DE69908650D1 - Mahlverfahren zur herstellung feingemahlener medizinischer substanzen - Google Patents

Mahlverfahren zur herstellung feingemahlener medizinischer substanzen

Info

Publication number
DE69908650D1
DE69908650D1 DE69908650T DE69908650T DE69908650D1 DE 69908650 D1 DE69908650 D1 DE 69908650D1 DE 69908650 T DE69908650 T DE 69908650T DE 69908650 T DE69908650 T DE 69908650T DE 69908650 D1 DE69908650 D1 DE 69908650D1
Authority
DE
Germany
Prior art keywords
milling
medical substances
fluid
producing hardening
mill
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69908650T
Other languages
English (en)
Other versions
DE69908650T2 (de
Inventor
N Murti Vemuri
Andrew B Brown
Jean-Rene Authelin
Patrick Hosek
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis UK Holdings Ltd
Original Assignee
Aventis Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Ltd filed Critical Aventis Pharma Ltd
Application granted granted Critical
Publication of DE69908650D1 publication Critical patent/DE69908650D1/de
Publication of DE69908650T2 publication Critical patent/DE69908650T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B02CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
    • B02CCRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
    • B02C19/00Other disintegrating devices or methods
    • B02C19/06Jet mills
DE69908650T 1998-12-01 1999-12-01 Mahlverfahren zur herstellung feingemahlener medizinischer substanzen Expired - Lifetime DE69908650T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9826284.3A GB9826284D0 (en) 1998-12-01 1998-12-01 Process
GB9826284 1998-12-01
PCT/GB1999/004041 WO2000032165A1 (en) 1998-12-01 1999-12-01 Milling process for the production of finely milled medicinal substances

Publications (2)

Publication Number Publication Date
DE69908650D1 true DE69908650D1 (de) 2003-07-10
DE69908650T2 DE69908650T2 (de) 2004-05-13

Family

ID=10843360

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69908650T Expired - Lifetime DE69908650T2 (de) 1998-12-01 1999-12-01 Mahlverfahren zur herstellung feingemahlener medizinischer substanzen

Country Status (24)

Country Link
US (1) US6641063B2 (de)
EP (1) EP1143928B1 (de)
JP (1) JP4680389B2 (de)
KR (1) KR100606319B1 (de)
CN (1) CN1198583C (de)
AT (1) ATE241958T1 (de)
AU (1) AU763352B2 (de)
BR (1) BR9916153B1 (de)
CA (1) CA2352796C (de)
CZ (1) CZ301914B6 (de)
DE (1) DE69908650T2 (de)
DK (1) DK1143928T3 (de)
ES (1) ES2201842T3 (de)
GB (1) GB9826284D0 (de)
HK (1) HK1037525A1 (de)
HU (1) HU224615B1 (de)
IL (2) IL143344A0 (de)
MX (1) MXPA01005472A (de)
NO (1) NO20012677D0 (de)
NZ (1) NZ512089A (de)
PL (1) PL193800B1 (de)
PT (1) PT1143928E (de)
RU (1) RU2219908C2 (de)
WO (1) WO2000032165A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10204470C1 (de) * 2002-02-05 2003-08-14 Degussa Verfahren und Vorrichtung zur Herstellung von Dispersionen
DE10317461A1 (de) * 2003-04-16 2004-10-28 Boehringer Ingelheim Pharma Gmbh & Co. Kg Radioaktiv markierte Mikropartikel, Verfahren zu deren Herstellung und deren Verwendung
GB0409703D0 (en) 2004-04-30 2004-06-02 Vectura Ltd Pharmaceutical compositions
US20070197486A1 (en) * 2005-12-20 2007-08-23 Verus Pharmaceuticals, Inc. Methods and systems for the delivery of corticosteroids
US20070185066A1 (en) * 2005-12-20 2007-08-09 Verus Pharmaceuticals, Inc. Systems and methods for the delivery of corticosteroids
US20070249572A1 (en) * 2005-12-20 2007-10-25 Verus Pharmaceuticals, Inc. Systems and methods for the delivery of corticosteroids
US20070160542A1 (en) * 2005-12-20 2007-07-12 Verus Pharmaceuticals, Inc. Methods and systems for the delivery of corticosteroids having an enhanced pharmacokinetic profile
WO2007095341A2 (en) * 2006-02-15 2007-08-23 Tika Läkemedel Ab Sterilization of corticosteroids with reduced mass loss
DE102006030166A1 (de) * 2006-06-29 2008-01-10 Boehringer Ingelheim Pharma Gmbh & Co. Kg Tempern
EP2183262A1 (de) * 2007-07-27 2010-05-12 Cargill, Incorporated Mikronisierung von polyolen
CN101618019B (zh) * 2008-07-01 2011-08-03 上海通用药业股份有限公司 一种醋酸曲安奈德微粒及其制备方法和药物组合物
US8815258B2 (en) 2009-05-29 2014-08-26 Pearl Therapeutics, Inc. Compositions, methods and systems for respiratory delivery of two or more active agents
CN102596176B (zh) 2009-05-29 2017-09-19 珍珠治疗公司 经呼吸递送活性剂的组合物及相关方法和系统
JO3510B1 (ar) 2011-03-04 2020-07-05 Heptares Therapeutics Ltd استخدام جلايكوبيرولات لعلاج عدم انتظام دقات القلب
DE102011102614A1 (de) * 2011-05-27 2012-11-29 Roland Nied Verfahren zum Betrieb einer Strahlmühle sowie Strahlmühle
DE102013000426A1 (de) * 2013-01-14 2014-07-17 Roland Nied Verfahren zur Strahlmahlung sowie Strahlmühle dafür
SG11201507286QA (en) * 2013-03-15 2015-10-29 Pearl Therapeutics Inc Methods and systems for conditioning of particulate crystalline materials
WO2015071841A1 (en) 2013-11-12 2015-05-21 Druggability Technologies Holdings Limited Complexes of dabigatran and its derivatives, process for the preparation thereof and pharmaceutical compositions containing them
PL3191081T3 (pl) 2014-09-09 2020-09-07 Vectura Limited Formulacja zawierająca glikopirolan, sposób i urządzenie
ES2794775T3 (es) 2015-09-09 2020-11-19 Vectura Ltd Procedimiento de molienda por chorro
CN106111304B (zh) * 2016-06-28 2018-05-22 山东大学齐鲁医院 营养补剂研磨加温装置
EP3595631A1 (de) * 2017-03-15 2020-01-22 Vectura Limited Verfahren und formulierung

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3937405A (en) * 1973-12-18 1976-02-10 Fluid Energy Processing And Equipment Company Apparatus for mixing pulverizing and grinding black powder
KR890000664B1 (ko) * 1981-10-19 1989-03-22 바리 안소니 뉴우샘 미분된 베클로메타손 디프로피오네이트 일수화물의 제조방법
US4767612A (en) * 1987-01-23 1988-08-30 Rorer Pharmaceutical Corporation Triamcinolone acetonide for the treatment of allergic rhinitis
SE9101090D0 (sv) * 1991-04-11 1991-04-11 Astra Ab Process for conditioning of water-soluble substances
SE9302777D0 (sv) * 1993-08-27 1993-08-27 Astra Ab Process for conditioning substances
GB9226993D0 (en) * 1992-12-24 1993-02-17 Tioxide Group Services Ltd Method of simultaneous milling and drying
AUPM411494A0 (en) * 1994-02-25 1994-03-24 Central Sydney Area Health Service Method and device for the provocation of upper or lower airway narrowing and/or the induction of sputum
US5747002A (en) * 1995-04-05 1998-05-05 Genentech, Inc. Preparation of sodium chloride aerosol formulations
SE9501384D0 (sv) * 1995-04-13 1995-04-13 Astra Ab Process for the preparation of respirable particles
US5730795A (en) * 1996-09-24 1998-03-24 E. I. Du Pont De Nemours And Company Process for manufacturing titanium dioxide pigment having a hydrous oxide coating using a media mill
SE9700135D0 (sv) * 1997-01-20 1997-01-20 Astra Ab New formulation
GB9808470D0 (en) * 1998-04-22 1998-06-17 Smithkline Beecham Plc Novel process and apparatus

Also Published As

Publication number Publication date
HK1037525A1 (en) 2002-02-15
HUP0104478A3 (en) 2002-12-28
WO2000032165A1 (en) 2000-06-08
KR20010093129A (ko) 2001-10-27
PL348614A1 (en) 2002-06-03
HUP0104478A2 (hu) 2002-03-28
JP2002531390A (ja) 2002-09-24
IL143344A0 (en) 2002-04-21
CZ20011804A3 (cs) 2002-06-12
PL193800B1 (pl) 2007-03-30
US20020109025A1 (en) 2002-08-15
NZ512089A (en) 2002-09-27
NO20012677L (no) 2001-05-31
RU2219908C2 (ru) 2003-12-27
MXPA01005472A (es) 2003-03-27
DE69908650T2 (de) 2004-05-13
BR9916153B1 (pt) 2010-07-13
CA2352796C (en) 2009-06-09
BR9916153A (pt) 2001-09-04
EP1143928B1 (de) 2003-06-04
JP4680389B2 (ja) 2011-05-11
KR100606319B1 (ko) 2006-07-28
DK1143928T3 (da) 2003-09-22
IL143344A (en) 2006-06-11
CN1354652A (zh) 2002-06-19
PT1143928E (pt) 2003-10-31
AU1401100A (en) 2000-06-19
NO20012677D0 (no) 2001-05-31
AU763352B2 (en) 2003-07-17
CA2352796A1 (en) 2000-06-08
ES2201842T3 (es) 2004-03-16
CZ301914B6 (cs) 2010-07-28
ATE241958T1 (de) 2003-06-15
EP1143928A1 (de) 2001-10-17
HU224615B1 (hu) 2005-11-28
CN1198583C (zh) 2005-04-27
GB9826284D0 (en) 1999-01-20
US6641063B2 (en) 2003-11-04

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: PFENNING MEINIG & PARTNER GBR, 80339 MUENCHEN

8328 Change in the person/name/address of the agent

Representative=s name: MAIWALD PATENTANWALTSGESELLSCHAFT MBH, 80335 MUENC