DE69839946D1 - Methoden zum Screening von Affinitätsmarker-Bibliotheken - Google Patents
Methoden zum Screening von Affinitätsmarker-BibliothekenInfo
- Publication number
- DE69839946D1 DE69839946D1 DE69839946T DE69839946T DE69839946D1 DE 69839946 D1 DE69839946 D1 DE 69839946D1 DE 69839946 T DE69839946 T DE 69839946T DE 69839946 T DE69839946 T DE 69839946T DE 69839946 D1 DE69839946 D1 DE 69839946D1
- Authority
- DE
- Germany
- Prior art keywords
- methods
- affinity marker
- molecule
- screening affinity
- marker libraries
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000003550 marker Substances 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000012216 screening Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000032 diagnostic agent Substances 0.000 abstract 1
- 229940039227 diagnostic agent Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000009870 specific binding Effects 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6901—Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0041—Xanthene dyes, used in vivo, e.g. administered to a mice, e.g. rhodamines, rose Bengal
- A61K49/0043—Fluorescein, used in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0056—Peptides, proteins, polyamino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6470597P | 1997-11-07 | 1997-11-07 | |
| US7792798P | 1998-03-13 | 1998-03-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE69839946D1 true DE69839946D1 (de) | 2008-10-09 |
Family
ID=26744806
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69806066T Expired - Lifetime DE69806066T2 (de) | 1997-11-07 | 1998-11-06 | Affinitätsmarkierer für menschliches serum albumin |
| DE69839946T Expired - Fee Related DE69839946D1 (de) | 1997-11-07 | 1998-11-06 | Methoden zum Screening von Affinitätsmarker-Bibliotheken |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69806066T Expired - Lifetime DE69806066T2 (de) | 1997-11-07 | 1998-11-06 | Affinitätsmarkierer für menschliches serum albumin |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7166695B2 (de) |
| EP (2) | EP2033661A1 (de) |
| AT (2) | ATE218892T1 (de) |
| AU (1) | AU1519699A (de) |
| CA (2) | CA2628053A1 (de) |
| DE (2) | DE69806066T2 (de) |
| ES (1) | ES2178854T3 (de) |
| WO (1) | WO1999024075A2 (de) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE443714T1 (de) * | 1999-05-17 | 2009-10-15 | Conjuchem Biotechnologies Inc | Lang wirkende peptidinhibitoren der virusfusion mit körperzellen bei viralen infektionen |
| US20040266673A1 (en) * | 2002-07-31 | 2004-12-30 | Peter Bakis | Long lasting natriuretic peptide derivatives |
| US7144854B1 (en) | 1999-09-10 | 2006-12-05 | Conjuchem, Inc. | Long lasting anti-angiogenic peptides |
| US20090175821A1 (en) * | 1999-05-17 | 2009-07-09 | Bridon Dominique P | Modified therapeutic peptides with extended half-lives in vivo |
| CN1191273C (zh) * | 1999-05-17 | 2005-03-02 | 康久化学公司 | 长效促胰岛肽 |
| AU765753B2 (en) * | 1999-05-17 | 2003-09-25 | Conjuchem Biotechnologies Inc. | Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components |
| US6887470B1 (en) | 1999-09-10 | 2005-05-03 | Conjuchem, Inc. | Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components |
| US6849714B1 (en) | 1999-05-17 | 2005-02-01 | Conjuchem, Inc. | Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components |
| CN101289500A (zh) * | 1999-05-17 | 2008-10-22 | 康久化学生物技术公司 | 病毒感染的长效融合肽抑制剂 |
| US6514500B1 (en) | 1999-10-15 | 2003-02-04 | Conjuchem, Inc. | Long lasting synthetic glucagon like peptide {GLP-!} |
| US7601691B2 (en) | 1999-05-17 | 2009-10-13 | Conjuchem Biotechnologies Inc. | Anti-obesity agents |
| US6706892B1 (en) | 1999-09-07 | 2004-03-16 | Conjuchem, Inc. | Pulmonary delivery for bioconjugation |
| US7090851B1 (en) | 1999-09-10 | 2006-08-15 | Conjuchem Inc. | Long lasting fusion peptide inhibitors of viral infection |
| BR0206919A (pt) | 2001-02-02 | 2004-07-06 | Conjuchem Inc | Derivados de fator de liberação de hormÈnio de crescimento de longa duração |
| AU2002233089B2 (en) | 2001-02-16 | 2005-12-22 | Conjuchem Biotechnologies Inc. | Long lasting glucagon-like peptide 2 (GLP-2) for the treatment of gastrointestinal diseases and disorders |
| JP4463545B2 (ja) | 2001-05-31 | 2010-05-19 | コンジュケム バイオテクノロジーズ インコーポレイテッド | Ｈｉｖ感染に対する長時間持続する融合ペプチドインヒビター |
| ATE466953T1 (de) | 2003-01-17 | 2010-05-15 | Advanced Proteome Therapeutics | Verfahren zur identifizierung aktivierter polymer-komplexe zur sekundären stellen-spezifischen modifikation von protein ziel-gruppen. |
| AU2005235634B2 (en) * | 2004-04-23 | 2011-10-20 | Conjuchem Biotechnologies Inc. | Method for the purification of albumin conjugates |
| US8039432B2 (en) * | 2005-11-09 | 2011-10-18 | Conjuchem, Llc | Method of treatment of diabetes and/or obesity with reduced nausea side effect |
| CA2634495A1 (en) * | 2005-12-22 | 2007-06-28 | Conjuchem Biotechnologies Inc. | Process for the production of preformed conjugates of albumin and a therapeutic agent |
| US20090099074A1 (en) * | 2007-01-10 | 2009-04-16 | Conjuchem Biotechnologies Inc. | Modulating food intake |
| EP2231191A2 (de) * | 2007-12-11 | 2010-09-29 | ConjuChem Biotechnologies Inc. | Formulierung von insulinotropen peptid-konjugaten |
| EP3413921A4 (de) * | 2016-02-09 | 2019-08-14 | Alexander Krantz | Ortsselektive funktionalisierung von proteinen mittels spurloser affinitätsmarkierungen |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3862928A (en) | 1969-07-09 | 1975-01-28 | Akzona Inc | Psychopharmacological hexa-peptides containing a d-phenylalanyl residue |
| US4244946A (en) | 1979-06-11 | 1981-01-13 | The Salk Institute For Biological Studies | Water-soluble peptides affecting gonadal function |
| US4933288A (en) | 1986-11-21 | 1990-06-12 | Cetus Corporation | Use of a modified soluble Pseudomonas exotoxin A in immunoconjugates |
| US4808705A (en) | 1986-12-19 | 1989-02-28 | Cetus Corporation | Stable formulations of ricin toxin a chain and of RTA-immunoconjugates and stabilizer screening methods therefor |
| GB8713240D0 (en) | 1987-06-05 | 1987-07-08 | Proteus Biotech Ltd | Hormones |
| US4981979A (en) | 1987-09-10 | 1991-01-01 | Neorx Corporation | Immunoconjugates joined by thioether bonds having reduced toxicity and improved selectivity |
| DE3731297C1 (de) | 1987-09-17 | 1989-05-18 | Rexroth Mannesmann Gmbh | Schaltventilanordnung |
| US5010175A (en) | 1988-05-02 | 1991-04-23 | The Regents Of The University Of California | General method for producing and selecting peptides with specific properties |
| JP3092811B2 (ja) | 1988-07-23 | 2000-09-25 | デルタ バイオテクノロジー リミテッド | ペプチドおよびｄｎａ配列 |
| EP0440740B1 (de) | 1988-10-12 | 1993-09-22 | Centocor, Inc. | Radiotherapeutische immunokonjugate, etikettiert mit iod-125 |
| US5250662A (en) | 1989-10-05 | 1993-10-05 | Alpha Therapeutic Corporation | Albumin purification |
| US5116944A (en) | 1989-12-29 | 1992-05-26 | Neorx Corporation | Conjugates having improved characteristics for in vivo administration |
| US5182366A (en) | 1990-05-15 | 1993-01-26 | Huebner Verena D | Controlled synthesis of peptide mixtures using mixed resins |
| US5650489A (en) | 1990-07-02 | 1997-07-22 | The Arizona Board Of Regents | Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof |
| US5612034A (en) | 1990-10-03 | 1997-03-18 | Redcell, Inc. | Super-globuling for in vivo extended lifetimes |
| US5843440A (en) | 1990-10-03 | 1998-12-01 | Redcell Canada, Inc. | Cellular and serum protein anchors for modulating pharmacokinetics |
| DE69130831T2 (de) | 1990-11-21 | 1999-09-16 | Iterex Pharma Lp | Synthese äquimolarer mischungen vielzähliger oligomere, speziell oligopeptidmischungen |
| US5616311A (en) | 1991-01-15 | 1997-04-01 | Hemosphere, Inc. | Non-crosslinked protein particles for therapeutic and diagnostic use |
| DE69217497T2 (de) | 1991-09-18 | 1997-06-12 | Affymax Tech Nv | Verfahren zur synthese der verschiedenen sammlungen von oligomeren |
| US5270170A (en) | 1991-10-16 | 1993-12-14 | Affymax Technologies N.V. | Peptide library and screening method |
| US5573905A (en) | 1992-03-30 | 1996-11-12 | The Scripps Research Institute | Encoded combinatorial chemical libraries |
| US5288514A (en) | 1992-09-14 | 1994-02-22 | The Regents Of The University Of California | Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support |
| JPH0692968A (ja) * | 1992-09-16 | 1994-04-05 | Nakarai Tesuku Kk | ビオチン導入試薬 |
| BR9307092A (pt) | 1992-09-24 | 1999-03-30 | Chiron Corp | Processo para sintetizar monômero de poliamida n-substituida oligômero mistura de pelo menos dois oligômeros diferentes poli (n-substituida glicina) processo de tratamento anti-sentido composição processo de sintetizar composto de poliamida composto e processo para preparar mistura de compostos de amida |
| US5565324A (en) | 1992-10-01 | 1996-10-15 | The Trustees Of Columbia University In The City Of New York | Complex combinatorial chemical libraries encoded with tags |
| US5741893A (en) | 1993-08-16 | 1998-04-21 | Hsia; Jen-Chang | Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules |
| US5571681A (en) | 1994-03-10 | 1996-11-05 | The Scripps Research Institute | Chemical event selection by suicide substrate conjugates |
| DK0868427T3 (da) | 1995-12-18 | 2003-09-15 | Praecis Pharm Inc | Fremgangsmåder til at idenficere forbindelser, der binder til et mål |
| WO1997025074A2 (en) * | 1996-01-12 | 1997-07-17 | Redcell Canada, Inc. | Cellular and serum protein anchors for diagnostic imaging |
| US6277583B1 (en) * | 1996-02-07 | 2001-08-21 | Conjuchem, Inc. | Affinity labeling libraries and applications thereof |
| US5840733A (en) | 1996-07-01 | 1998-11-24 | Redcell, Canada, Inc. | Methods and compositions for producing novel conjugates of thrombin inhibitors and endogenous carriers resulting in anti-thrombins with extended lifetimes |
| AU4351897A (en) | 1996-09-16 | 1998-04-02 | Conjuchem, Inc. | Affinity labeling libraries with tagged leaving groups |
| US6203820B1 (en) | 1998-05-28 | 2001-03-20 | Brice E. Vickery | Compositions and methods for enhancing protein anabolism and detoxification |
-
1998
- 1998-11-06 CA CA002628053A patent/CA2628053A1/en not_active Abandoned
- 1998-11-06 EP EP08162256A patent/EP2033661A1/de not_active Withdrawn
- 1998-11-06 DE DE69806066T patent/DE69806066T2/de not_active Expired - Lifetime
- 1998-11-06 EP EP98959387A patent/EP1056474B1/de not_active Expired - Lifetime
- 1998-11-06 AT AT98959387T patent/ATE218892T1/de active
- 1998-11-06 ES ES98959387T patent/ES2178854T3/es not_active Expired - Lifetime
- 1998-11-06 AT AT01126379T patent/ATE406577T1/de not_active IP Right Cessation
- 1998-11-06 WO PCT/US1998/023705 patent/WO1999024075A2/en active IP Right Grant
- 1998-11-06 DE DE69839946T patent/DE69839946D1/de not_active Expired - Fee Related
- 1998-11-06 CA CA002305597A patent/CA2305597C/en not_active Expired - Fee Related
- 1998-11-06 AU AU15196/99A patent/AU1519699A/en not_active Abandoned
-
2004
- 2004-09-02 US US10/934,841 patent/US7166695B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE69806066D1 (de) | 2002-07-18 |
| CA2305597A1 (en) | 1999-05-20 |
| WO1999024075A3 (en) | 1999-09-02 |
| ATE406577T1 (de) | 2008-09-15 |
| CA2628053A1 (en) | 1999-05-20 |
| ES2178854T3 (es) | 2003-01-01 |
| DE69806066T2 (de) | 2003-02-06 |
| EP1056474B1 (de) | 2002-06-12 |
| EP2033661A1 (de) | 2009-03-11 |
| US20050037974A1 (en) | 2005-02-17 |
| EP1056474A2 (de) | 2000-12-06 |
| ATE218892T1 (de) | 2002-06-15 |
| US7166695B2 (en) | 2007-01-23 |
| CA2305597C (en) | 2008-07-29 |
| WO1999024075A2 (en) | 1999-05-20 |
| AU1519699A (en) | 1999-05-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69839946D1 (de) | Methoden zum Screening von Affinitätsmarker-Bibliotheken | |
| DE69834596D1 (de) | Etectrochirurghische, blutstillende klammervorrichtung | |
| DE69421206D1 (de) | Verfahren zum installieren von Klammern | |
| DE69022115T2 (de) | Hämostatische, chirurgische Clips. | |
| DE9418694U1 (de) | Schuhkonstruktion zum vereinfachten Zusammenbau | |
| NO980110D0 (no) | Gjennomtrengningsmål for et innföringssystem | |
| BR9611436A (pt) | D-tartarato de (-)-cis-6(s)-fenil-5(r)-[4-(2-pirrolidin-1-iletóxi) fenil]-5,6,7,8,-tetra-hidronaftalen-2-ol | |
| DE69417960T2 (de) | Ungleichgewichtiger Fehlerschutz für kombinierte Informationssignale | |
| DE69731794D1 (de) | Innenschutz für eine vaskuläre Anastomose | |
| DE69617007T2 (de) | Zweifach härtbares bindemittelsystem | |
| TR200002921T2 (tr) | Yarı-Sentetik ekteinasidinler | |
| DE69604261T2 (de) | Härtbare, photochromische zusammensetzung | |
| DE59710195D1 (de) | Trokar für laparoskopische Operationen | |
| DK1571208T3 (da) | Fremgangsmåde til ny faktor IX-rensning | |
| DK1053355T3 (da) | PNA- og DNA-konjugater og metoder til fremstilling heraf | |
| DE69806367D1 (de) | Rot färbende hyperchromische 3h-naphto(2,1-b)pyranen | |
| DE69818135D1 (de) | Verfahren zum Zugriff auf Datenbankinformation | |
| WO2000018439A3 (de) | Verwendung von neoangiogenese-markern für diagnose und therapie von tumoren | |
| ATE247955T1 (de) | Selenophen-antitumormittel | |
| DE69811000D1 (de) | System zum Herstellen von Bändern | |
| BR9710386A (pt) | Composto processo de prepara-Æo do composto e processo de transforma-Æo do composto | |
| DE69715668D1 (de) | N-(pyridinylamino)isoindoline und verwandte verbindungen | |
| DK1123396T3 (da) | Minimale promotorer og anvendelser deraf | |
| DE69312417D1 (de) | Chirurgisches Instrument zum Anlegen von Klammern | |
| FR2708942B1 (fr) | Fer à repasser à vapeur. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8339 | Ceased/non-payment of the annual fee |