DE69842082D1 - Verhinderung und Behandlung der amyloidogenen Erkrankung - Google Patents
Verhinderung und Behandlung der amyloidogenen ErkrankungInfo
- Publication number
- DE69842082D1 DE69842082D1 DE69842082T DE69842082T DE69842082D1 DE 69842082 D1 DE69842082 D1 DE 69842082D1 DE 69842082 T DE69842082 T DE 69842082T DE 69842082 T DE69842082 T DE 69842082T DE 69842082 D1 DE69842082 D1 DE 69842082D1
- Authority
- DE
- Germany
- Prior art keywords
- prevention
- treatment
- amyloidogenic disease
- amyloidogenic
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000009091 Amyloidogenic Proteins Human genes 0.000 title 1
- 108010048112 Amyloidogenic Proteins Proteins 0.000 title 1
- 230000003942 amyloidogenic effect Effects 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 230000002265 prevention Effects 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/739—Lipopolysaccharides
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
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- A61K9/2022—Organic macromolecular compounds
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- A61K9/4866—Organic macromolecular compounds
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
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- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
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- A—HUMAN NECESSITIES
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- A61K2039/55511—Organic adjuvants
- A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
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- A—HUMAN NECESSITIES
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- A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
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- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Neurosurgery (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Marine Sciences & Fisheries (AREA)
- Virology (AREA)
- Microbiology (AREA)
- Toxicology (AREA)
- Mycology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6774097P | 1997-12-02 | 1997-12-02 | |
US8097098P | 1998-04-07 | 1998-04-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
DE69842082D1 true DE69842082D1 (de) | 2011-02-10 |
Family
ID=26748211
Family Applications (7)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69840922T Expired - Lifetime DE69840922D1 (de) | 1997-12-02 | 1998-11-30 | Vorbeugung und Behandlung von amyloidogener Krankheit |
DE69842082T Expired - Lifetime DE69842082D1 (de) | 1997-12-02 | 1998-11-30 | Verhinderung und Behandlung der amyloidogenen Erkrankung |
DE06075479T Pending DE06075479T1 (de) | 1997-12-02 | 1998-11-30 | Vorbeugung und Behandlung von amyloidogener Krankheit |
DE06075704T Pending DE06075704T1 (de) | 1997-12-02 | 1998-11-30 | Vorbeugung und Behandlung von amyloidogener Krankheit |
DE69839647T Expired - Lifetime DE69839647D1 (de) | 1997-12-02 | 1998-11-30 | Vorbeugung und behandlung von amyloidogener krankheit |
DE1033996T Pending DE1033996T1 (de) | 1997-12-02 | 1998-11-30 | Vorbeugung und behandlung von amyloidogener krankheit |
DE69840969T Expired - Lifetime DE69840969D1 (de) | 1997-12-02 | 1998-11-30 | Vorbeugung und Behandlung von amyloidogener Krankheit |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69840922T Expired - Lifetime DE69840922D1 (de) | 1997-12-02 | 1998-11-30 | Vorbeugung und Behandlung von amyloidogener Krankheit |
Family Applications After (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE06075479T Pending DE06075479T1 (de) | 1997-12-02 | 1998-11-30 | Vorbeugung und Behandlung von amyloidogener Krankheit |
DE06075704T Pending DE06075704T1 (de) | 1997-12-02 | 1998-11-30 | Vorbeugung und Behandlung von amyloidogener Krankheit |
DE69839647T Expired - Lifetime DE69839647D1 (de) | 1997-12-02 | 1998-11-30 | Vorbeugung und behandlung von amyloidogener krankheit |
DE1033996T Pending DE1033996T1 (de) | 1997-12-02 | 1998-11-30 | Vorbeugung und behandlung von amyloidogener krankheit |
DE69840969T Expired - Lifetime DE69840969D1 (de) | 1997-12-02 | 1998-11-30 | Vorbeugung und Behandlung von amyloidogener Krankheit |
Country Status (38)
Country | Link |
---|---|
US (26) | US20040171815A1 (de) |
EP (5) | EP1033996B1 (de) |
JP (4) | JP4677094B2 (de) |
KR (3) | KR20120135915A (de) |
CN (1) | CN100374151C (de) |
AR (1) | AR020050A1 (de) |
AT (4) | ATE399016T1 (de) |
AU (1) | AU1706199A (de) |
BG (1) | BG104562A (de) |
BR (1) | BR9815357A (de) |
CA (1) | CA2312920C (de) |
CO (1) | CO4980846A1 (de) |
CY (3) | CY1108331T1 (de) |
CZ (1) | CZ303137B6 (de) |
DE (7) | DE69840922D1 (de) |
DK (4) | DK1033996T3 (de) |
EA (3) | EA009283B1 (de) |
EE (1) | EE05377B1 (de) |
ES (4) | ES2262460T1 (de) |
GE (2) | GEP20043319B (de) |
HK (2) | HK1095265A1 (de) |
HR (2) | HRP20000443B1 (de) |
HU (2) | HU228061B1 (de) |
ID (1) | ID25504A (de) |
IL (5) | IL136252A0 (de) |
IS (1) | IS5500A (de) |
MY (1) | MY134906A (de) |
NO (3) | NO328865B1 (de) |
NZ (1) | NZ504569A (de) |
PE (1) | PE20001383A1 (de) |
PL (2) | PL202698B1 (de) |
PT (4) | PT1679080E (de) |
SA (1) | SA99191269B1 (de) |
SG (1) | SG111083A1 (de) |
SI (4) | SI1994937T1 (de) |
TR (1) | TR200001608T2 (de) |
TW (1) | TWI239847B (de) |
WO (1) | WO1999027944A1 (de) |
Families Citing this family (293)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997021728A1 (en) | 1995-12-12 | 1997-06-19 | Karolinska Innovations Ab | PEPTIDE BINDING THE KLVFF-SEQUENCE OF AMYLOID $g(b) |
US8173127B2 (en) * | 1997-04-09 | 2012-05-08 | Intellect Neurosciences, Inc. | Specific antibodies to amyloid beta peptide, pharmaceutical compositions and methods of use thereof |
US6703015B1 (en) | 1999-09-03 | 2004-03-09 | Ramot At Tel-Aviv University Ltd. | Filamentous bacteriophage displaying an β-amyloid epitope |
US7964192B1 (en) * | 1997-12-02 | 2011-06-21 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidgenic disease |
US6761888B1 (en) * | 2000-05-26 | 2004-07-13 | Neuralab Limited | Passive immunization treatment of Alzheimer's disease |
US20080050367A1 (en) | 1998-04-07 | 2008-02-28 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
US7790856B2 (en) | 1998-04-07 | 2010-09-07 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize beta amyloid peptide |
US6787523B1 (en) | 1997-12-02 | 2004-09-07 | Neuralab Limited | Prevention and treatment of amyloidogenic disease |
US6905686B1 (en) | 1997-12-02 | 2005-06-14 | Neuralab Limited | Active immunization for treatment of alzheimer's disease |
US7588766B1 (en) * | 2000-05-26 | 2009-09-15 | Elan Pharma International Limited | Treatment of amyloidogenic disease |
TWI239847B (en) | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
US7179892B2 (en) * | 2000-12-06 | 2007-02-20 | Neuralab Limited | Humanized antibodies that recognize beta amyloid peptide |
US6750324B1 (en) | 1997-12-02 | 2004-06-15 | Neuralab Limited | Humanized and chimeric N-terminal amyloid beta-antibodies |
US20050059802A1 (en) * | 1998-04-07 | 2005-03-17 | Neuralab Ltd | Prevention and treatment of amyloidogenic disease |
US20030147882A1 (en) | 1998-05-21 | 2003-08-07 | Alan Solomon | Methods for amyloid removal using anti-amyloid antibodies |
MXPA00011348A (es) * | 1998-05-21 | 2003-04-22 | Univ Tennesse Res Corp | Metodos para la remocion de material amiloide utilizando anticuerpos anti-amiloide. |
US7060670B1 (en) | 1999-05-05 | 2006-06-13 | Neurochem (International) Limited | Stereoselective antifibrillogenic peptides and peptidomimetics thereof |
HUP0201220A3 (en) | 1999-05-13 | 2004-07-28 | Wyeth Holdings Corp Madison | Adjuvant combination formulations |
AU2008203784B2 (en) * | 1999-05-28 | 2012-01-19 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidogenic disease |
US6787637B1 (en) | 1999-05-28 | 2004-09-07 | Neuralab Limited | N-Terminal amyloid-β antibodies |
UA81216C2 (en) | 1999-06-01 | 2007-12-25 | Prevention and treatment of amyloid disease | |
AU2005202644B2 (en) * | 1999-06-01 | 2009-03-05 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidogenic disease |
AR024558A1 (es) * | 1999-06-01 | 2002-10-16 | Neuralab Ltd | Composiciones del peptido a-beta y procesos para producir las mismas |
ES2312348T3 (es) | 1999-06-16 | 2009-03-01 | Boston Biomedical Research Institute | Control inmunologico de niveles de beta-amiloide in vivo. |
EP1180938B1 (de) * | 1999-09-03 | 2010-03-24 | Ramot University Authority For Applied Research & Industrial Development Ltd. | Verbindungen, zusammensetzungen und verfahren zur behandlung oder vorsorge von alzheimer erkrankung |
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