DE69837151D1 - Verfahren zur erkennung von transplantabstossungen - Google Patents
Verfahren zur erkennung von transplantabstossungenInfo
- Publication number
- DE69837151D1 DE69837151D1 DE69837151T DE69837151T DE69837151D1 DE 69837151 D1 DE69837151 D1 DE 69837151D1 DE 69837151 T DE69837151 T DE 69837151T DE 69837151 T DE69837151 T DE 69837151T DE 69837151 D1 DE69837151 D1 DE 69837151D1
- Authority
- DE
- Germany
- Prior art keywords
- methods
- discharges
- transplant rejection
- detecting transplant
- evaluating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/24—Immunology or allergic disorders
- G01N2800/245—Transplantation related diseases, e.g. graft versus host disease
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US937063 | 1997-09-24 | ||
| US08/937,063 US6187534B1 (en) | 1997-09-24 | 1997-09-24 | Methods of evaluating transplant rejection |
| PCT/US1998/019549 WO1999015700A1 (en) | 1997-09-24 | 1998-09-22 | Methods of evaluating transplant rejection |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69837151D1 true DE69837151D1 (de) | 2007-04-05 |
| DE69837151T2 DE69837151T2 (de) | 2008-01-03 |
Family
ID=25469437
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69837151T Expired - Lifetime DE69837151T2 (de) | 1997-09-24 | 1998-09-22 | Verfahren zur erkennung von transplantabstossungen |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6187534B1 (de) |
| EP (1) | EP1015639B1 (de) |
| JP (1) | JP2001517459A (de) |
| AT (1) | ATE354674T1 (de) |
| AU (1) | AU9493198A (de) |
| CA (1) | CA2304159C (de) |
| DE (1) | DE69837151T2 (de) |
| ES (1) | ES2280103T3 (de) |
| HK (1) | HK1029143A1 (de) |
| WO (1) | WO1999015700A1 (de) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030104371A1 (en) * | 1997-09-24 | 2003-06-05 | Strom Terry B. | Methods of evaluating transplant rejection |
| US6187534B1 (en) | 1997-09-24 | 2001-02-13 | Cornell Research Foundation, Inc. | Methods of evaluating transplant rejection |
| US20070082356A1 (en) * | 1997-09-24 | 2007-04-12 | Cornell Research Foundation Inc., a New York, NY corporation | Methods of evaluating transplant rejection |
| US6465215B1 (en) | 1999-12-14 | 2002-10-15 | Reneuron Limited | Identification of cells for transplantation |
| GB9925210D0 (en) * | 1999-10-25 | 1999-12-22 | Reneuron Ltd | Identification of cells for transplantation |
| US6900015B2 (en) * | 2000-04-24 | 2005-05-31 | Beth Israel Deaconess Medical Center, Inc. | Measurement of protective genes in allograft rejection |
| EP1170589A1 (de) * | 2000-06-05 | 2002-01-09 | Stichting Sanquin Bloedvoorziening | Verfahren zur Histokompatibilitätsuntersuchung |
| NZ525336A (en) * | 2000-10-20 | 2006-03-31 | Expression Diagnostics Inc | Leukocyte expression profiling |
| US6905827B2 (en) * | 2001-06-08 | 2005-06-14 | Expression Diagnostics, Inc. | Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases |
| US7026121B1 (en) * | 2001-06-08 | 2006-04-11 | Expression Diagnostics, Inc. | Methods and compositions for diagnosing and monitoring transplant rejection |
| US7235358B2 (en) * | 2001-06-08 | 2007-06-26 | Expression Diagnostics, Inc. | Methods and compositions for diagnosing and monitoring transplant rejection |
| WO2003027242A2 (en) * | 2001-09-24 | 2003-04-03 | Duke University | Fas ligand |
| US20030224422A1 (en) * | 2002-04-08 | 2003-12-04 | St. Jude Children's Research Hospital, Inc. | Pre-and post therapy gene expression profiling to identify drug targets |
| ATE546547T1 (de) * | 2002-08-22 | 2012-03-15 | Novartis Pharma Gmbh | Diagnose der chronischen abstossung |
| AU2003275363A1 (en) * | 2002-10-01 | 2004-04-23 | The Johns Hopkins University | Use of biomarkers for detecting acute renal transplant rejection |
| US7892745B2 (en) | 2003-04-24 | 2011-02-22 | Xdx, Inc. | Methods and compositions for diagnosing and monitoring transplant rejection |
| US20070248978A1 (en) * | 2006-04-07 | 2007-10-25 | Expression Diagnostics, Inc. | Steroid responsive nucleic acid expression and prediction of disease activity |
| US20070111210A1 (en) * | 2003-12-03 | 2007-05-17 | Marc Bigaud | Biomarkers for graft rejection |
| US8053182B2 (en) | 2004-01-30 | 2011-11-08 | The Trustees Of The University Of Pennsylvania | Predictors of transplant rejection determined by peripheral blood gene-expression profiling |
| JP2006014722A (ja) * | 2004-06-02 | 2006-01-19 | Keio Gijuku | 遺伝子マーカー及びその利用 |
| GB0419728D0 (en) * | 2004-09-06 | 2004-10-06 | Novartis Ag | Organic compounds |
| US7645575B2 (en) * | 2004-09-08 | 2010-01-12 | Xdx, Inc. | Genes useful for diagnosing and monitoring inflammation related disorders |
| WO2006075682A1 (ja) * | 2005-01-13 | 2006-07-20 | Keio University | 遺伝子マーカー及びその利用 |
| EP1885889A4 (de) * | 2005-05-11 | 2010-01-20 | Expression Diagnostics Inc | Verfahren zur überwachung des betriebsstatus von transplantaten über genlisten |
| WO2006124827A2 (en) * | 2005-05-13 | 2006-11-23 | University Of Miami | Molecular dissection of cellular responses to alloantigen or autoantigen in graft rejection and autoimmune disease |
| GB0607943D0 (en) * | 2006-04-21 | 2006-05-31 | Novartis Ag | Biomarkers for chronic transplant dysfunction |
| WO2008021431A2 (en) * | 2006-08-14 | 2008-02-21 | Xdx, Inc. | Methods and compositions for diagnosing and monitoring the status of transplant rejection and immune disorders |
| US20080131441A1 (en) | 2006-09-26 | 2008-06-05 | Manikkam Suthanthiran | Methods of Using FOXP3 Levels to Predict the Outcome of Organs Undergoing Acute Rejection |
| US8148067B2 (en) * | 2006-11-09 | 2012-04-03 | Xdx, Inc. | Methods for diagnosing and monitoring the status of systemic lupus erythematosus |
| WO2010105275A2 (en) | 2009-03-13 | 2010-09-16 | Cornell University | Method to assess human allograft status from microrna expression levels |
| US9752191B2 (en) | 2009-07-09 | 2017-09-05 | The Scripps Research Institute | Gene expression profiles associated with chronic allograft nephropathy |
| US9746479B2 (en) | 2010-03-09 | 2017-08-29 | Cornell University | Methods and compositions to predict and detect acute rejection |
| WO2014074501A1 (en) * | 2012-11-06 | 2014-05-15 | Quest Diagnostics Investments Incorporated | Molecular markers for diagnosis of acute cellular rejection and acute tubular necrosis |
| US9758828B2 (en) | 2013-01-31 | 2017-09-12 | Cornell University | Methods to detect, treat and prevent acute cellular rejection in kidney allografts |
| US9982301B2 (en) | 2014-01-07 | 2018-05-29 | Cornell University | Urine mRNA profile and acute dysfunction of kidney allograft |
| KR101501085B1 (ko) * | 2014-05-02 | 2015-03-12 | 순천향대학교 산학협력단 | 돼지 췌장의 발달단계별 차이를 나타내는 단백질을 포함하는 이종기관이식 거부반응 검출을 위한 신규한 항원 및 이를 포함하는 검출용 키트 |
| US10443100B2 (en) | 2014-05-22 | 2019-10-15 | The Scripps Research Institute | Gene expression profiles associated with sub-clinical kidney transplant rejection |
| US11104951B2 (en) | 2014-05-22 | 2021-08-31 | The Scripps Research Institute | Molecular signatures for distinguishing liver transplant rejections or injuries |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5213961A (en) | 1989-08-31 | 1993-05-25 | Brigham And Women's Hospital | Accurate quantitation of RNA and DNA by competetitive polymerase chain reaction |
| US6187534B1 (en) | 1997-09-24 | 2001-02-13 | Cornell Research Foundation, Inc. | Methods of evaluating transplant rejection |
-
1997
- 1997-09-24 US US08/937,063 patent/US6187534B1/en not_active Expired - Lifetime
-
1998
- 1998-09-22 CA CA2304159A patent/CA2304159C/en not_active Expired - Lifetime
- 1998-09-22 DE DE69837151T patent/DE69837151T2/de not_active Expired - Lifetime
- 1998-09-22 EP EP98948342A patent/EP1015639B1/de not_active Expired - Lifetime
- 1998-09-22 WO PCT/US1998/019549 patent/WO1999015700A1/en active IP Right Grant
- 1998-09-22 JP JP2000512987A patent/JP2001517459A/ja active Pending
- 1998-09-22 AU AU94931/98A patent/AU9493198A/en not_active Abandoned
- 1998-09-22 ES ES98948342T patent/ES2280103T3/es not_active Expired - Lifetime
- 1998-09-22 AT AT98948342T patent/ATE354674T1/de not_active IP Right Cessation
-
2000
- 2000-12-28 HK HK00108485A patent/HK1029143A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ATE354674T1 (de) | 2007-03-15 |
| EP1015639A1 (de) | 2000-07-05 |
| DE69837151T2 (de) | 2008-01-03 |
| US6187534B1 (en) | 2001-02-13 |
| JP2001517459A (ja) | 2001-10-09 |
| AU9493198A (en) | 1999-04-12 |
| CA2304159A1 (en) | 1999-04-01 |
| CA2304159C (en) | 2012-07-10 |
| ES2280103T3 (es) | 2007-09-01 |
| HK1029143A1 (en) | 2001-03-23 |
| WO1999015700A1 (en) | 1999-04-01 |
| EP1015639B1 (de) | 2007-02-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8332 | No legal effect for de | ||
| 8370 | Indication related to discontinuation of the patent is to be deleted | ||
| 8364 | No opposition during term of opposition |