DE69812886T2 - Optische messungen mit räumlicher auflösung - Google Patents

Optische messungen mit räumlicher auflösung

Info

Publication number
DE69812886T2
DE69812886T2 DE69812886T DE69812886T DE69812886T2 DE 69812886 T2 DE69812886 T2 DE 69812886T2 DE 69812886 T DE69812886 T DE 69812886T DE 69812886 T DE69812886 T DE 69812886T DE 69812886 T2 DE69812886 T2 DE 69812886T2
Authority
DE
Germany
Prior art keywords
electromagnetic radiation
optical assembly
volume elements
sample
sequentially
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69812886T
Other languages
English (en)
Other versions
DE69812886D1 (de
Inventor
Mark Modell
Ze Ev Hed
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medispectra Inc
Original Assignee
Medispectra Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medispectra Inc filed Critical Medispectra Inc
Publication of DE69812886D1 publication Critical patent/DE69812886D1/de
Application granted granted Critical
Publication of DE69812886T2 publication Critical patent/DE69812886T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00002—Operational features of endoscopes
    • A61B1/00059—Operational features of endoscopes provided with identification means for the endoscope
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/4795—Scattering, i.e. diffuse reflection spatially resolved investigating of object in scattering medium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
    • A61B1/043—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances for fluorescence imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/08—Sensors provided with means for identification, e.g. barcodes or memory chips
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0062—Arrangements for scanning
    • A61B5/0068—Confocal scanning

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Medical Informatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Optics & Photonics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Length Measuring Devices By Optical Means (AREA)
DE69812886T 1997-01-13 1998-01-09 Optische messungen mit räumlicher auflösung Expired - Lifetime DE69812886T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/782,936 US6104945A (en) 1995-08-01 1997-01-13 Spectral volume microprobe arrays
PCT/US1998/000481 WO1998030889A1 (en) 1997-01-13 1998-01-09 Spatially resolved optical measurements

Publications (2)

Publication Number Publication Date
DE69812886D1 DE69812886D1 (de) 2003-05-08
DE69812886T2 true DE69812886T2 (de) 2003-12-04

Family

ID=25127644

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69812886T Expired - Lifetime DE69812886T2 (de) 1997-01-13 1998-01-09 Optische messungen mit räumlicher auflösung

Country Status (8)

Country Link
US (1) US6104945A (de)
EP (2) EP1262763A3 (de)
JP (1) JP3992113B2 (de)
AT (1) ATE236388T1 (de)
CA (1) CA2277095C (de)
DE (1) DE69812886T2 (de)
ES (1) ES2192320T3 (de)
WO (1) WO1998030889A1 (de)

Families Citing this family (131)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5690894A (en) * 1995-05-23 1997-11-25 The Regents Of The University Of California High density array fabrication and readout method for a fiber optic biosensor
US6411835B1 (en) * 1997-01-13 2002-06-25 Medispectra, Inc. Spectral volume microprobe arrays
US6826422B1 (en) * 1997-01-13 2004-11-30 Medispectra, Inc. Spectral volume microprobe arrays
AU749690B2 (en) * 1998-08-21 2002-07-04 Surromed, Inc. Novel optical architectures for microvolume laser-scanning cytometers
EP1137928B1 (de) * 1998-11-11 2005-04-06 The University of Manchester Überwachung der verteilung und mischung eines chemischen spezies
EP1161178A2 (de) 1998-12-23 2001-12-12 Medispectra Inc. Systeme und verfahren zur optischen untersuchung von proben
US6937330B2 (en) 1999-04-23 2005-08-30 Ppd Biomarker Discovery Sciences, Llc Disposable optical cuvette cartridge with low fluorescence material
DE19919092A1 (de) * 1999-04-27 2000-11-02 Zeiss Carl Jena Gmbh Anordnung zur optischen Auswertung eines Gegenstandsarrays
EP1190232A1 (de) 1999-06-26 2002-03-27 Packard Instrument Company, Inc. Mikroplattenleser
US6687395B1 (en) * 1999-07-21 2004-02-03 Surromed, Inc. System for microvolume laser scanning cytometry
US6587711B1 (en) * 1999-07-22 2003-07-01 The Research Foundation Of Cuny Spectral polarizing tomographic dermatoscope
US20040111031A1 (en) * 1999-07-22 2004-06-10 Alfano Robert R. Spectral polarizing tomographic dermatoscope
DE19948587A1 (de) * 1999-10-08 2001-04-12 Dade Behring Marburg Gmbh Spektralphotometrische und nephelometrische Detektionseinheit
US6411373B1 (en) * 1999-10-08 2002-06-25 Instrumentation Metrics, Inc. Fiber optic illumination and detection patterns, shapes, and locations for use in spectroscopic analysis
US6343228B1 (en) * 1999-10-19 2002-01-29 The Hong Kong University Of Science And Technology Method and apparatus for fluorescence imaging of tissue
US6369888B1 (en) 1999-11-17 2002-04-09 Applied Materials, Inc. Method and apparatus for article inspection including speckle reduction
AU2001245329A1 (en) * 2000-02-22 2001-09-03 Shofner Engineering Associates, Inc. Measurement of aerosol mass concentration and mass delivery rate
US6329661B1 (en) * 2000-02-29 2001-12-11 The University Of Chicago Biochip scanner device
JP2002005835A (ja) * 2000-06-23 2002-01-09 宏夫 ▲浜▼口 ラマン分光測定装置及びそれを用いた生体試料分析方法
US20030160957A1 (en) * 2000-07-14 2003-08-28 Applera Corporation Scanning system and method for scanning a plurality of samples
WO2002012854A2 (en) * 2000-08-04 2002-02-14 Photonify Technologies, Inc. Systems and methods for providing information concerning chromophores in physiological media
US6516209B2 (en) * 2000-08-04 2003-02-04 Photonify Technologies, Inc. Self-calibrating optical imaging system
US6597931B1 (en) 2000-09-18 2003-07-22 Photonify Technologies, Inc. System and method for absolute oxygen saturation
US6587703B2 (en) 2000-09-18 2003-07-01 Photonify Technologies, Inc. System and method for measuring absolute oxygen saturation
JP4241038B2 (ja) 2000-10-30 2009-03-18 ザ ジェネラル ホスピタル コーポレーション 組織分析のための光学的な方法及びシステム
US6787761B2 (en) * 2000-11-27 2004-09-07 Surromed, Inc. Median filter for liquid chromatography-mass spectrometry data
AU2002217904A1 (en) * 2000-11-28 2002-06-11 Surromed, Inc. Methods for efficiently minig broad data sets for biological markers
AU2002243602A1 (en) * 2001-01-19 2002-07-30 U.S. Army Medical Research And Materiel Command A method and apparatus for generating two-dimensional images of cervical tissue from three-dimensional hyperspectral cubes
US6538730B2 (en) * 2001-04-06 2003-03-25 Kla-Tencor Technologies Corporation Defect detection system
DE10131687A1 (de) * 2001-06-29 2003-01-16 Eppendorf Ag Vorrichtung zur Durchführung von Nukleinsäure-Amplifikationsreaktionen bei gleichzeitiger Verfolgung der Bildung von Amplifikationsprodukten
US6873915B2 (en) * 2001-08-24 2005-03-29 Surromed, Inc. Peak selection in multidimensional data
US20030078739A1 (en) * 2001-10-05 2003-04-24 Surromed, Inc. Feature list extraction from data sets such as spectra
US7298461B2 (en) * 2001-10-09 2007-11-20 Ruprecht-Karls-Universitat Far field light microscopical method, system and computer program product for analysing at least one object having a subwavelength size
DE10206004A1 (de) * 2002-02-14 2003-08-28 Zeiss Carl Jena Gmbh Vorrichtung zur konfokalen optischen Mikroanalyse
US8131332B2 (en) * 2002-04-04 2012-03-06 Veralight, Inc. Determination of a measure of a glycation end-product or disease state using tissue fluorescence of various sites
CA2484625A1 (en) * 2002-05-09 2003-11-20 Surromed, Inc. Methods for time-alignment of liquid chromatography-mass spectrometry data
US6818903B2 (en) 2002-07-09 2004-11-16 Medispectra, Inc. Method and apparatus for identifying spectral artifacts
US6768918B2 (en) 2002-07-10 2004-07-27 Medispectra, Inc. Fluorescent fiberoptic probe for tissue health discrimination and method of use thereof
US20030016357A1 (en) * 2002-07-30 2003-01-23 Shofner Frederick M. Measurement of aerosol mass concentration and mass delivery rate
US7116413B2 (en) * 2002-09-13 2006-10-03 Kla-Tencor Corporation Inspection system for integrated applications
DE10249526A1 (de) * 2002-10-23 2004-05-06 Leica Microsystems (Schweiz) Ag Augenschutz an einem elektronisch gesteuerten Fluoreszenzmikroskop
JP2004222870A (ja) * 2003-01-21 2004-08-12 Pentax Corp 内視鏡用プローブ
JP2004271519A (ja) * 2003-02-18 2004-09-30 Topcon Corp 表面検査装置
EP2436307B1 (de) 2003-03-31 2015-10-21 The General Hospital Corporation Fleckenreduzierung bei der optischen Kohärenztomografie durch pfadlängencodierte Winkelmischung
EP2280260B1 (de) 2003-06-06 2017-03-08 The General Hospital Corporation Verfahren und Vorrichtung für eine Lichtquelle mit Abstimmung der Wellenlänge
EP1660870A2 (de) 2003-08-26 2006-05-31 Blueshift Biotechnologies, Inc. Zeitabhängige fluoreszenzmessungen
US7248360B2 (en) * 2004-04-02 2007-07-24 Ppd Biomarker Discovery Sciences, Llc Polychronic laser scanning system and method of use
US20060253261A1 (en) * 2004-05-05 2006-11-09 Chem Image Corporation Digitizing biology
EP1759248A1 (de) * 2004-06-04 2007-03-07 Carl Zeiss SMT AG Projektionssystem mit kompensation von intensitätsschwankungen und kompensationselement dafür
US7447408B2 (en) 2004-07-02 2008-11-04 The General Hospital Corproation Imaging system and related techniques
JP2006023221A (ja) * 2004-07-09 2006-01-26 Tokyo Seimitsu Co Ltd 外観検査装置及び投影方法
US7697808B2 (en) * 2004-07-27 2010-04-13 Ut-Battelle, Llc Multi-tipped optical component
EP1793731B1 (de) 2004-08-24 2013-12-25 The General Hospital Corporation Bildgebungsgerät mit einer Fluidabgabevorrichtung und einer Pull-Back-Vorrichntung
US8965487B2 (en) 2004-08-24 2015-02-24 The General Hospital Corporation Process, system and software arrangement for measuring a mechanical strain and elastic properties of a sample
JP2008521516A (ja) 2004-11-29 2008-06-26 ザ ジェネラル ホスピタル コーポレイション サンプル上の複数の地点を同時に照射し検出することによって光学画像生成を実行する構成、装置、内視鏡、カテーテル、及び方法
US8351665B2 (en) 2005-04-28 2013-01-08 The General Hospital Corporation Systems, processes and software arrangements for evaluating information associated with an anatomical structure by an optical coherence ranging technique
JP5702049B2 (ja) 2005-06-01 2015-04-15 ザ ジェネラル ホスピタル コーポレイション 位相分解光学周波数領域画像化を行うための装置、方法及びシステム
EP2267404B1 (de) 2005-08-09 2016-10-05 The General Hospital Corporation Gerät und Verfahren zur Durchführung von polarisationsbasierter Quadraturdemulation bei optischer Kohärenztomographie
EP1937137B1 (de) 2005-09-29 2022-06-15 General Hospital Corporation Verfahren und gerät zur optischen darstellung via spektrale codierung
US20070161876A1 (en) 2005-11-18 2007-07-12 Spectrx, Inc. Method and apparatus for rapid detection and diagnosis of tissue abnormalities
US8145018B2 (en) 2006-01-19 2012-03-27 The General Hospital Corporation Apparatus for obtaining information for a structure using spectrally-encoded endoscopy techniques and methods for producing one or more optical arrangements
WO2007084995A2 (en) 2006-01-19 2007-07-26 The General Hospital Corporation Methods and systems for optical imaging of epithelial luminal organs by beam scanning thereof
WO2007149603A2 (en) 2006-02-01 2007-12-27 The General Hospital Corporation Apparatus for applying a plurality of electro-magnetic radiations to a sample
JP5524487B2 (ja) 2006-02-01 2014-06-18 ザ ジェネラル ホスピタル コーポレイション コンフォーマルレーザ治療手順を用いてサンプルの少なくとも一部分に電磁放射を放射する方法及びシステム。
EP2306141A1 (de) 2006-02-24 2011-04-06 The General Hospital Corporation Verfahren und Systeme zur Durchführung von winkelaufgelöster optischer Kohärenztomografie im Fourier-Bereich
GB0604231D0 (en) * 2006-03-02 2006-04-12 Ucl Biomedica Plc Cancer detection system
JP5204093B2 (ja) * 2006-04-18 2013-06-05 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 光学測定装置
WO2007133961A2 (en) 2006-05-10 2007-11-22 The General Hospital Corporation Processes, arrangements and systems for providing frequency domain imaging of a sample
EP1898206A1 (de) 2006-09-06 2008-03-12 DKFZ Deutsches Krebsforschungszentrum Zweimodige Bilderzeugung
WO2008049118A2 (en) 2006-10-19 2008-04-24 The General Hospital Corporation Apparatus and method for obtaining and providing imaging information associated with at least one portion of a sample and effecting such portion(s)
JP5002813B2 (ja) * 2007-02-06 2012-08-15 国立大学法人浜松医科大学 蛍光測定装置
WO2008118781A2 (en) 2007-03-23 2008-10-02 The General Hospital Corporation Methods, arrangements and apparatus for utilizing a wavelength-swept laser using angular scanning and dispersion procedures
US10534129B2 (en) 2007-03-30 2020-01-14 The General Hospital Corporation System and method providing intracoronary laser speckle imaging for the detection of vulnerable plaque
EP2209412B1 (de) * 2007-11-12 2018-08-29 Cornell University Nicht-konfokales fluoreszenzemissionsendoskop mit mehrfachem weg und mehrfacher vergrösserung sowie verfahren
US20100270479A1 (en) * 2007-11-12 2010-10-28 Cornell University Non-imaging, weakly focused fluorescence emission apparatus and method
RU2440591C2 (ru) 2008-04-10 2012-01-20 Шлюмбергер Текнолоджи Б.В. Способ получения характеристик геологической формации, пересекаемой скважиной
US8725477B2 (en) * 2008-04-10 2014-05-13 Schlumberger Technology Corporation Method to generate numerical pseudocores using borehole images, digital rock samples, and multi-point statistics
CN104939806B (zh) 2008-05-20 2021-12-10 大学健康网络 用于基于荧光的成像和监测的装置和方法
EP2163885A1 (de) * 2008-06-24 2010-03-17 Koninklijke Philips Electronics N.V. System und Verfahren zur Mikroarraycharakterisierung
EP2291643B1 (de) * 2008-06-24 2016-11-23 Koninklijke Philips N.V. System und verfahren zur mikroarraycharakterisierung
US9254089B2 (en) 2008-07-14 2016-02-09 The General Hospital Corporation Apparatus and methods for facilitating at least partial overlap of dispersed ration on at least one sample
WO2010068764A2 (en) 2008-12-10 2010-06-17 The General Hospital Corporation Systems, apparatus and methods for extending imaging depth range of optical coherence tomography through optical sub-sampling
EP2389093A4 (de) 2009-01-20 2013-07-31 Gen Hospital Corp Endoskopische biopsievorrichtung sowie entsprechendes system und verfahren
CA2749670A1 (en) 2009-02-04 2010-08-12 The General Hospital Corporation Apparatus and method for utilization of a high-speed optical wavelength tuning source
US8311788B2 (en) * 2009-07-01 2012-11-13 Schlumberger Technology Corporation Method to quantify discrete pore shapes, volumes, and surface areas using confocal profilometry
US20110004447A1 (en) * 2009-07-01 2011-01-06 Schlumberger Technology Corporation Method to build 3D digital models of porous media using transmitted laser scanning confocal mircoscopy and multi-point statistics
EP2453791B1 (de) 2009-07-14 2023-09-06 The General Hospital Corporation Vorrichtung zum messen des flusses und drucks in einem gefäss
FR2949856B1 (fr) * 2009-09-04 2011-09-16 Centre Nat Etd Spatiales Interferometre a compensation de champ
US20120289947A1 (en) * 2010-01-18 2012-11-15 Wolfgang Neuberger Device and method for removing veins
SI2542145T1 (sl) 2010-03-05 2021-01-29 The General Hospital Corporation Sistemi, ki zagotavljajo mikroskopske slike vsaj ene anatomske strukture pri določeni ločljivosti
US9069130B2 (en) 2010-05-03 2015-06-30 The General Hospital Corporation Apparatus, method and system for generating optical radiation from biological gain media
WO2011149972A2 (en) 2010-05-25 2011-12-01 The General Hospital Corporation Systems, devices, methods, apparatus and computer-accessible media for providing optical imaging of structures and compositions
EP2575598A2 (de) 2010-05-25 2013-04-10 The General Hospital Corporation Vorrichtungen, systeme, verfahren und computerlesbares medium zur spektralanalyse von bildern aus einer optischen kohärenz-tomographie
WO2011153434A2 (en) 2010-06-03 2011-12-08 The General Hospital Corporation Apparatus and method for devices for imaging structures in or at one or more luminal organs
CN103260501B (zh) 2010-10-06 2015-09-02 普罗弗萨股份有限公司 组织整合性传感器
EP2632324A4 (de) 2010-10-27 2015-04-22 Gen Hospital Corp Vorrichtungen, systeme und verfahren zur blutdruckmessung in mindestens einem gefäss
WO2013013049A1 (en) 2011-07-19 2013-01-24 The General Hospital Corporation Systems, methods, apparatus and computer-accessible-medium for providing polarization-mode dispersion compensation in optical coherence tomography
US9341783B2 (en) 2011-10-18 2016-05-17 The General Hospital Corporation Apparatus and methods for producing and/or providing recirculating optical delay(s)
US9629528B2 (en) 2012-03-30 2017-04-25 The General Hospital Corporation Imaging system, method and distal attachment for multidirectional field of view endoscopy
WO2013165888A2 (en) * 2012-04-30 2013-11-07 Mayo Foundation For Medical Education And Research Spectrometric systems and methods for improved focus localization of time-and space-varying measurements
EP2852315A4 (de) 2012-05-21 2016-06-08 Gen Hospital Corp Einrichtung, vorrichtung und verfahren für kapselmikroskopie
EP2888616A4 (de) 2012-08-22 2016-04-27 Gen Hospital Corp System, verfahren, und über computer zugängliches medium zur herstellung eines miniaturendoskops mit weicher lithografie
JP6542130B2 (ja) * 2013-01-28 2019-07-10 オスロ ユニヴェルジテットサイケフス ホーエフ 循環不全の評価
US9968261B2 (en) 2013-01-28 2018-05-15 The General Hospital Corporation Apparatus and method for providing diffuse spectroscopy co-registered with optical frequency domain imaging
WO2014120791A1 (en) 2013-01-29 2014-08-07 The General Hospital Corporation Apparatus, systems and methods for providing information regarding the aortic valve
WO2014121082A1 (en) 2013-02-01 2014-08-07 The General Hospital Corporation Objective lens arrangement for confocal endomicroscopy
CN108013881B (zh) 2013-03-14 2021-06-15 普罗菲尤萨股份有限公司 用于校正光学信号的方法和装置
EP2967491B1 (de) 2013-03-15 2022-05-11 The General Hospital Corporation Ein transösophageales endoskopisches system zur bestimmung einer gemischten venösen sauerstoffsättigung einer lungenarterie
CA2911035C (en) 2013-05-02 2022-05-10 Atonarp Inc. Monitor and system for monitoring an organism
EP2997354A4 (de) 2013-05-13 2017-01-18 The General Hospital Corporation Erkennung einer selbstinterferierenden fluoreszenzphase und amplitude
EP3777656A1 (de) * 2013-06-06 2021-02-17 Profusa, Inc. Vorrichtung und verfahren zur detektion optischer signale aus implantierten sensoren
WO2014199885A1 (ja) * 2013-06-13 2014-12-18 コニカミノルタ株式会社 マルチアングル測色計
US10413359B2 (en) 2013-07-18 2019-09-17 International Business Machines Corporation Laser-assisted transdermal delivery of nanoparticulates and hydrogels
EP4349242A2 (de) 2013-07-19 2024-04-10 The General Hospital Corporation Bildgebungsvorrichtung und verfahren mit multidirektionaler sichtfeldendoskopie
WO2015010133A1 (en) 2013-07-19 2015-01-22 The General Hospital Corporation Determining eye motion by imaging retina. with feedback
US9668652B2 (en) 2013-07-26 2017-06-06 The General Hospital Corporation System, apparatus and method for utilizing optical dispersion for fourier-domain optical coherence tomography
US9733460B2 (en) 2014-01-08 2017-08-15 The General Hospital Corporation Method and apparatus for microscopic imaging
WO2015116986A2 (en) 2014-01-31 2015-08-06 The General Hospital Corporation System and method for facilitating manual and/or automatic volumetric imaging with real-time tension or force feedback using a tethered imaging device
US9828284B2 (en) 2014-03-28 2017-11-28 Ut-Battelle, Llc Thermal history-based etching
WO2015153982A1 (en) 2014-04-04 2015-10-08 The General Hospital Corporation Apparatus and method for controlling propagation and/or transmission of electromagnetic radiation in flexible waveguide(s)
DE102014108143A1 (de) * 2014-06-10 2015-12-10 Kist Europe-Korea Institute of Science and Technologie Europe Forschungsgesellschaft mbh An optical system for detecting fluorescent or luminescent signals of at least two samples
US10438356B2 (en) 2014-07-24 2019-10-08 University Health Network Collection and analysis of data for diagnostic purposes
WO2016015052A1 (en) 2014-07-25 2016-01-28 The General Hospital Corporation Apparatus, devices and methods for in vivo imaging and diagnosis
US9766041B2 (en) * 2014-12-08 2017-09-19 The Charles Stark Draper Laboratory, Inc. Multi-target optical designator
CA2988822C (en) 2015-01-30 2022-06-28 Japan Science And Technology Agency Multifocal spectrometric measurement device and optical system for multifocal spectrometric measurement device
FR3032527B1 (fr) * 2015-02-06 2020-03-13 Commissariat A L'energie Atomique Et Aux Energies Alternatives Dispositif de mesure d'un signal optique retrodiffuse par un echantillon
DE102016200271A1 (de) * 2016-01-13 2017-07-13 Institut Dr. Foerster Gmbh & Co. Kg Vorrichtung zur Erzeugung und Messung einer Emission
US9939383B2 (en) 2016-02-05 2018-04-10 Sciaps, Inc. Analyzer alignment, sample detection, localization, and focusing method and system
US10473766B2 (en) 2017-03-13 2019-11-12 The Charles Stark Draper Laboratory, Inc. Light detection and ranging (LiDAR) system and method
WO2021070170A1 (en) * 2019-10-10 2021-04-15 Check-Cap Ltd. Fail safe radiation concealment mechanism
JP2022032193A (ja) * 2020-08-11 2022-02-25 株式会社ヴィーネックス 異物・欠陥検査装置、異物・欠陥検査における画像生成装置、及び異物・欠陥検査方法

Family Cites Families (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US34214A (en) * 1862-01-21 Improvement in washers for paper-pulp
US3013467A (en) * 1957-11-07 1961-12-19 Minsky Marvin Microscopy apparatus
US4017192A (en) * 1975-02-06 1977-04-12 Neotec Corporation Optical analysis of biomedical specimens
GB1595422A (en) * 1977-04-28 1981-08-12 Nat Res Dev Scaning microscopes
US4357075A (en) * 1979-07-02 1982-11-02 Hunter Thomas M Confocal reflector system
US4254421A (en) * 1979-12-05 1981-03-03 Communications Satellite Corporation Integrated confocal electromagnetic wave lens and feed antenna system
DE2951459C2 (de) * 1979-12-20 1984-03-29 Heimann Gmbh, 6200 Wiesbaden Optische Anordnung für einen Rauchmelder nach dem Lichtstreuungsprinzip
US4515165A (en) * 1980-02-04 1985-05-07 Energy Conversion Devices, Inc. Apparatus and method for detecting tumors
ATE23752T1 (de) * 1980-08-21 1986-12-15 Oriel Scient Ltd Optische analyseeinrichtung.
US5139025A (en) * 1983-10-14 1992-08-18 Somanetics Corporation Method and apparatus for in vivo optical spectroscopic examination
SU1223092A1 (ru) * 1984-03-11 1986-04-07 Предприятие П/Я Р-6681 Малоугловой нефелометр
US4930516B1 (en) * 1985-11-13 1998-08-04 Laser Diagnostic Instr Inc Method for detecting cancerous tissue using visible native luminescence
US5042494A (en) * 1985-11-13 1991-08-27 Alfano Robert R Method and apparatus for detecting cancerous tissue using luminescence excitation spectra
JPS62138819A (ja) * 1985-12-13 1987-06-22 Hitachi Ltd 走査型レ−ザ顕微鏡
US5011243A (en) * 1986-09-16 1991-04-30 Laser Precision Corporation Reflectance infrared microscope having high radiation throughput
US4852955A (en) * 1986-09-16 1989-08-01 Laser Precision Corporation Microscope for use in modular FTIR spectrometer system
NL8603108A (nl) * 1986-12-08 1988-07-01 Philips Nv Mikroskoop.
US4810875A (en) * 1987-02-02 1989-03-07 Wyatt Technology Corporation Method and apparatus for examining the interior of semi-opaque objects
NZ223988A (en) * 1987-03-24 1990-11-27 Commw Scient Ind Res Org Optical distance measuring
US5235457A (en) * 1987-09-24 1993-08-10 Washington University Kit for converting a standard microscope into a single aperture confocal scanning epi-illumination microscope
US4844617A (en) * 1988-01-20 1989-07-04 Tencor Instruments Confocal measuring microscope with automatic focusing
FR2626383B1 (fr) * 1988-01-27 1991-10-25 Commissariat Energie Atomique Procede de microscopie optique confocale a balayage et en profondeur de champ etendue et dispositifs pour la mise en oeuvre du procede
US4997242A (en) * 1988-03-07 1991-03-05 Medical Research Council Achromatic scanning system
US4934811A (en) * 1988-04-01 1990-06-19 Syntex (U.S.A.) Inc. Apparatus and method for detection of fluorescence or light scatter
US5032720A (en) * 1988-04-21 1991-07-16 White John G Confocal imaging system
JPH026730A (ja) * 1988-06-25 1990-01-10 Shimadzu Corp 光走査装置
EP1245987B1 (de) * 1988-07-13 2008-01-23 Optiscan Pty Ltd Konfokales Rastermikroskop
CA1325537C (en) * 1988-08-01 1993-12-28 Timothy Peter Dabbs Confocal microscope
US4972258A (en) * 1989-07-31 1990-11-20 E. I. Du Pont De Nemours And Company Scanning laser microscope system and methods of use
US5421337A (en) * 1989-04-14 1995-06-06 Massachusetts Institute Of Technology Spectral diagnosis of diseased tissue
US5201318A (en) * 1989-04-24 1993-04-13 Rava Richard P Contour mapping of spectral diagnostics
JPH0378720A (ja) * 1989-08-22 1991-04-03 Nikon Corp 共焦点型レーザ走査顕微鏡
US5065008A (en) * 1989-10-18 1991-11-12 Fuji Photo Film Co., Ltd. Scanning microscope and scanning mechanism for the same
DE8912757U1 (de) * 1989-10-27 1989-12-07 Fa. Carl Zeiss, 7920 Heidenheim, De
US5034613A (en) * 1989-11-14 1991-07-23 Cornell Research Foundation, Inc. Two-photon laser microscopy
US5028802A (en) * 1990-01-11 1991-07-02 Eye Research Institute Of Retina Foundation Imaging apparatus and methods utilizing scannable microlaser source
US5274240A (en) * 1990-01-12 1993-12-28 The Regents Of The University Of California Capillary array confocal fluorescence scanner and method
US5091652A (en) * 1990-01-12 1992-02-25 The Regents Of The University Of California Laser excited confocal microscope fluorescence scanner and method
DE69118429T2 (de) * 1990-01-26 1996-09-12 Canon Kk Verfahren zur Messung einer Spezies unter Verwendung von Fluoreszenzlicht
US5074306A (en) * 1990-02-22 1991-12-24 The General Hospital Corporation Measurement of burn depth in skin
US5083220A (en) * 1990-03-22 1992-01-21 Tandem Scanning Corporation Scanning disks for use in tandem scanning reflected light microscopes and other optical systems
JP2613118B2 (ja) * 1990-04-10 1997-05-21 富士写真フイルム株式会社 共焦点走査型顕微鏡
DE69121633T2 (de) * 1990-05-22 1997-01-16 Japan Res Dev Corp Verfahren und Apparat zur Messung spektraler Absorption in undurchsichtigem Material und Verfahren und Apparat zur Messung einer Verteilung mikroskopischer Absorption
GB9014263D0 (en) * 1990-06-27 1990-08-15 Dixon Arthur E Apparatus and method for spatially- and spectrally- resolvedmeasurements
GB9016587D0 (en) * 1990-07-27 1990-09-12 Isis Innovation Infra-red scanning microscopy
US5324979A (en) * 1990-09-26 1994-06-28 Futrex, Inc. Method and means for generating synthetic spectra allowing quantitative measurement in near infrared measuring instruments
DE59107758D1 (de) * 1990-11-10 1996-06-05 Groskopf Rudolf Dr Ing Optische Abtastvorrichtung mit konfokalem Strahlengang, in der Lichtquellen- und Detektormatrix verwendet werden
US5239178A (en) * 1990-11-10 1993-08-24 Carl Zeiss Optical device with an illuminating grid and detector grid arranged confocally to an object
US5168157A (en) * 1990-11-20 1992-12-01 Fuji Photo Film Co., Ltd. Scanning microscope with means for detecting a first and second polarized light beams along first and second optical receiving paths
US5162641A (en) * 1991-02-19 1992-11-10 Phoenix Laser Systems, Inc. System and method for detecting, correcting and measuring depth movement of target tissue in a laser surgical system
US5303026A (en) * 1991-02-26 1994-04-12 The Regents Of The University Of California Los Alamos National Laboratory Apparatus and method for spectroscopic analysis of scattering media
US5260578A (en) * 1991-04-10 1993-11-09 Mayo Foundation For Medical Education And Research Confocal imaging system for visible and ultraviolet light
DE4111903A1 (de) * 1991-04-12 1992-10-15 Bayer Ag Spektroskopiekorrelierte licht-rastermikroskopie
US5257085A (en) * 1991-04-24 1993-10-26 Kaman Aerospace Corporation Spectrally dispersive imaging lidar system
JP2975719B2 (ja) * 1991-05-29 1999-11-10 オリンパス光学工業株式会社 共焦点光学系
US5319200A (en) * 1991-06-05 1994-06-07 Zeltex, Inc. Rapid near-infrared measurement of nonhomogeneous samples
US5313567A (en) * 1991-06-13 1994-05-17 At&T Bell Laboratories Arrangement for determining and displaying volumetric data in an imaging system
US5162941A (en) * 1991-07-23 1992-11-10 The Board Of Governors Of Wayne State University Confocal microscope
JPH0527177A (ja) * 1991-07-25 1993-02-05 Fuji Photo Film Co Ltd 走査型顕微鏡
JP3082346B2 (ja) * 1991-09-12 2000-08-28 株式会社ニコン 蛍光コンフォーカル顕微鏡
JP3018687B2 (ja) * 1991-12-12 2000-03-13 松下電器産業株式会社 走査型レーザー顕微鏡
US5284149A (en) * 1992-01-23 1994-02-08 Dhadwal Harbans S Method and apparatus for determining the physical characteristics of ocular tissue
US5248876A (en) * 1992-04-21 1993-09-28 International Business Machines Corporation Tandem linear scanning confocal imaging system with focal volumes at different heights
US5306902A (en) * 1992-09-01 1994-04-26 International Business Machines Corporation Confocal method and apparatus for focusing in projection lithography
CH684556A5 (de) * 1992-09-14 1994-10-14 Cerberus Ag Optischer Rauchmelder.
US5418797A (en) * 1993-01-15 1995-05-23 The United States Of America As Represented By The Secretary Of The Navy Time gated imaging through scattering material using polarization and stimulated raman amplification
US5294799A (en) * 1993-02-01 1994-03-15 Aslund Nils R D Apparatus for quantitative imaging of multiple fluorophores
US5421339A (en) * 1993-05-12 1995-06-06 Board Of Regents, The University Of Texas System Diagnosis of dysplasia using laser induced fluoroescence
US5598842A (en) * 1993-09-03 1997-02-04 Toa Medical Electronics Co., Ltd. Non-invasive blood analyzer and method using the same
US5587832A (en) * 1993-10-20 1996-12-24 Biophysica Technologies, Inc. Spatially light modulated confocal microscope and method
US5493444A (en) * 1994-04-28 1996-02-20 The United States Of America As Represented By The Secretary Of The Air Force Photorefractive two-beam coupling nonlinear joint transform correlator
US5477382A (en) * 1994-08-05 1995-12-19 Northrop Grumman Corporation Optical correlator system
JP3779352B2 (ja) * 1995-05-17 2006-05-24 聡 河田 赤外顕微分光分析方法及び装置
US5713364A (en) * 1995-08-01 1998-02-03 Medispectra, Inc. Spectral volume microprobe analysis of materials
WO1997005473A1 (en) * 1995-08-01 1997-02-13 Medispectra, Inc. Optical microprobes and methods for spectral analysis of materials

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CA2277095C (en) 2003-09-16
ES2192320T3 (es) 2003-10-01
US6104945A (en) 2000-08-15
EP1262763A3 (de) 2004-03-03
JP3992113B2 (ja) 2007-10-17
ATE236388T1 (de) 2003-04-15
EP0951643A1 (de) 1999-10-27
JP2001508340A (ja) 2001-06-26
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DE69812886D1 (de) 2003-05-08
EP0951643B1 (de) 2003-04-02

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