DE69838789D1 - Verfahren zur behandlung oder prävention der alzheimerischen krankheit - Google Patents
Verfahren zur behandlung oder prävention der alzheimerischen krankheitInfo
- Publication number
- DE69838789D1 DE69838789D1 DE69838789T DE69838789T DE69838789D1 DE 69838789 D1 DE69838789 D1 DE 69838789D1 DE 69838789 T DE69838789 T DE 69838789T DE 69838789 T DE69838789 T DE 69838789T DE 69838789 D1 DE69838789 D1 DE 69838789D1
- Authority
- DE
- Germany
- Prior art keywords
- disease
- treating
- preventing alzheimer
- alzheimer
- preventing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/30—Insulin-like growth factors (Somatomedins), e.g. IGF-1, IGF-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/48—Ergoline derivatives, e.g. lysergic acid, ergotamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Neurosurgery (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Hospice & Palliative Care (AREA)
- Emergency Medicine (AREA)
- Psychiatry (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3960797P | 1997-03-12 | 1997-03-12 | |
US39607P | 1997-03-12 | ||
PCT/US1998/004731 WO1998039967A1 (en) | 1997-03-12 | 1998-03-12 | A method for treating or preventing alzheimer's disease |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69838789D1 true DE69838789D1 (de) | 2008-01-10 |
DE69838789T2 DE69838789T2 (de) | 2008-10-30 |
Family
ID=21906390
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69838789T Expired - Lifetime DE69838789T2 (de) | 1997-03-12 | 1998-03-12 | Verfahren zur behandlung oder prävention der alzheimerischen krankheit |
Country Status (6)
Country | Link |
---|---|
US (3) | US7300927B2 (de) |
EP (1) | EP1006794B1 (de) |
JP (2) | JP2001514663A (de) |
CA (1) | CA2323889A1 (de) |
DE (1) | DE69838789T2 (de) |
WO (1) | WO1998039967A1 (de) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2001514663A (ja) * | 1997-03-12 | 2001-09-11 | エスモンド,ロバート ダブリュー. | アルツハイマー病を処置または予防するための方法 |
ES2257824T3 (es) * | 1998-01-28 | 2006-08-01 | Warner-Lambert Company Llc | Metodo para tratar la enfermedad de alzheimer. |
US6191154B1 (en) | 1998-11-27 | 2001-02-20 | Case Western Reserve University | Compositions and methods for the treatment of Alzheimer's disease, central nervous system injury, and inflammatory diseases |
WO2000043006A1 (fr) * | 1999-01-19 | 2000-07-27 | Sankyo Company, Limited | Inhibiteur de la mort des cellules nerveuses imputable à la cytotoxicité de l'acide glutamique |
US20070179197A1 (en) * | 2000-05-01 | 2007-08-02 | Accera, Inc. | Compositions and methods for improving or preserving brain function |
EP1292294B1 (de) | 2000-05-01 | 2009-03-18 | Accera, Inc. | Verwendung von triglyceriden mit mittellangen ketten zur behandlung und vorbeugung der alzheimerschen erkrankung |
US8124589B2 (en) * | 2000-05-01 | 2012-02-28 | Accera, Inc. | Use of ketogenic compounds for treatment of age-associated memory impairment |
US6835750B1 (en) | 2000-05-01 | 2004-12-28 | Accera, Inc. | Use of medium chain triglycerides for the treatment and prevention of alzheimer's disease and other diseases resulting from reduced neuronal metabolism II |
US6770797B2 (en) | 2001-06-01 | 2004-08-03 | Rhode Island Hospital | Non-Transgenic nonhuman model for Alzheimer's Disease using a AD7c-NTP nucleic acid |
JP2004043443A (ja) * | 2002-05-14 | 2004-02-12 | Kumamoto Technology & Industry Foundation | アミロイドーシスの予防及び治療のための医薬 |
CN100457122C (zh) * | 2002-05-14 | 2009-02-04 | 尼普洛株式会社 | 包含三价铬离子的化合物在制备用于预防和/或治疗淀粉样变性的药物的应用 |
JP2006508952A (ja) * | 2002-11-12 | 2006-03-16 | ロレアル | 皮膚をマット(つや消し)にするセルロースマイクロビーズの使用 |
EP1605950A4 (de) * | 2003-03-06 | 2008-01-09 | Accera Inc | Neue chemische stoffe und verfahren zu ihrer verwendung bei der behandlung von stoffwechselstörungen |
WO2005110468A2 (en) * | 2004-05-10 | 2005-11-24 | The Burnham Institute | Treatment of insulin resistance/metabolic syndrome to alleviate the risks of dementia |
US7833513B2 (en) * | 2004-12-03 | 2010-11-16 | Rhode Island Hospital | Treatment of Alzheimer's Disease |
US8114847B2 (en) | 2005-03-16 | 2012-02-14 | Case Western Reserve University | Selective inhibitors of translesion DNA replication |
WO2008147454A1 (en) | 2006-11-16 | 2008-12-04 | Case Western Reserve University | Selective inhibitors of translesion dna replication |
US20060252775A1 (en) * | 2005-05-03 | 2006-11-09 | Henderson Samuel T | Methods for reducing levels of disease associated proteins |
EP2468273A3 (de) * | 2005-06-20 | 2012-07-11 | Accera, Inc. | Verfahren zur Reduzierung von oxidativer Schädigung und zur Verbesserung der mitochondrialen Effizienz |
ES2556534T3 (es) | 2007-07-31 | 2016-01-18 | Accera, Inc. | Uso de ensayo genómico y compuestos cetogénicos para tratamiento de una función cognitiva reducida |
US20090216178A1 (en) * | 2008-02-26 | 2009-08-27 | Lee Susan J | Method And Apparatus For Preventing Localized Stasis Of Cerebrospinal Fluid |
EP2303036A1 (de) * | 2008-07-03 | 2011-04-06 | Accera, Inc. | Acetoacetat-monoglyzeride und derivate zur behandlung neurologischer erkrankungen |
US8105809B2 (en) * | 2008-07-03 | 2012-01-31 | Accera, Inc. | Enzymatic synthesis of acetoacetate esters and derivatives |
CN102177436B (zh) * | 2008-08-12 | 2015-05-13 | 金帆德尔制药股份有限公司 | 鉴定疾病风险因子的方法 |
US8846315B2 (en) | 2008-08-12 | 2014-09-30 | Zinfandel Pharmaceuticals, Inc. | Disease risk factors and methods of use |
PL2448412T3 (pl) * | 2009-07-01 | 2019-11-29 | Jds Therapeutics Llc | Kompleksy chromu jako środki podnoszące poziom transporterów glukozy w mózgu |
EP3106165B1 (de) | 2011-01-10 | 2019-02-27 | Zinfandel Pharmaceuticals, Inc. | Verfahren und arzneimittelprodukte zur behandlung von morbus alzheimer |
US9988680B2 (en) | 2011-09-01 | 2018-06-05 | Case Western Reserve University | Non-natural nucleosides as theranostic agents |
US9821173B2 (en) | 2013-02-08 | 2017-11-21 | Case Western Reserve University | Anti-cancer agents and methods of use |
KR101642042B1 (ko) * | 2013-10-24 | 2016-07-22 | 건국대학교 글로컬산학협력단 | 티아졸리딘디온의 p35 및 p25 활성 변화에 대한 용도 |
MX2018009748A (es) | 2016-02-11 | 2019-02-07 | Nutrition 21 Llc | Composiciones que contienen cromo para mejorar la salud y el estado físico. |
CN110944639A (zh) * | 2017-06-28 | 2020-03-31 | 国立大学法人京都大学 | 用于预防和/或治疗阿尔茨海默病的药剂 |
Family Cites Families (94)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5522636A (en) | 1978-08-04 | 1980-02-18 | Takeda Chem Ind Ltd | Thiazoliding derivative |
JPS5697277A (en) | 1980-01-07 | 1981-08-05 | Takeda Chem Ind Ltd | Thiazolidine derivative |
US5039665A (en) | 1980-07-21 | 1991-08-13 | Markov Angel K | Use of fructose-1,6-diphosphate for treating myocardial infarction |
US4546095A (en) | 1980-07-21 | 1985-10-08 | Markov Angel K | Use of fructose-1,6-diphosphate for treating myocardial infarction |
US4873191A (en) | 1981-06-12 | 1989-10-10 | Ohio University | Genetic transformation of zygotes |
JPS58118577A (ja) | 1982-01-07 | 1983-07-14 | Takeda Chem Ind Ltd | チアゾリジン誘導体 |
US4540564A (en) | 1982-05-18 | 1985-09-10 | University Of Florida | Brain-specific drug delivery |
US4757052A (en) | 1982-09-03 | 1988-07-12 | Markov Angel K | Method of preserving blood |
US4775665A (en) | 1983-05-16 | 1988-10-04 | Massachusetts Institute Of Technology | Method and composition for treating neurological disorders and aging |
JPS6051189A (ja) | 1983-08-30 | 1985-03-22 | Sankyo Co Ltd | チアゾリジン誘導体およびその製造法 |
CN1003445B (zh) | 1984-10-03 | 1989-03-01 | 武田药品工业株式会社 | 噻唑烷二酮衍生物,其制备方法和用途 |
AR240698A1 (es) | 1985-01-19 | 1990-09-28 | Takeda Chemical Industries Ltd | Procedimiento para preparar compuestos de 5-(4-(2-(5-etil-2-piridil)-etoxi)benzil)-2,4-tiazolidindiona y sus sales |
US4683195A (en) * | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
US4965188A (en) | 1986-08-22 | 1990-10-23 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme |
US4683202A (en) * | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
US4703040A (en) | 1985-04-03 | 1987-10-27 | Markov Angel K | Treatment of adult respiratory distress syndrome (ARDS) using fructose diphosphate (FDP) |
US4703052A (en) | 1985-05-21 | 1987-10-27 | Pfizer Inc. | Hypoglycemic thiazolidinediones |
US5039794A (en) | 1986-09-19 | 1991-08-13 | Otsuka Pharmaceutical Co., Ltd. | Tumor egress factor and processes for producing the same |
US4873255A (en) | 1987-02-04 | 1989-10-10 | Sankyo Company Limited | Thiazolidinone derivatives, their preparation and their use |
FI91869C (fi) | 1987-03-18 | 1994-08-25 | Tanabe Seiyaku Co | Menetelmä antidiabeettisena aineena käytettävien bensoksatsolijohdannaisten valmistamiseksi |
NL8800823A (nl) * | 1987-04-10 | 1988-11-01 | Sandoz Ag | Werkwijze voor het toepassen van dopamine-receptor agonisten en farmaceutische preparaten die deze agonisten bevatten. |
EP0295828A1 (de) | 1987-06-13 | 1988-12-21 | Beecham Group Plc | Chemische Verbindungen |
US5232925A (en) | 1987-09-04 | 1993-08-03 | Beecham Group P.L.C. | Compounds |
EP0842925A1 (de) | 1987-09-04 | 1998-05-20 | Beecham Group Plc | Substituierte Thiazolidindionderivate |
US5260445A (en) | 1987-09-04 | 1993-11-09 | Beecham Group P.L.C. | 2,4-thiazolidinediones |
US5194443A (en) | 1987-09-04 | 1993-03-16 | Beecham Group P.L.C. | Compounds |
US4980350A (en) | 1988-02-25 | 1990-12-25 | Merck & Co., Inc. | Piperazinylalkylpyrimidines as hypoglycemic agents |
MX15171A (es) | 1988-03-08 | 1993-05-01 | Pfizer | Derivados de tiazolidinodiona hipoglicemicos |
US5223522A (en) | 1988-03-08 | 1993-06-29 | Pfizer Inc. | Thiazolidinedione hypoglycemic agents |
WO1989008650A1 (en) | 1988-03-08 | 1989-09-21 | Pfizer Inc. | Thiazolidinedione hypoglycemic agents |
US5120754A (en) | 1988-03-08 | 1992-06-09 | Pfizer Inc. | Thiazolidinedione hypoglycemic agents |
US5468755A (en) | 1988-05-10 | 1995-11-21 | The Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Therapeutic process for the treatment of the pathologies of Type II diabetes |
US5208250A (en) | 1988-05-25 | 1993-05-04 | Warner-Lambert Company | Known and selected novel arylmethylenyl derivatives of thiazolidinones, imidazolidinones and oxazolidinones useful as antiallergy agents and anti-inflammatory agents |
US5948634A (en) | 1988-12-21 | 1999-09-07 | The General Hospital Coporation | Neural thread protein gene expression and detection of alzheimer's disease |
GB8901778D0 (en) | 1989-01-27 | 1989-03-15 | Univ Court Of The University O | Manipulatory technique |
US4897405A (en) | 1989-04-21 | 1990-01-30 | American Home Products Corporation | Novel naphthalenylalkyl-3H-1,2,3,5-oxathiadiazole 2-oxides useful as antihyperglycemic agents |
GB8919434D0 (en) | 1989-08-25 | 1989-10-11 | Beecham Group Plc | Novel compounds |
WO1991007107A1 (en) | 1989-11-13 | 1991-05-30 | Pfizer Inc. | Oxazolidinedione hypoglycemic agents |
US5143928A (en) | 1990-03-27 | 1992-09-01 | Warner-Lambert Company | 3,5-di-tertiarybutyl-4-hydroxyphenylmethylene derivatives of 2-substituted thiazolidinones, oxazolidinones, and imidazolidinones as antiinflammatory agents |
HU214872B (hu) | 1990-04-27 | 1998-07-28 | Orion-Yhtymä Oy | Eljárás farmakológiailag aktív új katecholszármazékok és ezeket tartalmazó gyógyászati készítmények előállítására |
GB9017218D0 (en) | 1990-08-06 | 1990-09-19 | Beecham Group Plc | Novel compounds |
HUT70153A (en) | 1990-08-23 | 1995-09-28 | Pfizer | Hypoglycemic hydroxyurea derivatives |
US5364769A (en) | 1990-09-25 | 1994-11-15 | Genentech, Inc. | Nucleic acid encoding neurotrophic factor four (NT-4), vectors, host cells and methods of production |
US5668117A (en) * | 1991-02-22 | 1997-09-16 | Shapiro; Howard K. | Methods of treating neurological diseases and etiologically related symptomology using carbonyl trapping agents in combination with previously known medicaments |
US6746678B1 (en) * | 1991-02-22 | 2004-06-08 | Howard K. Shapiro | Method of treating neurological diseases and etiologically related symptomology using carbonyl trapping agents in combination with medicaments |
US5192753A (en) | 1991-04-23 | 1993-03-09 | Mcgeer Patrick L | Anti-rheumatoid arthritic drugs in the treatment of dementia |
US5143929A (en) | 1991-05-09 | 1992-09-01 | Warner-Lambert Company | 2-substituted thiazolidinone, oxazolidinone, and imidazolidinone derivatives of fenamates as antiinflammatory agents |
US5164384A (en) | 1991-06-19 | 1992-11-17 | Metagenics, Inc. | Anabolic mineral formula |
US5714470A (en) | 1991-08-22 | 1998-02-03 | Merrell Pharmaceuticals, Inc. | Orally-active elastase inhibitors |
US5270319A (en) | 1991-09-09 | 1993-12-14 | Warner-Lambert Company | 5-hydroxy-2-pyrimidinylmethylene derivatives useful as antiinflammatory agents |
US5256697A (en) | 1992-04-16 | 1993-10-26 | Abbott Laboratories | Method of administering pyruvate and methods of synthesizing pyruvate precursors |
US5326770A (en) | 1992-07-17 | 1994-07-05 | The Du Pont Merck Pharmaceutical Company | Monoamine oxidase-B (MAO-B) inhibitory 5-substituted 2,4-thiazolidinediones useful in treating memory disorders of mammals |
IT1260155B (it) | 1992-08-03 | 1996-03-28 | Fidia Spa | Uso terapeutico della fosforil-l-serina-n-acil-sfingosina |
GB2269992A (en) | 1992-08-14 | 1994-03-02 | Rh Ne Poulenc Rorer Limited | Powder inhalation formulations |
ZA936492B (en) | 1992-09-10 | 1995-03-02 | Lilly Co Eli | Compounds useful as hypoglycemic agents and for treating Alzheimer's disease. |
US5543297A (en) | 1992-12-22 | 1996-08-06 | Merck Frosst Canada, Inc. | Human cyclooxygenase-2 cDNA and assays for evaluating cyclooxygenase-2 activity |
CA2132871A1 (en) | 1993-01-25 | 1994-08-04 | Alan C. Moses | Method for modifying, diagnosing, and screening for igf-i sensitive cell barrier properties |
PT690863E (pt) | 1993-04-06 | 2003-07-31 | Abbott Lab | Compostos tetraciclicos como agonistas da dopamina |
PT1564293E (pt) | 1993-04-20 | 2008-12-02 | Gen Hospital Corp | Expressão génica de proteínas de filamento neural e detecção de doença de alzheimer |
US5360614A (en) | 1993-04-26 | 1994-11-01 | The Estee Corporation | Method of controlling the release of carbohydrates by encapsulation and composition therefor |
US5478852C1 (en) | 1993-09-15 | 2001-03-13 | Sankyo Co | Use of thiazolidinedione derivatives and related antihyperglycemic agents in the treatment of impaired glucose tolerance in order to prevent or delay the onset of noninsulin-dependent diabetes mellitus |
US5395822A (en) | 1993-09-20 | 1995-03-07 | Izumi; Yukitoshi | Use of pyruvate to prevent neuronal degeneration associated with ischemia |
WO1995013823A1 (en) * | 1993-11-15 | 1995-05-26 | Celtrix Pharmaceuticals, Inc. | Method of treating neurological disorders |
JPH09511492A (ja) | 1994-02-03 | 1997-11-18 | ザ ピコワー インスティテュート フォア メディカル リサーチ | アミロイドーシスの前進性グリコシル化終末産物仲介モジュレーション用組成物及び方法 |
JPH07238035A (ja) * | 1994-02-28 | 1995-09-12 | Kyowa Hakko Kogyo Co Ltd | βアミロイド蛋白質分解剤 |
US6251928B1 (en) * | 1994-03-16 | 2001-06-26 | Eli Lilly And Company | Treatment of alzheimer's disease employing inhibitors of cathepsin D |
US5534615A (en) | 1994-04-25 | 1996-07-09 | Genentech, Inc. | Cardiac hypertrophy factor and uses therefor |
US5594015A (en) | 1994-06-22 | 1997-01-14 | Regents Of The University Of California | Thiazolidine derivatives for the treatment of psoriasis |
JPH10503105A (ja) | 1994-07-22 | 1998-03-24 | ユニバーシティ オブ ワシントン | 定位固定移植方法 |
US5483070A (en) * | 1994-08-02 | 1996-01-09 | Packard Instrument Company | Scintillation counter |
US5607967A (en) | 1994-10-27 | 1997-03-04 | Merck & Co., Inc. | Treatment of alzheimer's disease with 5-(tetradecyloxy)-2-furan carboxylic acid |
US5641796A (en) | 1994-11-01 | 1997-06-24 | Eli Lilly And Company | Oral hypoglycemic agents |
US5602121A (en) | 1994-12-12 | 1997-02-11 | Allelix Biopharmaceuticals, Inc. | Alkyl-substituted compounds having dopamine receptor affinity |
US5602120A (en) | 1994-12-12 | 1997-02-11 | Allelix Biopharmaceuticals, Inc. | Benzyl-substituted compounds having dopamine receptor affinity |
US5824692A (en) | 1995-01-06 | 1998-10-20 | Lippiello; Patrick Michael | Pharmaceutical compositions for prevention and treatment of central nervous system disorders |
US6022897A (en) | 1995-04-25 | 2000-02-08 | The Salk Institute For Biological Studies | Selective modulators of peroxisome proliferator activated receptor-gamma, and methods for the use thereof |
US5708012A (en) * | 1995-04-28 | 1998-01-13 | Sankyo Company, Limited | Use of thiazolidinedione derivatives and related antihyperglycemic agents in the treatment of insulin resistant subjects with normal glucose tolerance in order to prevent or delay the onset of noninsulin-dependent mellitus |
US5707971A (en) | 1995-06-07 | 1998-01-13 | Life Resuscitation Technologies, Inc. | Modulation of glycolytic ATP production |
US5618835A (en) | 1996-02-01 | 1997-04-08 | The Procter & Gamble Company | Dihydrobenzofuran and related compounds useful as anti-inflammatory agents |
IN182496B (de) | 1996-02-20 | 1999-04-17 | Reddy Research Foundation | |
GB9604242D0 (en) | 1996-02-28 | 1996-05-01 | Glaxo Wellcome Inc | Chemical compounds |
US5783556A (en) | 1996-08-13 | 1998-07-21 | Genentech, Inc. | Formulated insulin-containing composition |
GB9627006D0 (en) | 1996-12-27 | 1997-02-12 | Knoll Ag | Therapeutic agents |
GB9627005D0 (en) | 1996-12-27 | 1997-02-12 | Knoll Ag | Therapeutic agents |
US6025157A (en) | 1997-02-18 | 2000-02-15 | Genentech, Inc. | Neurturin receptor |
US5814647A (en) | 1997-03-04 | 1998-09-29 | Board Of Regents, The University Of Texas System | Use of troglitazone and related compounds for the treatment of the climacteric symptoms |
JP2001514663A (ja) * | 1997-03-12 | 2001-09-11 | エスモンド,ロバート ダブリュー. | アルツハイマー病を処置または予防するための方法 |
AU6959898A (en) | 1997-04-11 | 1998-11-11 | David J. Grainger | Compounds and therapies for the prevention of vascular and non-vascular pathol ogies |
US5925657A (en) | 1997-06-18 | 1999-07-20 | The General Hospital Corporation | Use of PPARγ agonists for inhibition of inflammatory cytokine production |
US5789401A (en) * | 1997-08-08 | 1998-08-04 | Nutrition 21 | High-dose chromium/biotin treatment of type II diabetes |
ATE325607T1 (de) | 1997-11-19 | 2006-06-15 | Takeda Pharmaceutical | Aptoptoseinhibitoren |
US20040058873A1 (en) * | 1998-03-12 | 2004-03-25 | Esmond Robert W. | Method for treating or preventing Alzheimer's disease |
US6028088A (en) | 1998-10-30 | 2000-02-22 | The University Of Mississippi | Flavonoid derivatives |
US6191154B1 (en) | 1998-11-27 | 2001-02-20 | Case Western Reserve University | Compositions and methods for the treatment of Alzheimer's disease, central nervous system injury, and inflammatory diseases |
-
1998
- 1998-03-12 JP JP53974498A patent/JP2001514663A/ja active Pending
- 1998-03-12 DE DE69838789T patent/DE69838789T2/de not_active Expired - Lifetime
- 1998-03-12 WO PCT/US1998/004731 patent/WO1998039967A1/en active IP Right Grant
- 1998-03-12 EP EP98909105A patent/EP1006794B1/de not_active Expired - Lifetime
- 1998-03-12 CA CA002323889A patent/CA2323889A1/en not_active Abandoned
-
2003
- 2003-09-23 US US10/669,217 patent/US7300927B2/en not_active Expired - Fee Related
-
2004
- 2004-09-09 US US10/936,709 patent/US20050043242A1/en not_active Abandoned
-
2009
- 2009-06-23 JP JP2009148356A patent/JP2009280586A/ja active Pending
- 2009-07-20 US US12/505,868 patent/US20090280192A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
DE69838789T2 (de) | 2008-10-30 |
EP1006794A1 (de) | 2000-06-14 |
JP2001514663A (ja) | 2001-09-11 |
US20050043242A1 (en) | 2005-02-24 |
JP2009280586A (ja) | 2009-12-03 |
US20090280192A1 (en) | 2009-11-12 |
WO1998039967A1 (en) | 1998-09-17 |
EP1006794A4 (de) | 2004-07-07 |
EP1006794B1 (de) | 2007-11-28 |
US20040060077A1 (en) | 2004-03-25 |
CA2323889A1 (en) | 1998-09-17 |
US7300927B2 (en) | 2007-11-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69838789D1 (de) | Verfahren zur behandlung oder prävention der alzheimerischen krankheit | |
DE69806970T2 (de) | Verfahren zur behandlung von hartgeweben | |
DE69227380T2 (de) | Verfahren zur bestimmung und behandlung von alzheimer-krankheit | |
DE69821913D1 (de) | Verfahren zur behandlung der hautpigmentierung | |
DE696923T1 (de) | Verfahren zur behandlung endo-ostealer materialen | |
ATE282591T1 (de) | Thioharnstoffverbindungen, zusammensetzungen sowie verfahren zur behandlung oder verhütung von entzündlichen erkrankungen und atherosklerose | |
DE69507500T3 (de) | Verfahren zur behandlung von kunststoffgiessformen | |
ATE225185T1 (de) | Verfahren zur behandlung von allergischem asthma | |
DE69807868T2 (de) | Verfahren zur behandlung von abwasserstroemen | |
DE69714828D1 (de) | Verfahren zur Behandlung von Abfallstoffen | |
KR970704445A (ko) | 페노티아진 및/또는 티옥산틴을 사용한 알츠하이머 병의 치료 및/또는 예방 방법(methods for treating and/or preventing alzheimer's disease using phenothiazines and/or thioxanthenes | |
ATE257189T1 (de) | Verfahren zur behandlung von cellulosischen formkörpern | |
DE69526796D1 (de) | Verfahren zur inhibierung von pflanzenkrankheiten | |
DE69912254D1 (de) | Kosmetisches verfahren zur hautbehandlung | |
ATE371453T1 (de) | Verfahren zur behandlung von okularen neovaskularen erkrankungen | |
DE69626311T2 (de) | Zusammensetzung zur behandlung von wäsche sowie verfahren hierfür | |
DE69607559T2 (de) | Verfahren zur Behandlung von Phenolteer | |
DE69609082D1 (de) | Verfahren zur behandlung von abfällen | |
DE69307803T2 (de) | Verfahren zur elektrolytischen Behandlung | |
DE69802904T2 (de) | Verbessertes verfahren zur behandlung von aluminiummonohydratreichen bauxiten | |
DE69701726D1 (de) | Verfahren zur behandlung von knitterempfindlichen geweben | |
DE69006509T2 (de) | Verfahren zur behandlung von häuten. | |
DE69533397D1 (de) | Verfahren zur behandlung von hypertonie | |
DE69900699D1 (de) | Verfahren zur Behandlung von Schutzhüllen | |
ATA17272000A (de) | Verfahren zur behandlung von dämpfen |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |