DE69838811D1 - Verfahren zur darstellung von abgestorbenen zellen in-vivo - Google Patents
Verfahren zur darstellung von abgestorbenen zellen in-vivoInfo
- Publication number
- DE69838811D1 DE69838811D1 DE69838811T DE69838811T DE69838811D1 DE 69838811 D1 DE69838811 D1 DE 69838811D1 DE 69838811 T DE69838811 T DE 69838811T DE 69838811 T DE69838811 T DE 69838811T DE 69838811 D1 DE69838811 D1 DE 69838811D1
- Authority
- DE
- Germany
- Prior art keywords
- vivo
- deadly
- leaved
- displaying
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
- A61B6/02—Devices for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
- A61B6/03—Computerised tomographs
- A61B6/037—Emission tomography
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
- A61B6/40—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment with arrangements for generating radiation specially adapted for radiation diagnosis
- A61B6/4057—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment with arrangements for generating radiation specially adapted for radiation diagnosis by using radiation sources located in the interior of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
- A61B6/42—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment with arrangements for detecting radiation specially adapted for radiation diagnosis
- A61B6/4208—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment with arrangements for detecting radiation specially adapted for radiation diagnosis characterised by using a particular type of detector
- A61B6/425—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment with arrangements for detecting radiation specially adapted for radiation diagnosis characterised by using a particular type of detector using detectors specially adapted to be used in the interior of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
- A61B6/42—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment with arrangements for detecting radiation specially adapted for radiation diagnosis
- A61B6/4208—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment with arrangements for detecting radiation specially adapted for radiation diagnosis characterised by using a particular type of detector
- A61B6/4258—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment with arrangements for detecting radiation specially adapted for radiation diagnosis characterised by using a particular type of detector for detecting non x-ray radiation, e.g. gamma radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/087—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being an annexin, e.g. annexin V
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4539997P | 1997-04-30 | 1997-04-30 | |
US45399P | 1997-04-30 | ||
PCT/US1998/008769 WO1998048699A1 (en) | 1997-04-30 | 1998-04-28 | Method of imaging cell death in vivo |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69838811D1 true DE69838811D1 (de) | 2008-01-17 |
DE69838811T2 DE69838811T2 (de) | 2008-10-30 |
Family
ID=21937648
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69838811T Expired - Lifetime DE69838811T2 (de) | 1997-04-30 | 1998-04-28 | Verfahren zur darstellung von abgestorbenen zellen in-vivo |
Country Status (16)
Country | Link |
---|---|
US (3) | US6197278B1 (de) |
EP (1) | EP1017318B1 (de) |
JP (1) | JP4963748B2 (de) |
KR (1) | KR20010020443A (de) |
CN (1) | CN1265572A (de) |
AT (1) | ATE379990T1 (de) |
AU (1) | AU754577B2 (de) |
CA (1) | CA2288131A1 (de) |
DE (1) | DE69838811T2 (de) |
ES (1) | ES2398118T3 (de) |
HU (1) | HUP0001261A3 (de) |
NZ (1) | NZ500598A (de) |
PL (1) | PL336571A1 (de) |
RU (1) | RU2228765C2 (de) |
TW (1) | TW541184B (de) |
WO (1) | WO1998048699A1 (de) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4963748B2 (ja) * | 1997-04-30 | 2012-06-27 | ザ ボード オブ トラスティーズ オブ ザ リランド スタンフォード ジュニア ユニバーシティー | 細胞死をin vivoで撮像する方法 |
US7736651B1 (en) * | 2000-11-24 | 2010-06-15 | Sloan-Kettering Institute For Cancer Research | Alpha emitting constructs and uses thereof |
US6818213B1 (en) * | 1998-07-13 | 2004-11-16 | Board Of Regents, The University Of Texas System | Cancer treatment compositions comprising therapeutic conjugates that bind to aminophospholipids |
ATE276763T1 (de) | 1998-07-13 | 2004-10-15 | Univ Texas | Verwendung von antikörper gegen aminophospholipide zur krebsbehandlung |
AU750414B2 (en) * | 1998-07-13 | 2002-07-18 | Board Of Regents, The University Of Texas System | Cancer treatment methods using therapeutic conjugates that bind to aminophospholipids |
US6406693B1 (en) | 1998-07-13 | 2002-06-18 | Board Of Regents, The University Of Texas System | Cancer treatment methods using antibodies to aminophospholipids |
US6692724B1 (en) | 1999-10-25 | 2004-02-17 | Board Of Regents, The University Of Texas System | Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging |
US7067111B1 (en) * | 1999-10-25 | 2006-06-27 | Board Of Regents, University Of Texas System | Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging |
CA2410906C (en) | 2000-06-02 | 2012-10-02 | Board Of Regents, The University Of Texas System | Ethylenedicysteine (ec)-drug conjugates |
WO2001097678A2 (en) * | 2000-06-22 | 2001-12-27 | Henry Ford Health System | Imaging and targeting tumors using sickle cells |
WO2002080754A2 (en) * | 2001-04-03 | 2002-10-17 | Theseus Imaging Corporation | Methods for using annexin for detecting cell death in vivo and treating associated conditions |
US6726895B2 (en) * | 2001-04-03 | 2004-04-27 | Board Of Trustees Of The Leland Stanford Junior University | Method of imaging cell death in vivo |
US20050013778A1 (en) * | 2001-04-03 | 2005-01-20 | Theseus Imaging Corporation | Methods and compositions for predicting the response to a therapeutic regimen in a subject having a disease associated with cell death |
EP1389090A2 (de) * | 2001-04-26 | 2004-02-18 | Board of Regents, The University of Texas System | Diagnostische bildgebende zusammensetzungen, ihre syntheseverfahren und ihre verwendung |
US20030202937A1 (en) * | 2001-06-05 | 2003-10-30 | Sabbadini Roger A. | Minicell-based diagnostics |
US20030152513A1 (en) * | 2001-09-06 | 2003-08-14 | Imetrix, Inc. | Intravascular delivery of therapeutic and imaging agents to stressed and apoptotic cells using annexin V as a targeting vector |
US7261875B2 (en) | 2001-12-21 | 2007-08-28 | Board Of Regents, The University Of Texas System | Dendritic poly (amino acid) carriers and methods of use |
US20040042959A1 (en) * | 2002-08-28 | 2004-03-04 | Michael Montalto | Imaging cell death in vivo using non-radionuclide contrast agents |
CN1723042B (zh) * | 2002-11-07 | 2010-12-01 | 得克萨斯大学体系董事会 | 乙二半胱氨酸(ec)-药物结合物、组合物及用于组织特异性疾病显像的方法 |
US20070031333A1 (en) * | 2003-01-02 | 2007-02-08 | Mease Ronnie C | Novel F-18 labeled annexin V, synthesis thereof, and use thereof |
US9050378B2 (en) * | 2003-12-10 | 2015-06-09 | Board Of Regents, The University Of Texas System | N2S2 chelate-targeting ligand conjugates |
US7511016B2 (en) * | 2004-07-07 | 2009-03-31 | Mosamedix B.V. | Annexins, derivatives thereof, and annexin-cys variants, as well as therapeutic and diagnostic uses thereof |
US7874975B2 (en) * | 2005-07-20 | 2011-01-25 | Clear Vascular, Inc. | Methods and compositions for treating luminal inflammatory disease |
US9623129B2 (en) * | 2005-09-26 | 2017-04-18 | Snip Holdings, Inc. | Methods and therapies for treating inflammatory conditions with exposed collagen |
EP1946101A4 (de) * | 2005-10-21 | 2011-08-10 | Immunochemistry Technologies Llc | In-vivo-apoptosenachweis |
US7871623B2 (en) * | 2005-12-21 | 2011-01-18 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for imaging pain and stress in vivo |
US8758723B2 (en) | 2006-04-19 | 2014-06-24 | The Board Of Regents Of The University Of Texas System | Compositions and methods for cellular imaging and therapy |
US10925977B2 (en) * | 2006-10-05 | 2021-02-23 | Ceil>Point, LLC | Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications |
WO2008093057A1 (en) * | 2007-01-30 | 2008-08-07 | Ge Healthcare Limited | Tools for aiding in the diagnosis of neurodegenerative diseases |
WO2008142590A2 (en) * | 2007-05-16 | 2008-11-27 | Koninklijke Philips Electronics N.V. | Virtual pet detector and quasi-pixelated readout scheme for pet |
US8055039B2 (en) * | 2008-02-21 | 2011-11-08 | General Electric Company | System and method to obtain noise mitigated monochromatic representation for varying energy level |
US8916570B2 (en) | 2008-03-31 | 2014-12-23 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | A3 adenosine receptor agonists and antagonists |
WO2009123881A1 (en) * | 2008-03-31 | 2009-10-08 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Purine derivatives as a3 receptor- selective agonists |
US9181253B2 (en) | 2008-08-01 | 2015-11-10 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Adenosine receptor agonists, partial agonists, and antagonists |
EP2331542B1 (de) * | 2008-08-01 | 2016-07-27 | The United States of America, as Represented by The Secretary, Department of Health and Human Services | Antagonisten und partielle agonisten des a3-adenosinrezeptors |
ES2530228T3 (es) | 2008-08-26 | 2015-02-27 | Mosamedix B.V. | Anexinas radiomarcadas |
US8283167B2 (en) * | 2009-02-11 | 2012-10-09 | Clear Vascular Inc. | Preparation of annexin derivatives |
CN103582504B (zh) | 2011-04-04 | 2016-04-27 | 艾迪国际研发有限公司 | 用于无针注射器的安全注射筒 |
US10286093B2 (en) * | 2013-05-23 | 2019-05-14 | Neurosn, Inc. | Method of diagnosing and treating Alzheimer's disease |
CN105669855B (zh) * | 2016-02-04 | 2020-02-11 | 江苏省原子医学研究所 | 一种18F快速标记Cys-Annexin V的方法及其应用 |
RU2622983C1 (ru) * | 2016-07-25 | 2017-06-21 | федеральное государственное бюджетное образовательное учреждение высшего образования "Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова" Министерства здравоохранения Российской Федерации | Способ интраоперационной визуализации ишемически-реперфузионного повреждения миокарда |
WO2019169241A1 (en) * | 2018-03-02 | 2019-09-06 | Serene, Llc | Methods of treating and imaging ungulate laminitis |
JP2024022034A (ja) * | 2022-08-05 | 2024-02-16 | 浜松ホトニクス株式会社 | プログラムされた細胞死を起こした細胞の領域を決定する方法、決定部を備える装置及び決定ステップを含む情報処理プログラム |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4671256A (en) * | 1984-05-25 | 1987-06-09 | Lemelson Jerome H | Medical scanning, monitoring and treatment system and method |
US5627036A (en) | 1989-12-27 | 1997-05-06 | Boehringer Ingelheim International Gmbh | Use of an anticoagulant as a diagnostic agent |
US5552525A (en) | 1991-02-08 | 1996-09-03 | Diatech Inc. | Technetium-99m labeled peptides for imaging inflammation |
CA2086437A1 (en) | 1991-05-09 | 1992-11-10 | Jonathan Tait | Phospholipid-targeted thrombolytic agents |
US5632986A (en) * | 1991-05-09 | 1997-05-27 | The University Of Washington | Phospholipid-targeted thrombolytic agents |
US5519221A (en) | 1992-01-22 | 1996-05-21 | Ansel M. Schwartz | Dedicated apparatus and method for emission mammography |
DK0627940T3 (da) | 1992-03-05 | 2003-09-01 | Univ Texas | Anvendelse af immunokonjugater til diagnose og/eller terapi af vaskulariserede tumorer |
US5965132A (en) | 1992-03-05 | 1999-10-12 | Board Of Regents, The University Of Texas System | Methods and compositions for targeting the vasculature of solid tumors |
US5776427A (en) | 1992-03-05 | 1998-07-07 | Board Of Regents, The University Of Texas System | Methods for targeting the vasculature of solid tumors |
GB9223168D0 (en) | 1992-11-05 | 1992-12-16 | Johnson Matthey Plc | Improvements in molecule labelling |
US5968477A (en) | 1994-01-24 | 1999-10-19 | Neorx Corporation | Radiolabeled annexin conjugates with hexose and a chelator |
US5834196A (en) | 1994-04-11 | 1998-11-10 | Nexins Research B.V. | Method for detecting and/or optionally quantifying and/or separating apoptotic cells in or from a sample |
JPH10504534A (ja) | 1994-06-16 | 1998-05-06 | ネオルクス コーポレイション | 放射性標識アネキシン−ガラクトース結合体 |
WO1996017618A1 (en) | 1994-12-07 | 1996-06-13 | Neorx Corporation | Radiolabeled annexin-galactose cluster conjugates |
JP4963748B2 (ja) * | 1997-04-30 | 2012-06-27 | ザ ボード オブ トラスティーズ オブ ザ リランド スタンフォード ジュニア ユニバーシティー | 細胞死をin vivoで撮像する方法 |
ATE276763T1 (de) | 1998-07-13 | 2004-10-15 | Univ Texas | Verwendung von antikörper gegen aminophospholipide zur krebsbehandlung |
US6406693B1 (en) | 1998-07-13 | 2002-06-18 | Board Of Regents, The University Of Texas System | Cancer treatment methods using antibodies to aminophospholipids |
AU750414B2 (en) | 1998-07-13 | 2002-07-18 | Board Of Regents, The University Of Texas System | Cancer treatment methods using therapeutic conjugates that bind to aminophospholipids |
-
1998
- 1998-04-28 JP JP54740298A patent/JP4963748B2/ja not_active Expired - Lifetime
- 1998-04-28 CN CN98804718A patent/CN1265572A/zh active Pending
- 1998-04-28 AT AT98920065T patent/ATE379990T1/de not_active IP Right Cessation
- 1998-04-28 AU AU72714/98A patent/AU754577B2/en not_active Ceased
- 1998-04-28 HU HU0001261A patent/HUP0001261A3/hu unknown
- 1998-04-28 PL PL98336571A patent/PL336571A1/xx unknown
- 1998-04-28 TW TW087106507A patent/TW541184B/zh not_active IP Right Cessation
- 1998-04-28 KR KR1019997010074A patent/KR20010020443A/ko active IP Right Grant
- 1998-04-28 DE DE69838811T patent/DE69838811T2/de not_active Expired - Lifetime
- 1998-04-28 RU RU99125653/14A patent/RU2228765C2/ru not_active IP Right Cessation
- 1998-04-28 CA CA002288131A patent/CA2288131A1/en not_active Abandoned
- 1998-04-28 NZ NZ500598A patent/NZ500598A/en unknown
- 1998-04-28 EP EP98920065A patent/EP1017318B1/de not_active Expired - Lifetime
- 1998-04-28 ES ES07023446T patent/ES2398118T3/es not_active Expired - Lifetime
- 1998-04-28 WO PCT/US1998/008769 patent/WO1998048699A1/en active IP Right Grant
- 1998-04-29 US US09/069,878 patent/US6197278B1/en not_active Expired - Lifetime
-
2002
- 2002-08-02 US US10/210,986 patent/US7357915B2/en not_active Expired - Fee Related
-
2007
- 2007-11-15 US US11/985,567 patent/US7666389B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DE69838811T2 (de) | 2008-10-30 |
RU2228765C2 (ru) | 2004-05-20 |
US20080138279A1 (en) | 2008-06-12 |
CN1265572A (zh) | 2000-09-06 |
US6197278B1 (en) | 2001-03-06 |
KR20010020443A (ko) | 2001-03-15 |
TW541184B (en) | 2003-07-11 |
HUP0001261A3 (en) | 2001-11-28 |
EP1017318A4 (de) | 2003-04-23 |
AU754577B2 (en) | 2002-11-21 |
JP4963748B2 (ja) | 2012-06-27 |
HUP0001261A2 (hu) | 2000-08-28 |
AU7271498A (en) | 1998-11-24 |
ATE379990T1 (de) | 2007-12-15 |
US20070243133A1 (en) | 2007-10-18 |
JP2002500757A (ja) | 2002-01-08 |
NZ500598A (en) | 2001-09-28 |
PL336571A1 (en) | 2000-07-03 |
WO1998048699A1 (en) | 1998-11-05 |
US7357915B2 (en) | 2008-04-15 |
CA2288131A1 (en) | 1998-11-05 |
EP1017318A1 (de) | 2000-07-12 |
EP1017318B1 (de) | 2007-12-05 |
ES2398118T3 (es) | 2013-03-13 |
US7666389B2 (en) | 2010-02-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |