DE69836734D1 - Plasmon-schwingteilchen, methode und vorrichtung - Google Patents

Plasmon-schwingteilchen, methode und vorrichtung

Info

Publication number
DE69836734D1
DE69836734D1 DE69836734T DE69836734T DE69836734D1 DE 69836734 D1 DE69836734 D1 DE 69836734D1 DE 69836734 T DE69836734 T DE 69836734T DE 69836734 T DE69836734 T DE 69836734T DE 69836734 D1 DE69836734 D1 DE 69836734D1
Authority
DE
Germany
Prior art keywords
field
plasmon
pres
pattern
image
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69836734T
Other languages
English (en)
Inventor
Sheldon Schultz
A Schultz
R Smith
J Mock
J Silva
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
Original Assignee
University of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California filed Critical University of California
Application granted granted Critical
Publication of DE69836734D1 publication Critical patent/DE69836734D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00Nanotechnology for materials or surface science, e.g. nanocomposites
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06KGRAPHICAL DATA READING; PRESENTATION OF DATA; RECORD CARRIERS; HANDLING RECORD CARRIERS
    • G06K19/00Record carriers for use with machines and with at least a part designed to carry digital markings
    • G06K19/06Record carriers for use with machines and with at least a part designed to carry digital markings characterised by the kind of the digital marking, e.g. shape, nature, code
    • G06K19/06009Record carriers for use with machines and with at least a part designed to carry digital markings characterised by the kind of the digital marking, e.g. shape, nature, code with optically detectable marking
    • G06K19/06046Constructional details
    • G06K19/06084Constructional details the marking being based on nanoparticles or microbeads
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • C12Q1/6825Nucleic acid detection involving sensors
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/55Specular reflectivity
    • G01N21/552Attenuated total reflection
    • G01N21/553Attenuated total reflection and using surface plasmons
    • G01N21/554Attenuated total reflection and using surface plasmons detecting the surface plasmon resonance of nanostructured metals, e.g. localised surface plasmon resonance
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/645Specially adapted constructive features of fluorimeters
    • G01N21/648Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65Raman scattering
    • G01N21/658Raman scattering enhancement Raman, e.g. surface plasmons
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06KGRAPHICAL DATA READING; PRESENTATION OF DATA; RECORD CARRIERS; HANDLING RECORD CARRIERS
    • G06K7/00Methods or arrangements for sensing record carriers, e.g. for reading patterns
    • G06K7/10Methods or arrangements for sensing record carriers, e.g. for reading patterns by electromagnetic radiation, e.g. optical sensing; by corpuscular radiation
    • G06K7/14Methods or arrangements for sensing record carriers, e.g. for reading patterns by electromagnetic radiation, e.g. optical sensing; by corpuscular radiation using light without selection of wavelength, e.g. sensing reflected white light
    • G06K7/1404Methods for optical code recognition
    • G06K7/1408Methods for optical code recognition the method being specifically adapted for the type of code
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/0054Means for coding or tagging the apparatus or the reagents
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00603Making arrays on substantially continuous surfaces
    • B01J2219/00646Making arrays on substantially continuous surfaces the compounds being bound to beads immobilised on the solid supports
    • B01J2219/00648Making arrays on substantially continuous surfaces the compounds being bound to beads immobilised on the solid supports by the use of solid beads
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00603Making arrays on substantially continuous surfaces
    • B01J2219/00659Two-dimensional arrays
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068Means for controlling the apparatus of the process
    • B01J2219/00702Processes involving means for analysing and characterising the products
    • B01J2219/00707Processes involving means for analysing and characterising the products separated from the reactor apparatus
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B70/00Tags or labels specially adapted for combinatorial chemistry or libraries, e.g. fluorescent tags or bar codes
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/805Optical property
DE69836734T 1997-02-20 1998-02-20 Plasmon-schwingteilchen, methode und vorrichtung Expired - Lifetime DE69836734D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3867797P 1997-02-20 1997-02-20
PCT/US1998/002995 WO1998037417A1 (en) 1997-02-20 1998-02-20 Plasmon resonant particles, methods and apparatus

Publications (1)

Publication Number Publication Date
DE69836734D1 true DE69836734D1 (de) 2007-02-08

Family

ID=21901272

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69836734T Expired - Lifetime DE69836734D1 (de) 1997-02-20 1998-02-20 Plasmon-schwingteilchen, methode und vorrichtung

Country Status (8)

Country Link
US (6) US6180415B1 (de)
EP (1) EP0979409B1 (de)
JP (1) JP4209471B2 (de)
AT (1) ATE349697T1 (de)
AU (1) AU748939B2 (de)
CA (1) CA2280794A1 (de)
DE (1) DE69836734D1 (de)
WO (1) WO1998037417A1 (de)

Families Citing this family (332)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6490913B1 (en) * 1995-05-19 2002-12-10 The United States Of America As Represented By The Secretary Of Commerce Humidity chamber for scanning stylus atomic force microscope with cantilever tracking
JP2000510582A (ja) * 1996-04-25 2000-08-15 ゼニコン・サイエンシーズ・コーポレーション 微粒子標識を使用した分析物アッセイ
US6586193B2 (en) 1996-04-25 2003-07-01 Genicon Sciences Corporation Analyte assay using particulate labels
US6582921B2 (en) 1996-07-29 2003-06-24 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses thereof
US6413786B1 (en) 1997-01-23 2002-07-02 Union Biometrica Technology Holdings, Inc. Binding assays using optical resonance of colloidal particles
AU748939B2 (en) 1997-02-20 2002-06-13 Regents Of The University Of California, The Plasmon resonant particles, methods and apparatus
US7144627B2 (en) * 1997-03-12 2006-12-05 William Marsh Rice University Multi-layer nanoshells comprising a metallic or conducting shell
US6344272B1 (en) * 1997-03-12 2002-02-05 Wm. Marsh Rice University Metal nanoshells
US6852252B2 (en) 1997-03-12 2005-02-08 William Marsh Rice University Use of metalnanoshells to impede the photo-oxidation of conjugated polymer
US6699724B1 (en) 1998-03-11 2004-03-02 Wm. Marsh Rice University Metal nanoshells for biosensing applications
US6428811B1 (en) 1998-03-11 2002-08-06 Wm. Marsh Rice University Temperature-sensitive polymer/nanoshell composites for photothermally modulated drug delivery
JP3380744B2 (ja) * 1998-05-19 2003-02-24 株式会社日立製作所 センサおよびこれを利用した測定装置
US6723517B1 (en) * 1998-06-02 2004-04-20 Minerva Biotechnologies Corporation Use of self-assembled monolayers to probe the structure of a target molecule
ATE376671T1 (de) * 1998-08-11 2007-11-15 Union Biometrica Technology Ho Bindungsassay unter verwendung optischer resonanz kolloidaler teilchen
US7079241B2 (en) 2000-04-06 2006-07-18 Invitrogen Corp. Spatial positioning of spectrally labeled beads
IL126776A (en) 1998-10-27 2001-04-30 Technion Res & Dev Foundation A method of investing gold
JP2002532728A (ja) * 1998-12-17 2002-10-02 ライカ ミクロジュステムス ハイデルベルク ゲーエムベーハー 有利には生体試料における種々の構造体を識別検査するための方法
US6633660B1 (en) * 1999-02-05 2003-10-14 John Carl Schotland Near-field tomography
JP3468149B2 (ja) * 1999-02-19 2003-11-17 松下電器産業株式会社 微細物体の操作装置および操作方法
US6136541A (en) * 1999-02-22 2000-10-24 Vialogy Corporation Method and apparatus for analyzing hybridized biochip patterns using resonance interactions employing quantum expressor functions
US6142681A (en) * 1999-02-22 2000-11-07 Vialogy Corporation Method and apparatus for interpreting hybridized bioelectronic DNA microarray patterns using self-scaling convergent reverberant dynamics
GB2364704B (en) * 1999-04-15 2004-07-14 Virtual Arrays Inc Combinatorial chemical library supports having indicia at coding positions and methods of use
US20030096321A1 (en) * 1999-05-19 2003-05-22 Jose Remacle Method for the identification and/or the quantification of a target compound obtained from a biological sample upon chips
US7074586B1 (en) * 1999-06-17 2006-07-11 Source Precision Medicine, Inc. Quantitative assay for low abundance molecules
US6441945B1 (en) 1999-08-13 2002-08-27 California Of Technology Optoelectronic device and method utilizing nanometer-scale particles
DE19943704C1 (de) * 1999-09-08 2001-05-10 Inst Physikalische Hochtech Ev Affinitätssensor zum Nachweis biologischer und/oder chemischer Spezies und dessen Verwendung
US8497131B2 (en) * 1999-10-06 2013-07-30 Becton, Dickinson And Company Surface enhanced spectroscopy-active composite nanoparticles comprising Raman-active reporter molecules
US20020154803A1 (en) * 1999-11-01 2002-10-24 Inflamet Ltd. Biological sample carrier
IL132687A0 (en) * 1999-11-01 2001-03-19 Keren Mechkarim Ichilov Pnimit System and method for evaluating body fluid samples
US6528993B1 (en) * 1999-11-29 2003-03-04 Korea Advanced Institute Of Science & Technology Magneto-optical microscope magnetometer
US7198939B2 (en) * 2000-01-28 2007-04-03 Agilent Technologies, Inc. Apparatus for interrogating an addressable array
FR2804784B1 (fr) * 2000-02-04 2003-04-11 Novatec Procede universel d'identification et d'authentification d'objets, de vegetaux ou d'etres vivants
US6530944B2 (en) 2000-02-08 2003-03-11 Rice University Optically-active nanoparticles for use in therapeutic and diagnostic methods
US6970811B1 (en) * 2000-03-22 2005-11-29 Hewlett-Packard Development Company, L.P. Hardware modeling of LED relative brightness
US6760124B1 (en) 2000-03-22 2004-07-06 Hewlett-Packard Development Company, L.P. Software determination of led brightness and exposure
WO2001096604A2 (en) * 2000-06-12 2001-12-20 Genicon Sciences Corporation Assay for genetic polymorphisms using scattered light detectable labels
US20020102617A1 (en) * 2000-08-03 2002-08-01 Macbeath Gavin Protein microarrays
EP1330532B1 (de) * 2000-10-03 2011-12-14 Mirari Biosciences, Inc. Verfahren und zusammensetzungen für die gerichtete mikrowellenchemiie
US7348182B2 (en) * 2000-10-03 2008-03-25 Mirari Biosciences, Inc. Directed microwave chemistry
US20040209303A1 (en) 2000-10-03 2004-10-21 Martin Mark T. Methods and compositions for directed microwave chemistry
US6818907B2 (en) * 2000-10-17 2004-11-16 The President And Fellows Of Harvard College Surface plasmon enhanced illumination system
US7094595B2 (en) * 2000-10-30 2006-08-22 Sru Biosystems, Inc. Label-free high-throughput optical technique for detecting biomolecular interactions
US6953694B2 (en) * 2000-12-06 2005-10-11 The Trustees Of Columbia University In The City Of New York Attachment of second harmonic-active moiety to molecules for detection of molecules at interfaces
WO2002054071A1 (en) * 2001-01-08 2002-07-11 Salafsky Joshua S Method and apparatus using a surface-selective nonlinear optical technique
US6515749B2 (en) * 2001-01-10 2003-02-04 The United States Of America As Represented By The Secretary Of Commerce Sensitive and selective chemical sensor with nanostructured surfaces
US6861263B2 (en) * 2001-01-26 2005-03-01 Surromed, Inc. Surface-enhanced spectroscopy-active sandwich nanoparticles
US6696362B2 (en) * 2001-02-08 2004-02-24 Applied Materials Inc. Method for using an in situ particle sensor for monitoring particle performance in plasma deposition processes
JP2005507489A (ja) 2001-02-23 2005-03-17 ジェニコン サイエンスィズ コーポレーション 検体分析において拡張ダイナミックレンジを提供する方法
US7203342B2 (en) * 2001-03-07 2007-04-10 Schlumberger Technology Corporation Image feature extraction
AU2002251449B2 (en) * 2001-03-29 2008-01-31 Cellect Technologies Corp. Methods devices and systems for sorting and separating particles
US6838121B2 (en) * 2001-05-10 2005-01-04 Zyvex Corporation System and method for controlling deposition parameters in producing a surface to tune the surface's plasmon resonance wavelength
US7147687B2 (en) * 2001-05-25 2006-12-12 Nanosphere, Inc. Non-alloying core shell nanoparticles
WO2002096262A2 (en) * 2001-05-25 2002-12-05 Northwestern University Non-alloying core shell nanoparticles
US20030129545A1 (en) * 2001-06-29 2003-07-10 Kik Pieter G Method and apparatus for use of plasmon printing in near-field lithography
US7473767B2 (en) 2001-07-03 2009-01-06 The Institute For Systems Biology Methods for detection and quantification of analytes in complex mixtures
US6714299B2 (en) * 2001-07-13 2004-03-30 Genicon Sciences Corporation Use of light scattering particles in design, manufacture, and quality control of small volume instruments, devices, and processes
WO2003064991A2 (en) * 2001-07-17 2003-08-07 Salafsky Joshua S Method and apparatus using a nonlinear optical technique for detection of probe-target interactions in a field
US6991939B2 (en) * 2001-07-19 2006-01-31 Tufts University Optical array device and methods of use thereof for screening, analysis and manipulation of particles
DE60231309D1 (de) * 2001-08-03 2009-04-09 Nanosphere Inc Nanopartikelabbildungssystem und -verfahren
EP1286152B1 (de) * 2001-08-07 2005-10-26 Sysmex Corporation Vorrichtung und Verfahren zur Messung von Teilchengrössen
EP2302363A2 (de) * 2001-09-05 2011-03-30 Life Technologies Corporation Verfahren zur Normalisierung von Analysedaten
US20030049866A1 (en) * 2001-09-05 2003-03-13 Genicon Sciences Corporation Sample device preservation
WO2003025635A1 (en) * 2001-09-19 2003-03-27 Technion Research & Development Foundation Ltd. Space-variant subwavelength dielectric grating and applications thereof
US7238477B2 (en) * 2001-09-24 2007-07-03 Intel Corporation Methods to increase nucleotide signals by Raman scattering
US6972173B2 (en) 2002-03-14 2005-12-06 Intel Corporation Methods to increase nucleotide signals by raman scattering
US7135054B2 (en) * 2001-09-26 2006-11-14 Northwestern University Nanoprisms and method of making them
US20030148391A1 (en) * 2002-01-24 2003-08-07 Salafsky Joshua S. Method using a nonlinear optical technique for detection of interactions involving a conformational change
US20070059760A1 (en) * 2002-02-21 2007-03-15 Dorsel Andreas N Multi-featured arrays with reflective coating
US6795777B1 (en) * 2002-03-04 2004-09-21 The Texas A&M University System Identifying molecules of a sample
US20040110208A1 (en) * 2002-03-26 2004-06-10 Selena Chan Methods and device for DNA sequencing using surface enhanced Raman scattering (SERS)
US7476501B2 (en) * 2002-03-26 2009-01-13 Intel Corporation Methods and device for DNA sequencing using surface enhanced raman scattering (SERS)
EP1594607A1 (de) * 2002-05-06 2005-11-16 Universität Tübingen Verfahren zur erzeugung von mustern von physikalischen, chemischen oder biochemischen strukturen auf trägern
EP1508027A4 (de) * 2002-05-28 2009-04-22 Autogenomics Inc Mikroarray-detektor und -verfahren
JP4409426B2 (ja) * 2002-05-28 2010-02-03 オウトジエノミクス・インコーポレーテツド マイクロアレイ検出器および方法
AU2002337504A1 (en) * 2002-06-08 2003-12-22 Kwon Soo Ha Method for protein chip analysis by using surface plasmon resonance spectroscopic imaging technology
US7361313B2 (en) * 2003-02-18 2008-04-22 Intel Corporation Methods for uniform metal impregnation into a nanoporous material
US6970239B2 (en) * 2002-06-12 2005-11-29 Intel Corporation Metal coated nanocrystalline silicon as an active surface enhanced Raman spectroscopy (SERS) substrate
US6989897B2 (en) * 2002-06-12 2006-01-24 Intel Corporation Metal coated nanocrystalline silicon as an active surface enhanced Raman spectroscopy (SERS) substrate
US6788477B2 (en) 2002-10-22 2004-09-07 Taiwan Semiconductor Manufacturing Co., Ltd. Apparatus for method for immersion lithography
WO2004042403A2 (en) * 2002-11-04 2004-05-21 Ludwig-Maximilian-Uni Versität München Methods, device and instrument for detection of analytes
US7122384B2 (en) * 2002-11-06 2006-10-17 E. I. Du Pont De Nemours And Company Resonant light scattering microparticle methods
US20040101822A1 (en) * 2002-11-26 2004-05-27 Ulrich Wiesner Fluorescent silica-based nanoparticles
EP1445601A3 (de) * 2003-01-30 2004-09-22 Fuji Photo Film Co., Ltd. Messchips für lokale Oberflächenplasmonenresonanzmesssensoren, Herstellungsverfahren für diese Messchips und Sensoren welche diese Chips verwenden
US7192703B2 (en) * 2003-02-14 2007-03-20 Intel Corporation, Inc. Biomolecule analysis by rolling circle amplification and SERS detection
WO2004074508A2 (en) * 2003-02-15 2004-09-02 Golovlev Valeri V Method of visualization and quantification of biopolymer molecules immobilized on solid support
US20080050842A1 (en) * 2003-02-15 2008-02-28 Golovlev Valeri V Method of visualization and quanitification of biopolymer molecules immobilized on solid support
AU2003900924A0 (en) * 2003-02-28 2003-03-13 Medsaic Pty Ltd Imaging device
JP2007524755A (ja) * 2003-04-02 2007-08-30 ノースウエスタン ユニバーシティ ナノ粒子の成長制御方法
US20040197841A1 (en) * 2003-04-02 2004-10-07 Apffel James Alexander Methods and reagents for multiplexed analyses
US7976169B2 (en) * 2003-05-14 2011-07-12 Sun Innovations, Inc. Waveguide display
US20040227694A1 (en) * 2003-05-14 2004-11-18 Xiao-Dong Sun System and method for a three-dimensional color image display utilizing laser induced fluorescence of nanopartcles and organometallic molecules in a transparent medium
US7002681B1 (en) * 2003-06-25 2006-02-21 The United States Of America As Represented By The Secretary Of The Navy Spectroscopy system for the detection of chemicals
WO2005029031A2 (en) * 2003-08-01 2005-03-31 Biacore Ab Method and apparatus for quantitating surface-binding optical resonance profiles
IL157206A0 (en) * 2003-08-03 2004-02-19 Correlating spatial position of chemical species on a substrate with molecular weight, structure and chemical reactivity
US7361410B2 (en) * 2003-12-29 2008-04-22 Intel Corporation External modification of composite organic inorganic nanoclusters comprising raman active organic compound
US20050147963A1 (en) * 2003-12-29 2005-07-07 Intel Corporation Composite organic-inorganic nanoparticles and methods for use thereof
US20050191665A1 (en) * 2003-12-29 2005-09-01 Xing Su Composite organic-inorganic nanoclusters
US20080076119A9 (en) * 2003-12-29 2008-03-27 Lei Sun Composite organic inorganic nanoclusters
US20050148100A1 (en) * 2003-12-30 2005-07-07 Intel Corporation Methods and devices for using Raman-active probe constructs to assay biological samples
US20050141843A1 (en) * 2003-12-31 2005-06-30 Invitrogen Corporation Waveguide comprising scattered light detectable particles
CA2834041C (en) 2003-12-31 2017-05-16 President And Fellows Of Harvard College Assay device and method
JP4261375B2 (ja) * 2004-01-15 2009-04-30 富士フイルム株式会社 押し形の採取方法
US7243548B2 (en) * 2004-04-07 2007-07-17 Ut-Battelle, Llc Surface wave chemical detector using optical radiation
ES2752457T3 (es) * 2004-04-23 2020-04-06 Becton Dickinson Co Nanopartículas compuestas activas espectroscópicamente potenciadas superficialmente
JP2005309295A (ja) * 2004-04-26 2005-11-04 Nec Corp 光増幅素子、光増幅装置および光増幅システム
JP4806411B2 (ja) * 2004-05-19 2011-11-02 ブィピー ホールディング、エルエルシー 可視光レーザ励起ビーム及びラマン分光検出器と共に使用する光センサ、及び分析物の化学基を検出する方法
US9008471B2 (en) * 2004-06-18 2015-04-14 The Trustees Of The University Of Pennsylvania Optical circuits and circuit elements
US7511285B2 (en) * 2004-07-16 2009-03-31 The Charles Stark Draper Laboratory, Inc. Methods and apparatus for biomolecule identification
US20070048797A1 (en) * 2004-08-11 2007-03-01 Xing Su Composite organic inorganic nanoclusters as carriers and identifiers of tester molecules
US7626179B2 (en) * 2005-09-30 2009-12-01 Virgin Island Microsystems, Inc. Electron beam induced resonance
US7791290B2 (en) * 2005-09-30 2010-09-07 Virgin Islands Microsystems, Inc. Ultra-small resonating charged particle beam modulator
US20070034518A1 (en) * 2005-08-15 2007-02-15 Virgin Islands Microsystems, Inc. Method of patterning ultra-small structures
US7586097B2 (en) * 2006-01-05 2009-09-08 Virgin Islands Microsystems, Inc. Switching micro-resonant structures using at least one director
US8057655B1 (en) * 2004-08-20 2011-11-15 The Board Of Trustees Of The Leland Stanford Junior University Sub-micron object control arrangement and approach therefor
US9494581B2 (en) 2004-08-24 2016-11-15 University Of Wyoming System and method for Raman spectroscopy assay using paramagnetic particles
US7776547B2 (en) * 2004-08-26 2010-08-17 Intel Corporation Cellular analysis using Raman surface scanning
EP1792263A2 (de) 2004-09-02 2007-06-06 Vialogy Corporation Erkennung von interessensereignissen unter verwendung von quantenresonanzinterferometrie
US7612769B2 (en) * 2004-09-14 2009-11-03 E.I. Du Pont De Nemours And Company Computer-implemented methods for organizing image data produced by resonant Mie scattering of light from microparticles and resulting data structures
US7321422B2 (en) * 2004-09-16 2008-01-22 Hewlett-Packard Development Company, L.P. SERS-active structures having nanoscale dimensions
ITMI20041801A1 (it) * 2004-09-21 2004-12-21 Solvay Solexis Spa Uso di lattici submicrometrici di perfluoropolimeri nella determinazione di interazione molecolari mediante laser light scattering (lls)
US7285427B2 (en) * 2004-10-06 2007-10-23 General Electric Company Raman-active particles and methods of making and using them
JP2006118920A (ja) * 2004-10-20 2006-05-11 Institute Of Physical & Chemical Research 相互作用観察方法
US7658991B2 (en) * 2004-10-21 2010-02-09 University Of Georgia Research Foundation, Inc. Structures having aligned nanorods and methods of making
US7583379B2 (en) 2005-07-28 2009-09-01 University Of Georgia Research Foundation Surface enhanced raman spectroscopy (SERS) systems and methods of use thereof
US7738096B2 (en) * 2004-10-21 2010-06-15 University Of Georgia Research Foundation, Inc. Surface enhanced Raman spectroscopy (SERS) systems, substrates, fabrication thereof, and methods of use thereof
US7656525B2 (en) * 2004-10-21 2010-02-02 University Of Georgia Research Foundation, Inc. Fiber optic SERS sensor systems and SERS probes
US7880876B2 (en) * 2004-10-21 2011-02-01 University Of Georgia Research Foundation, Inc. Methods of use for surface enhanced raman spectroscopy (SERS) systems for the detection of bacteria
WO2006060734A2 (en) * 2004-12-03 2006-06-08 Trustees Of Boston University Nanostructured substrate for for surface enhanced raman scattering
US20060147941A1 (en) * 2004-12-30 2006-07-06 Intel Corporation Methods and apparatus for SERS assay of biological analytes
US20060170444A1 (en) * 2005-02-02 2006-08-03 Wu Zong M Novel fluorescent and photoemission apparatus and method for submicron IC failure analysis
US7889334B2 (en) * 2005-03-15 2011-02-15 University Of Georgia Research Foundation, Inc. Surface enhanced Raman spectroscopy (SERS) systems for the detection of bacteria and methods of use thereof
US7940387B2 (en) * 2005-03-15 2011-05-10 Univeristy Of Georgia Research Foundation, Inc. Surface enhanced Raman spectroscopy (SERS) systems for the detection of viruses and methods of use thereof
JP2006279228A (ja) * 2005-03-28 2006-10-12 Fuji Xerox Co Ltd 撮像装置
US20060222869A1 (en) * 2005-04-04 2006-10-05 Yuguang Cai Electropen lithography
US7956991B2 (en) 2005-04-04 2011-06-07 Chemimage Corporation Method and apparatus for interactive hyperspectral image subtraction
US20060221335A1 (en) * 2005-04-04 2006-10-05 Bangalore Arjun S Method and apparatus for interactive hyperspectral image subtraction
US20060250613A1 (en) * 2005-04-14 2006-11-09 Chem Image Corporation Method and applications to enhance and image optical signals from biological objects
EP1715326A1 (de) * 2005-04-22 2006-10-25 Universität Heidelberg Sensorchip mit einer Schicht aus miteinander verbundenen nicht-metallischen Partikeln mit einer metallischen Beschichtung
US8084001B2 (en) * 2005-05-02 2011-12-27 Cornell Research Foundation, Inc. Photoluminescent silica-based sensors and methods of use
US20070111327A1 (en) * 2005-05-05 2007-05-17 Jay Gregory D Methods of detecting lubricin
US8254227B2 (en) * 2005-05-10 2012-08-28 The Trustees Of The University Of Pennsylvania Frequency-modulated coding and data recording and storage using plasmonic nanostructures
WO2007053201A2 (en) * 2005-06-15 2007-05-10 University Of Maryland Biotechnology Institute Bioassays using plasmonic scattering from noble metal nanostructures
US7471388B1 (en) * 2005-06-22 2008-12-30 University Of Central Florida Research Foundation, Inc. Frequency tunable resonant apparatus
US8987004B2 (en) * 2005-08-02 2015-03-24 University Of Maryland, Baltimore County Nanostructures for polarized imaging and receptor/ligan quantization: breaking the diffraction limit for imaging
DE102005037531A1 (de) * 2005-08-09 2007-02-15 Leica Microsystems Cms Gmbh Verfahren und Vorrichtung zur Reduzierung systematischer Messfehler bei der mikroskopischen Untersuchung von Objekten
US20070042510A1 (en) * 2005-08-19 2007-02-22 Wafermasters, Incorporated In situ process monitoring and control
US20070092870A1 (en) * 2005-10-20 2007-04-26 Yiping Zhao Detection of biomolecules
FR2893131A1 (fr) * 2005-11-09 2007-05-11 Centre Nat Rech Scient Procede de detection de nanoparticules et ses applications
US7579609B2 (en) * 2005-12-14 2009-08-25 Virgin Islands Microsystems, Inc. Coupling light of light emitting resonator to waveguide
US7649180B2 (en) * 2005-12-21 2010-01-19 Searete Llc Multi-stage waveform detector
US7391032B1 (en) * 2005-12-21 2008-06-24 Searete Llc Multi-stage waveform detector
US8207907B2 (en) * 2006-02-16 2012-06-26 The Invention Science Fund I Llc Variable metamaterial apparatus
US7649182B2 (en) * 2006-10-26 2010-01-19 Searete Llc Variable multi-stage waveform detector
US7601967B2 (en) * 2005-12-21 2009-10-13 Searete Llc Multi-stage waveform detector
US7427762B2 (en) * 2005-12-21 2008-09-23 Searete Llc Variable multi-stage waveform detector
AU2006330830B2 (en) 2005-12-23 2013-01-10 Institute For Systems Biology Nanoreporters and methods of manufacturing and use thereof
US20070155022A1 (en) * 2005-12-30 2007-07-05 Mineo Yamakawa Degenerate binding detection and protein identification using Raman spectroscopy nanoparticle labels
US7470920B2 (en) * 2006-01-05 2008-12-30 Virgin Islands Microsystems, Inc. Resonant structure-based display
US7619373B2 (en) * 2006-01-05 2009-11-17 Virgin Islands Microsystems, Inc. Selectable frequency light emitter
US20070152781A1 (en) * 2006-01-05 2007-07-05 Virgin Islands Microsystems, Inc. Switching micro-resonant structures by modulating a beam of charged particles
US20070190794A1 (en) * 2006-02-10 2007-08-16 Virgin Islands Microsystems, Inc. Conductive polymers for the electroplating
US20070200063A1 (en) * 2006-02-28 2007-08-30 Virgin Islands Microsystems, Inc. Wafer-level testing of light-emitting resonant structures
US7443358B2 (en) * 2006-02-28 2008-10-28 Virgin Island Microsystems, Inc. Integrated filter in antenna-based detector
US7605835B2 (en) * 2006-02-28 2009-10-20 Virgin Islands Microsystems, Inc. Electro-photographic devices incorporating ultra-small resonant structures
US20070200646A1 (en) * 2006-02-28 2007-08-30 Virgin Island Microsystems, Inc. Method for coupling out of a magnetic device
US7697135B1 (en) * 2006-03-03 2010-04-13 Nanometrics Incorporated Scanning focal length metrology
US8259297B1 (en) * 2006-03-03 2012-09-04 Nanometrics Incorporated Scanning focal length metrology
EP1993758A2 (de) * 2006-03-08 2008-11-26 Northwestern University Lichtinduzierte phasenentmischung von gold in zweikomponenten-nanoteilchen, um nanoprismen zu bilden
US9068917B1 (en) * 2006-03-14 2015-06-30 Kla-Tencor Technologies Corp. Systems and methods for inspection of a specimen
ITMI20060480A1 (it) * 2006-03-16 2007-09-17 Solvay Solexis Spa Usom di perfluoropolimeri nella dtermibnazione della costante di legame recettore-ligando
US7923240B2 (en) * 2006-03-31 2011-04-12 Intel Corporation Photo-activated field effect transistor for bioanalyte detection
US7558490B2 (en) * 2006-04-10 2009-07-07 Virgin Islands Microsystems, Inc. Resonant detector for optical signals
US20070247729A1 (en) * 2006-04-25 2007-10-25 Rudolph Technologies, Inc. Reflective objective
US7876793B2 (en) 2006-04-26 2011-01-25 Virgin Islands Microsystems, Inc. Micro free electron laser (FEL)
US7492868B2 (en) * 2006-04-26 2009-02-17 Virgin Islands Microsystems, Inc. Source of x-rays
US7646991B2 (en) * 2006-04-26 2010-01-12 Virgin Island Microsystems, Inc. Selectable frequency EMR emitter
US20070264023A1 (en) * 2006-04-26 2007-11-15 Virgin Islands Microsystems, Inc. Free space interchip communications
US20070252089A1 (en) * 2006-04-26 2007-11-01 Virgin Islands Microsystems, Inc. Charged particle acceleration apparatus and method
JP4890926B2 (ja) * 2006-04-28 2012-03-07 キヤノン株式会社 検出方法、およびキット
US7554083B2 (en) * 2006-05-05 2009-06-30 Virgin Islands Microsystems, Inc. Integration of electromagnetic detector on integrated chip
US20070257273A1 (en) * 2006-05-05 2007-11-08 Virgin Island Microsystems, Inc. Novel optical cover for optical chip
US7746532B2 (en) * 2006-05-05 2010-06-29 Virgin Island Microsystems, Inc. Electro-optical switching system and method
US7718977B2 (en) 2006-05-05 2010-05-18 Virgin Island Microsystems, Inc. Stray charged particle removal device
US7583370B2 (en) * 2006-05-05 2009-09-01 Virgin Islands Microsystems, Inc. Resonant structures and methods for encoding signals into surface plasmons
US7569836B2 (en) * 2006-05-05 2009-08-04 Virgin Islands Microsystems, Inc. Transmission of data between microchips using a particle beam
US7723698B2 (en) * 2006-05-05 2010-05-25 Virgin Islands Microsystems, Inc. Top metal layer shield for ultra-small resonant structures
US7732786B2 (en) * 2006-05-05 2010-06-08 Virgin Islands Microsystems, Inc. Coupling energy in a plasmon wave to an electron beam
US7728702B2 (en) * 2006-05-05 2010-06-01 Virgin Islands Microsystems, Inc. Shielding of integrated circuit package with high-permeability magnetic material
US7557647B2 (en) * 2006-05-05 2009-07-07 Virgin Islands Microsystems, Inc. Heterodyne receiver using resonant structures
US7728397B2 (en) * 2006-05-05 2010-06-01 Virgin Islands Microsystems, Inc. Coupled nano-resonating energy emitting structures
US20070272931A1 (en) * 2006-05-05 2007-11-29 Virgin Islands Microsystems, Inc. Methods, devices and systems producing illumination and effects
US7710040B2 (en) * 2006-05-05 2010-05-04 Virgin Islands Microsystems, Inc. Single layer construction for ultra small devices
US7741934B2 (en) * 2006-05-05 2010-06-22 Virgin Islands Microsystems, Inc. Coupling a signal through a window
US7586167B2 (en) * 2006-05-05 2009-09-08 Virgin Islands Microsystems, Inc. Detecting plasmons using a metallurgical junction
US7986113B2 (en) * 2006-05-05 2011-07-26 Virgin Islands Microsystems, Inc. Selectable frequency light emitter
US20070258720A1 (en) * 2006-05-05 2007-11-08 Virgin Islands Microsystems, Inc. Inter-chip optical communication
US8188431B2 (en) * 2006-05-05 2012-05-29 Jonathan Gorrell Integration of vacuum microelectronic device with integrated circuit
US20070258675A1 (en) * 2006-05-05 2007-11-08 Virgin Islands Microsystems, Inc. Multiplexed optical communication between chips on a multi-chip module
US7656094B2 (en) 2006-05-05 2010-02-02 Virgin Islands Microsystems, Inc. Electron accelerator for ultra-small resonant structures
WO2007129325A2 (en) * 2006-05-09 2007-11-15 Xceed Imaging Ltd. Optical sub wavelength super resolution imaging system and method
US7573045B2 (en) * 2006-05-15 2009-08-11 Virgin Islands Microsystems, Inc. Plasmon wave propagation devices and methods
US8980179B2 (en) * 2006-05-17 2015-03-17 University Of Maryland, Baltimore County Angular-dependent metal-enhanced fluorescence
US20070274365A1 (en) * 2006-05-26 2007-11-29 Virgin Islands Microsystems, Inc. Periodically complex resonant structures
US7679067B2 (en) * 2006-05-26 2010-03-16 Virgin Island Microsystems, Inc. Receiver array using shared electron beam
JP4923763B2 (ja) 2006-06-09 2012-04-25 富士ゼロックス株式会社 銀三角錐粒子の製造方法、及び銀三角錐粒子
US7655934B2 (en) 2006-06-28 2010-02-02 Virgin Island Microsystems, Inc. Data on light bulb
JP5151097B2 (ja) * 2006-09-01 2013-02-27 株式会社リコー 複合金属ナノ粒子、複合金属ナノ粒子を含む多光子吸収反応材料と反応生成物、複合金属ナノ粒子を含む多光子吸収反応助剤
JP2008058209A (ja) * 2006-09-01 2008-03-13 Ricoh Co Ltd 複合金属ナノ粒子、複合金属ナノ粒子を含む多光子吸収反応材料と反応生成物、複合金属ナノ粒子を含む多光子吸収反応助剤
US8124598B2 (en) 2006-09-14 2012-02-28 Sharon Sageman 7-keto DHEA for psychiatric use
US7560716B2 (en) * 2006-09-22 2009-07-14 Virgin Islands Microsystems, Inc. Free electron oscillator
WO2008108824A2 (en) * 2006-10-10 2008-09-12 The Trustees Of The University Of Pennsylvania Lumped plasmonic diode and lumped plasmonic rectifier
EP2097751A4 (de) * 2006-10-30 2013-05-08 Stc Unm Magnetisch empfängliche partikel und mischgeräte dafür
US7714997B2 (en) * 2006-11-07 2010-05-11 Hitachi High-Technologies Corporation Apparatus for inspecting defects
US8078420B2 (en) * 2006-11-15 2011-12-13 Miller Gary L Raman spectrometry authentication
US7659513B2 (en) * 2006-12-20 2010-02-09 Virgin Islands Microsystems, Inc. Low terahertz source and detector
FR2910632B1 (fr) * 2006-12-22 2010-08-27 Commissariat Energie Atomique Dispositif de codage optique par effet plasmon et methode d'authentification le mettant en oeuvre
US7738094B2 (en) 2007-01-26 2010-06-15 Becton, Dickinson And Company Method, system, and compositions for cell counting and analysis
US20080199880A1 (en) * 2007-02-21 2008-08-21 Porter Marc D Spin array method
ES2500219T3 (es) 2007-03-20 2014-09-30 Becton Dickinson And Company Ensayos que utilizan partículas activas en espectroscopia Raman potenciada en superficie (SERS)
GB2447698A (en) * 2007-03-23 2008-09-24 Univ Exeter Fabrication of photonic biosensor arrays
GB2447696A (en) * 2007-03-23 2008-09-24 Univ Exeter Photonic biosensor arrays
US20080241853A1 (en) * 2007-03-29 2008-10-02 Concurrent Analytical, Inc. Microtiter spin array
JP2010525333A (ja) * 2007-04-18 2010-07-22 ベクトン・ディキンソン・アンド・カンパニー Sersナノタグを用いる分析法
US7460238B2 (en) * 2007-04-24 2008-12-02 Corporation De L'ecole Polytechnique De Montreal Plasmon excitation by the gaussian-like core mode of a photonic crystal waveguide
JP5116362B2 (ja) * 2007-05-28 2013-01-09 株式会社リコー バイオセンサ
US7990336B2 (en) * 2007-06-19 2011-08-02 Virgin Islands Microsystems, Inc. Microwave coupled excitation of solid state resonant arrays
US7692791B2 (en) 2007-06-21 2010-04-06 Canon Kabushiki Kaisha Target substance-detecting apparatus and target substance-detecting method
JP5157284B2 (ja) 2007-06-28 2013-03-06 株式会社リコー 光増感型複合材料及び三次元メモリ材料と記録媒体、光制限材料と素子、光硬化材料と光造形システム、多光子蛍光顕微鏡用蛍光材料と装置
ES2561203T3 (es) * 2007-08-22 2016-02-25 Phadia Ab Método y aparato de lectura
WO2009029262A1 (en) * 2007-08-27 2009-03-05 The Regents Of The University Of California Systems and methods for producing multi-component colloidal structures
US20100160274A1 (en) * 2007-09-07 2010-06-24 Sharon Sageman 7-KETO DHEA for Psychiatric Use
US7791053B2 (en) 2007-10-10 2010-09-07 Virgin Islands Microsystems, Inc. Depressed anode with plasmon-enabled devices such as ultra-small resonant structures
JP2009098010A (ja) * 2007-10-17 2009-05-07 Fujifilm Corp 近接場光学顕微鏡用カンチレバー、それを用いたプラズモン増強蛍光顕微鏡及び蛍光検出方法
WO2009055702A1 (en) * 2007-10-24 2009-04-30 Purdue Research Foundation Time of death biosensor
US9302116B2 (en) 2007-11-06 2016-04-05 Duke University Non-invasive energy upconversion methods and systems for in-situ photobiomodulation
US8507785B2 (en) 2007-11-06 2013-08-13 Pacific Integrated Energy, Inc. Photo induced enhanced field electron emission collector
US8004673B2 (en) * 2007-11-21 2011-08-23 Hitachi High-Technologies Corporation Photometric instrument
US9086400B2 (en) * 2007-11-29 2015-07-21 Cornell Research Foundation, Inc. Amplifier and array for measuring small current
KR20090070886A (ko) * 2007-12-27 2009-07-01 삼성전자주식회사 압전 센서를 이용한 바이오 센서에서 신호의 주파수변화량을 증폭하는 방법
JP5094484B2 (ja) * 2008-03-11 2012-12-12 富士フイルム株式会社 蛍光検出方法および蛍光検出装置
CL2009000560A1 (es) 2008-03-11 2010-02-19 Univ Duke Un metodo para endurecer un medio endurecible por radiacion que comprende colocar una composicion dentro de un objeto para ser endurecido, la aplicacion de al menos uno elegido entre rayos x, rayos gama o haz de electrones a traves del objeto y dentro de la composicion.
JP2009229103A (ja) * 2008-03-19 2009-10-08 Toshiba Corp 金属コロイドの定量方法
JP5097590B2 (ja) * 2008-03-26 2012-12-12 富士フイルム株式会社 ラマン信号測定方法およびラマン信号測定装置
JP5450993B2 (ja) * 2008-07-14 2014-03-26 富士フイルム株式会社 検出方法、検出用試料セルおよび検出用キット
US9182406B2 (en) 2008-08-04 2015-11-10 Biodesy, Inc. Nonlinear optical detection of molecules comprising an unnatural amino acid possessing a hyperpolarizability
ES2614810T3 (es) 2008-08-14 2017-06-02 Nanostring Technologies, Inc Nanoindicadores estables
WO2010029471A1 (en) * 2008-09-09 2010-03-18 Koninklijke Philips Electronics N.V. Method for determining the presence of a sample on a sample receiving surface
CA2738688A1 (en) * 2008-09-30 2010-04-08 Universite De Montreal High resolution surface plasmon resonance instrument using a dove prism
JP5707021B2 (ja) * 2008-09-30 2015-04-22 株式会社日立ハイテクノロジーズ 磁場計測装置
GB2464747B (en) * 2008-10-10 2013-05-15 Hai Kang Life Corp Ltd Method for detection of analyte in microarray of samples and apparatus for performing such method
GB2464300A (en) * 2008-10-10 2010-04-14 Univ Dublin City Microfluidic multiplexed cellular and molecular analysis device and method
DK200801722A (en) * 2008-12-05 2010-06-06 Unisensor As Optical sectioning of a sample and detection of particles in a sample
US20100163759A1 (en) * 2008-12-31 2010-07-01 Stmicroelectronics S.R.L. Radiation sensor with photodiodes being integrated on a semiconductor substrate and corresponding integration process
US20100197508A1 (en) * 2009-02-03 2010-08-05 The Administrator of the National Aeronautics and Space Administration, United States of America Integrated Universal Chemical Detector with Selective Diffraction Array
EP2414795A4 (de) 2009-03-02 2018-01-24 Genia Photonics Inc. Verfahren zur untersuchung einer interaktion einer probe mit lichtstrahlen verschiedener wellenlängen und vorrichtung zur ausführung des verfahrens
US8039272B2 (en) 2009-04-01 2011-10-18 Nova Biomedical Rapid quantification assay involving concentrated and ligand-coated gold colloid
US20100252514A1 (en) * 2009-04-03 2010-10-07 Min-Ju Chung Foldable baseball equipment rack
US8697435B2 (en) * 2009-08-31 2014-04-15 Mbio Diagnostics, Inc. Integrated sample preparation and analyte detection
AU2010306862B2 (en) 2009-10-13 2015-08-27 Nanostring Technologies, Inc. Protein detection via nanoreporters
WO2011073867A1 (en) * 2009-12-18 2011-06-23 Koninklijke Philips Electronics N.V. Substance determining apparatus
AU2011215753B2 (en) 2010-02-11 2015-09-03 Nanostring Technologies, Inc. Compositions and methods for the detection of small RNAs
EP2372348A1 (de) * 2010-03-22 2011-10-05 Imec Verfahren und Systeme zur oberflächenverstärkten optischen Detektion
JP5609241B2 (ja) * 2010-04-28 2014-10-22 セイコーエプソン株式会社 分光方法及び分析装置
EP2580788A2 (de) 2010-06-08 2013-04-17 Pacific Integrated Energy, Inc. Optische antennen mit erweiterten feldern und erweiterter elektronenemission
US8950684B1 (en) * 2010-10-25 2015-02-10 The Boeing Company Fluorescent barcode for identification
US9036144B2 (en) * 2010-11-05 2015-05-19 Ondavia, Inc. Nano-/micro-droplets for the detection of analytes
CA2819181C (en) * 2010-11-29 2020-03-10 Dako Denmark A/S Methods and systems for analyzing images of specimens processed by a programmable quantitative assay
CN102162792B (zh) * 2011-01-10 2012-10-24 南京航空航天大学 基于表面等离激元共振的hprt体基因突变检测方法
CN103492859B (zh) * 2011-02-28 2017-05-24 皇家飞利浦有限公司 物质确定装置
US9428789B2 (en) 2011-03-21 2016-08-30 Biodesy, Inc. Classification of kinase inhibitors using nonlinear optical techniques
US9072473B2 (en) 2011-03-24 2015-07-07 The Arizona Board Of Regents On Behalf Of The University Of Arizona In-vivo optical sensor
US9758834B2 (en) 2011-03-28 2017-09-12 Nanostring Technologies, Inc. Compositions and methods for diagnosing cancer
US8810789B2 (en) 2011-11-07 2014-08-19 University Of Georgia Research Foundation, Inc. Thin layer chromatography-surfaced enhanced Raman spectroscopy chips and methods of use
TR201818881T4 (tr) 2011-11-21 2019-01-21 Abay Sa Sinyal Amplifikasyonu İmmünodeneyleri
US20130135617A1 (en) * 2011-11-30 2013-05-30 General Electric Company Plasmonic optical transducer
US20130196449A1 (en) * 2012-01-17 2013-08-01 Hewlett-Packard Development Company, L.P. Electrically driven devices for surface enhanced raman spectroscopy
US9395358B2 (en) 2012-02-05 2016-07-19 Biodesy, Inc. Methods for detecting allosteric modulators of protein
US9938560B2 (en) 2012-02-05 2018-04-10 Biodesy, Inc. Methods for identifying modulators of Ras using nonlinear techniques
US20130288271A1 (en) 2012-04-25 2013-10-31 Biodesy, Llc Methods for detecting allosteric modulators of protein
TWI554651B (zh) 2012-06-22 2016-10-21 蘋果公司 白色外觀陽極氧化膜及其形成方法
WO2014011409A1 (en) * 2012-07-09 2014-01-16 Thermo Electron Scientific Instruments Llc Motorized variable path length cell for spectroscopy
US9493876B2 (en) * 2012-09-14 2016-11-15 Apple Inc. Changing colors of materials
WO2014164929A1 (en) * 2013-03-11 2014-10-09 Kla-Tencor Corporation Defect detection using surface enhanced electric field
WO2014143155A1 (en) 2013-03-12 2014-09-18 Ventana Medical Systems, Inc. Digitally enhanced microscopy for multiplexed histology
JP6717741B2 (ja) * 2013-05-28 2020-07-08 シェモメテック・アクティーゼルスカブChemometec A/S 画像形成サイトメータ
US20150049332A1 (en) * 2013-07-30 2015-02-19 The Curators Of The University Of Missouri Gold nanoisland arrays
CN105723195B (zh) 2013-08-07 2019-09-03 撒拉弗生物科学有限责任公司 基于显微拉曼的手持式检测仪器及检测方法
KR102362630B1 (ko) 2013-08-26 2022-02-15 바이오엔테크 리서치 앤드 디벨롭먼트 인코포레이티드 시알릴-루이스 a에 대한 사람 항체 코드화 핵산
US9181629B2 (en) 2013-10-30 2015-11-10 Apple Inc. Methods for producing white appearing metal oxide films by positioning reflective particles prior to or during anodizing processes
US9839974B2 (en) 2013-11-13 2017-12-12 Apple Inc. Forming white metal oxide films by oxide structure modification or subsurface cracking
US9097737B2 (en) 2013-11-25 2015-08-04 Oxford Instruments Asylum Research, Inc. Modular atomic force microscope with environmental controls
US9492840B2 (en) * 2013-12-02 2016-11-15 Samsung Electronics Co., Ltd. Methods of removing surface ligand compounds
CN104808329B (zh) * 2014-01-25 2017-08-08 清华大学 一种光学显微镜系统
ES2920777T3 (es) * 2014-02-17 2022-08-09 Eaton Intelligent Power Ltd Sensor de oxígeno que comprende una fibra óptica recubierta en la punta con un diámetro grande
US9659360B2 (en) * 2014-02-26 2017-05-23 Georg-August-Universitaet Goettingen Stiftung Oeffentlichen Rechts Identifying an original object in a forgery-proof way
US20150247846A1 (en) 2014-02-26 2015-09-03 Lamdagen Corporation Digital lspr for enhanced assay sensitivity
HUE055189T2 (hu) 2014-06-04 2021-11-29 Biontech Res And Development Inc Humán monoklonális antitestek a GD2 ganglioziddal ellen
CN107075575B (zh) 2014-06-30 2021-12-03 蓝光治疗公司 用于生物实体中的构象的高通量分析的系统和方法
TWI691716B (zh) 2014-08-13 2020-04-21 美商艾巴希斯公司 電漿特異性結合搭配物檢定中之信號放大
CA2969643A1 (en) 2014-12-03 2016-06-09 Bombardier Inc. Online inspection for composite structures
WO2016106286A1 (en) 2014-12-23 2016-06-30 Biodesy, Inc. Attachment of proteins to interfaces for use in nonlinear optical detection
EP3037861A1 (de) * 2014-12-23 2016-06-29 Commissariat à l'Énergie Atomique et aux Énergies Alternatives Bildgebungsverfahren und System zum Erhalt eines hochauflösenden Bildes eines Objekts
CN107430352B (zh) * 2015-03-25 2020-01-21 Asml荷兰有限公司 量测方法、量测设备和器件制造方法
EP3278087A4 (de) 2015-04-02 2018-12-19 Biodesy, Inc. Verfahren zur bestimmung der proteinstruktur anhand einer oberflächenselektiven nichtlinearen optischen technik
CN107924513A (zh) 2015-04-14 2018-04-17 第资本服务公司 用于动态交易卡的系统、方法和设备
WO2017006314A1 (en) * 2015-07-05 2017-01-12 THE WHOLLYSEE.Ltd. Optical identification and characterization system and tagss
US10640816B2 (en) 2015-07-17 2020-05-05 Nanostring Technologies, Inc. Simultaneous quantification of gene expression in a user-defined region of a cross-sectioned tissue
SG10202107055SA (en) 2015-07-17 2021-08-30 Nanostring Technologies Inc Simultaneous quantification of a plurality of proteins in a user-defined region of a cross-sectioned tissue
AU2016301375B2 (en) * 2015-08-04 2022-03-03 Zoetis Services Llc Signal amplification in solution-based plasmonic specific-binding partner assays
US10395895B2 (en) 2015-08-27 2019-08-27 Mks Instruments, Inc. Feedback control by RF waveform tailoring for ion energy distribution
US11531024B2 (en) 2015-09-24 2022-12-20 Purdue Research Foundation Mass tag analysis for rare cells and cell free molecules
CN108603227A (zh) 2015-11-18 2018-09-28 卡利姆·U·米尔 超分辨率测序
CN108474741A (zh) * 2015-12-23 2018-08-31 皇家飞利浦有限公司 流体中粒子的光学检测
US10060847B2 (en) 2015-12-30 2018-08-28 Bio-Rad Laboratories, Inc. Detection and signal processing system for particle assays
WO2017117461A1 (en) * 2015-12-30 2017-07-06 Bio-Rad Laboratories, Inc. Optical detection system for particles
TW201725385A (zh) * 2016-01-05 2017-07-16 財團法人工業技術研究院 具有薄層層析之拉曼檢測晶片及分離檢測分析物之方法
US11232940B2 (en) * 2016-08-02 2022-01-25 Virgin Instruments Corporation Method and apparatus for surgical monitoring using MALDI-TOF mass spectrometry
KR20190076952A (ko) * 2016-08-22 2019-07-02 조요한 매트릭스 지원 레이저 탈착/이온화 비행 시간 질량 분광계를 이용한 데이터베이스 관리
KR101810846B1 (ko) 2016-08-23 2017-12-20 한국기초과학지원연구원 원거리장 플라즈모닉 렌즈 및 원거리장 플라즈모닉 렌즈 조립체
US10409052B2 (en) * 2016-09-28 2019-09-10 University Of Washington Inverted light-sheet microscope
JP6747939B2 (ja) * 2016-10-28 2020-08-26 日本電信電話株式会社 検出方法及びデバイス
CA3043489A1 (en) 2016-11-21 2018-05-24 Nanostring Technologies, Inc. Chemical compositions and methods of using same
CN111630069A (zh) 2017-10-13 2020-09-04 勃林格殷格翰国际有限公司 针对Thomsen-nouvelle(Tn)抗原的人抗体
JP7372927B6 (ja) 2018-02-12 2023-11-27 ナノストリング テクノロジーズ,インコーポレイティド 遺伝子およびタンパク質の発現を検出する生体分子プローブおよびその検出方法
AU2019271028A1 (en) 2018-05-14 2020-12-03 Nanostring Technologies, Inc. Chemical compositions and methods of using same
US11698304B2 (en) 2019-02-15 2023-07-11 Wayne State University Apparatuses, systems, and methods for detecting materials based on Raman spectroscopy
KR102191673B1 (ko) * 2019-03-04 2020-12-17 한국과학기술원 초소형 렌즈형 광섬유 프로브를 갖는 내시현미경
WO2021021024A1 (en) * 2019-07-31 2021-02-04 Nanyang Technological University Platform for stand-off and real-time sers sensing of airborne analytes
US10613012B1 (en) * 2019-10-17 2020-04-07 Horiba Instruments Incorporated Apparatus and method for observation of microscopic movements and counting of particles in colloids
EP4067102A1 (de) 2021-04-02 2022-10-05 Kaunas University of Technology Optische vorrichtung mit geordneten streuer-arrays für sichere identität und verfahren zu deren herstellung
CN113281323B (zh) * 2021-06-29 2024-01-26 集美大学 一种复杂体系中有机污染物特征信息提取方法及其快速检测方法、系统
WO2023243490A1 (ja) * 2022-06-14 2023-12-21 国立大学法人徳島大学 ナノ粒子体、ナノ粒子体を含む複合体、ならびにナノ粒子体に含まれる高分子膜の形成方法

Family Cites Families (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3856398A (en) 1972-11-13 1974-12-24 D Taylor Apparatus and method for wide area, dark field, high resolution autoradiography
US3801183A (en) * 1973-06-01 1974-04-02 Minnesota Mining & Mfg Retro-reflective film
US4099854A (en) 1976-10-12 1978-07-11 The Unites States Of America As Represented By The Secretary Of The Navy Optical notch filter utilizing electric dipole resonance absorption
US4202626A (en) * 1978-02-24 1980-05-13 A Patent Partnership Signature verification and authentication systems
NL7807532A (nl) 1978-07-13 1980-01-15 Akzo Nv Metaal-immunotest.
US4481091A (en) 1981-02-17 1984-11-06 At&T Bell Laboratories Chemical processing using electromagnetic field enhancement
US4416998A (en) 1981-04-02 1983-11-22 The Upjohn Company Silver stain procedure and kit for same
US4514085A (en) * 1982-06-28 1985-04-30 Beckman Instruments, Inc. Marking and authenticating documents with liquid crystal materials
US4645301A (en) * 1983-02-07 1987-02-24 Minnesota Mining And Manufacturing Company Transparent sheet containing authenticating image and method of making same
US5501949A (en) 1985-12-10 1996-03-26 Murex Diagnostics Corporation Particle bound binding component immunoassay
US5236826A (en) * 1985-12-10 1993-08-17 Murex Corporation Immunoassay for the detection or quantitation of an analyte
US4877647A (en) 1986-04-17 1989-10-31 Kansas State University Research Foundation Method of coating substrates with solvated clusters of metal particles
EP0308537B1 (de) 1987-09-25 1991-08-28 International Business Machines Corporation Sensor zur Umsetzung eines Abstandes in optische und weiterhin in elektrische Energie; Vorrichtung zur Abtastung einer Oberfläche unter Verwendung desselben
US4979821A (en) * 1988-01-27 1990-12-25 Ortho Diagnostic Systems Inc. Cuvette for receiving liquid sample
GB8830039D0 (en) * 1988-12-22 1989-02-15 Renishaw Plc Raman microscope
US5023139A (en) 1989-04-04 1991-06-11 Research Corporation Technologies, Inc. Nonlinear optical materials
US5338353A (en) 1989-04-07 1994-08-16 Nippon Shokubai Kagaku Kogyo Method for production of powder of fine inorganic particles
US5376556A (en) 1989-10-27 1994-12-27 Abbott Laboratories Surface-enhanced Raman spectroscopy immunoassay
US5790693A (en) * 1990-02-05 1998-08-04 Cummins-Allison Corp. Currency discriminator and authenticator
GB9012099D0 (en) * 1990-05-31 1990-07-18 Kodak Ltd Optical article for multicolour imaging
FI85768C (fi) 1990-07-04 1992-05-25 Valtion Teknillinen Foerfarande foer utfoerning av ytplasmonresonansmaetning samt i foerfarandet anvaendbar givare.
US5225900A (en) * 1990-12-31 1993-07-06 Xerox Corporation Method of storing information within a reproduction system
US5817462A (en) * 1995-02-21 1998-10-06 Applied Spectral Imaging Method for simultaneous detection of multiple fluorophores for in situ hybridization and multicolor chromosome painting and banding
DE69110032T2 (de) * 1991-06-08 1995-12-21 Hewlett Packard Gmbh Verfahren und Gerät zur Feststellung und/oder Konzentrationsbestimmung von Biomolekülen.
US5249077A (en) 1991-12-12 1993-09-28 Microvideo Instruments, Inc. Darkfield illuminator for a microscope slide
US5248772A (en) 1992-01-29 1993-09-28 Coulter Corporation Formation of colloidal metal dispersions using aminodextrans as reductants and protective agents
US5451525A (en) 1992-02-14 1995-09-19 Coulter Corporation Method and materials for determining particle count in a flow cytometer
CA2076709A1 (en) * 1992-08-24 1994-02-25 Ulrich J. Krull Amplified fluorescence emission for chemical transduction
US5618063A (en) * 1992-12-09 1997-04-08 Wallace Computer Services, Inc. Multicolor heat-sensitive verification and highlighting system
DE4244086C2 (de) * 1992-12-24 1994-10-27 Florin Ernst Ludwig Verfahren und Vorrichtung zum Nachweis von Oberflächenplasmonen
US5485277A (en) * 1994-07-26 1996-01-16 Physical Optics Corporation Surface plasmon resonance sensor and methods for the utilization thereof
US5479024A (en) 1994-08-11 1995-12-26 The Regents Of The University Of California Method and apparatus for performing near-field optical microscopy
US5599668A (en) 1994-09-22 1997-02-04 Abbott Laboratories Light scattering optical waveguide method for detecting specific binding events
US6025202A (en) * 1995-02-09 2000-02-15 The Penn State Research Foundation Self-assembled metal colloid monolayers and detection methods therewith
US6363164B1 (en) * 1996-05-13 2002-03-26 Cummins-Allison Corp. Automated document processing system using full image scanning
CA2220551A1 (en) * 1995-05-12 1996-11-14 Schering Corporation Surface plasmon resonance based enzymatic assay
US5935755A (en) * 1995-08-21 1999-08-10 Xerox Corporation Method for document marking and recognition
US5633724A (en) * 1995-08-29 1997-05-27 Hewlett-Packard Company Evanescent scanning of biochemical array
US6174677B1 (en) * 1995-10-13 2001-01-16 Ut-Battelle, Llc Advanced surface-enhanced Raman gene probe systems and methods thereof
US5815278A (en) * 1995-10-25 1998-09-29 University Of Washington Surface plasmon resonance light pipe sensing probe and related interface optics
JP2000510582A (ja) 1996-04-25 2000-08-15 ゼニコン・サイエンシーズ・コーポレーション 微粒子標識を使用した分析物アッセイ
US5717518A (en) * 1996-07-22 1998-02-10 Kla Instruments Corporation Broad spectrum ultraviolet catadioptric imaging system
AU748939B2 (en) * 1997-02-20 2002-06-13 Regents Of The University Of California, The Plasmon resonant particles, methods and apparatus
US6344272B1 (en) * 1997-03-12 2002-02-05 Wm. Marsh Rice University Metal nanoshells
US6002476A (en) * 1998-04-22 1999-12-14 Chemicon Inc. Chemical imaging system
US6992770B2 (en) * 2001-01-25 2006-01-31 Fuji Photo Film Co., Ltd. Sensor utilizing attenuated total reflection
US6914668B2 (en) * 2003-05-14 2005-07-05 International Technologies (Laser) Ltd. Personal identification verification and controlled substance detection and identification system
US7956997B2 (en) * 2003-05-27 2011-06-07 Optotrace Technologies, Inc. Systems and methods for food safety detection
US7820064B2 (en) * 2005-05-10 2010-10-26 The Regents Of The University Of California Spinodally patterned nanostructures
CA2666507A1 (en) * 2006-10-16 2008-04-24 The Arizona Board Of Regents, A Body Corporate Of The State Of Arizona A Cting For And On Behalf Of Arizona State University Synthetic antibodies
US7869030B2 (en) * 2007-01-03 2011-01-11 Research Foundation Of State University Of New York Aggregates of plural transition metal nanoparticles and plural cyanine dye molecules
AU2009221976B2 (en) * 2008-03-03 2014-02-27 Kansas State University Research Foundation Protease assay
US20120021967A1 (en) * 2008-04-23 2012-01-26 Arizona Board of Regents, A Body Corporate of the State Of Arizona Acting for and Behalf of Arizona Synthetic antibodies
US20120065123A1 (en) * 2009-03-24 2012-03-15 Johnston Stephen A Synthetic Antibodies
WO2010123941A2 (en) * 2009-04-20 2010-10-28 Enhanced Spectrometry, Inc. Method for storing and coding information with raman-active substances
CA2731892A1 (fr) * 2011-02-18 2012-08-18 Universite De Montreal Sondes a diffusion raman a capsule nanometrique, methode de fabrication et utilisation

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US20090161104A1 (en) 2009-06-25
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