DE69839709D1 - Vorrichtung und Verfahren zur Lyse - Google Patents

Vorrichtung und Verfahren zur Lyse

Info

Publication number
DE69839709D1
DE69839709D1 DE69839709T DE69839709T DE69839709D1 DE 69839709 D1 DE69839709 D1 DE 69839709D1 DE 69839709 T DE69839709 T DE 69839709T DE 69839709 T DE69839709 T DE 69839709T DE 69839709 D1 DE69839709 D1 DE 69839709D1
Authority
DE
Germany
Prior art keywords
sample
cartridge
fluid
component
flow path
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69839709T
Other languages
English (en)
Inventor
Farzad Pourahmadi
William A Mcmillian
Jesus Ching
Ronald Chang
Lee A Christel
Gregory T Kovacs
M Allen Northrup
Kurt E Petersen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cepheid
Original Assignee
Cepheid
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cepheid filed Critical Cepheid
Application granted granted Critical
Publication of DE69839709D1 publication Critical patent/DE69839709D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6095—Micromachined or nanomachined, e.g. micro- or nanosize
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/02—Separating microorganisms from the culture medium; Concentration of biomass
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/06—Hydrolysis; Cell lysis; Extraction of intracellular or cell wall material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6091—Cartridges
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00427—Means for dispensing and evacuation of reagents using masks
    • B01J2219/00432—Photolithographic masks
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00527—Sheets
    • B01J2219/00529—DNA chips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0621—Control of the sequence of chambers filled or emptied
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0631—Purification arrangements, e.g. solid phase extraction [SPE]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0636—Focussing flows, e.g. to laminate flows
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0883—Serpentine channels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1827—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0421—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic electrophoretic flow
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/046—Chemical or electrochemical formation of bubbles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0622—Valves, specific forms thereof distribution valves, valves having multiple inlets and/or outlets, e.g. metering valves, multi-way valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0644—Valves, specific forms thereof with moving parts rotary valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
    • G01F1/00—Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow
    • G01F1/704—Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow using marked regions or existing inhomogeneities within the fluid stream, e.g. statistically occurring variations in a fluid parameter
    • G01F1/708—Measuring the time taken to traverse a fixed distance
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
    • Y10T436/255—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.] including use of a solid sorbent, semipermeable membrane, or liquid extraction
DE69839709T 1997-12-24 1998-12-24 Vorrichtung und Verfahren zur Lyse Expired - Lifetime DE69839709D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US99818897A 1997-12-24 1997-12-24
US11545498A 1998-07-14 1998-07-14

Publications (1)

Publication Number Publication Date
DE69839709D1 true DE69839709D1 (de) 2008-08-21

Family

ID=26813217

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69839709T Expired - Lifetime DE69839709D1 (de) 1997-12-24 1998-12-24 Vorrichtung und Verfahren zur Lyse

Country Status (10)

Country Link
US (3) US6440725B1 (de)
EP (2) EP1042061A1 (de)
JP (3) JP4209589B2 (de)
AT (1) ATE400358T1 (de)
AU (1) AU758407B2 (de)
CA (1) CA2312102C (de)
DE (1) DE69839709D1 (de)
DK (1) DK1179585T3 (de)
ES (1) ES2309022T3 (de)
WO (1) WO1999033559A1 (de)

Families Citing this family (646)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6048734A (en) 1995-09-15 2000-04-11 The Regents Of The University Of Michigan Thermal microvalves in a fluid flow method
DE69839709D1 (de) * 1997-12-24 2008-08-21 Cepheid Vorrichtung und Verfahren zur Lyse
US6660228B1 (en) 1998-03-02 2003-12-09 Cepheid Apparatus for performing heat-exchanging, chemical reactions
US20060029926A1 (en) * 1998-05-06 2006-02-09 Metrika, Inc. Blocking compositions for immunoassays
US6780617B2 (en) * 2000-12-29 2004-08-24 Chen & Chen, Llc Sample processing device and method
CA2632856C (en) * 1998-06-24 2010-10-12 Chen & Chen, Llc Fluid sample testing system
US7799521B2 (en) * 1998-06-24 2010-09-21 Chen & Chen, Llc Thermal cycling
US6576478B1 (en) * 1998-07-14 2003-06-10 Zyomyx, Inc. Microdevices for high-throughput screening of biomolecules
US6948843B2 (en) * 1998-10-28 2005-09-27 Covaris, Inc. Method and apparatus for acoustically controlling liquid solutions in microfluidic devices
US7687039B2 (en) 1998-10-28 2010-03-30 Covaris, Inc. Methods and systems for modulating acoustic energy delivery
US7981368B2 (en) 1998-10-28 2011-07-19 Covaris, Inc. Method and apparatus for acoustically controlling liquid solutions in microfluidic devices
US6719449B1 (en) * 1998-10-28 2004-04-13 Covaris, Inc. Apparatus and method for controlling sonic treatment
US7914994B2 (en) * 1998-12-24 2011-03-29 Cepheid Method for separating an analyte from a sample
US7214544B2 (en) * 1999-03-02 2007-05-08 Qualigen, Inc. Semi-continuous blood separation using magnetic beads
TW496775B (en) * 1999-03-15 2002-08-01 Aviva Bioscience Corp Individually addressable micro-electromagnetic unit array chips
US20020177135A1 (en) * 1999-07-27 2002-11-28 Doung Hau H. Devices and methods for biochip multiplexing
US6942771B1 (en) 1999-04-21 2005-09-13 Clinical Micro Sensors, Inc. Microfluidic systems in the electrochemical detection of target analytes
US6818185B1 (en) 1999-05-28 2004-11-16 Cepheid Cartridge for conducting a chemical reaction
US20040200909A1 (en) * 1999-05-28 2004-10-14 Cepheid Apparatus and method for cell disruption
US9073053B2 (en) 1999-05-28 2015-07-07 Cepheid Apparatus and method for cell disruption
US8815521B2 (en) 2000-05-30 2014-08-26 Cepheid Apparatus and method for cell disruption
DE60014676T2 (de) 1999-05-28 2005-11-17 Cepheid, Sunnyvale Vorrichtung und verfahren zur analyse flüssiger proben
US6706519B1 (en) * 1999-06-22 2004-03-16 Tecan Trading Ag Devices and methods for the performance of miniaturized in vitro amplification assays
US6878540B2 (en) * 1999-06-25 2005-04-12 Cepheid Device for lysing cells, spores, or microorganisms
US7052545B2 (en) * 2001-04-06 2006-05-30 California Institute Of Technology High throughput screening of crystallization of materials
US7195670B2 (en) 2000-06-27 2007-03-27 California Institute Of Technology High throughput screening of crystallization of materials
US8709153B2 (en) 1999-06-28 2014-04-29 California Institute Of Technology Microfludic protein crystallography techniques
US6692697B1 (en) * 1999-07-30 2004-02-17 Texas Instruments Incorporated Versatile flow cell front-end for optically-based integrated sensors
US7329388B2 (en) 1999-11-08 2008-02-12 Princeton Biochemicals, Inc. Electrophoresis apparatus having staggered passage configuration
US6406604B1 (en) * 1999-11-08 2002-06-18 Norberto A. Guzman Multi-dimensional electrophoresis apparatus
US6875619B2 (en) 1999-11-12 2005-04-05 Motorola, Inc. Microfluidic devices comprising biochannels
GB2357288A (en) * 1999-12-13 2001-06-20 Ortho Clinical Diagnostics Solid phase carrier coated with a polymer for adsorbing macromolecules
US20030091477A1 (en) * 1999-12-22 2003-05-15 Paul Eric A. Flow-thru chip cartridge, chip holder, system & method thereof
JP2001188061A (ja) * 1999-12-28 2001-07-10 Shimadzu Corp 分析用マイクロチップ
US6403037B1 (en) * 2000-02-04 2002-06-11 Cepheid Reaction vessel and temperature control system
EP1123739B1 (de) * 2000-02-11 2006-11-29 STMicroelectronics S.r.l. Integrierte Vorrichtung zur mikrofluidischen Temperaturregelung und dessen Herstellungsverfahren
JP3442338B2 (ja) 2000-03-17 2003-09-02 株式会社日立製作所 Ｄｎａ分析装置、ｄｎａ塩基配列決定装置、ｄｎａ塩基配列決定方法、および反応モジュール
US8105553B2 (en) * 2004-01-25 2012-01-31 Fluidigm Corporation Crystal forming devices and systems and methods for using the same
US7867763B2 (en) 2004-01-25 2011-01-11 Fluidigm Corporation Integrated chip carriers with thermocycler interfaces and methods of using the same
JP5046412B2 (ja) * 2000-04-06 2012-10-10 カリパー・ライフ・サイエンシズ・インク． 被覆層を組み込んだミクロ流体装置及びシステム
US6561208B1 (en) 2000-04-14 2003-05-13 Nanostream, Inc. Fluidic impedances in microfluidic system
AU2001261657A1 (en) * 2000-05-15 2001-11-26 Tecan Trading Ag Use of vapor-deposited conformal coatings in microfluidic structures
US8329118B2 (en) * 2004-09-02 2012-12-11 Honeywell International Inc. Method and apparatus for determining one or more operating parameters for a microfluidic circuit
DE60023464T2 (de) * 2000-06-05 2006-07-20 Stmicroelectronics S.R.L., Agrate Brianza Verfahren zur Herstellung integrierter chemischer Mikroreaktoren aus Halbleitermaterial sowie integrierter Mikroreaktor
US6374684B1 (en) 2000-08-25 2002-04-23 Cepheid Fluid control and processing system
US8048386B2 (en) 2002-02-25 2011-11-01 Cepheid Fluid processing and control
JP3993372B2 (ja) 2000-09-13 2007-10-17 独立行政法人理化学研究所 リアクタの製造方法
US20020155033A1 (en) * 2000-10-06 2002-10-24 Protasis Corporation Fluid Separate conduit cartridge
US6613224B1 (en) * 2000-10-06 2003-09-02 Waters Investments Limited Liquid separation column smart cartridge
AU2001297014A1 (en) * 2000-10-10 2002-04-22 Aviva Biosciences Corporation An integrated biochip system for sample preparation and analysis
AU2002239354A1 (en) * 2000-11-03 2002-06-11 Clinical Mirco Sensors, Inc. Devices and methods for biochip multiplexing
US20090118139A1 (en) * 2000-11-07 2009-05-07 Caliper Life Sciences, Inc. Microfluidic method and system for enzyme inhibition activity screening
US7105304B1 (en) * 2000-11-07 2006-09-12 Caliper Life Sciences, Inc. Pressure-based mobility shift assays
US20050221385A1 (en) * 2000-11-07 2005-10-06 Caliper Life Sciences, Inc. Pressure based mobility shift assays
US6623700B1 (en) * 2000-11-22 2003-09-23 Xerox Corporation Level sense and control system for biofluid drop ejection devices
US20020123134A1 (en) * 2000-12-26 2002-09-05 Mingxian Huang Active and biocompatible platforms prepared by polymerization of surface coating films
US20020098122A1 (en) * 2001-01-22 2002-07-25 Angad Singh Active disposable microfluidic system with externally actuated micropump
US6692700B2 (en) 2001-02-14 2004-02-17 Handylab, Inc. Heat-reduction methods and systems related to microfluidic devices
ITMI20010434A1 (it) * 2001-03-02 2002-09-02 Oglio Stefano Dall Unita' monouso sterilizzabile di campionamento per determinazioni in microbiologia e chimica-clinica
US7010391B2 (en) 2001-03-28 2006-03-07 Handylab, Inc. Methods and systems for control of microfluidic devices
US8895311B1 (en) 2001-03-28 2014-11-25 Handylab, Inc. Methods and systems for control of general purpose microfluidic devices
US6852287B2 (en) 2001-09-12 2005-02-08 Handylab, Inc. Microfluidic devices having a reduced number of input and output connections
US7323140B2 (en) 2001-03-28 2008-01-29 Handylab, Inc. Moving microdroplets in a microfluidic device
US7829025B2 (en) 2001-03-28 2010-11-09 Venture Lending & Leasing Iv, Inc. Systems and methods for thermal actuation of microfluidic devices
US7192557B2 (en) * 2001-03-28 2007-03-20 Handylab, Inc. Methods and systems for releasing intracellular material from cells within microfluidic samples of fluids
WO2002082057A2 (en) * 2001-04-03 2002-10-17 Micronics, Inc. Split focusing cytometer
DE10117772C2 (de) 2001-04-09 2003-04-03 Advalytix Ag Mischvorrichtung und Mischverfahren für die Durchmischung kleiner Flüssigkeitsmengen
GB2374560B (en) * 2001-04-17 2005-04-06 Rawson Francis F H Processing vessel
US6727479B2 (en) * 2001-04-23 2004-04-27 Stmicroelectronics S.R.L. Integrated device based upon semiconductor technology, in particular chemical microreactor
US6729352B2 (en) 2001-06-07 2004-05-04 Nanostream, Inc. Microfluidic synthesis devices and methods
US6981522B2 (en) 2001-06-07 2006-01-03 Nanostream, Inc. Microfluidic devices with distributing inputs
US6811695B2 (en) 2001-06-07 2004-11-02 Nanostream, Inc. Microfluidic filter
US6919046B2 (en) 2001-06-07 2005-07-19 Nanostream, Inc. Microfluidic analytical devices and methods
US7014747B2 (en) 2001-06-20 2006-03-21 Sandia Corporation Dielectrophoretic systems without embedded electrodes
CA2468260A1 (en) * 2001-07-02 2003-01-16 Matthew Torres Flow-thru chip cartridge, chip holder, system & method thereof
US20030108949A1 (en) * 2001-07-03 2003-06-12 Gang Bao Filtration-based microarray chip
EP1277438A1 (de) * 2001-07-10 2003-01-22 Agilent Technologies, Inc. (a Delaware corporation) Pflegeplatz Diagnose und/oder Analyse System
WO2003033740A2 (en) * 2001-07-10 2003-04-24 Massachusetts Institute Of Technology Apparatus and method for isolating a nucleic acid
EP1427531B1 (de) 2001-09-11 2016-10-19 Iquum, Inc. Probenbehälter
DE10146545A1 (de) * 2001-09-21 2003-04-10 Merck Patent Gmbh Mikrokomponente
US7344894B2 (en) * 2001-10-16 2008-03-18 Agilent Technologies, Inc. Thermal regulation of fluidic samples within a diagnostic cartridge
CN1327223C (zh) * 2001-10-29 2007-07-18 爱科来株式会社 试验设备
US7767437B2 (en) * 2001-11-02 2010-08-03 Genefluidics, Inc. System for detection of a component in a liquid
US20030087455A1 (en) * 2001-11-07 2003-05-08 Eggers Mitchell D Sample carrier system
FR2832507B1 (fr) * 2001-11-20 2004-02-20 Stago Diagnostica Methode de detection d'analyte(s) a l'aide de particules magnetiques colloidales
DE60235326D1 (de) 2001-12-14 2010-03-25 Arkray Inc Probenmessvorrichtung
US6739576B2 (en) 2001-12-20 2004-05-25 Nanostream, Inc. Microfluidic flow control device with floating element
US20030116552A1 (en) * 2001-12-20 2003-06-26 Stmicroelectronics Inc. Heating element for microfluidic and micromechanical applications
US6889468B2 (en) 2001-12-28 2005-05-10 3M Innovative Properties Company Modular systems and methods for using sample processing devices
JP3721334B2 (ja) * 2002-02-01 2005-11-30 富士写真フイルム株式会社 リセプター・リガンド会合反応方法およびそれに用いるリアクタ
US6814859B2 (en) 2002-02-13 2004-11-09 Nanostream, Inc. Frit material and bonding method for microfluidic separation devices
CA2472945A1 (en) 2002-02-13 2003-08-21 Nanostream, Inc. Microfluidic separation column devices and fabrication methods
US7261812B1 (en) 2002-02-13 2007-08-28 Nanostream, Inc. Multi-column separation devices and methods
DE10206464A1 (de) * 2002-02-16 2003-08-28 Micronas Gmbh Verfahren zur Herstellung einer Sensor- oder Aktuatoranordnung sowie Sensor- oder Aktuatoranordnung
US7419821B2 (en) 2002-03-05 2008-09-02 I-Stat Corporation Apparatus and methods for analyte measurement and immunoassay
WO2003082730A1 (en) * 2002-03-31 2003-10-09 Gyros Ab Efficient mmicrofluidic devices
US10155082B2 (en) 2002-04-10 2018-12-18 Baxter International Inc. Enhanced signal detection for access disconnection systems
US7052480B2 (en) 2002-04-10 2006-05-30 Baxter International Inc. Access disconnection systems and methods
US7022098B2 (en) 2002-04-10 2006-04-04 Baxter International Inc. Access disconnection systems and methods
US20040254513A1 (en) 2002-04-10 2004-12-16 Sherwin Shang Conductive polymer materials and applications thereof including monitoring and providing effective therapy
JP2005532043A (ja) * 2002-04-11 2005-10-27 シークエノム， インコーポレイテッド 固相支持体上で化学反応を実行するための方法および装置
US9943847B2 (en) 2002-04-17 2018-04-17 Cytonome/St, Llc Microfluidic system including a bubble valve for regulating fluid flow through a microchannel
DE10216947B4 (de) * 2002-04-17 2007-10-04 Ehrfeld Mikrotechnik Bts Gmbh Verfahren zum Homogenisieren von Emulsionen
JP4095886B2 (ja) * 2002-05-08 2008-06-04 株式会社日立ハイテクノロジーズ 化学分析装置及び遺伝子診断装置
JP4106977B2 (ja) 2002-06-21 2008-06-25 株式会社日立製作所 分析チップ及び分析装置
US20040124085A1 (en) * 2002-06-26 2004-07-01 California Institute Of Technology Microfluidic devices and methods with electrochemically actuated sample processing
EP1552005A4 (de) * 2002-07-10 2010-12-15 Massachusetts Inst Technology Vorrichtung und verfahren zur isolierung einer nukleinsäure aus einer probe
US7452507B2 (en) * 2002-08-02 2008-11-18 Sandia Corporation Portable apparatus for separating sample and detecting target analytes
JP2004081019A (ja) * 2002-08-23 2004-03-18 Jsr Corp 細胞反応検査用装置および細胞反応検査方法
US20040038385A1 (en) * 2002-08-26 2004-02-26 Langlois Richard G. System for autonomous monitoring of bioagents
US7094345B2 (en) * 2002-09-09 2006-08-22 Cytonome, Inc. Implementation of microfluidic components, including molecular fractionation devices, in a microfluidic system
US7455770B2 (en) * 2002-09-09 2008-11-25 Cytonome, Inc. Implementation of microfluidic components in a microfluidic system
US6878271B2 (en) * 2002-09-09 2005-04-12 Cytonome, Inc. Implementation of microfluidic components in a microfluidic system
CN101199917A (zh) * 2002-09-09 2008-06-18 塞通诺米公司 微射流系统中的微射流部件的实现
ITTO20020809A1 (it) * 2002-09-17 2004-03-18 St Microelectronics Srl Micropompa, in particolare per un dispositivo integrato di analisi del dna.
ITTO20020808A1 (it) * 2002-09-17 2004-03-18 St Microelectronics Srl Dispositivo integrato di analisi del dna.
JP3725109B2 (ja) * 2002-09-19 2005-12-07 財団法人生産技術研究奨励会 マイクロ流体デバイス
US20040115830A1 (en) * 2002-09-25 2004-06-17 Igor Touzov Components for nano-scale Reactor
US7143900B2 (en) * 2002-10-28 2006-12-05 Hewlett-Packard Development Company, L.P. Separation device and method of making the same
US7932098B2 (en) * 2002-10-31 2011-04-26 Hewlett-Packard Development Company, L.P. Microfluidic system utilizing thin-film layers to route fluid
US7010964B2 (en) 2002-10-31 2006-03-14 Nanostream, Inc. Pressurized microfluidic devices with optical detection regions
KR20040044336A (ko) * 2002-11-12 2004-05-28 마쯔시다덴기산교 가부시키가이샤 특이결합반응 측정방법과 이에 이용하는 시약키트 및특이결합반응 측정장치
FR2846957B1 (fr) * 2002-11-13 2005-09-30 Commissariat Energie Atomique Micro-systeme a remplissage de micro-billes et procede d'obtention
GB2395196B (en) * 2002-11-14 2006-12-27 Univ Cardiff Microfluidic device and methods for construction and application
US7175810B2 (en) * 2002-11-15 2007-02-13 Eksigent Technologies Processing of particles
AU2003278682B2 (en) * 2002-11-18 2007-07-19 Agency For Science, Technology And Research Method and system for cell and/or nucleic acid molecules isolation
US7842234B2 (en) * 2002-12-02 2010-11-30 Epocal Inc. Diagnostic devices incorporating fluidics and methods of manufacture
CN102620959B (zh) * 2002-12-26 2015-12-16 梅索磅秤技术有限公司 检定盒及其使用方法
CA2513880A1 (en) * 2003-01-21 2004-08-05 Micronics Inc. Method and system for microfluidic manipulation, amplification and analysis of fluids, for example, bacteria assays and antiglobulin testing
WO2004083806A2 (en) 2003-01-22 2004-09-30 University Of South Florida Autonomous genosensor apparatus and methods for use
US7338637B2 (en) * 2003-01-31 2008-03-04 Hewlett-Packard Development Company, L.P. Microfluidic device with thin-film electronic devices
CA2515075C (en) 2003-02-05 2012-10-02 Iquum, Inc. Sample processing
WO2004076056A2 (en) * 2003-02-26 2004-09-10 Lake Shore Cryotronics Inc. Microfluidic chemical reactor for the manufacture of chemically-produced nanoparticles
US8501402B2 (en) * 2003-03-24 2013-08-06 Boehringer Ingelheim Rcv Gmbh & Co Kg Methods and devices for producing biomolecules
GB0307999D0 (en) * 2003-04-07 2003-05-14 Glaxo Group Ltd A system
DE10319045A1 (de) * 2003-04-25 2004-12-09 november Aktiengesellschaft Gesellschaft für Molekulare Medizin Vorrichtung und Verfahren zur Aufbereitung Biopolymerhaltiger Flüssigkeiten
CA2526409A1 (en) * 2003-05-19 2004-12-02 Brandeis University Nucleic acid processing methods, kits and devices
US7170594B2 (en) * 2003-05-28 2007-01-30 Smiths Detection, Inc. Device for polymerase chain reactions
ES2220227B1 (es) 2003-05-30 2006-02-16 INSTITUTO NACIONAL DE TECNICA AEROESPACIAL "ESTEBAN TERRADAS" Metodo y aparato para la deteccion de sustancias o analitos a partir del analisis de una o varias muestras.
JP4758891B2 (ja) * 2003-06-06 2011-08-31 マイクロニクス， インコーポレイテッド 微小流体デバイス上の加熱、冷却および熱サイクリングのためのシステムおよび方法
US7648835B2 (en) * 2003-06-06 2010-01-19 Micronics, Inc. System and method for heating, cooling and heat cycling on microfluidic device
WO2005029030A2 (en) 2003-06-10 2005-03-31 University Of Louisville Research Foundation, Inc. Micro scale flow through sorbent plate collection device
US20040259076A1 (en) * 2003-06-23 2004-12-23 Accella Scientific, Inc. Nano and micro-technology virus detection method and device
US20050013106A1 (en) 2003-07-17 2005-01-20 Takiar Hem P. Peripheral card with hidden test pins
US7416132B2 (en) * 2003-07-17 2008-08-26 Sandisk Corporation Memory card with and without enclosure
KR101199600B1 (ko) 2003-07-17 2012-11-12 샌디스크 테크놀로지스, 인코포레이티드 융기 부분을 구비한 메모리 카드
EP2402089A1 (de) 2003-07-31 2012-01-04 Handylab, Inc. Verarbeitung partikelhaltiger Proben
US7541166B2 (en) * 2003-09-19 2009-06-02 Microfluidic Systems, Inc. Sonication to selectively lyse different cell types
WO2005028635A2 (en) 2003-09-19 2005-03-31 Microfluidic Systems Inc. Microfluidic differential extraction cartridge
US7524464B2 (en) 2003-09-26 2009-04-28 Ahn Chong H Smart disposable plastic lab-on-a-chip for point-of-care testing
SE0302649D0 (sv) * 2003-10-04 2003-10-04 Gyros Ab Compact dispenser system
US7032605B1 (en) 2003-10-15 2006-04-25 Douglas B. Dority Dual piston rotary valve
JP2007510935A (ja) 2003-11-07 2007-04-26 プリンストン・バイオケミカルズ・インコーポレーテッド 多次元電気泳動装置
US8030092B2 (en) * 2003-11-07 2011-10-04 Princeton Biochemicals, Inc. Controlled electrophoresis method
DE10353985A1 (de) * 2003-11-19 2005-06-23 Olympus Biosystems Gmbh Einrichtung und Verfahren zum Manipulieren und Analysieren von Mikroobjekten auf Grundlage eines zumindest bereichsweise als fluidisches Mikrosystem oder/und Chipsystem ausgeführten Mikrosystems
WO2005055804A2 (en) * 2003-12-02 2005-06-23 Musc Foundation For Research Development Methods and compositions for diagnosing epithelial cell cancer
WO2005056748A1 (en) 2003-12-08 2005-06-23 Covaris, Inc. Apparatus and methods for sample preparation
US7476360B2 (en) 2003-12-09 2009-01-13 Genefluidics, Inc. Cartridge for use with electrochemical sensor
US7322254B2 (en) * 2003-12-12 2008-01-29 3M Innovative Properties Company Variable valve apparatus and methods
US20050130177A1 (en) 2003-12-12 2005-06-16 3M Innovative Properties Company Variable valve apparatus and methods
FR2863626B1 (fr) 2003-12-15 2006-08-04 Commissariat Energie Atomique Procede et dispositif de division d'un echantillon biologique par effet magnetique
EP1702211A2 (de) * 2003-12-23 2006-09-20 Fastraq, Inc. Point-of-care-diagnoseplattform
US20050142570A1 (en) * 2003-12-24 2005-06-30 3M Innovative Properties Company Methods for nucleic acid isolation and kits using a microfluidic device and sedimenting reagent
US7939249B2 (en) 2003-12-24 2011-05-10 3M Innovative Properties Company Methods for nucleic acid isolation and kits using a microfluidic device and concentration step
US20050142571A1 (en) * 2003-12-24 2005-06-30 3M Innovative Properties Company Methods for nucleic acid isolation and kits using solid phase material
US20050142565A1 (en) * 2003-12-30 2005-06-30 Agency For Science, Technology And Research Nucleic acid purification chip
US7384791B2 (en) * 2004-01-21 2008-06-10 Hewlett-Packard Development Company, L.P. Method of analyzing blood
GB2416030B (en) * 2004-01-28 2008-07-23 Norchip As A diagnostic system for carrying out a nucleic acid sequence amplification and detection process
FR2865806B1 (fr) * 2004-01-30 2007-02-02 Commissariat Energie Atomique Laboratoire sur puce comprenant un reseau micro-fluidique et un nez d'electronebulisation coplanaires
ATE520340T1 (de) * 2004-02-03 2011-09-15 Sysmex Corp Analysegerät, patrone, patronenkit
US8101431B2 (en) * 2004-02-27 2012-01-24 Board Of Regents, The University Of Texas System Integration of fluids and reagents into self-contained cartridges containing sensor elements and reagent delivery systems
WO2005084254A2 (en) * 2004-02-27 2005-09-15 Musc Foundation For Research Development Enhanced detection of rna using a panel of truncated gene-specific primers for reverse transcription
US7160425B2 (en) * 2004-03-25 2007-01-09 Hewlett-Packard Development Company, L.P. Cell transporter for a biodevice
US7390387B2 (en) * 2004-03-25 2008-06-24 Hewlett-Packard Development Company, L.P. Method of sorting cells in series
US7390388B2 (en) * 2004-03-25 2008-06-24 Hewlett-Packard Development Company, L.P. Method of sorting cells on a biodevice
US20050244837A1 (en) * 2004-04-28 2005-11-03 Cepheid Method and device for sample preparation control
DE102004021822B3 (de) 2004-04-30 2005-11-17 Siemens Ag Verfahren und Anordnung zur DNA-Amplifikation mittels PCR unter Einsatz von Trockenreagenzien
DE102004021780B4 (de) * 2004-04-30 2008-10-02 Siemens Ag Verfahren und Anordnung zur DNA-Isolierung mit Trockenreagenzien
US8852862B2 (en) 2004-05-03 2014-10-07 Handylab, Inc. Method for processing polynucleotide-containing samples
WO2005108620A2 (en) * 2004-05-03 2005-11-17 Handylab, Inc. Processing polynucleotide-containing samples
JP4373947B2 (ja) * 2004-05-04 2009-11-25 ミリポア・コーポレイション 微生物を計数し特定するための方法
JP3952036B2 (ja) * 2004-05-13 2007-08-01 コニカミノルタセンシング株式会社 マイクロ流体デバイス並びに試液の試験方法および試験システム
WO2005116081A2 (en) 2004-05-24 2005-12-08 Genvault Corporation Stable protein storage and stable nucleic acid storage in recoverable form
US7043838B2 (en) 2004-06-30 2006-05-16 Lexmark International, Inc. Process for manufacturing a micro-fluid ejection device
US7311386B2 (en) 2004-06-30 2007-12-25 Lexmark Interntional, Inc. Die attach methods and apparatus for micro-fluid ejection device
US20080125330A1 (en) * 2004-07-01 2008-05-29 Cornell Research Foundation, Inc. Real-Time Pcr Detection of Microorganisms Using an Integrated Microfluidics Platform
ITBO20040420A1 (it) 2004-07-07 2004-10-07 Type S R L Macchina per taglio e formatura di piattine metalliche
WO2006017150A2 (en) 2004-07-09 2006-02-16 University Of Pittsburgh - Of The Commonwealth System Of Higher Educatiion Identification of markers in lung and breast cancer
US8329437B1 (en) 2004-07-29 2012-12-11 E.I. Spectra, Llc Disposable particle counter cartridge
JP4661125B2 (ja) * 2004-08-04 2011-03-30 日立電線株式会社 成分分離素子およびその製造方法
US20060051265A1 (en) * 2004-09-08 2006-03-09 Health Research, Inc. Apparatus and method for sorting microstructures in a fluid medium
CA2583498A1 (en) 2004-09-09 2006-03-16 Microfluidic Systems Inc. A handheld and portable microfluidic device to automatically prepare nucleic acids for analysis
US8053214B2 (en) 2004-09-09 2011-11-08 Microfluidic Systems, Inc. Apparatus and method of extracting and optically analyzing an analyte from a fluid-based sample
CN102759466A (zh) * 2004-09-15 2012-10-31 英特基因有限公司 微流体装置
CN101068937A (zh) * 2004-09-20 2007-11-07 匹兹堡大学 多重模式复合反应测序方法
US20080193961A1 (en) * 2004-09-29 2008-08-14 Easley Christopher J Localized Control of Thermal Properties on Microdevices and Applications Thereof
EP1795899B1 (de) * 2004-09-30 2012-06-06 ARKRAY, Inc. Analyseinstrument mit schichtheizgerät
CN100565207C (zh) 2004-10-01 2009-12-02 株式会社日立高新技术 化学分析装置
JPWO2006038643A1 (ja) * 2004-10-06 2008-08-07 ユニバーサル・バイオ・リサーチ株式会社 反応容器、および反応制御装置
US8056881B2 (en) 2004-10-13 2011-11-15 University Of Virginia Patent Foundation Electrostatic actuation for management of flow in micro-total analysis systems (μ-TAS) and related method thereof
DE102004050575B3 (de) * 2004-10-15 2006-01-05 Siemens Ag Verfahren zur kombinierten Isolierung von Magnet-Beads aus einer flüssigen Probe und anschließender Thermozyklisierung für die PCR und zugehörige Anordnung
US20060094028A1 (en) * 2004-11-04 2006-05-04 Welch Allyn, Inc. Rapid diagnostic assay
US7785868B2 (en) 2004-12-02 2010-08-31 Microfluidic Systems, Inc. Apparatus to automatically lyse a sample
ZA200704952B (en) 2004-12-03 2008-11-26 Cytonome Inc Unitary cartridge for particle processing
US9260693B2 (en) 2004-12-03 2016-02-16 Cytonome/St, Llc Actuation of parallel microfluidic arrays
US20070141576A1 (en) * 2004-12-13 2007-06-21 Bbk Bio Corporpation Biological chip and use thereof
WO2006069305A2 (en) * 2004-12-22 2006-06-29 University Of Virginia Patent Foundation The use of microwaves for thermal and non-thermal applications in micro and nanoscale devices
EP1871527B1 (de) 2004-12-23 2017-09-27 Abbott Point of Care Inc. Molekulares diagnostiksystem
CN101095187B (zh) * 2004-12-31 2010-10-13 麦莫斯弗罗有限公司 用于例如细胞裂解的脉动压力波的产生
JP4053081B2 (ja) * 2005-01-07 2008-02-27 積水化学工業株式会社 カートリッジを使用する検出装置
JP4361879B2 (ja) 2005-01-07 2009-11-11 株式会社日立ハイテクノロジーズ 化学分析装置及び化学分析カートリッジ
US20060246575A1 (en) * 2005-01-13 2006-11-02 Micronics, Inc. Microfluidic rare cell detection device
JP4422623B2 (ja) 2005-01-17 2010-02-24 株式会社日立ハイテクノロジーズ 化学分析装置および化学分析カートリッジ
US20060252087A1 (en) * 2005-01-18 2006-11-09 Biocept, Inc. Recovery of rare cells using a microchannel apparatus with patterned posts
WO2006078470A2 (en) 2005-01-18 2006-07-27 Biocept, Inc. Cell separation using microchannel having patterned posts
US20060166223A1 (en) * 2005-01-26 2006-07-27 Reed Michael W DNA purification and analysis on nanoengineered surfaces
US20070017812A1 (en) * 2005-03-30 2007-01-25 Luc Bousse Optimized Sample Injection Structures in Microfluidic Separations
CA2517299A1 (en) * 2005-08-26 2007-02-26 Chromedx Inc. Hollow needle assembly
CA2507323A1 (en) * 2005-05-13 2006-11-13 Chromedx Inc. Diagnostic whole blood and plasma apparatus
US8206650B2 (en) * 2005-04-12 2012-06-26 Chromedx Inc. Joint-diagnostic spectroscopic and biosensor meter
US20100245803A1 (en) * 2005-04-12 2010-09-30 Chromedx Inc. Blood sample holder for spectroscopic analysis
EP1712284B1 (de) * 2005-04-15 2012-10-10 Samsung Electronics Co., Ltd. Methode zur Zelltrennung mit Benutzung hydrophober fester Träger
JP2006300548A (ja) * 2005-04-15 2006-11-02 Hitachi Software Eng Co Ltd 検査チップ及び検査チップシステム
KR101381331B1 (ko) 2005-05-09 2014-04-04 테라노스, 인코포레이티드 현장진료 유체 시스템 및 그 용도
EP3556868A1 (de) * 2005-05-09 2019-10-23 BioFire Diagnostics, LLC In sich geschlossene biologische analyse
US8206974B2 (en) 2005-05-19 2012-06-26 Netbio, Inc. Ruggedized apparatus for analysis of nucleic acid and proteins
PL1883474T3 (pl) * 2005-05-25 2021-10-18 Boehringer Ingelheim Vetmedica Gmbh System do zintegrowanej i zautomatyzowanej analizy dna lub białka oraz sposób działania takiego systemu
US10816563B2 (en) 2005-05-25 2020-10-27 Boehringer Ingelheim Vetmedica Gmbh System for operating a system for the integrated and automated analysis of DNA or protein
US8377398B2 (en) 2005-05-31 2013-02-19 The Board Of Regents Of The University Of Texas System Methods and compositions related to determination and use of white blood cell counts
US20060275852A1 (en) * 2005-06-06 2006-12-07 Montagu Jean I Assays based on liquid flow over arrays
US20060280029A1 (en) * 2005-06-13 2006-12-14 President And Fellows Of Harvard College Microfluidic mixer
JP4870946B2 (ja) * 2005-06-17 2012-02-08 凸版印刷株式会社 反応容器および反応方法
RU2432205C2 (ru) * 2005-06-23 2011-10-27 Биокартис С.А. Картридж, система и способ автоматизированной медицинской диагностики
CA2613078A1 (en) * 2005-06-24 2007-01-04 Board Of Regents, The University Of Texas System Systems and methods including self-contained cartridges with detection systems and fluid delivery systems
US7323660B2 (en) 2005-07-05 2008-01-29 3M Innovative Properties Company Modular sample processing apparatus kits and modules
US7763210B2 (en) 2005-07-05 2010-07-27 3M Innovative Properties Company Compliant microfluidic sample processing disks
US7754474B2 (en) 2005-07-05 2010-07-13 3M Innovative Properties Company Sample processing device compression systems and methods
ITBO20050481A1 (it) 2005-07-19 2007-01-20 Silicon Biosystems S R L Metodo ed apparato per la manipolazione e/o l'individuazione di particelle
US7757561B2 (en) * 2005-08-01 2010-07-20 Covaris, Inc. Methods and systems for processing samples using acoustic energy
US8343755B2 (en) * 2005-08-01 2013-01-01 University Of Virginia Patent Foundation Microdevices for chemical sensing and chemical actuation
TW200712489A (en) * 2005-08-02 2007-04-01 3M Innovative Properties Co Apparatus assembly and method for detecting an analyte
TW200712487A (en) * 2005-08-02 2007-04-01 3M Innovative Properties Co Apparatus and method for detecting an analyte
TW200712495A (en) * 2005-08-02 2007-04-01 3M Innovative Properties Co Apparatus and method for detecting an analyte
TW200714898A (en) * 2005-08-02 2007-04-16 3M Innovative Properties Co Apparatus and method for detecting an analyte
KR100714988B1 (ko) * 2005-08-09 2007-05-09 삼성전자주식회사 산화막이 표면에 형성된 실리콘 구조물 표면을 이용한ｄｎａ 정제 방법 및 정제장치
US7618588B2 (en) 2005-08-10 2009-11-17 Microfluidic Systems, Inc. Disposable integrated heater and tube assembly for thermally-driven chemical reactions
AU2006283177B2 (en) * 2005-08-23 2011-11-17 University Of Virginia Patent Foundation Passive components for micro-fluidic flow profile shaping and related method thereof
ES2558797T3 (es) * 2005-10-04 2016-02-08 Headway Technologies, Inc. Detección microfluídica de analitos
US20110033922A1 (en) * 2005-10-04 2011-02-10 Landers James P Microchip-based acoustic trapping or capture of cells for forensic analysis and related method thereof
US20070090026A1 (en) * 2005-10-06 2007-04-26 Jongyoon Han Continuous biomolecule separation in a nanofilter
JP2009511059A (ja) * 2005-10-11 2009-03-19 ハンディーラブ インコーポレイテッド ポリヌクレオチドサンプル調製装置
WO2007047336A2 (en) * 2005-10-12 2007-04-26 University Of Virginia Patent Foundation Integrated microfluidic analysis systems
US9233846B2 (en) * 2005-10-14 2016-01-12 The Regents Of The University Of California Formation and encapsulation of molecular bilayer and monolayer membranes
US7727473B2 (en) * 2005-10-19 2010-06-01 Progentech Limited Cassette for sample preparation
US7754148B2 (en) 2006-12-27 2010-07-13 Progentech Limited Instrument for cassette for sample preparation
ITBO20050646A1 (it) 2005-10-26 2007-04-27 Silicon Biosystem S R L Metodo ed apparato per la caratterizzazione ed il conteggio di particelle
WO2007061943A2 (en) * 2005-11-21 2007-05-31 Applera Corporation Portable preparation, analysis, and detection apparatus for nucleic acid processing
DE102005059536B4 (de) * 2005-12-13 2008-08-28 Siemens Ag Verfahren und Biochip zur Untersuchung einer biologischen Probe
US8703445B2 (en) 2005-12-29 2014-04-22 Abbott Point Of Care Inc. Molecular diagnostics amplification system and methods
JP5000666B2 (ja) * 2006-01-25 2012-08-15 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 流体を分析する装置
US8263360B2 (en) * 2006-01-30 2012-09-11 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Hydrophilic IR transparent membrane, spectroscopic sample holder comprising same and method of using same
JP4906362B2 (ja) 2006-01-30 2012-03-28 株式会社日立ハイテクノロジーズ 化学分析前処理装置
US20110189714A1 (en) * 2010-02-03 2011-08-04 Ayliffe Harold E Microfluidic cell sorter and method
US9452429B2 (en) 2006-02-02 2016-09-27 E. I. Spectra, Llc Method for mutiplexed microfluidic bead-based immunoassay
US8171778B2 (en) * 2006-05-05 2012-05-08 E I Spectra, LLC Thin film particle sensor
US9293311B1 (en) 2006-02-02 2016-03-22 E. I. Spectra, Llc Microfluidic interrogation device
US8616048B2 (en) * 2006-02-02 2013-12-31 E I Spectra, LLC Reusable thin film particle sensor
EP1979079A4 (de) 2006-02-03 2012-11-28 Integenx Inc Mikrofluidische vorrichtungen
US7815868B1 (en) * 2006-02-28 2010-10-19 Fluidigm Corporation Microfluidic reaction apparatus for high throughput screening
ATE497797T1 (de) 2006-03-14 2011-02-15 Univ Southern California Mems-vorrichtung zur wirkstofffreisetzung
US10900066B2 (en) 2006-03-24 2021-01-26 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US11806718B2 (en) 2006-03-24 2023-11-07 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US11287421B2 (en) 2006-03-24 2022-03-29 Labrador Diagnostics Llc Systems and methods of sample processing and fluid control in a fluidic system
US8741230B2 (en) * 2006-03-24 2014-06-03 Theranos, Inc. Systems and methods of sample processing and fluid control in a fluidic system
US7998708B2 (en) 2006-03-24 2011-08-16 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
EP2001990B1 (de) 2006-03-24 2016-06-29 Handylab, Inc. Integriertes system zur verarbeitung von mikrofluidischen proben und verwendungsverfahren
US8088616B2 (en) 2006-03-24 2012-01-03 Handylab, Inc. Heater unit for microfluidic diagnostic system
ITTO20060226A1 (it) 2006-03-27 2007-09-28 Silicon Biosystem S P A Metodo ed apparato per il processamento e o l'analisi e o la selezione di particelle, in particolare particelle biologiche
US20100120132A1 (en) * 2006-03-31 2010-05-13 Intel Corporation Bioassays by direct optical detection of nanoparticles
JP4685691B2 (ja) * 2006-04-13 2011-05-18 株式会社日立ソリューションズ 検査チップ及び検査チップシステム
CA2646309C (en) 2006-04-21 2016-07-26 Nanobiosym, Inc. Single-molecule platform for drug discovery: methods and apparatuses for drug discovery, including discovery of anticancer and antiviral agents
WO2008036121A2 (en) * 2006-04-25 2008-03-27 University Of South Florida Portable reactor for real-time nucleic acid amplification and detection
US8007999B2 (en) 2006-05-10 2011-08-30 Theranos, Inc. Real-time detection of influenza virus
US20100216657A1 (en) * 2006-05-16 2010-08-26 Arcxis Biotechnologies, Inc. Pcr-free sample preparation and detection systems for high speed biologic analysis and identification
WO2007136715A2 (en) * 2006-05-16 2007-11-29 Arcxis Biotechnologies Pcr-free sample preparation and detection systems for high speed biologic analysis and identification
KR100785016B1 (ko) * 2006-05-22 2007-12-12 삼성전자주식회사 단일 마이크로 챔버에서 핵산의 농축 및 증폭을 수행하는방법 및 장치
JP4759451B2 (ja) 2006-06-16 2011-08-31 株式会社日立ソリューションズ 生体物質の前処理チップ及び前処理チップシステム
DE102006028101B4 (de) * 2006-06-19 2014-02-13 Siemens Aktiengesellschaft Verfahren zur Analyse von amplifizierten Nukleinsäuren
US8119352B2 (en) * 2006-06-20 2012-02-21 Cepheld Multi-stage amplification reactions by control of sequence replication times
US7549349B2 (en) * 2006-06-22 2009-06-23 Evogen, Inc. Sample cartridge for air-sampling device
US20100240022A1 (en) * 2006-06-23 2010-09-23 Mcneely Michael R Reagent preparation and valving design for liquid testing
KR101269741B1 (ko) * 2006-07-04 2013-05-30 쓰리엠 이노베이티브 프로퍼티즈 캄파니 탄성 및 접착성을 갖는 전자기파 차단용 가스켓
US8187557B2 (en) 2006-07-13 2012-05-29 Cepheid Reagent reservoir system for analytical instruments
EP1878802A1 (de) * 2006-07-14 2008-01-16 Roche Diagnostics GmbH Einwegvorrichtung zur Analyse einer Nukleinsäure enthaltenden Probe mit einem Amplifikation-Apparatus
EP1878496A1 (de) * 2006-07-14 2008-01-16 Roche Diagnostics GmbH Vorrichtung zur Durchführung von Nukleinsäureanalyse
US7858363B2 (en) * 2006-07-22 2010-12-28 Zymo Research Corporation Plasmid DNA isolation
JP2008051803A (ja) * 2006-07-28 2008-03-06 Sharp Corp 分析用マイクロ流路デバイス
US8252160B2 (en) * 2006-07-28 2012-08-28 Hewlett-Packard Development Company, L.P. Prevention of fluid delivered to reservoir from wicking into channels within microfluidic device
WO2008016691A2 (en) * 2006-08-01 2008-02-07 Covaris, Inc. Methods and apparatus for treating samples with acoustic energy
US20080044884A1 (en) * 2006-08-21 2008-02-21 Samsung Electronics Co., Ltd. Method and device for separating cells from a sample using a nonplanar solid substrate
US8158411B2 (en) * 2006-08-21 2012-04-17 Samsung Electronics Co., Ltd. Method of separating microorganism using nonplanar solid substrate and device for separating microorganism using the same
US20080069732A1 (en) * 2006-09-20 2008-03-20 Robert Yi Diagnostic test system
GB0618966D0 (en) * 2006-09-26 2006-11-08 Iti Scotland Ltd Cartridge system
JP5382347B2 (ja) * 2006-10-11 2014-01-08 フルイディウム コーポレーション 使い捨て可能なマイクロ精製カード、方法、およびそのシステム
US8012744B2 (en) 2006-10-13 2011-09-06 Theranos, Inc. Reducing optical interference in a fluidic device
CN101578520B (zh) * 2006-10-18 2015-09-16 哈佛学院院长等 基于形成图案的多孔介质的横向流动和穿过生物测定装置、及其制备方法和使用方法
US20080153096A1 (en) * 2006-11-02 2008-06-26 Vectrant Technologies Inc. Cartridge for conducting diagnostic assays
WO2008060604A2 (en) 2006-11-14 2008-05-22 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
WO2008061165A2 (en) 2006-11-14 2008-05-22 Handylab, Inc. Microfluidic cartridge and method of making same
US20080113391A1 (en) 2006-11-14 2008-05-15 Ian Gibbons Detection and quantification of analytes in bodily fluids
US9102911B2 (en) 2009-05-15 2015-08-11 Biofire Diagnostics, Llc High density self-contained biological analysis
US8702836B2 (en) 2006-11-22 2014-04-22 Covaris, Inc. Methods and apparatus for treating samples with acoustic energy to form particles and particulates
ITMI20062272A1 (it) * 2006-11-27 2008-05-28 Genedia S R L Reattore per lo svolgimento di processi biochimici particolarmente di estrazione purificazione arricchimento sedimentazione
US20080121591A1 (en) * 2006-11-29 2008-05-29 Canon U.S. Life Sciences, Inc. Device for nucleic acid preparation
US7993525B2 (en) * 2006-12-29 2011-08-09 Intel Corporation Device and method for particle complex handling
US8338166B2 (en) * 2007-01-04 2012-12-25 Lawrence Livermore National Security, Llc Sorting, amplification, detection, and identification of nucleic acid subsequences in a complex mixture
US10001496B2 (en) * 2007-01-29 2018-06-19 Gearbox, Llc Systems for allergen detection
NL1033317C2 (nl) * 2007-02-01 2008-08-04 C2V B V Inrichting voor capillaire chromatografie en werkwijze voor het vervaardigen van zo een inrichting.
US8367397B2 (en) * 2007-02-15 2013-02-05 Honeywell International Inc. Active biochip for nucleic acid analysis
WO2008101196A1 (en) * 2007-02-15 2008-08-21 Osmetech Molecular Diagnostics Fluidics devices
US20090011417A1 (en) * 2007-03-07 2009-01-08 George Maltezos Testing Device
ES2797951T3 (es) 2007-04-04 2020-12-04 Ande Corp Análisis integrado de ácidos nucleicos
DE102007020444A1 (de) * 2007-04-27 2008-11-06 Bayer Materialscience Ag Verfahren zur Oxidation eines Chlorwasserstoffenthaltenden Gasgemisches
FR2917095B1 (fr) * 2007-06-07 2009-07-17 Biomerieux Sa Dispositif de lyse de microorganismes presents dans un echantillon environnemental ou clinique et d'extraction des acides nucleiques desdits microorganismes aux fins d'analyse.
US9458451B2 (en) 2007-06-21 2016-10-04 Gen-Probe Incorporated Multi-channel optical measurement instrument
JP5433139B2 (ja) * 2007-06-29 2014-03-05 株式会社東芝 マイクロ化学分析装置、その測定方法、及びマイクロカセット
US8182763B2 (en) 2007-07-13 2012-05-22 Handylab, Inc. Rack for sample tubes and reagent holders
US20090136385A1 (en) 2007-07-13 2009-05-28 Handylab, Inc. Reagent Tube
US9186677B2 (en) 2007-07-13 2015-11-17 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US8287820B2 (en) 2007-07-13 2012-10-16 Handylab, Inc. Automated pipetting apparatus having a combined liquid pump and pipette head system
US8133671B2 (en) 2007-07-13 2012-03-13 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US9618139B2 (en) 2007-07-13 2017-04-11 Handylab, Inc. Integrated heater and magnetic separator
USD621060S1 (en) 2008-07-14 2010-08-03 Handylab, Inc. Microfluidic cartridge
EP3741869A1 (de) 2007-07-13 2020-11-25 Handylab, Inc. Materialien zur erfassung von polynukleotiden und verfahren zur verwendung davon
US8105783B2 (en) 2007-07-13 2012-01-31 Handylab, Inc. Microfluidic cartridge
CA2722242C (en) * 2007-07-23 2018-07-17 Clondiag Gmbh Methods and devices for determining values indicative of the presence and/or amount of nucleic acids
US8088341B2 (en) * 2007-07-25 2012-01-03 University Of Louisville Research Foundation, Inc. Analyte collection devices and methods
US20090030342A1 (en) * 2007-07-27 2009-01-29 3M Innovative Properties Company Apparatus and method for releasing a sample of material
EP2171420A1 (de) * 2007-07-31 2010-04-07 Micronics, Inc. Tupferaufnahmesystem, mikrofluidische testvorrichtung und verfahren für diagnosetests
GB0715171D0 (en) 2007-08-03 2007-09-12 Enigma Diagnostics Ltd Sample processor
GB0715170D0 (en) 2007-08-03 2007-09-12 Enigma Diagnostics Ltd Reaction vessel
EP2178640A1 (de) * 2007-08-03 2010-04-28 Enigma Diagnostics Limited Reaktionsgefäss
US8158430B1 (en) 2007-08-06 2012-04-17 Theranos, Inc. Systems and methods of fluidic sample processing
ITBO20070588A1 (it) 2007-08-13 2009-02-14 Silicon Biosystems Spa Metodo per legare uno strato di silicone ad un substrato di polimero metacrilico
WO2009023257A1 (en) * 2007-08-15 2009-02-19 Massachusetts Institute Of Technology Microstructures for fluidic ballasting and flow control
US8308926B2 (en) 2007-08-20 2012-11-13 Purdue Research Foundation Microfluidic pumping based on dielectrophoresis
WO2009045343A1 (en) * 2007-09-29 2009-04-09 El Spectra, Llc Instrumented pipette tip
CN103323610B (zh) 2007-10-02 2016-12-28 赛拉诺斯股份有限公司 模块化现场护理装置及其应用
EP2056114A1 (de) * 2007-10-29 2009-05-06 Koninklijke Philips Electronics N.V. Automatische Erkennung von Infektionserkrankungen
ITTO20070771A1 (it) 2007-10-29 2009-04-30 Silicon Biosystems Spa Metodo e apparato per la identificazione e manipolazione di particelle
EP2214833A4 (de) * 2007-11-27 2012-11-14 El Spectra Llc Pipetteninstrument auf fluoreszenzbasis
US8178045B2 (en) * 2007-12-17 2012-05-15 University Of Louisville Research Foundation, Inc. Interchangeable preconcentrator connector assembly
MX364408B (es) 2007-12-20 2019-04-25 Univ Southern California Aparatos y metodos para suministrar agentes terapeuticos.
JP5663311B2 (ja) * 2008-01-09 2015-02-04 ケック グラデュエイト インスティテュート 物質の調整及び／又は取扱システム、装置及び方法
JP2011510675A (ja) * 2008-02-07 2011-04-07 フォレンシック サイエンシーズ サーヴィス リミテッド 分析の及び分析に関する改善
EP2250286A1 (de) 2008-02-15 2010-11-17 Life Technologies Corporation Verfahren und zusammensetzungen zum scheren von polymeren mittels ultraschallbehandlung
WO2009115950A1 (en) * 2008-03-17 2009-09-24 Koninklijke Philips Electronics N.V. Biosensor device having reduced electrical power consumption
US9829488B2 (en) * 2008-03-27 2017-11-28 President And Fellows Of Havard College Paper-based cellular arrays
WO2009121043A2 (en) * 2008-03-27 2009-10-01 President And Fellows Of Harvard College Cotton thread as a low-cost multi-assay diagnostic platform
CN102016595B (zh) 2008-03-27 2014-08-06 哈佛学院院长等 三维微流体装置
CN102016596B (zh) * 2008-03-27 2014-09-17 哈佛学院院长等 纸基微流体系统
EP2265923A4 (de) 2008-04-07 2016-05-04 El Spectra Llc Verfahren zur herstellung eines mikrofluidischen sensors
US8961902B2 (en) 2008-04-23 2015-02-24 Bioscale, Inc. Method and apparatus for analyte processing
CN102202708B (zh) 2008-05-08 2015-01-21 迷你泵有限责任公司 药物输送泵及其制造方法
EP2163239A1 (de) 2008-05-27 2010-03-17 Qiagen GmbH Produkte, die Biopartikel enthalten, Verfahren zu ihrer Herstellung
KR101102532B1 (ko) * 2008-07-10 2012-01-03 삼성전자주식회사 시약 카트리지, 시약 카트리지를 구비하는 미세유동장치, 그 제조방법, 및 이를 이용한 시료분석방법
USD618820S1 (en) 2008-07-11 2010-06-29 Handylab, Inc. Reagent holder
USD787087S1 (en) 2008-07-14 2017-05-16 Handylab, Inc. Housing
US8114043B2 (en) * 2008-07-25 2012-02-14 Baxter International Inc. Electromagnetic induction access disconnect sensor
US8771613B2 (en) * 2008-07-31 2014-07-08 University Of Louisville Research Foundation, Inc. Large volume analyte preconcentrator
US11235323B2 (en) * 2008-08-27 2022-02-01 Life Technologies Corporation Apparatus for and method of processing biological samples
EP2331954B1 (de) * 2008-08-27 2020-03-25 Life Technologies Corporation Vorrichtung und verfahren zur verarbeitung biologischer proben
US8133451B2 (en) 2008-08-28 2012-03-13 Microfluidic Systems, Inc. Sample preparation apparatus
EP2334792B1 (de) 2008-09-12 2020-09-09 GenTegra LLC Matrizes und medien zur lagerung und stabilisierung von biomolekülen
US20100104485A1 (en) * 2008-10-28 2010-04-29 Microfluidic Systems, Inc. Flow-through thermal cycling device
US10895575B2 (en) 2008-11-04 2021-01-19 Menarini Silicon Biosystems S.P.A. Method for identification, selection and analysis of tumour cells
IT1391619B1 (it) 2008-11-04 2012-01-11 Silicon Biosystems Spa Metodo per l'individuazione, selezione e analisi di cellule tumorali
FR2938062B1 (fr) * 2008-11-05 2014-02-28 Biomerieux Sa Dispositif de preparation et/ou de traitement d'un echantillon biologique
FR2938063B1 (fr) 2008-11-05 2014-09-19 Commissariat Energie Atomique Dispositif de preparation et/ou de traitement d'un echantillon biologique
GB0901593D0 (en) 2009-01-30 2009-03-11 Touchlight Genetics Ltd Production of closed linear DNA
EP2394152B1 (de) 2009-02-03 2019-05-01 ANDE Corporation Nukleinsäureaufreinigung
US20100267092A1 (en) * 2009-02-09 2010-10-21 Frederic Zenhausern Components
US9739771B2 (en) * 2009-02-27 2017-08-22 Yale University Physiologic sample preparation for nanosensors
CA2754577C (en) 2009-03-06 2018-07-10 President And Fellows Of Harvard College Microfluidic, electrochemical devices
KR20100102926A (ko) * 2009-03-12 2010-09-27 삼성전자주식회사 표적물질 정제를 위한 필터유닛 및 이를 채용한 미세유동장치
ITBO20090152A1 (it) * 2009-03-17 2010-09-18 Silicon Biosystems Spa Dispositivo microfluidico
ITBO20090154A1 (it) * 2009-03-17 2010-09-18 Silicon Biosystems Spa Sistema microfluidico
WO2010106434A1 (en) 2009-03-17 2010-09-23 Silicon Biosystems S.P.A. Microfluidic device for isolation of cells
ITBO20090155A1 (it) * 2009-03-17 2010-09-18 Silicon Biosystems Spa Metodo per l'isolamento di particelle
US8448532B2 (en) * 2009-03-18 2013-05-28 The United States Of America As Represented By The Secretary Of The Navy Actively cooled vapor preconcentrator
US9410948B2 (en) 2009-03-23 2016-08-09 Koninklijke Philips N.V. Manipulation of magnetic particles in a biological sample
WO2010110741A1 (en) * 2009-03-25 2010-09-30 Haiqing Gong Apparatus and method for detection of organisms
EP2478369A4 (de) * 2009-03-25 2012-11-14 Lyzer Diagnostics Inc Vorrichtung und verfahren zur analyse von flüssigkeitsvariablen
DE112010001428B4 (de) * 2009-03-31 2021-03-18 Hitachi High-Tech Corporation Flüssigkeitschromatograph
US8709356B2 (en) 2009-04-10 2014-04-29 Canon U.S. Life Sciences, Inc. Systems and methods for minimization or elimination of diffusion effects in a microfluidic system
KR20120017038A (ko) 2009-04-14 2012-02-27 비오까르띠 에스아 감소된 파워 임계치를 갖는 ｈｉｆｕ 유도 캐비테이션
WO2010118542A1 (en) 2009-04-15 2010-10-21 Biocartis Sa Protection of bioanalytical sample chambers
CN102341710B (zh) 2009-04-15 2015-04-01 比奥卡尔齐什股份有限公司 用于监视rtPCR反应的光学检测系统
JP5766180B2 (ja) 2009-05-06 2015-08-19 ビオカルティ ナームローゼ フェノーツハップＢｉｏｃａｒｔｉｓ ＮＶ 試料キャリヤを切断するための装置
DE102009040151B4 (de) * 2009-05-26 2013-09-12 Analytik Jena Ag Anordnung zur Detektion von Chemolumineszenz an Gasen
US20100300882A1 (en) * 2009-05-26 2010-12-02 General Electric Company Devices and methods for in-line sample preparation of materials
WO2010141921A1 (en) 2009-06-05 2010-12-09 Integenx Inc. Universal sample preparation system and use in an integrated analysis system
JP2012529908A (ja) 2009-06-15 2012-11-29 ネットバイオ・インコーポレーテッド 法医学的ｄｎａの定量化のための改善された方法
WO2010151705A2 (en) 2009-06-26 2010-12-29 Claremont Biosolutions Llc Capture and elution of bio-analytes via beads that are used to disrupt specimens
JP2011010616A (ja) * 2009-07-03 2011-01-20 Olympus Corp 脂肪組織処理容器
EP2459994A4 (de) * 2009-07-27 2017-11-22 Meso Scale Technologies, LLC Vorrichtungen und verfahren zur verwaltung von assay-informationen
EP2459999A1 (de) * 2009-07-28 2012-06-06 Yeda Research and Development Co. Ltd. Ultraschallgestützter immuntest
ES2658169T3 (es) 2009-08-02 2018-03-08 Qvella Corporation Dispositivos de concentración, captura y lisis de células y método de utilización de los mismos
EP2311563A1 (de) * 2009-08-07 2011-04-20 F. Hoffmann-La Roche AG Verarbeitungseinheiten und Verfahren zur Verarbeitung von flüssigen Proben
US20110039267A1 (en) * 2009-08-13 2011-02-17 Cha-Mei Tang Sample Preparation And Detection Of Analytes Using Silica Beads
DE102009029305A1 (de) * 2009-09-09 2011-03-10 Endress + Hauser Conducta Gesellschaft für Mess- und Regeltechnik mbH + Co. KG Analysegerät zur automatisierten Bestimmung einer Messgröße einer Flüssigkeitsprobe
FR2950358B1 (fr) 2009-09-18 2015-09-11 Biomerieux Sa Dispositif d'amplification d'acides nucleiques simplifie et son procede de mise en oeuvre
US8664377B2 (en) * 2009-09-30 2014-03-04 Samsung Electronics Co., Ltd. Method and apparatus for isolating nucleic acids
US8862448B2 (en) 2009-10-19 2014-10-14 Theranos, Inc. Integrated health data capture and analysis system
GB0919159D0 (en) 2009-11-02 2009-12-16 Sec Dep For Environment Food A Device and apparatus
USD638550S1 (en) 2009-11-13 2011-05-24 3M Innovative Properties Company Sample processing disk cover
USD638951S1 (en) 2009-11-13 2011-05-31 3M Innovative Properties Company Sample processing disk cover
USD667561S1 (en) 2009-11-13 2012-09-18 3M Innovative Properties Company Sample processing disk cover
US8834792B2 (en) 2009-11-13 2014-09-16 3M Innovative Properties Company Systems for processing sample processing devices
US8569691B2 (en) 2009-11-24 2013-10-29 University Of Louisville Research Foundation Preconcentrator for analysis instruments
CA3028780C (en) * 2009-12-07 2022-05-31 Meso Scale Technologies, Llc Assay cartridges and methods of using the same
KR101155085B1 (ko) * 2009-12-18 2012-06-11 광주과학기술원 세포 용해 장치 및 그 제조 방법
FR2955508B1 (fr) 2010-01-25 2012-03-30 Corning Inc Microreacteurs avec dispositif microfluidique plan et systeme d'application d'ultrasons ; mise en oeuvre de reactions chimiques en leur sein
US8438903B2 (en) * 2010-01-27 2013-05-14 International Business Machines Corporation Molecule detection device formed in a semiconductor structure
AU2011212916B2 (en) 2010-02-03 2015-07-02 President And Fellows Of Harvard College Devices and methods for multiplexed assays
JP5691187B2 (ja) * 2010-02-10 2015-04-01 ソニー株式会社 核酸増幅反応用マイクロチップ及びその製造方法
CA2789447A1 (en) * 2010-02-12 2011-08-18 Northwestern University Assay card for sample acquisition, treatment and reaction
AU2015221472B2 (en) * 2010-02-23 2017-01-19 Luminex Corporation Apparatus and methods for integrated sample preparation, reaction and detection
CN105004596B (zh) 2010-02-23 2018-12-21 卢米尼克斯公司 用于整合的样品制备、反应和检测的器械和方法
JP5308390B2 (ja) * 2010-03-31 2013-10-09 富士フイルム株式会社 被検物質検出方法および被検物質検出装置
US20110262989A1 (en) 2010-04-21 2011-10-27 Nanomr, Inc. Isolating a target analyte from a body fluid
FR2959312B1 (fr) 2010-04-23 2023-01-20 Biomerieux Sa Dispositif de preparation et/ou de traitement d'un echantillon biologique
CN102869974B (zh) * 2010-04-28 2014-10-15 松下电器产业株式会社 化学传感器
JP5775929B2 (ja) * 2010-05-27 2015-09-09 コーニンクレッカ フィリップス エヌ ヴェ 超音波及び熱を選択的に生成する超音波トランスデューサ
WO2011151804A1 (en) 2010-06-03 2011-12-08 Spinomix S.A. A fluidic interfacing system and assembly
US20110312727A1 (en) * 2010-06-17 2011-12-22 Geneasys Pty Ltd Loc device with parallel nucleic acid amplification functionality
WO2012044387A2 (en) * 2010-07-06 2012-04-05 T2 Biosystems, Inc. Methods and compositions for detection of analytes
ITBO20100503A1 (it) * 2010-08-04 2012-02-05 Silicon Biosystems Spa Sistema microfluidico
ITBO20100504A1 (it) * 2010-08-04 2012-02-05 Silicon Biosystems Spa Sistema microfluidico
GB201013153D0 (en) 2010-08-04 2010-09-22 Touchlight Genetics Ltd Primer for production of closed linear DNA
WO2012016357A1 (en) 2010-08-06 2012-02-09 Capitalbio Corporation Microarray-based assay integrated with particles for analyzing molecular interactions
WO2012024658A2 (en) 2010-08-20 2012-02-23 IntegenX, Inc. Integrated analysis system
CN102375069A (zh) * 2010-08-26 2012-03-14 南京神州英诺华医疗科技有限公司 一种新型的呼吸道样本自动处理仪
US8459121B2 (en) 2010-10-28 2013-06-11 Covaris, Inc. Method and system for acoustically treating material
KR101776215B1 (ko) * 2010-10-29 2017-09-08 삼성전자 주식회사 세포 파쇄용 마이크로 디바이스 및 이를 이용한 세포 파쇄 방법
CN102465110B (zh) * 2010-10-29 2015-08-19 三星电子株式会社 细胞裂解装置和使细胞或病毒裂解的方法
IT1403518B1 (it) 2010-12-22 2013-10-31 Silicon Biosystems Spa Dispositivo microfluidico per la manipolazione di particelle
US8709359B2 (en) 2011-01-05 2014-04-29 Covaris, Inc. Sample holder and method for treating sample material
CN106323876B (zh) 2011-01-21 2020-02-14 西拉诺斯知识产权有限责任公司 样品使用最大化的系统和方法
WO2012116308A1 (en) 2011-02-24 2012-08-30 Gen-Probe Incorporated Systems and methods for distinguishing optical signals of different modulation frequencies in an optical signal detector
PT3270141T (pt) 2011-03-08 2020-08-28 Univ Laval Dispositivo centrípeto fluídico
JP5637300B2 (ja) * 2011-03-28 2014-12-10 学校法人加計学園 試料溶液濃度測定方法及び試料溶液濃度測定装置
JP5931347B2 (ja) * 2011-04-12 2016-06-08 株式会社東芝 自動分析装置
CA2833262C (en) 2011-04-15 2020-08-18 Becton, Dickinson And Company Scanning real-time microfluidic thermocycler and methods for synchronized thermocycling and scanning optical detection
AU2012250619B2 (en) 2011-05-04 2015-11-26 Luminex Corporation Apparatus and methods for integrated sample preparation, reaction and detection
USD672467S1 (en) 2011-05-18 2012-12-11 3M Innovative Properties Company Rotatable sample processing disk
EP2709762B1 (de) 2011-05-18 2021-03-31 DiaSorin S.p.A. Vorrichtung und verfahren zum erkennen eines vorbestimmten volumens eines materials in einer probenverarbeitungsvorrichtung
EP2709760B1 (de) 2011-05-18 2019-06-05 DiaSorin S.p.A. Systeme und verfahren zur ventilmanipulation auf einer probenverarbeitungsvorrichtung
KR20140022399A (ko) 2011-05-18 2014-02-24 쓰리엠 이노베이티브 프로퍼티즈 컴파니 샘플 처리 장치 상의 체적 계량을 위한 시스템 및 방법
EP2726838A4 (de) * 2011-07-01 2015-05-06 Univ Singapore System und verfahren zum nachweis eines oder mehrerer analyte in einer flüssigkeit
CA2842720C (en) 2011-07-25 2023-10-10 Qvella Corporation Methods and devices for electrical sample preparation
US9670538B2 (en) * 2011-08-05 2017-06-06 Ibis Biosciences, Inc. Nucleic acid sequencing by electrochemical detection
US8599009B2 (en) 2011-08-16 2013-12-03 Elwha Llc Systematic distillation of status data relating to regimen compliance
US20140170735A1 (en) 2011-09-25 2014-06-19 Elizabeth A. Holmes Systems and methods for multi-analysis
US9632102B2 (en) * 2011-09-25 2017-04-25 Theranos, Inc. Systems and methods for multi-purpose analysis
US8840838B2 (en) 2011-09-25 2014-09-23 Theranos, Inc. Centrifuge configurations
US9268915B2 (en) 2011-09-25 2016-02-23 Theranos, Inc. Systems and methods for diagnosis or treatment
US8475739B2 (en) 2011-09-25 2013-07-02 Theranos, Inc. Systems and methods for fluid handling
US9619627B2 (en) 2011-09-25 2017-04-11 Theranos, Inc. Systems and methods for collecting and transmitting assay results
US9664702B2 (en) 2011-09-25 2017-05-30 Theranos, Inc. Fluid handling apparatus and configurations
US8435738B2 (en) 2011-09-25 2013-05-07 Theranos, Inc. Systems and methods for multi-analysis
US9810704B2 (en) 2013-02-18 2017-11-07 Theranos, Inc. Systems and methods for multi-analysis
US10012664B2 (en) 2011-09-25 2018-07-03 Theranos Ip Company, Llc Systems and methods for fluid and component handling
US9250229B2 (en) 2011-09-25 2016-02-02 Theranos, Inc. Systems and methods for multi-analysis
USD692162S1 (en) 2011-09-30 2013-10-22 Becton, Dickinson And Company Single piece reagent holder
KR102121853B1 (ko) 2011-09-30 2020-06-12 벡톤 디킨슨 앤드 컴퍼니 일체화된 시약 스트립
EP2578207A3 (de) 2011-10-05 2015-10-07 Jacob J. Schmidt Maskierungsvorrichtung, die Automatisierung und Lösungsaustausch in sessilen Fetttröpfchen-Doppelschichten ermöglicht
US10865440B2 (en) 2011-10-21 2020-12-15 IntegenX, Inc. Sample preparation, processing and analysis systems
US20150136604A1 (en) 2011-10-21 2015-05-21 Integenx Inc. Sample preparation, processing and analysis systems
ITTO20110990A1 (it) 2011-10-28 2013-04-29 Silicon Biosystems Spa Metodo ed apparato per l'analisi ottica di particelle a basse temperature
CN104040238B (zh) 2011-11-04 2017-06-27 汉迪拉布公司 多核苷酸样品制备装置
US9050593B2 (en) * 2011-11-23 2015-06-09 Wisconsin Alumni Research Foundation Self-loading microfluidic device and methods of use
ITBO20110766A1 (it) 2011-12-28 2013-06-29 Silicon Biosystems Spa Dispositivi, apparato, kit e metodo per il trattamento di un campione biologico
CA2863637C (en) 2012-02-03 2021-10-26 Becton, Dickinson And Company External files for distribution of molecular diagnostic tests and determination of compatibility between tests
US11485968B2 (en) 2012-02-13 2022-11-01 Neumodx Molecular, Inc. Microfluidic cartridge for processing and detecting nucleic acids
CN114134029A (zh) 2012-02-13 2022-03-04 纽莫德克斯莫勒库拉尔公司 用于处理和检测核酸的微流体盒
US9637775B2 (en) 2012-02-13 2017-05-02 Neumodx Molecular, Inc. System and method for processing biological samples
US11648561B2 (en) 2012-02-13 2023-05-16 Neumodx Molecular, Inc. System and method for processing and detecting nucleic acids
US9604213B2 (en) 2012-02-13 2017-03-28 Neumodx Molecular, Inc. System and method for processing and detecting nucleic acids
US8804105B2 (en) 2012-03-27 2014-08-12 E. I. Spectra, Llc Combined optical imaging and electrical detection to characterize particles carried in a fluid
WO2013158972A1 (en) 2012-04-20 2013-10-24 Cepheid Methods of detecting bladder cancer
US10132728B2 (en) * 2012-04-27 2018-11-20 Cepheid Apparatus with heterogeneous processing modules
US9063121B2 (en) 2012-05-09 2015-06-23 Stat-Diagnostica & Innovation, S.L. Plurality of reaction chambers in a test cartridge
US9625465B2 (en) 2012-05-15 2017-04-18 Defined Diagnostics, Llc Clinical diagnostic systems
US9213043B2 (en) 2012-05-15 2015-12-15 Wellstat Diagnostics, Llc Clinical diagnostic system including instrument and cartridge
US9081001B2 (en) 2012-05-15 2015-07-14 Wellstat Diagnostics, Llc Diagnostic systems and instruments
TWI512261B (zh) 2012-06-22 2015-12-11 Panasonic Corp 微流體元件
DE102012107651A1 (de) 2012-08-21 2014-02-27 Astrium Gmbh Verfahren zur Durchführung einer biochemischen Analyse, insbesondere im Weltraum
EP2705899A1 (de) 2012-09-07 2014-03-12 Fluigent Mikrofluidisches System mit einer homogenisierenden Komponente
DE102012109026A1 (de) * 2012-09-25 2014-03-27 Eads Deutschland Gmbh Detektionsvorrichtung und Detektionsverfahren zur automatischen Bestimmung von Biomasse
JP2015530113A (ja) 2012-09-28 2015-10-15 セファイド マイクロｒｎａ多重アッセイのための２プライマーｐｃｒ
EP2906269B1 (de) 2012-10-11 2018-01-03 Magnolia Medical Technologies, Inc. System zur abgabe einer flüssigkeit an einen patienten mit reduzierter kontamination
EP2908949A1 (de) * 2012-10-19 2015-08-26 École Polytechnique Fédérale de Lausanne (EPFL) Immunoassay-nanochip mit hohem durchsatz
US20140322706A1 (en) 2012-10-24 2014-10-30 Jon Faiz Kayyem Integrated multipelx target analysis
JP1628115S (de) 2012-10-24 2019-04-01
JP2013019911A (ja) * 2012-10-25 2013-01-31 Seiko Instruments Inc マイクロ流体装置
DK2912174T3 (da) 2012-10-25 2019-08-26 Neumodx Molecular Inc Fremgangsmåde og materialer til isolering af nukleinsyrematerialer
US9987576B2 (en) 2012-12-10 2018-06-05 University Of Virginia Patent Foundation Frequency-based filtering of mechanical actuation using fluidic device
US9434940B2 (en) 2012-12-19 2016-09-06 Dna Electronics, Inc. Methods for universal target capture
US10000557B2 (en) 2012-12-19 2018-06-19 Dnae Group Holdings Limited Methods for raising antibodies
US20140206007A1 (en) * 2013-01-18 2014-07-24 The Johns Hopkins University Electromagnetically actuated droplet microfluidic chip and system
US10329622B2 (en) 2013-03-06 2019-06-25 Cepheid Methods of detecting bladder cancer
US9623409B2 (en) 2013-03-11 2017-04-18 Cue Inc. Cartridges, kits, and methods for enhanced mixing for detection and quantification of analytes
CA3160098A1 (en) 2013-03-11 2014-10-09 Cue Health Inc. Systems and methods for detection and quantification of analytes
US10545161B2 (en) 2013-03-11 2020-01-28 Cue Health Inc. Systems and methods for detection and quantification of analytes
US9359632B2 (en) 2013-03-15 2016-06-07 Theranos, Inc. Devices, systems and methods for sample preparation
WO2014150290A1 (en) * 2013-03-15 2014-09-25 Theranos, Inc. Devices, systems and methods for sample preparation
JP2016522676A (ja) 2013-03-15 2016-08-04 ナノバイオシム・インコーポレイテッド 核酸及びタンパク質の移動式デバイス分析のためのシステム及び方法
EP3520895A1 (de) 2013-03-15 2019-08-07 Genmark Diagnostics Inc. Flüssigkeitsbehälter mit freitragender lanze
US10933417B2 (en) 2013-03-15 2021-03-02 Nanobiosym, Inc. Systems and methods for mobile device analysis of nucleic acids and proteins
US20150028876A1 (en) * 2013-07-24 2015-01-29 Nathan McLaughlin Method and apparatus for testing a lighting device under temperature
KR20150016036A (ko) * 2013-08-02 2015-02-11 삼성전자주식회사 핵산 증폭 방법
JP6295578B2 (ja) * 2013-09-30 2018-03-20 凸版印刷株式会社 反応容器、核酸解析装置、および核酸解析方法
US9498778B2 (en) 2014-11-11 2016-11-22 Genmark Diagnostics, Inc. Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system
USD881409S1 (en) 2013-10-24 2020-04-14 Genmark Diagnostics, Inc. Biochip cartridge
EP3071333A4 (de) 2013-11-18 2017-11-15 IntegenX Inc. Kassetten und instrumente zur probenanalyse
US9283560B2 (en) * 2013-11-22 2016-03-15 Sharp Kabushiki Kaisha Passive microfluidic metering device
WO2015083165A1 (en) 2013-12-04 2015-06-11 Pocared Diagnostics Ltd. Filter arrangement with slider valve and method for using the same
DE102014200501A1 (de) 2014-01-14 2015-07-16 Robert Bosch Gmbh Aufschlussvorrichtung und Verfahren zum Aufschließen einer Zellen enthaltenden, biologischen Probe sowie Verfahren zum Herstellen einer Aufschlussvorrichtung
DE102014200505A1 (de) 2014-01-14 2015-07-16 Robert Bosch Gmbh Behälter und Vorrichtung für einen Aufschluss und/oder eine Homogenisierung eines Fluids sowie Verfahren zum Aufschließen und/oder Homogenisieren eines Fluids
US10195610B2 (en) 2014-03-10 2019-02-05 Click Diagnostics, Inc. Cartridge-based thermocycler
EP3116651B1 (de) * 2014-03-11 2020-04-22 Illumina, Inc. Wegwerfbare, integrierte mikrofluidische kartusche und verfahren zur herstellung davon
PT3594360T (pt) 2014-04-24 2021-08-19 Lucira Health Inc Deteção colorimétrica da amplificação do ácido nucleico
DE102014207775A1 (de) 2014-04-25 2015-10-29 Robert Bosch Gmbh Verfahren und mikrofluidisches System zum Aufbereiten von organischen Zellen und Herstellungsverfahren zum Herstellen eines mikrofluidischen Systems zum Aufbereiten von organischen Zellen
DE102014207774B4 (de) * 2014-04-25 2015-12-31 Robert Bosch Gmbh Verfahren und Vorrichtung zur Aufreinigung von biologischen Molekülen
AU2014391652B2 (en) * 2014-04-25 2018-02-22 Hewlett-Packard Development Company, L.P. Diagnostic cassette
USD745423S1 (en) 2014-05-12 2015-12-15 Cue Inc. Automated analyzer test cartridge and sample collection device for analyte detection
WO2015179098A1 (en) 2014-05-21 2015-11-26 Integenx Inc. Fluidic cartridge with valve mechanism
WO2015187849A2 (en) 2014-06-04 2015-12-10 Lucigen Corporation Sample collection and analysis devices
MX2016016828A (es) * 2014-06-18 2017-06-19 Scandinavian Micro Biodevices Aps Un sistema de deteccion microfluidico y un cartucho microfluidico.
KR102238956B1 (ko) * 2014-06-24 2021-04-13 삼성전자주식회사 유체 분석 시트, 이를 포함하는 유체 분석 카트리지 및 유체 분석 카트리지의 제조방법
US10596492B2 (en) * 2014-07-09 2020-03-24 Sudhin Biopharma Particle settling devices
US20190210042A1 (en) * 2014-07-09 2019-07-11 Sudhin Biopharma Particle setting devices
US20160041156A1 (en) * 2014-08-11 2016-02-11 OncoGenesis Inc. Integrated Device for Measuring Multiple Analytes
US10480036B2 (en) 2014-08-22 2019-11-19 Cepheid Methods of detecting influenza
GB201415789D0 (en) 2014-09-05 2014-10-22 Touchlight Genetics Ltd Synthesis of DNA
US10196678B2 (en) 2014-10-06 2019-02-05 ALVEO Technologies Inc. System and method for detection of nucleic acids
EP3552690A1 (de) 2014-10-22 2019-10-16 IntegenX Inc. Systeme und verfahren zur automatisierten vorbereitung, verarbeitung und analyse von proben
WO2016069853A2 (en) 2014-10-30 2016-05-06 Cepheid Methods of detecting ebola
US10005080B2 (en) 2014-11-11 2018-06-26 Genmark Diagnostics, Inc. Instrument and cartridge for performing assays in a closed sample preparation and reaction system employing electrowetting fluid manipulation
US9598722B2 (en) 2014-11-11 2017-03-21 Genmark Diagnostics, Inc. Cartridge for performing assays in a closed sample preparation and reaction system
WO2016083550A1 (en) * 2014-11-26 2016-06-02 Imec Vzw Compact glass-based fluid analysis device and method to fabricate
WO2016087957A1 (en) * 2014-12-05 2016-06-09 Diasys Diagnostics India Private Limited Multiplexed microfluidic device
CA2971006A1 (en) 2014-12-15 2016-06-23 Cepheid Exponential base-greater-than-2 nucleic acid amplification
CN204330461U (zh) * 2014-12-29 2015-05-13 徕卡显微系统(上海)有限公司 包埋机
CN105806685B (zh) * 2014-12-29 2020-05-05 徕卡显微系统(上海)有限公司 具有移动式分配器的包埋机
CN114958990A (zh) 2014-12-31 2022-08-30 维斯比医学公司 使用分子诊断测试装置检测靶核酸的方法
EP3256253A1 (de) * 2015-02-13 2017-12-20 Ecole Supérieure de Physique et de Chimie Industrielles de la Ville de Paris Papiervorrichtung zur genetischen diagnose
US9861982B2 (en) * 2015-03-09 2018-01-09 Emd Millipore Corporation Connectors for pneumatic devices in microfluidic systems
EP3290900A4 (de) * 2015-04-28 2018-04-18 Panasonic Corporation Verflüssiger chemischer substanzen
US20190376882A1 (en) 2015-05-27 2019-12-12 Qiagen Gmbh Composition and Method for Disrupting Tissue Material
CN108025904B (zh) * 2015-06-12 2021-10-15 芯易诊有限公司 用于多分析物分析的流体单元和流体卡式盒
US10634602B2 (en) 2015-06-12 2020-04-28 Cytochip Inc. Fluidic cartridge for cytometry and additional analysis
WO2016205233A2 (en) * 2015-06-15 2016-12-22 Cepheid Integrated purification and measurement of dna methylation and co-measurement of mutations and/or mrna expression levels in an automated reaction cartridge
US11248255B2 (en) * 2015-06-19 2022-02-15 The Governing Council Of The University Of Toronto Amplification of nanoparticle based assay
US20160367918A1 (en) * 2015-06-22 2016-12-22 Fuji Electric Co., Ltd. Filter system
EP3112869A1 (de) * 2015-06-30 2017-01-04 IMEC vzw Sensorvorrichtung
WO2017011554A1 (en) 2015-07-14 2017-01-19 Cytochip Inc. Volume sensing in fluidic cartridge
CN112881730A (zh) 2015-07-17 2021-06-01 克忧健康公司 用于增强检测和分析物定量的系统及方法
US10775370B2 (en) 2015-07-17 2020-09-15 Stat-Diagnostica & Innovation, S.L. Fluidic system for performing assays
CA2993447C (en) 2015-07-24 2024-01-02 Cepheid Compositions and methods for dna and rna extraction from tissue samples
US11071982B2 (en) * 2015-08-27 2021-07-27 Ativa Medical Corporation Fluid holding and dispensing micro-feature
USD799715S1 (en) 2015-10-23 2017-10-10 Gene POC, Inc. Fluidic centripetal device
US11169060B2 (en) * 2015-11-18 2021-11-09 Beckman Coulter, Inc. Filtering device for analyzing instrument
US11123736B2 (en) 2016-03-14 2021-09-21 Lucira Health, Inc. Systems and methods for performing biological assays
AU2017232342B2 (en) 2016-03-14 2022-04-21 Pfizer Inc. Devices and methods for biological assay sample preparation and delivery
CA3015378C (en) * 2016-03-14 2023-09-26 Diassess Inc. Selectively vented biological assay devices and associated methods
WO2017185067A1 (en) 2016-04-22 2017-10-26 Click Diagnostics, Inc. Printed circuit board heater for an amplification module
WO2017197040A1 (en) 2016-05-11 2017-11-16 Click Diagnostics, Inc. Devices and methods for nucleic acid extraction
US10774393B2 (en) 2016-05-20 2020-09-15 Roche Molecular Systems, Inc. Cell surface marker depletion in a sample processing device
JP7106461B2 (ja) 2016-06-07 2022-07-26 セファイド 熱安定性ポリメラーゼ阻害剤組成物及び方法
EP3478857A1 (de) 2016-06-29 2019-05-08 Click Diagnostics, Inc. Vorrichtungen und verfahren zur detektion von molekülen unter verwendung einer durchflusszelle
USD800331S1 (en) 2016-06-29 2017-10-17 Click Diagnostics, Inc. Molecular diagnostic device
USD800914S1 (en) 2016-06-30 2017-10-24 Click Diagnostics, Inc. Status indicator for molecular diagnostic device
USD800913S1 (en) 2016-06-30 2017-10-24 Click Diagnostics, Inc. Detection window for molecular diagnostic device
EP3481968A4 (de) * 2016-07-08 2019-12-18 California Institute of Technology Verfahren und vorrichtungen zur durchflusserfassung von niedrigkonzentrierten analyten
US11440009B2 (en) 2016-07-15 2022-09-13 Hewlett-Packard Development Company, L.P. Plurality of filters
CA3036186C (en) * 2016-09-08 2021-03-30 Hemex Health, Inc. A point-of-care system for diagnosing disease, infection or condition of a patient
US10349589B2 (en) 2016-09-08 2019-07-16 Hemex Health, Inc. Diagnostics systems and methods
WO2018057647A1 (en) * 2016-09-23 2018-03-29 Alveo Technologies, Inc. Methods and compositions for detecting analytes
CA3035141A1 (en) 2016-10-07 2018-04-12 Boehringer Ingelheim Vetmedica Gmbh Method and analysis system for testing a sample
MX2019003922A (es) 2016-10-07 2019-06-10 Boehringer Ingelheim Vetmedica Gmbh Dispositivo de analisis y metodo para analizar una muestra.
EP3523032A2 (de) 2016-10-07 2019-08-14 Boehringer Ingelheim Vetmedica GmbH Kartusche zum testen einer probe
US10422012B2 (en) 2016-10-10 2019-09-24 Roche Molecular Systems, Inc. Devices comprising bacteriophage PHI6 internal control compositions
CN106568982B (zh) * 2016-10-31 2018-05-29 浙江大学 一种用于二维液滴阵列形成和筛选的装置及其使用方法
KR102103582B1 (ko) * 2016-11-29 2020-04-23 삼육대학교산학협력단 실리카 나노입자를 포함하는 미세유체칩 및 그의 제조방법
KR102479432B1 (ko) * 2016-12-12 2022-12-20 세페이드 자동화 반응 카트리지에서 DNA 메틸화의 통합 정제 및 측정 및 돌연변이 및/또는 mRNA 발현도의 동시 측정
TWI611171B (zh) 2016-12-14 2018-01-11 財團法人工業技術研究院 生物樣品處理裝置
WO2018140540A1 (en) 2017-01-25 2018-08-02 Cue Health Inc. Systems and methods for enhanced detection and quantification of analytes
CN108654138B (zh) * 2017-04-01 2023-06-16 四川大学 一种离心力微流体萃取装置及其萃取方法
US20190093155A1 (en) 2017-05-25 2019-03-28 Roche Molecular Systems, Inc. Multiplex Nucleic Acid Amplification Assay
US11602750B2 (en) 2017-05-30 2023-03-14 Roche Molecular Systems, Inc. Customizable sample processing device
WO2019026026A1 (en) 2017-08-02 2019-02-07 Pocared Diagnostics Ltd. PROCESSOR FILTER ARRANGEMENT COMPRISING A METHOD AND APPARATUS FOR REMOVING A RESIDUAL FLUID THROUGH A FILTER
WO2019055487A1 (en) 2017-09-12 2019-03-21 Magnolia Medical Technologies, Inc. FLUID CONTROL DEVICES AND METHODS OF USE
US10549275B2 (en) 2017-09-14 2020-02-04 Lucira Health, Inc. Multiplexed biological assay device with electronic readout
DE102017008908A1 (de) 2017-09-22 2019-03-28 Friz Biochem Gesellschaft Für Bioanalytik Mbh Tragbarer Behälter für die Tuberkulose-Präanalytik
WO2019083844A1 (en) 2017-10-23 2019-05-02 Cytochip Inc. DEVICES AND METHOD FOR MEASURING TARGET ANALYTES AND PARTICLES
WO2019086517A1 (en) 2017-10-31 2019-05-09 Roche Diagnostics Gmbh Improved magnetic particles and uses thereof
AU2018364741B2 (en) 2017-11-09 2021-03-25 Visby Medical, Inc. Portable molecular diagnostic device and methods for the detection of target viruses
CN109868205A (zh) * 2017-12-05 2019-06-11 台达电子国际（新加坡）私人有限公司 生物样本处理装置及其生物样本处理方法
JP7052044B2 (ja) 2017-12-19 2022-04-11 エフ．ホフマン－ラ ロシュ アーゲー 試料処理デバイスにおいて脆いシールを製造する方法
AU2019239860A1 (en) * 2018-03-21 2020-09-03 Precision Planting Llc Reagent cartridge
RU2764775C1 (ru) 2018-04-18 2022-01-21 Судхин Биофарма Устройства для осаждения частиц
CN112119311A (zh) * 2018-07-27 2020-12-22 泽普托生命技术有限责任公司 用于处理基于gmr的生物标志物检测中的分析物信号的系统和方法
JP2020024202A (ja) * 2018-08-06 2020-02-13 積水化学工業株式会社 分析用具及び洗浄方法
AU2019371797A1 (en) 2018-10-29 2021-05-20 Cepheid Exponential base-3 nucleic acid amplification with reduced amplification time using nested overlapping primers
FR3088340B1 (fr) 2018-11-12 2021-01-22 Commissariat Energie Atomique Systeme automatise de preparation, de detection et d'analyse d'un echantillon fluidique
CN109406238B (zh) * 2018-12-07 2023-10-17 郑州机械研究所有限公司 一种用于金相试样制备的多功能卡具及金相试样制备方法
USD907232S1 (en) 2018-12-21 2021-01-05 Lucira Health, Inc. Medical testing device
WO2020139210A1 (en) * 2018-12-28 2020-07-02 Mikro Biyosistemler Elektronik Sanayi Ve Ticaret A.S. A method of microfluidic particle separation enhancement and the device thereof
WO2020146583A1 (en) * 2019-01-10 2020-07-16 Instrumentation Laboratory Company Ultrasound lysing of whole blood
GB201902810D0 (en) * 2019-03-01 2019-04-17 Vidya Holdings Ltd Disposition of reagents in assay device
WO2020185914A1 (en) 2019-03-11 2020-09-17 Magnolia Medical Technologies, Inc. Fluid control devices and methods of using the same
US11740203B2 (en) 2019-06-25 2023-08-29 Hemex Health, Inc. Diagnostics systems and methods
US11730193B2 (en) 2019-12-15 2023-08-22 Shaheen Innovations Holding Limited Hookah device
US11254979B2 (en) 2020-06-01 2022-02-22 Shaheen Innovations Holding Limited Systems and devices for infectious disease screening
US11352675B2 (en) 2020-01-03 2022-06-07 Visby Medical, Inc. Devices and methods for antibiotic susceptability testing
AU2021236679B2 (en) 2020-03-19 2024-02-15 Sudhin Biopharma Particle settling devices
CA3174154A1 (en) * 2020-04-06 2021-10-14 Imad Lahoud Cell lysis systems and methods
WO2021205151A2 (en) * 2020-04-06 2021-10-14 Shaheen Innovations Holding Limited Cell lysis systems and methods
WO2021216070A1 (en) * 2020-04-23 2021-10-28 Hewlett-Packard Development Company, L.P. Measuring deformability of a cell
USD953561S1 (en) 2020-05-05 2022-05-31 Lucira Health, Inc. Diagnostic device with LED display
US11181451B1 (en) 2020-06-01 2021-11-23 Shaheen Innovations Holding Limited Infectious disease screening system
WO2021245391A1 (en) * 2020-06-01 2021-12-09 Shaheen Innovations Holding Limited An infectious disease screening device
EP3919176A1 (de) * 2020-06-01 2021-12-08 Shaheen Innovations Holding Limited Testvorrichtungen und systeme zum screening auf infektionskrankheiten
EP3919175A1 (de) * 2020-06-01 2021-12-08 Shaheen Innovations Holding Limited Systeme und vorrichtungen zur untersuchung infektiöser erkrankungen
USD962470S1 (en) 2020-06-03 2022-08-30 Lucira Health, Inc. Assay device with LCD display
KR20230030639A (ko) 2020-06-26 2023-03-06 세페이드 Sars-cov-2, 인플루엔자 및 rsv를 검출하는 방법
US11904314B2 (en) * 2020-07-30 2024-02-20 Wainamics, Inc. System and self-metering cartridges for point of care bioassays
CN116348767A (zh) 2020-10-06 2023-06-27 西菲伊德公司 诊断结核病以及区分活动性和潜伏性结核病的方法
EP4308729A1 (de) 2021-03-16 2024-01-24 Cepheid Verfahren zur unterscheidung bakterieller und viraler infektionen bei einer person
WO2022251508A1 (en) * 2021-05-28 2022-12-01 Proof Diagnostics Reaction cartridge
CN113686843A (zh) * 2021-07-19 2021-11-23 清华大学深圳国际研究生院 一种基于超声波裂解的比色反应微流控快速检测设备
CN116635538A (zh) 2021-10-22 2023-08-22 塞弗德公司 诊断和治疗结核病的组合物和方法
WO2023177748A1 (en) * 2022-03-15 2023-09-21 Cepheid Unitary cartridge body and associated components and methods of manufacture
CN115141739A (zh) * 2022-09-06 2022-10-04 至美时代生物智能科技(北京)有限公司 一种空气微生物采样检测一体化装置及采样检测方法

Family Cites Families (117)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB938163A (en) 1960-09-20 1963-10-02 Boots Pure Drug Co Ltd Improvements in or relating to particle size reduction or cellular disruption
US3799742A (en) 1971-12-20 1974-03-26 C Coleman Miniaturized integrated analytical test container
ZA784744B (en) 1977-08-31 1979-08-29 C Jottier Apparatus for the treatment of fluids
US4426451A (en) 1981-01-28 1984-01-17 Eastman Kodak Company Multi-zoned reaction vessel having pressure-actuatable control means between zones
SE8102316L (sv) 1981-04-10 1982-10-11 Pharmacia Diagnostics Ab Anordning for genomforande av analyser
AU570439B2 (en) 1983-03-28 1988-03-17 Compression Labs, Inc. A combined intraframe and interframe transform coding system
US4963498A (en) 1985-08-05 1990-10-16 Biotrack Capillary flow device
US4822731A (en) * 1986-01-09 1989-04-18 Cetus Corporation Process for labeling single-stranded nucleic acids and hybridizaiton probes
AU604684B2 (en) * 1986-03-20 1991-01-03 Gen-Probe Incorporated Method for releasing RNA and DNA from cells
GB2191110B (en) 1986-06-06 1989-12-06 Plessey Co Plc Chromatographic separation device
US4789628A (en) 1986-06-16 1988-12-06 Vxr, Inc. Devices for carrying out ligand/anti-ligand assays, methods of using such devices and diagnostic reagents and kits incorporating such devices
US4915812A (en) 1986-06-20 1990-04-10 Molecular Devices Corporation Zero volume cell
US5714380A (en) 1986-10-23 1998-02-03 Amoco Corporation Closed vessel for isolating target molecules and for performing amplification
CH667599A5 (fr) 1986-12-11 1988-10-31 Battelle Memorial Institute Enceinte destinee a contenir un milieu liquide.
US4918025A (en) 1987-03-03 1990-04-17 Pb Diagnostic Systems, Inc. Self contained immunoassay element
US4855240A (en) 1987-05-13 1989-08-08 Becton Dickinson And Company Solid phase assay employing capillary flow
AU1983588A (en) * 1987-06-23 1989-01-19 Norman G. Anderson Centrifugal fast chromatograph
US4908318A (en) 1987-09-04 1990-03-13 Integrated Genetics, Inc. Nucleic acid extraction methods
US4923978A (en) 1987-12-28 1990-05-08 E. I. Du Pont De Nemours & Company Process for purifying nucleic acids
WO1989006280A1 (en) * 1988-01-04 1989-07-13 E.I. Du Pont De Nemours And Company Multiple stage affinity process for isolation of specific cells from a cell mixture
US4921952A (en) 1988-01-21 1990-05-01 The United States Of America As Represented By The United States Department Of Energy Nucleic acid isolation process
JPH0721485B2 (ja) * 1988-03-11 1995-03-08 ダイソー株式会社 苛性アルカリ中塩化物イオンの流れ分析法
US4983523A (en) 1988-04-08 1991-01-08 Gene-Trak Systems Methods for preparing sample nucleic acids for hybridization
SE8801299L (sv) 1988-04-08 1989-10-09 Bertil Hoeoek Mikromekanisk envaegsventil
US5374533A (en) 1988-05-10 1994-12-20 Tetjin Limited Method for determining chondrocalcin
US4908112A (en) 1988-06-16 1990-03-13 E. I. Du Pont De Nemours & Co. Silicon semiconductor wafer for analyzing micronic biological samples
FR2634892B1 (fr) 1988-07-28 1990-09-14 Guigan Jean Dispositif pour la realisation d'analyses biologiques par detection immuno-enzymatique d'anticorps ou d'antigenes dans un serum
US5188963A (en) 1989-11-17 1993-02-23 Gene Tec Corporation Device for processing biological specimens for analysis of nucleic acids
US5229297A (en) 1989-02-03 1993-07-20 Eastman Kodak Company Containment cuvette for PCR and method of use
US5234809A (en) 1989-03-23 1993-08-10 Akzo N.V. Process for isolating nucleic acid
US5207988A (en) 1989-07-06 1993-05-04 The Cleveland Clinic Foundation Apparatus for detecting and quantifying clot lysis and establishing optimum medication and dosages
US5124444A (en) 1989-07-24 1992-06-23 Microprobe Corporation Lactam-containing compositions and methods useful for the extraction of nucleic acids
US5231015A (en) 1989-10-18 1993-07-27 Eastman Kodak Company Methods of extracting nucleic acids and pcr amplification without using a proteolytic enzyme
AU642444B2 (en) 1989-11-30 1993-10-21 Mochida Pharmaceutical Co., Ltd. Reaction vessel
US5770029A (en) * 1996-07-30 1998-06-23 Soane Biosciences Integrated electrophoretic microdevices
US5858188A (en) 1990-02-28 1999-01-12 Aclara Biosciences, Inc. Acrylic microchannels and their use in electrophoretic applications
US5143084A (en) 1990-05-24 1992-09-01 Spacelabs, Inc. Disposable cartridge for sampling and analyzing body fluids
KR0182619B1 (ko) 1990-06-15 1999-05-01 로버트 피. 블랙버언 내장된 분석 조립체 및 장치
US5114858A (en) 1990-06-26 1992-05-19 E. I. Du Pont De Nemours And Company Cellular component extraction process in a disposable filtration vessel
DE4126436A1 (de) 1990-09-17 1992-03-19 Abion Ohg Einwegreaktionsgefaess fuer die festphasenimmunanalytik und verfahren zur messung von ueber immunreaktionen bestimmbaren komponenten
US5652141A (en) 1990-10-26 1997-07-29 Oiagen Gmbh Device and process for isolating nucleic acids from cell suspension
DE4034036C2 (de) * 1990-10-26 1994-03-03 Diagen Inst Molekularbio Vorrichtung und Verfahren zur Isolierung von Nukleinsäuren aus Zellsuspensionen
US5654179A (en) * 1990-11-14 1997-08-05 Hri Research, Inc. Nucleic acid preparation methods
US5352777A (en) 1990-12-26 1994-10-04 Pioneer Hi-Bred International, Inc. DNA isolation from animal cells
SE9100392D0 (sv) 1991-02-08 1991-02-08 Pharmacia Biosensor Ab A method of producing a sealing means in a microfluidic structure and a microfluidic structure comprising such sealing means
US5264184A (en) 1991-03-19 1993-11-23 Minnesota Mining And Manufacturing Company Device and a method for separating liquid samples
US5422241A (en) 1991-07-03 1995-06-06 Ambion, Inc. Methods for the recovery of nucleic acids from reaction mixtures
US5155018A (en) 1991-07-10 1992-10-13 Hahnemann University Process and kit for isolating and purifying RNA from biological sources
US5329000A (en) 1991-10-31 1994-07-12 Becton, Dickinson And Company Purification of DNA with silicon tetrahydrazide
US5605662A (en) 1993-11-01 1997-02-25 Nanogen, Inc. Active programmable electronic devices for molecular biological analysis and diagnostics
EP0555798B1 (de) 1992-02-13 1999-05-06 Becton, Dickinson and Company Celithydrat und Reinigung von DNS
US5223219A (en) 1992-04-10 1993-06-29 Biotrack, Inc. Analytical cartridge and system for detecting analytes in liquid samples
US5304487A (en) 1992-05-01 1994-04-19 Trustees Of The University Of Pennsylvania Fluid handling in mesoscale analytical devices
US5296375A (en) 1992-05-01 1994-03-22 Trustees Of The University Of Pennsylvania Mesoscale sperm handling devices
US5744366A (en) * 1992-05-01 1998-04-28 Trustees Of The University Of Pennsylvania Mesoscale devices and methods for analysis of motile cells
US5726026A (en) * 1992-05-01 1998-03-10 Trustees Of The University Of Pennsylvania Mesoscale sample preparation device and systems for determination and processing of analytes
US5498392A (en) * 1992-05-01 1996-03-12 Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification device and method
US5587128A (en) * 1992-05-01 1996-12-24 The Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification devices
US5409586A (en) 1992-08-26 1995-04-25 Hitachi, Ltd. Method for analyzing nucleic acid or protein and apparatus therefor
US5639423A (en) 1992-08-31 1997-06-17 The Regents Of The University Of Calfornia Microfabricated reactor
US5422271A (en) 1992-11-20 1995-06-06 Eastman Kodak Company Nucleic acid material amplification and detection without washing
US5795714A (en) * 1992-11-06 1998-08-18 Trustees Of Boston University Method for replicating an array of nucleic acid probes
US5399486A (en) 1993-02-18 1995-03-21 Biocircuits Corporation Disposable unit in diagnostic assays
US5798215A (en) 1993-02-18 1998-08-25 Biocircuits Corporation Device for use in analyte detection assays
US5503985A (en) 1993-02-18 1996-04-02 Cathey; Cheryl A. Disposable device for diagnostic assays
US5427663A (en) 1993-06-08 1995-06-27 British Technology Group Usa Inc. Microlithographic array for macromolecule and cell fractionation
GB9314249D0 (en) * 1993-07-09 1993-08-18 Proofname Ltd Purification method and apparatus
EP0722563A4 (de) 1993-08-24 1998-03-04 Metrika Lab Inc Neues elektronisches einweg-assaygerät
US5438129A (en) 1993-09-27 1995-08-01 Becton Dickinson And Company DNA purification by solid phase extraction using partially fluorinated aluminum hydroxide adsorbant
US5438127A (en) 1993-09-27 1995-08-01 Becton Dickinson And Company DNA purification by solid phase extraction using a PCl3 modified glass fiber membrane
WO1995011755A1 (en) 1993-10-28 1995-05-04 Houston Advanced Research Center Microfabricated, flowthrough porous apparatus for discrete detection of binding reactions
US5976824A (en) 1993-11-24 1999-11-02 Abbott Laboratories Method and apparatus for collecting a cell sample from a liquid specimen
DE69422604T2 (de) 1994-03-08 2000-06-08 Zeptosens Ag Witterwil Vorrichtung und Verfahren, die Bioaffinitätsassay und elektrophoretische Auftrennung kombinieren
DE69527585T2 (de) * 1994-06-08 2003-04-03 Affymetrix Inc Verfahren und Vorrichtung zum Verpacken von Chips
US5580435A (en) 1994-06-10 1996-12-03 The Board Of Trustees Of The Leland Stanford Junior University System for detecting components of a sample in electrophoretic separation
DE4420732A1 (de) 1994-06-15 1995-12-21 Boehringer Mannheim Gmbh Vorrichtung zur Behandlung von Nukleinsäuren aus einer Probe
US5639428A (en) 1994-07-19 1997-06-17 Becton Dickinson And Company Method and apparatus for fully automated nucleic acid amplification, nucleic acid assay and immunoassay
US5707799A (en) 1994-09-30 1998-01-13 Abbott Laboratories Devices and methods utilizing arrays of structures for analyte capture
US5500071A (en) 1994-10-19 1996-03-19 Hewlett-Packard Company Miniaturized planar columns in novel support media for liquid phase analysis
US5571410A (en) * 1994-10-19 1996-11-05 Hewlett Packard Company Fully integrated miniaturized planar liquid sample handling and analysis device
US5641400A (en) 1994-10-19 1997-06-24 Hewlett-Packard Company Use of temperature control devices in miniaturized planar column devices and miniaturized total analysis systems
US5585069A (en) 1994-11-10 1996-12-17 David Sarnoff Research Center, Inc. Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis
CN1192097C (zh) 1995-03-10 2005-03-09 梅索磅秤技术有限公司 多阵列、多特异性的电化学发光检验
JP3477918B2 (ja) * 1995-05-29 2003-12-10 株式会社島津製作所 キャピラリ電気泳動チップ
US5716852A (en) 1996-03-29 1998-02-10 University Of Washington Microfabricated diffusion-based chemical sensor
US5589136A (en) * 1995-06-20 1996-12-31 Regents Of The University Of California Silicon-based sleeve devices for chemical reactions
US6168948B1 (en) 1995-06-29 2001-01-02 Affymetrix, Inc. Miniaturized genetic analysis systems and methods
US5856174A (en) 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
JPH11509100A (ja) 1995-07-13 1999-08-17 イムノロジカル アソシエーツ オブ デンバー 核酸抽出、増幅および検出を統合する自己充足装置
ATE242303T1 (de) * 1995-08-17 2003-06-15 Hoffmann La Roche Chromatographie-verfahren
EP1291441A3 (de) 1995-09-12 2003-03-19 Becton, Dickinson and Company Verfahren und Vorrichtung zur DNS-Amplifikation und -Testung
US5705018A (en) 1995-12-13 1998-01-06 Hartley; Frank T. Micromachined peristaltic pump
US5863502A (en) 1996-01-24 1999-01-26 Sarnoff Corporation Parallel reaction cassette and associated devices
AU1989197A (en) * 1996-03-06 1997-09-22 Akzo Nobel N.V. Automated nucleic acid extraction from samples
US5707860A (en) 1996-03-12 1998-01-13 Becton Dickinson And Company Vehicle for delivery of particles to a sample
US5846727A (en) 1996-06-06 1998-12-08 Board Of Supervisors Of Louisiana State University And Agricultural & Mechanical College Microsystem for rapid DNA sequencing
US5863801A (en) 1996-06-14 1999-01-26 Sarnoff Corporation Automated nucleic acid isolation
EP0909385B1 (de) 1996-06-28 2008-09-10 Caliper Life Sciences, Inc. Verfahren zum Transport von Fluidproben durch einen mikrofluidischen Kanal
US5779868A (en) 1996-06-28 1998-07-14 Caliper Technologies Corporation Electropipettor and compensation means for electrophoretic bias
AU730718B2 (en) * 1996-09-18 2001-03-15 Promega Corporation Improved filtration system and method
US5874046A (en) 1996-10-30 1999-02-23 Raytheon Company Biological warfare agent sensor system employing ruthenium-terminated oligonucleotides complementary to target live agent DNA sequences
US5882903A (en) 1996-11-01 1999-03-16 Sarnoff Corporation Assay system and method for conducting assays
WO1998033585A1 (en) 1997-02-05 1998-08-06 California Institute Of Technology Microfluidic sub-millisecond mixers
JP3356784B2 (ja) 1997-02-28 2002-12-16 バースタイン テクノロジーズ，インコーポレイティド 光ディスク、及び試料の光学分析を実施するための方法
US5939259A (en) 1997-04-09 1999-08-17 Schleicher & Schuell, Inc. Methods and devices for collecting and storing clinical samples for genetic analysis
WO1998049548A1 (en) 1997-04-25 1998-11-05 Caliper Technologies Corporation Microfluidic devices incorporating improved channel geometries
US5786182A (en) 1997-05-02 1998-07-28 Biomerieux Vitek, Inc. Dual chamber disposable reaction vessel for amplification reactions, reaction processing station therefor, and methods of use
US6156273A (en) 1997-05-27 2000-12-05 Purdue Research Corporation Separation columns and methods for manufacturing the improved separation columns
US5922288A (en) 1997-05-29 1999-07-13 Herst; C. V. Taylor Device for isolating a component of a physiological sample
US5869004A (en) 1997-06-09 1999-02-09 Caliper Technologies Corp. Methods and apparatus for in situ concentration and/or dilution of materials in microfluidic systems
JP2001515216A (ja) * 1997-08-13 2001-09-18 シーフィード 流体試料を操作するための微小構造体
US5842787A (en) 1997-10-09 1998-12-01 Caliper Technologies Corporation Microfluidic systems incorporating varied channel dimensions
DE69839709D1 (de) * 1997-12-24 2008-08-21 Cepheid Vorrichtung und Verfahren zur Lyse
US6261848B1 (en) * 1998-05-08 2001-07-17 The Johns Hopkins University Miniature immuno-optical rapid analyte sensor platform
US6100084A (en) 1998-11-05 2000-08-08 The Regents Of The University Of California Micro-sonicator for spore lysis
US6261431B1 (en) 1998-12-28 2001-07-17 Affymetrix, Inc. Process for microfabrication of an integrated PCR-CE device and products produced by the same
US6878540B2 (en) * 1999-06-25 2005-04-12 Cepheid Device for lysing cells, spores, or microorganisms

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US7569346B2 (en) 2009-08-04
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US6893879B2 (en) 2005-05-17
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