DE69825994D1 - Substituierte 2-(2,6-dioxopiperidin-3-yl)-phthalimide und 1-oxoisoindoline und verfahren zur reduzierung des tnf-alpha-gehaltes - Google Patents

Substituierte 2-(2,6-dioxopiperidin-3-yl)-phthalimide und 1-oxoisoindoline und verfahren zur reduzierung des tnf-alpha-gehaltes

Info

Publication number
DE69825994D1
DE69825994D1 DE69825994T DE69825994T DE69825994D1 DE 69825994 D1 DE69825994 D1 DE 69825994D1 DE 69825994 T DE69825994 T DE 69825994T DE 69825994 T DE69825994 T DE 69825994T DE 69825994 D1 DE69825994 D1 DE 69825994D1
Authority
DE
Germany
Prior art keywords
carbon atoms
hydrogen
alkyl
oxoisoindolines
dioxopiperidin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69825994T
Other languages
English (en)
Other versions
DE69825994T2 (de
Inventor
W Muller
I Stirling
Shen-Chu Chen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Celgene Corp
Original Assignee
STIRLING DAVID J
Celgene Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by STIRLING DAVID J, Celgene Corp filed Critical STIRLING DAVID J
Application granted granted Critical
Publication of DE69825994D1 publication Critical patent/DE69825994D1/de
Publication of DE69825994T2 publication Critical patent/DE69825994T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/45—Non condensed piperidines, e.g. piperocaine having oxo groups directly attached to the heterocyclic ring, e.g. cycloheximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
DE1998625994 1997-05-30 1998-05-28 Substituierte 2-(2,6-dioxopiperidin-3-yl)-phthalimide und 1-oxoisoindoline und verfahren zur reduzierung des tnf-alpha-gehaltes Expired - Lifetime DE69825994T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4827897P 1997-05-30 1997-05-30
US48278P 1997-05-30
PCT/US1998/010886 WO1998054170A1 (en) 1997-05-30 1998-05-28 SUBSTITUTED 2-(2,6-DIOXOPIPERIDIN-3-YL)-PHTHALIMIDES AND 1-OXOISOINDOLINES AND METHOD OF REDUCING TNFα LEVELS

Publications (2)

Publication Number Publication Date
DE69825994D1 true DE69825994D1 (de) 2004-10-07
DE69825994T2 DE69825994T2 (de) 2005-09-29

Family

ID=21953674

Family Applications (2)

Application Number Title Priority Date Filing Date
DE1998625994 Expired - Lifetime DE69825994T2 (de) 1997-05-30 1998-05-28 Substituierte 2-(2,6-dioxopiperidin-3-yl)-phthalimide und 1-oxoisoindoline und verfahren zur reduzierung des tnf-alpha-gehaltes
DE69839739T Expired - Lifetime DE69839739D1 (de) 1997-05-30 1998-05-28 Substituierte 2-(2,6-Dioxopiperidin-3-yl)-Phthalimide und Verfahren zur Verminderung des TNF-Alpha Spiegels

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69839739T Expired - Lifetime DE69839739D1 (de) 1997-05-30 1998-05-28 Substituierte 2-(2,6-Dioxopiperidin-3-yl)-Phthalimide und Verfahren zur Verminderung des TNF-Alpha Spiegels

Country Status (25)

Country Link
US (3) US6395754B1 (de)
EP (3) EP0984955B1 (de)
JP (2) JP4307567B2 (de)
KR (1) KR100526212B1 (de)
CN (3) CN1911927A (de)
AT (2) ATE401319T1 (de)
AU (1) AU741982B2 (de)
CA (2) CA2291218C (de)
CY (1) CY1108348T1 (de)
CZ (1) CZ299812B6 (de)
DE (2) DE69825994T2 (de)
DK (2) DK0984955T3 (de)
ES (3) ES2229497T3 (de)
FI (1) FI19992490A (de)
HK (1) HK1072248A1 (de)
HU (2) HU228769B1 (de)
MC (1) MC225A7 (de)
NO (6) NO322080B1 (de)
NZ (1) NZ501429A (de)
PL (1) PL193276B1 (de)
PT (2) PT984955E (de)
RU (1) RU2209207C2 (de)
SK (1) SK163099A3 (de)
TR (4) TR201005282T2 (de)
WO (1) WO1998054170A1 (de)

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