DE69837141D1 - Polyhydroxyalkanoate für in vivo anwendungen - Google Patents

Polyhydroxyalkanoate für in vivo anwendungen

Info

Publication number
DE69837141D1
DE69837141D1 DE69837141T DE69837141T DE69837141D1 DE 69837141 D1 DE69837141 D1 DE 69837141D1 DE 69837141 T DE69837141 T DE 69837141T DE 69837141 T DE69837141 T DE 69837141T DE 69837141 D1 DE69837141 D1 DE 69837141D1
Authority
DE
Germany
Prior art keywords
phas
polymers
tissue
bone
vivo applications
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69837141T
Other languages
English (en)
Other versions
DE69837141T2 (de
Inventor
Simon F Williams
David P Martin
Tillman Gerngross
Daniel M Horowitz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Metabolix Inc
Original Assignee
Metabolix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Metabolix Inc filed Critical Metabolix Inc
Publication of DE69837141D1 publication Critical patent/DE69837141D1/de
Application granted granted Critical
Publication of DE69837141T2 publication Critical patent/DE69837141T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C12P7/625—Polyesters of hydroxy carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B42/00—Surgical gloves; Finger-stalls specially adapted for surgery; Devices for handling or treatment thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/593—Polyesters, e.g. PLGA or polylactide-co-glycolide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6957—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a device or a kit, e.g. stents or microdevices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
    • A61L17/06—At least partially resorbable materials
    • A61L17/10—At least partially resorbable materials containing macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/04—Macromolecular materials
    • A61L29/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/68—Polyesters containing atoms other than carbon, hydrogen and oxygen
    • C08G63/685—Polyesters containing atoms other than carbon, hydrogen and oxygen containing nitrogen
    • C08G63/6852—Polyesters containing atoms other than carbon, hydrogen and oxygen containing nitrogen derived from hydroxy carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/68—Polyesters containing atoms other than carbon, hydrogen and oxygen
    • C08G63/688—Polyesters containing atoms other than carbon, hydrogen and oxygen containing sulfur
    • C08G63/6882—Polyesters containing atoms other than carbon, hydrogen and oxygen containing sulfur derived from hydroxy carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/91—Polymers modified by chemical after-treatment
    • C08G63/912—Polymers modified by chemical after-treatment derived from hydroxycarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0068—General culture methods using substrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
    • A61B17/06—Needles ; Sutures; Needle-suture combinations; Holders or packages for needles or suture materials
    • A61B17/06166—Sutures
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/30—Synthetic polymers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/773—Nanoparticle, i.e. structure having three dimensions of 100 nm or less
    • Y10S977/775—Nanosized powder or flake, e.g. nanosized catalyst
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/13—Hollow or container type article [e.g., tube, vase, etc.]
    • Y10T428/1352—Polymer or resin containing [i.e., natural or synthetic]
    • Y10T428/139—Open-ended, self-supporting conduit, cylinder, or tube-type article
DE69837141T 1997-05-12 1998-05-12 Polyhydroxyalkanoate für in vivo anwendungen Expired - Lifetime DE69837141T2 (de)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US4621197P 1997-05-12 1997-05-12
US46211P 1997-05-12
US5428997P 1997-07-31 1997-07-31
US54289P 1997-07-31
US6350197P 1997-10-24 1997-10-24
US63501P 1997-10-24
US6592197P 1997-11-17 1997-11-17
US65921P 1997-11-17
PCT/US1998/009834 WO1998051812A2 (en) 1997-05-12 1998-05-12 Polyhydroxyalkanoates for in vivo applications

Publications (2)

Publication Number Publication Date
DE69837141D1 true DE69837141D1 (de) 2007-04-05
DE69837141T2 DE69837141T2 (de) 2007-10-31

Family

ID=27489042

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69837141T Expired - Lifetime DE69837141T2 (de) 1997-05-12 1998-05-12 Polyhydroxyalkanoate für in vivo anwendungen

Country Status (9)

Country Link
US (6) US6245537B1 (de)
EP (1) EP0981381B1 (de)
AT (1) ATE354600T1 (de)
AU (1) AU7486798A (de)
DE (1) DE69837141T2 (de)
DK (1) DK0981381T3 (de)
ES (1) ES2285770T3 (de)
PT (1) PT981381E (de)
WO (1) WO1998051812A2 (de)

Families Citing this family (226)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6323237B1 (en) 1997-03-17 2001-11-27 Btg International Limited Therapeutic compositions
US6316038B1 (en) 1997-03-17 2001-11-13 Btg International Limited Therapeutic compositions
US6610764B1 (en) 1997-05-12 2003-08-26 Metabolix, Inc. Polyhydroxyalkanoate compositions having controlled degradation rates
PT981381E (pt) 1997-05-12 2007-04-30 Metabolix Inc Poli-hidroxialcanoatos para aplicações in vivo
US6867248B1 (en) 1997-05-12 2005-03-15 Metabolix, Inc. Polyhydroxyalkanoate compositions having controlled degradation rates
US6828357B1 (en) 1997-07-31 2004-12-07 Metabolix, Inc. Polyhydroxyalkanoate compositions having controlled degradation rates
EP1042388B1 (de) * 1997-12-22 2006-11-15 Metabolix, Inc. Polyhydroxyalkanoatzusammensetzungen mit kontrollierten abbaugeschwindigkeiten
US20030040790A1 (en) * 1998-04-15 2003-02-27 Furst Joseph G. Stent coating
US7967855B2 (en) 1998-07-27 2011-06-28 Icon Interventional Systems, Inc. Coated medical device
US8070796B2 (en) 1998-07-27 2011-12-06 Icon Interventional Systems, Inc. Thrombosis inhibiting graft
DE69931800T2 (de) * 1998-10-28 2007-07-12 Cellon S.A. Strukturierter und poröser silikonkautschuk
EP1878451A1 (de) * 1999-03-04 2008-01-16 Tepha, Inc. Bioabsorbierbare und biokompatible Polymere zur Gewebeverarbeitung
CA2363262C (en) 1999-03-04 2010-09-28 Tepha, Inc. Bioabsorbable, biocompatible polymers for tissue engineering
AU2004242432B2 (en) * 1999-03-04 2007-07-05 Tepha, Inc. Bioabsorbable, biocompatible polymers for tissue engineering
WO2000056376A1 (en) * 1999-03-25 2000-09-28 Metabolix, Inc. Medical devices and applications of polyhydroxyalkanoate polymers
US6592892B1 (en) 1999-08-30 2003-07-15 Tepha, Inc. Flushable disposable polymeric products
US7025980B1 (en) 1999-09-14 2006-04-11 Tepha, Inc. Polyhydroxyalkanoate compositions for soft tissue repair, augmentation, and viscosupplementation
JP2003509128A (ja) * 1999-09-14 2003-03-11 テファ， インコーポレイテッド 軟部組織の修復、増強および粘性補充のためのポリヒドロキシアルカノエート組成物
US20030208279A1 (en) * 2001-04-30 2003-11-06 Anthony Atala Tissue engineered stents
WO2001087192A1 (en) * 2000-04-28 2001-11-22 Children's Medical Center Corporation Tissue engineered stents
US7419678B2 (en) * 2000-05-12 2008-09-02 Cordis Corporation Coated medical devices for the prevention and treatment of vascular disease
US20050002986A1 (en) * 2000-05-12 2005-01-06 Robert Falotico Drug/drug delivery systems for the prevention and treatment of vascular disease
US8236048B2 (en) 2000-05-12 2012-08-07 Cordis Corporation Drug/drug delivery systems for the prevention and treatment of vascular disease
CA2424029C (en) 2000-09-29 2008-01-29 Cordis Corporation Coated medical devices
JP5057629B2 (ja) * 2001-02-06 2012-10-24 マサチューセッツ インスティテュート オブ テクノロジー ペプチド足場での組織細胞のカプセル化およびその使用
US7763769B2 (en) 2001-02-16 2010-07-27 Kci Licensing, Inc. Biocompatible wound dressing
US7700819B2 (en) 2001-02-16 2010-04-20 Kci Licensing, Inc. Biocompatible wound dressing
JP2003015168A (ja) * 2001-04-27 2003-01-15 Canon Inc 電気泳動粒子、電気泳動粒子の製造方法、および電気泳動表示素子
DE10122128A1 (de) * 2001-04-27 2002-11-07 Inst Polymerforschung Dresden Resorbierbares Patch-Implantat, Verfahren zu seiner Herstellung und Verwendung
US6787179B2 (en) * 2001-06-29 2004-09-07 Ethicon, Inc. Sterilization of bioactive coatings
JP3990880B2 (ja) * 2001-07-10 2007-10-17 キヤノン株式会社 ポリヒドロキシアルカノエート被覆リポソームの製造方法
EP1429683B1 (de) 2001-09-28 2014-12-24 Boston Scientific Limited Medizinische vorrichtung mit nanomaterialen und therapeutische verfahren
WO2003048298A2 (en) * 2001-12-05 2003-06-12 Yissum Research Development Company Of The Hebrew University Of Jerusalem Nanoparticles containing polymeric nucleic acid homologs, pharmaceutical compositions and articles of manufacture containing same and methods of use thereof
US7318833B2 (en) 2001-12-19 2008-01-15 Nmt Medical, Inc. PFO closure device with flexible thrombogenic joint and improved dislodgement resistance
EP1467661A4 (de) * 2001-12-19 2008-11-05 Nmt Medical Inc Septumverschlusseinrichtung und zugehörige verfahren
NL1019888C2 (nl) * 2002-02-01 2003-08-25 Univ Twente Werkwijze voor het vervaardigen van een poreuze polymeerstructuur.
DE10212553A1 (de) * 2002-03-16 2003-09-25 Knoell Hans Forschung Ev Verwendung einer Formulierung zur in situ Biodegradation von Wundabdeckungen
WO2003082076A2 (en) 2002-03-25 2003-10-09 Nmt Medical, Inc. Patent foramen ovale (pfo) closure clips
SE527054C2 (sv) * 2002-04-23 2005-12-13 Gambro Lundia Ab Förfarande för framställning av ett regioselektivt membran
FR2839260B1 (fr) * 2002-05-03 2005-02-25 Inst Nat Sante Rech Med Microparticules a base d'un materiau bicompatible et biodegradable, supportant des cellules et des substances biologiquement actives
US20050129776A1 (en) 2002-05-03 2005-06-16 Inserm Microparticles supporting cells and active substances
US8039237B2 (en) * 2002-05-10 2011-10-18 Metabolix, Inc. Bioabsorbable polymer containing 2-hydroxyacid monomers
JP2005528181A (ja) 2002-06-05 2005-09-22 エヌエムティー メディカル インコーポレイテッド 放射状および円周状支持体を備える卵円孔開存（ｐｆｏ）閉塞デバイス
EP3351376B1 (de) 2002-06-24 2023-04-12 Tufts University Seidenbiomaterialien und verfahren zu ihrer verwendung
US8016881B2 (en) 2002-07-31 2011-09-13 Icon Interventional Systems, Inc. Sutures and surgical staples for anastamoses, wound closures, and surgical closures
KR100529209B1 (ko) * 2002-08-28 2005-11-17 한국과학기술연구원 세포 친화성이 향상된 생분해성의 조직 공학용 다공성고분자 지지체의 제조방법
KR101049871B1 (ko) * 2002-09-25 2011-07-15 가부시키가이샤 교토 이료 세케이 맥관 스텐트용 실 및 이 실을 사용한 맥관용 스텐트
WO2004037333A1 (en) 2002-10-25 2004-05-06 Nmt Medical, Inc. Expandable sheath tubing
CA2503349A1 (en) * 2002-11-06 2004-05-27 Nmt Medical, Inc. Medical devices utilizing modified shape memory alloy
US7285287B2 (en) 2002-11-14 2007-10-23 Synecor, Llc Carbon dioxide-assisted methods of providing biocompatible intraluminal prostheses
CA2503666A1 (en) 2002-12-09 2004-06-24 Nmt Medical, Inc. Septal closure devices
JP4698596B2 (ja) 2003-04-10 2011-06-08 タフツ ユニバーシティー 濃縮された水性シルクフィブロイン溶液およびそれらの使用
AU2004238229B2 (en) * 2003-05-08 2007-07-12 Tepha, Inc. Polyhydroxyalkanoate medical textiles and fibers
WO2005007195A1 (en) * 2003-07-08 2005-01-27 Tepha, Inc. Poly-4-hydroxybutyrate matrices for sustained drug delivery
US9861346B2 (en) * 2003-07-14 2018-01-09 W. L. Gore & Associates, Inc. Patent foramen ovale (PFO) closure device with linearly elongating petals
US8480706B2 (en) 2003-07-14 2013-07-09 W.L. Gore & Associates, Inc. Tubular patent foramen ovale (PFO) closure device with catch system
EP1651116B1 (de) 2003-07-14 2013-06-26 W.L. Gore & Associates, Inc. Röhrenförmige verschlussvorrichtung für patentes foramen ovale (pfo) mit riegelsystem
WO2005018728A2 (en) 2003-08-19 2005-03-03 Nmt Medical, Inc. Expandable sheath tubing
WO2005020825A1 (en) * 2003-08-22 2005-03-10 Tepha, Inc. Polyhydroxyalkanoate nerve regeneration devices
US20050273119A1 (en) 2003-12-09 2005-12-08 Nmt Medical, Inc. Double spiral patent foramen ovale closure clamp
US8328876B2 (en) * 2003-12-31 2012-12-11 Warsaw Orthopedic, Inc. Bone matrix compositions and methods
US20070231788A1 (en) * 2003-12-31 2007-10-04 Keyvan Behnam Method for In Vitro Assay of Demineralized Bone Matrix
US7211108B2 (en) * 2004-01-23 2007-05-01 Icon Medical Corp. Vascular grafts with amphiphilic block copolymer coatings
US7871419B2 (en) 2004-03-03 2011-01-18 Nmt Medical, Inc. Delivery/recovery system for septal occluder
US20050267524A1 (en) 2004-04-09 2005-12-01 Nmt Medical, Inc. Split ends closure device
US8361110B2 (en) 2004-04-26 2013-01-29 W.L. Gore & Associates, Inc. Heart-shaped PFO closure device
US20060240065A1 (en) * 2005-04-26 2006-10-26 Yung-Ming Chen Compositions for medical devices containing agent combinations in controlled volumes
US7842053B2 (en) 2004-05-06 2010-11-30 Nmt Medical, Inc. Double coil occluder
US8308760B2 (en) 2004-05-06 2012-11-13 W.L. Gore & Associates, Inc. Delivery systems and methods for PFO closure device with two anchors
US8257389B2 (en) 2004-05-07 2012-09-04 W.L. Gore & Associates, Inc. Catching mechanisms for tubular septal occluder
TW200617171A (en) * 2004-06-29 2006-06-01 Procter & Gamble Improved process for the solvent-based extraction of polyhydroxyalkanoates from biomass
EP1778615A4 (de) 2004-07-20 2010-01-06 Btg Int Ltd Oligomere ketonverbindungen
PT1778305E (pt) * 2004-08-03 2010-07-27 Tepha Inc Suturas de poli-hidroxialcanoato que n†o se enrolam
EP1781264B1 (de) 2004-08-04 2013-07-24 Evonik Corporation Verfahren zur herstellung von abgabevorrichtungen und damit erhaltene vorrichtungen
US7229471B2 (en) * 2004-09-10 2007-06-12 Advanced Cardiovascular Systems, Inc. Compositions containing fast-leaching plasticizers for improved performance of medical devices
EP1827247B8 (de) 2004-09-24 2020-05-06 W.L. Gore & Associates, Inc. Doppeltes sicherungssystem für eine okklusionsvorrichtung zur abgabe/wiedergewinnung einer okklusionsvorrichtung
US20060095021A1 (en) * 2004-11-02 2006-05-04 Casas-Bejar Jesus W Introduction of agent with medical device
WO2006066023A2 (en) * 2004-12-14 2006-06-22 C. R. Bard, Inc. Fast clear port
DE602006016915D1 (de) * 2005-01-28 2010-10-28 Tepha Inc Embolisierung unter verwendung von poly-4-hydroxybutyrat-partikeln
US9107899B2 (en) 2005-03-03 2015-08-18 Icon Medical Corporation Metal alloys for medical devices
WO2006110197A2 (en) 2005-03-03 2006-10-19 Icon Medical Corp. Polymer biodegradable medical device
US7540995B2 (en) 2005-03-03 2009-06-02 Icon Medical Corp. Process for forming an improved metal alloy stent
US20060200048A1 (en) * 2005-03-03 2006-09-07 Icon Medical Corp. Removable sheath for device protection
US8277480B2 (en) 2005-03-18 2012-10-02 W.L. Gore & Associates, Inc. Catch member for PFO occluder
WO2006124791A2 (en) * 2005-05-16 2006-11-23 Integra Lifesciences Corporation Pyrogen-free neurosurgical sponges
AU2006295515A1 (en) * 2005-09-27 2007-04-05 Polybatics Limited Polymer particles and uses thereof
WO2007053850A2 (en) 2005-11-01 2007-05-10 Osteotech, Inc. Bone matrix compositions and methods
EP1948722B1 (de) * 2005-11-04 2014-09-03 PPD Meditech Herstellungsverfahren von poröses Material
US20070131610A1 (en) * 2005-12-13 2007-06-14 General Electric Company Membrane-based apparatus and associated method
US20070131611A1 (en) * 2005-12-13 2007-06-14 General Electric Company Membrane-based article and associated method
US7976891B1 (en) 2005-12-16 2011-07-12 Advanced Cardiovascular Systems, Inc. Abluminal stent coating apparatus and method of using focused acoustic energy
EP1962695A1 (de) 2005-12-22 2008-09-03 NMT Medical, Inc. Fangglieder für verschlussvorrichtungen
ES2624589T3 (es) * 2006-02-07 2017-07-17 Tepha, Inc. Métodos y dispositivos para la reparación del manguito de los rotadores
WO2007092418A2 (en) 2006-02-07 2007-08-16 Tepha, Inc. Polymeric, degradable drug-eluting stents and coatings
US8979921B2 (en) 2006-02-07 2015-03-17 Tepha, Inc. Polymeric, degradable drug-eluting stents and coatings
US9592325B2 (en) * 2006-02-07 2017-03-14 Tepha, Inc. Polymeric, degradable drug-eluting stents and coatings
US8551135B2 (en) 2006-03-31 2013-10-08 W.L. Gore & Associates, Inc. Screw catch mechanism for PFO occluder and method of use
US8870913B2 (en) 2006-03-31 2014-10-28 W.L. Gore & Associates, Inc. Catch system with locking cap for patent foramen ovale (PFO) occluder
CA2647505C (en) 2006-03-31 2014-07-29 Nmt Medical, Inc. Deformable flap catch mechanism for occluder device
US7775178B2 (en) * 2006-05-26 2010-08-17 Advanced Cardiovascular Systems, Inc. Stent coating apparatus and method
US20070288088A1 (en) * 2006-06-13 2007-12-13 Christophe Bureau Drug eluting stent with a biodegradable release layer attached with an electro-grafted primer coating
US11039942B2 (en) 2006-06-13 2021-06-22 Sino Medical Sciences Technology Inc. Drug eluting stent and method of use of the same for enabling restoration of functional endothelial cell layers
US9884142B2 (en) 2006-06-13 2018-02-06 Alchimedics Drug eluting stent with a biodegradable release layer attached with an electro-grafted primer coating
WO2008118133A2 (en) 2006-09-26 2008-10-02 Trustees Of Tufts College Silk microspheres for encapsulation and controlled release
US9066996B1 (en) * 2006-10-13 2015-06-30 Hrl Laboratories, Llc Method to control the biodegradation rates of polymer structures
US7943683B2 (en) * 2006-12-01 2011-05-17 Tepha, Inc. Medical devices containing oriented films of poly-4-hydroxybutyrate and copolymers
ES2409759T3 (es) 2007-01-21 2013-06-27 Hemoteq Ag Producto médico para el tratamiento de la estenosis de los canales del cuerpo y para la prevención de la estenosis amenazante
JP2010517638A (ja) * 2007-02-02 2010-05-27 トアニエ， インコーポレイテッド 腱および靱帯を修復するシステムおよび方法
DE102007008479A1 (de) * 2007-02-21 2008-09-04 Orlowski, Michael, Dr. Beschichtetes Expandierbares System
JP2010522583A (ja) 2007-02-27 2010-07-08 トラスティーズ オブ タフツ カレッジ 組織工学的に作製された絹製臓器
WO2008124603A1 (en) 2007-04-05 2008-10-16 Nmt Medical, Inc. Septal closure device with centering mechanism
US9138562B2 (en) 2007-04-18 2015-09-22 W.L. Gore & Associates, Inc. Flexible catheter system
DE102007025452A1 (de) * 2007-05-31 2008-12-04 Ernst-Moritz-Arndt-Universität Greifswald Verfahren zur Beschichtung von Oberflächen mit Mikro- und Nanopartikeln mit Hilfe von Plasmaverfahren
EP2167180B1 (de) * 2007-06-01 2015-03-04 Covidien LP Verlängerungsschläuche für ballonkatheter
WO2008157492A2 (en) 2007-06-15 2008-12-24 Osteotech, Inc. Osteoinductive demineralized cancellous bone
CA2690457C (en) * 2007-06-15 2018-02-20 Osteotech, Inc. Bone matrix compositions and methods
US9554920B2 (en) * 2007-06-15 2017-01-31 Warsaw Orthopedic, Inc. Bone matrix compositions having nanoscale textured surfaces
WO2008157497A2 (en) * 2007-06-15 2008-12-24 Osteotech, Inc. Method of treating tissue
US9192697B2 (en) 2007-07-03 2015-11-24 Hemoteq Ag Balloon catheter for treating stenosis of body passages and for preventing threatening restenosis
US20110054408A1 (en) * 2007-07-10 2011-03-03 Guobao Wei Delivery systems, devices, tools, and methods of use
US9492278B2 (en) 2007-07-10 2016-11-15 Warsaw Orthopedic, Inc. Delivery system
WO2009023615A1 (en) 2007-08-10 2009-02-19 Trustees Of Tufts College Tubular silk compositions and methods of use thereof
DE102007000694B4 (de) * 2007-09-04 2009-06-10 Leibniz-Institut Für Polymerforschung Dresden E.V. Nukleierte Poly-3-Hydroxybuttersäure-Fäden und Verfahren zu ihrer Herstellung und Verwendung
WO2009052492A2 (en) 2007-10-19 2009-04-23 Osteotech, Inc. Demineralized bone matrix compositions and methods
US20090112259A1 (en) * 2007-10-31 2009-04-30 Angiotech Pharmaceuticals, Inc. Recombinant expressed bioadsorbable polyhydroxyalkonate monofilament and multi-filaments self-retaining sutures
US7833266B2 (en) 2007-11-28 2010-11-16 Boston Scientific Scimed, Inc. Bifurcated stent with drug wells for specific ostial, carina, and side branch treatment
US8287909B2 (en) * 2007-12-19 2012-10-16 Tepha, Inc. Medical devices containing melt-blown non-wovens of poly-4-hydroxybutyrate and copolymers thereof
EP2222281B1 (de) 2007-12-20 2018-12-05 Evonik Corporation Verfahren zur herstellung von mikropartikeln mit geringer restlösemittelmenge
US20130165967A1 (en) 2008-03-07 2013-06-27 W.L. Gore & Associates, Inc. Heart occlusion devices
WO2009158724A2 (en) * 2008-06-27 2009-12-30 Tepha, Inc. Improved injectable delivery of microparticles and compositions therefore
US7951193B2 (en) 2008-07-23 2011-05-31 Boston Scientific Scimed, Inc. Drug-eluting stent
WO2010093955A1 (en) 2009-02-12 2010-08-19 Osteotech,Inc. Segmented delivery system
US20120029556A1 (en) 2009-06-22 2012-02-02 Masters Steven J Sealing device and delivery system
US8956389B2 (en) 2009-06-22 2015-02-17 W. L. Gore & Associates, Inc. Sealing device and delivery system
EP2451496B1 (de) 2009-07-10 2015-07-22 Boston Scientific Scimed, Inc. Verwendung von nanokristallen für einen wirkstofffreisetzungsballon
EP2962707B1 (de) 2009-07-17 2019-07-24 Boston Scientific Scimed, Inc. Wirkstofffreisetzungsballons mit verbesserte kristallgrösse und -dichte
WO2011037658A1 (en) * 2009-09-25 2011-03-31 Tornier, Inc. Implantable patch and surgical kit for preparation thereof
US20110166598A1 (en) * 2009-12-02 2011-07-07 Entrigue Surgical, Inc. Devices and methods for tongue stabilization
US8398916B2 (en) 2010-03-04 2013-03-19 Icon Medical Corp. Method for forming a tubular medical device
EP2558133B1 (de) 2010-03-26 2020-01-22 Tepha, Inc. Beschichtungen für die herstellung und anwendung von medizinischen polyhydroxyalkanoatvorrichtungen
US9511169B2 (en) 2010-06-15 2016-12-06 Tepha, Inc. Medical devices containing dry spun non-wovens of poly-4-hydroxybutyrate and copolymers with anisotropic properties
EP2582866B1 (de) 2010-06-15 2014-09-17 Tepha, Inc. Medizinprodukte mit trockengesponnen vliesstoffe aus poly-4-hydroxybutyrat und copolymere
EP2598552A1 (de) * 2010-07-28 2013-06-05 University Of Akron Biologisch abbaubare funktionspolymere
EP2425865A1 (de) 2010-08-06 2012-03-07 Aesculap AG Medizinisches Gewinde mit Polyhydroxyalkanoatbeschichtung
EP2611476B1 (de) 2010-09-02 2016-08-10 Boston Scientific Scimed, Inc. Beschichtungsverfahren für wirkstofffreisetzungsballons mit wärmeinduziertem rewrap-gedächtnis
EP2625264B1 (de) 2010-10-08 2022-12-07 Terumo BCT, Inc. Verfahren und systeme für züchtung und ernte von zellen in einem hohlfaser-bioreaktorsystem mit steuerungsbedingungen
US9162010B2 (en) 2010-11-09 2015-10-20 Tepha, Inc. Drug eluting cochlear implants
FR2968506B1 (fr) * 2010-12-14 2013-02-08 Ifremer Nucleus recouvert de pha
CA2825624C (en) 2011-01-27 2020-01-14 Osa Holdings, Inc. Apparatus and methods for treatment of obstructive sleep apnea utilizing cryolysis of adipose tissues
US8920361B2 (en) * 2011-04-05 2014-12-30 The Texas A&M University System Plasma treatment and plasma enhanced chemical vapor deposition onto temperature sensitive biological materials
US10335519B2 (en) 2011-04-20 2019-07-02 Trustees Of Tufts College Dynamic silk coatings for implantable devices
DK2537540T3 (da) 2011-06-20 2014-06-02 Tech Universität Graz Hybridpolymermaterialer til medicinske anvendelser samt deres fremstilling
US8669360B2 (en) 2011-08-05 2014-03-11 Boston Scientific Scimed, Inc. Methods of converting amorphous drug substance into crystalline form
US9770232B2 (en) 2011-08-12 2017-09-26 W. L. Gore & Associates, Inc. Heart occlusion devices
US9056152B2 (en) 2011-08-25 2015-06-16 Boston Scientific Scimed, Inc. Medical device with crystalline drug coating
WO2013033209A1 (en) * 2011-08-29 2013-03-07 Novomer, Inc. Poly (hydroxy alkanoate) co-polymers
ES2659525T3 (es) 2011-09-27 2018-03-16 Tepha, Inc. Hidrólisis controlada de poli-4-hidroxibutirato y copolímeros
CA2867464A1 (en) 2012-03-20 2013-09-26 Trustees Of Tufts College Silk reservoirs for drug delivery
AU2013245785A1 (en) 2012-04-13 2014-10-23 Trustees Of Tufts College Methods and compositions for preparing a silk microsphere
ES2822000T3 (es) 2012-05-21 2021-04-28 Tepha Inc Composiciones biocerámicas reabsorbibles de poli-4-hidroxibutirato y copolímeros
WO2013181604A1 (en) 2012-05-31 2013-12-05 Micromidas, Inc. Polyhydroxyalkanoate derivatives, preparation and uses thereof
US10034945B2 (en) 2012-07-13 2018-07-31 Trustees Of Tufts College Silk powder compaction for production of constructs with high mechanical strength and stiffness
ES2774932T3 (es) 2012-11-14 2020-07-23 Cj Cheiljedang Corp Producción de sales de 4-hidroxibutirato utilizando materias primas de base biológica
ES2751398T3 (es) 2013-01-15 2020-03-31 Tepha Inc Implantes para regeneración de tejido blando y tejido duro
US10828019B2 (en) 2013-01-18 2020-11-10 W.L. Gore & Associates, Inc. Sealing device and delivery system
US9290612B2 (en) * 2013-03-13 2016-03-22 Tepha, Inc. Compositions and devices of poly-4-hydroxybutyrate
US10201640B2 (en) 2013-03-13 2019-02-12 Tepha, Inc. Ultrafine electrospun fibers of poly-4-hydroxybutyrate and copolymers thereof
KR20210149207A (ko) 2013-03-15 2021-12-08 트러스티즈 오브 터프츠 칼리지 저분자량 실크 조성물 및 안정화 실크 조성물
US11376329B2 (en) 2013-03-15 2022-07-05 Trustees Of Tufts College Low molecular weight silk compositions and stabilizing silk compositions
WO2014176458A2 (en) 2013-04-24 2014-10-30 Trustees Of Tufts College Bioresorbable biopolymer anastomosis devices
WO2014186435A2 (en) 2013-05-14 2014-11-20 University Of Georgia Research Foundation, Inc. Compositions and methods for reducing neointima formation
WO2014202627A2 (en) 2013-06-17 2014-12-24 Sanofi Whole-cell system for cytochrome p450 monooxygenases biocatalysis
US10689498B2 (en) 2013-08-20 2020-06-23 Tepha, Inc. Closed cell foams including poly-4-hydroxybutyrate and copolymers thereof
US9687585B2 (en) 2013-08-20 2017-06-27 Tepha, Inc. Thermoformed poly-4-hydroxybutyrate medical implants
US9302029B2 (en) 2013-10-31 2016-04-05 Tepha, Inc. Pultrusion of poly-4-hydroxybutyrate and copolymers thereof
CA2928731A1 (en) 2013-11-05 2015-05-14 Tepha, Inc. Compositions and devices of poly-4-hydroxybutyrate
WO2015073913A1 (en) 2013-11-16 2015-05-21 Terumo Bct, Inc. Expanding cells in a bioreactor
WO2015094619A1 (en) 2013-12-19 2015-06-25 Tornier, Inc. High-strength bioabsorbable suture
ES2834498T3 (es) 2013-12-26 2021-06-17 Tepha Inc Implantes médicos que incluyen laminados de poli-4-hidroxibutirato y copolímeros del mismo
ES2685963T3 (es) 2014-03-18 2018-10-15 Tepha, Inc. Bandas de microfibras de poli-4-hidroxibutirato y sus copolímeros producidas por hilado centrífugo
US11008547B2 (en) 2014-03-25 2021-05-18 Terumo Bct, Inc. Passive replacement of media
WO2015167807A1 (en) 2014-04-30 2015-11-05 Tepha, Inc. Three-dimensional resorbable implants for tissue reinforcement and hernia repair
ES2674807T3 (es) 2014-05-16 2018-07-04 Tepha, Inc. Dispositivos médicos que contienen materiales no tejidos hilados en seco de poli-4-hidroxibutirato y copolímeros con propiedades anisótropas
US9808230B2 (en) 2014-06-06 2017-11-07 W. L. Gore & Associates, Inc. Sealing device and delivery system
US9381280B2 (en) 2014-06-13 2016-07-05 Abbott Cardiovascular Systems Inc. Plasticizers for a biodegradable scaffolding and methods of forming same
WO2015199816A1 (en) 2014-06-24 2015-12-30 Icon Medical Corp. Improved metal alloys for medical devices
US10500303B2 (en) 2014-08-15 2019-12-10 Tepha, Inc. Self-retaining sutures of poly-4-hydroxybutyrate and copolymers thereof
CA2958544C (en) 2014-08-20 2019-05-21 Tepha, Inc. Thermoformed poly-4-hydroxybutyrate medical implants
US20160090569A1 (en) 2014-09-26 2016-03-31 Terumo Bct, Inc. Scheduled Feed
EP3200736B8 (de) 2014-10-01 2020-06-17 CryOSA, Inc. Vorrichtung zur behandlung von obstruktiver schlafapnoe durch kryolyse von adipösen geweben
US10626521B2 (en) 2014-12-11 2020-04-21 Tepha, Inc. Methods of manufacturing mesh sutures from poly-4-hydroxybutyrate and copolymers thereof
US9555155B2 (en) 2014-12-11 2017-01-31 Tepha, Inc. Methods of orienting multifilament yarn and monofilaments of poly-4-hydroxybutyrate and copolymers thereof
US10758645B2 (en) 2014-12-17 2020-09-01 Tufts University Injectable, flexible hydroxyapatite-silk foams for osteochondral and dental repair
JP7064880B2 (ja) 2015-04-01 2022-05-11 イェール ユニバーシティー 医療用インプラント上の生物製剤の付着のための鉄白金粒子
WO2017004592A1 (en) 2015-07-02 2017-01-05 Terumo Bct, Inc. Cell growth with mechanical stimuli
CA2995233C (en) 2015-07-20 2024-01-02 Tufts University Biodegradable silk ear tubes
US11766506B2 (en) 2016-03-04 2023-09-26 Mirus Llc Stent device for spinal fusion
US20180346943A1 (en) * 2016-03-25 2018-12-06 Kaneka Corporation Polyhydroxyalkanoic acid having functional group at terminal carboxy group and method for producing the same
WO2017189832A1 (en) 2016-04-29 2017-11-02 Trustees Of Tufts College An artificial silk based innervated cornea
EP3464565A4 (de) 2016-05-25 2020-01-01 Terumo BCT, Inc. Zellexpansion
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
EP3476943A4 (de) 2016-06-23 2020-03-04 Kaneka Corporation Verfahren zur herstellung von polyhydroxyalkansäure
WO2018006037A1 (en) 2016-07-01 2018-01-04 Trustees Of Tufts College Innervated artificial skin
WO2018026853A1 (en) 2016-08-01 2018-02-08 Trustees Of Tufts College Biomimetic mechanical tension driven fabrication of nanofibrillar architecture
US10072120B2 (en) 2016-12-02 2018-09-11 International Business Machines Corporation Functionalized polyhydroxyalkanoate materials formed from an unsaturated polyhydroxyalkanoate material
US10081706B2 (en) 2017-01-03 2018-09-25 International Business Machines Corporation Side-chain-functionalized polyhydroxyalkanoate materials
US20200000713A1 (en) 2017-01-20 2020-01-02 Massachusetts Institute Of Technology Injectable polymer micro-depots for controlled local drug delivery
GB201702475D0 (en) * 2017-02-15 2017-03-29 Locate Therapeutics Ltd Tissue scaffold and scaffold composition
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
US11629332B2 (en) 2017-03-31 2023-04-18 Terumo Bct, Inc. Cell expansion
US11040170B2 (en) 2017-05-25 2021-06-22 Tepha, Inc. Continuous formation of tubes of poly-4-hydroxybutyrate and copolymers thereof
EP3678715A1 (de) 2017-09-06 2020-07-15 Tepha, Inc. Kalandrierte chirurgische netze mit polyhydroxyalkanoaten
US11419947B2 (en) 2017-10-30 2022-08-23 Massachusetts Institute Of Technology Layer-by-layer nanoparticles for cytokine therapy in cancer treatment
WO2019094702A1 (en) 2017-11-10 2019-05-16 Cocoon Biotech Inc. Ocular applications of silk-based products
EP3720514B1 (de) 2017-12-04 2022-04-13 Tepha, Inc. Vakuummembran-thermogeformte medizinische poly-4-hydroxybutyrat-implantate
WO2019241227A2 (en) 2018-06-11 2019-12-19 Tepha, Inc. Methods for 3d printing of poly-4-hydroxybutyrate and copolymers
ES2956815T3 (es) 2018-10-29 2023-12-28 Tepha Inc Procedimientos de fabricación de suturas de malla a partir de poli-4-hidroxibutirato y sus copolímeros
AU2020288624A1 (en) 2019-06-04 2022-02-03 Cocoon Biotech Inc. Silk-based products, formulations, and methods of use
FR3109290A1 (fr) 2020-04-17 2021-10-22 Ph Tech Dispositif médical comprenant une matrice biologique acellulaire et au moins un polymère
FR3110077A1 (fr) 2020-05-12 2021-11-19 Ph Tech Procédé de fabrication d’un dispositif médical en trois dimensions et dispositif médical obtenu
FR3113371A1 (fr) 2020-08-12 2022-02-18 Ph Tech Dispositif médical comprenant un assemblage d’éléments de matrices biologiques acellulaires et au moins un polymère
JPWO2022092014A1 (de) 2020-10-26 2022-05-05
CN112552500B (zh) * 2021-01-04 2022-12-20 珠海麦得发生物科技股份有限公司 一种去除发酵法PHAs中内毒素的方法
CN113121807B (zh) * 2021-04-07 2022-05-06 珠海麦得发生物科技股份有限公司 一种去除发酵法PHAs中内毒素的方法
WO2023181762A1 (ja) * 2022-03-22 2023-09-28 株式会社カネカ ポリヒドロキシアルカン酸水性懸濁液及びその製造方法

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0145233B2 (de) 1983-11-23 1991-11-06 Imperial Chemical Industries Plc Trennungsverfahrenfür ein 3-hydroxybutyrat-Polymer
US4648978A (en) 1985-04-24 1987-03-10 American Sterilizer Company Process for the continuous preparation of sterile, depyrogenated solutions
US4711241A (en) 1986-09-05 1987-12-08 American Cyanamid Company Surgical filament coating
US5032638A (en) * 1986-09-05 1991-07-16 American Cyanamid Company Bioabsorbable coating for a surgical device
NL8603073A (nl) 1986-12-02 1988-07-01 Rijksuniversiteit Werkwijze voor het bereiden van polyesters door fermentatie; werkwijze voor het bereiden van optisch actieve carbonzuren en esters; polyester omvattende voortbrengselen.
US5245023A (en) 1987-06-29 1993-09-14 Massachusetts Institute Of Technology Method for producing novel polyester biopolymers
US5229279A (en) 1987-06-29 1993-07-20 Massachusetts Institute Of Technology Method for producing novel polyester biopolymers
US5480794A (en) 1987-06-29 1996-01-02 Massachusetts Institute Of Technology And Metabolix, Inc. Overproduction and purification of soluble PHA synthase
US5250430A (en) 1987-06-29 1993-10-05 Massachusetts Institute Of Technology Polyhydroxyalkanoate polymerase
SE8802414D0 (sv) 1988-06-27 1988-06-28 Astra Meditec Ab Nytt kirurgiskt material
US5026381A (en) 1989-04-20 1991-06-25 Colla-Tec, Incorporated Multi-layered, semi-permeable conduit for nerve regeneration comprised of type 1 collagen, its method of manufacture and a method of nerve regeneration using said conduit
IT1247157B (it) 1991-02-11 1994-12-12 Fidia Spa Canali di guida biodegradabili e bioassorbibili da impiegare per la rigenerazione nervosa.
DE69229261T2 (de) 1991-09-27 1999-11-04 Terumo Corp Flexibles teil zur medizinischen verwendung
GB9307674D0 (en) 1993-04-14 1993-06-02 Zeneca Ltd Production of plastics materials from microorganisms
JP3243334B2 (ja) * 1993-06-10 2002-01-07 テルモ株式会社 ヒドロキシアルカノエート重合体組成物
JPH07275344A (ja) 1994-04-05 1995-10-24 Nippon Zeon Co Ltd 軟組織用医療用材料
US5584885A (en) 1994-04-28 1996-12-17 Seckel; Brooke R. Nerve regeneration chamber
NL9401037A (nl) * 1994-06-23 1996-02-01 Soonn Stichting Onderzoek En O Werkwijze voor het bereiden van een biologisch afbreekbare polyhydroxyalkanoaat coating met behulp van een waterige dispersie van polyhydroxyalkanoaat.
US5563239A (en) 1994-11-09 1996-10-08 Eastman Chemical Company Composition and process for the production of poly(3-hydroxyalkanoates)
US5688900A (en) * 1995-01-19 1997-11-18 Ethicon, Inc. Absorbable polyalkylene diglycolates
ATE179757T1 (de) * 1995-02-09 1999-05-15 Monsanto Co Polyhydroxyalkanoatelatex
US5723010A (en) * 1995-03-31 1998-03-03 Toyo Boseki Kabushiki Kaisha Medical device and method for producing the same
AU3406495A (en) 1995-08-14 1997-03-12 University Of Massachusetts Medical Center Methods of controlling microbial polyester structure
US5842477A (en) * 1996-02-21 1998-12-01 Advanced Tissue Sciences, Inc. Method for repairing cartilage
EP0977882B1 (de) 1997-04-21 2007-06-13 Metabolix, Inc. Endstellige hydroxyl aufweisende polyhydroxyalkanoate
US6610764B1 (en) 1997-05-12 2003-08-26 Metabolix, Inc. Polyhydroxyalkanoate compositions having controlled degradation rates
PT981381E (pt) 1997-05-12 2007-04-30 Metabolix Inc Poli-hidroxialcanoatos para aplicações in vivo
US6420273B1 (en) 1997-06-30 2002-07-16 Koninklijke Philips Electronics N.V. Self-aligned etch-stop layer formation for semiconductor devices
EP1042388B1 (de) 1997-12-22 2006-11-15 Metabolix, Inc. Polyhydroxyalkanoatzusammensetzungen mit kontrollierten abbaugeschwindigkeiten
EP1070135B1 (de) 1998-04-08 2010-02-24 Metabolix, Inc. Verfahren für die trennung und reinigung von biopolymeren
US7025980B1 (en) 1999-09-14 2006-04-11 Tepha, Inc. Polyhydroxyalkanoate compositions for soft tissue repair, augmentation, and viscosupplementation
JP2007165558A (ja) 2005-12-13 2007-06-28 Matsushita Electric Ind Co Ltd 半導体装置およびその製造方法
US20070296052A1 (en) 2006-06-26 2007-12-27 Taiwan Semiconductor Manufacturing Company, Ltd. Methods of forming silicide regions and resulting MOS devices

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US7906135B2 (en) 2011-03-15
US20110135707A1 (en) 2011-06-09
DK0981381T3 (da) 2007-06-04
US20040053381A1 (en) 2004-03-18
US8231889B2 (en) 2012-07-31
WO1998051812A2 (en) 1998-11-19
DE69837141T2 (de) 2007-10-31
AU7486798A (en) 1998-12-08
WO1998051812A3 (en) 1999-02-11
EP0981381B1 (de) 2007-02-21
ATE354600T1 (de) 2007-03-15
US20120328523A1 (en) 2012-12-27
US8771720B2 (en) 2014-07-08
US7244442B2 (en) 2007-07-17
US20010009769A1 (en) 2001-07-26
US6623749B2 (en) 2003-09-23
US6245537B1 (en) 2001-06-12
EP0981381A2 (de) 2000-03-01
ES2285770T3 (es) 2007-11-16
US20070280899A1 (en) 2007-12-06
PT981381E (pt) 2007-04-30

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Inventor name: WILLIAMS, SIMON, F., SHERBORN, MA 01770, US

Inventor name: MARTIN, DAVID, P., ARLINGTON, MA 02174, US

Inventor name: GERNGROSS, TILLMAN, CAMBRIDGE, MA 02139, US

Inventor name: HOROWITZ, DANIEL, M., SOMERVILLE, MA 02143, US

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