | インスリン様成長因子結合タンパク質のリガンドインヒビターおよびそれらの使用方法 |
US6402715B2 (en) | 1996-04-25 | 2002-06-11 | Karl Storz Gmbh & Co. Kg | Surgical instrument system |
AU7891098A (en) | 1996-12-27 | 1998-07-31 | Daiichi Pharmaceutical Co., Ltd. | Method for elevating the concentration of free insulin-like growth factor |
US6420518B1 (en) * | 1997-04-04 | 2002-07-16 | Genetech, Inc. | Insulin-like growth factor agonist molecules |
WO2000023469A2 (en) | 1998-10-16 | 2000-04-27 | Musc Foundation For Research Development | Fragments of insulin-like growth factor binding protein and insulin-like growth factor, and uses thereof |
-
1997
- 1997-04-04 US US08/825,852 patent/US6121416A/en not_active Expired - Fee Related
-
1998
- 1998-03-31 EP EP02014880A patent/EP1251137A3/de not_active Withdrawn
- 1998-03-31 WO PCT/US1998/006514 patent/WO1998045427A2/en active IP Right Grant
- 1998-03-31 IL IL13192598A patent/IL131925A0/xx not_active IP Right Cessation
- 1998-03-31 DE DE69808258T patent/DE69808258T2/de not_active Expired - Lifetime
- 1998-03-31 ES ES98915236T patent/ES2183344T3/es not_active Expired - Lifetime
- 1998-03-31 AU AU69470/98A patent/AU732989B2/en not_active Ceased
- 1998-03-31 CA CA002286264A patent/CA2286264A1/en not_active Abandoned
- 1998-03-31 DK DK98915236T patent/DK0972020T3/da active
- 1998-03-31 JP JP54289498A patent/JP4562814B2/ja not_active Expired - Fee Related
- 1998-03-31 PT PT98915236T patent/PT972020E/pt unknown
- 1998-03-31 US US09/052,888 patent/US6251865B1/en not_active Expired - Fee Related
- 1998-03-31 AT AT98915236T patent/ATE224951T1/de active
- 1998-03-31 EP EP98915236A patent/EP0972020B1/de not_active Expired - Lifetime
-
2000
- 2000-11-28 US US09/723,890 patent/US6608031B1/en not_active Expired - Fee Related
- 2000-11-28 US US09/723,873 patent/US6677305B1/en not_active Expired - Fee Related
- 2000-11-28 US US09/723,913 patent/US6683053B1/en not_active Expired - Fee Related
- 2000-11-28 US US09/724,095 patent/US6693078B1/en not_active Expired - Fee Related
- 2000-11-28 US US09/724,065 patent/US6716586B1/en not_active Expired - Fee Related
- 2000-11-28 US US09/723,901 patent/US6620789B1/en not_active Expired - Fee Related
- 2000-11-28 US US09/723,912 patent/US6689751B1/en not_active Expired - Fee Related
- 2000-11-28 US US09/724,157 patent/US6693079B1/en not_active Expired - Fee Related
- 2000-11-28 US US09/723,931 patent/US6645775B1/en not_active Expired - Fee Related
- 2000-11-28 US US09/723,547 patent/US6632794B1/en not_active Expired - Lifetime
- 2000-11-28 US US09/724,114 patent/US6680298B1/en not_active Expired - Fee Related
- 2000-11-28 US US09/724,481 patent/US6949349B1/en not_active Expired - Fee Related
- 2000-11-28 US US09/724,127 patent/US6635619B1/en not_active Expired - Fee Related
- 2000-11-28 US US09/724,062 patent/US6713451B1/en not_active Expired - Fee Related
-
2002
- 2002-12-30 HK HK02109420.9A patent/HK1047755A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
CA2286264A1 (en) | 1998-10-15 |
US6608031B1 (en) | 2003-08-19 |
DK0972020T3 (da) | 2003-02-03 |
US6121416A (en) | 2000-09-19 |
EP1251137A3 (de) | 2003-04-16 |
US6645775B1 (en) | 2003-11-11 |
US6680298B1 (en) | 2004-01-20 |
US6251865B1 (en) | 2001-06-26 |
DE69808258T2 (de) | 2003-09-18 |
US6949349B1 (en) | 2005-09-27 |
AU6947098A (en) | 1998-10-30 |
JP4562814B2 (ja) | 2010-10-13 |
HK1047755A1 (zh) | 2003-03-07 |
US6689751B1 (en) | 2004-02-10 |
WO1998045427A2 (en) | 1998-10-15 |
WO1998045427A3 (en) | 1999-01-07 |
US6693078B1 (en) | 2004-02-17 |
EP1251137A2 (de) | 2002-10-23 |
US6716586B1 (en) | 2004-04-06 |
US6632794B1 (en) | 2003-10-14 |
US6713451B1 (en) | 2004-03-30 |
US6677305B1 (en) | 2004-01-13 |
AU732989B2 (en) | 2001-05-03 |
IL131925A0 (en) | 2001-03-19 |
EP0972020A1 (de) | 2000-01-19 |
ATE224951T1 (de) | 2002-10-15 |
EP0972020B1 (de) | 2002-09-25 |
JP2002510194A (ja) | 2002-04-02 |
PT972020E (pt) | 2003-02-28 |
US6693079B1 (en) | 2004-02-17 |
US6683053B1 (en) | 2004-01-27 |
US6620789B1 (en) | 2003-09-16 |
ES2183344T3 (es) | 2003-03-16 |
US6635619B1 (en) | 2003-10-21 |
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