DE69911221D1 - Methode und gerät zur darreichung von therapeutischen mitteln in verbindung mit dem plazieren von radioaktiven körnern - Google Patents

Methode und gerät zur darreichung von therapeutischen mitteln in verbindung mit dem plazieren von radioaktiven körnern

Info

Publication number
DE69911221D1
DE69911221D1 DE69911221T DE69911221T DE69911221D1 DE 69911221 D1 DE69911221 D1 DE 69911221D1 DE 69911221 T DE69911221 T DE 69911221T DE 69911221 T DE69911221 T DE 69911221T DE 69911221 D1 DE69911221 D1 DE 69911221D1
Authority
DE
Germany
Prior art keywords
placing
connection
therapeutic agents
administering therapeutic
radioactive grains
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69911221T
Other languages
English (en)
Other versions
DE69911221T2 (de
Inventor
D Lennox
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boston Scientific Ltd Barbados
Original Assignee
Boston Scientific Ltd Barbados
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boston Scientific Ltd Barbados filed Critical Boston Scientific Ltd Barbados
Application granted granted Critical
Publication of DE69911221D1 publication Critical patent/DE69911221D1/de
Publication of DE69911221T2 publication Critical patent/DE69911221T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/10X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1001X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
    • A61N5/1027Interstitial radiation therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1282Devices used in vivo and carrying the radioactive therapeutic or diagnostic agent, therapeutic or in vivo diagnostic kits, stents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/10X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1001X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
    • A61N2005/1019Sources therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/10X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1001X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
    • A61N2005/1019Sources therefor
    • A61N2005/1023Means for creating a row of seeds, e.g. spacers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/10X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1001X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
    • A61N2005/1019Sources therefor
    • A61N2005/1024Seeds
DE69911221T 1998-06-17 1999-06-03 Methode und gerät zur darreichung von therapeutischen mitteln in verbindung mit dem plazieren von radioaktiven körnern Expired - Lifetime DE69911221T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/098,617 US6159143A (en) 1998-06-17 1998-06-17 Method and device for delivery of therapeutic agents in conjunction with isotope seed placement
US98617 1998-06-17
PCT/US1999/012408 WO1999065532A1 (en) 1998-06-17 1999-06-03 Method and device for delivery of therapeutic agents in conjuction with isotope seed placement

Publications (2)

Publication Number Publication Date
DE69911221D1 true DE69911221D1 (de) 2003-10-16
DE69911221T2 DE69911221T2 (de) 2004-03-18

Family

ID=22270143

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69911221T Expired - Lifetime DE69911221T2 (de) 1998-06-17 1999-06-03 Methode und gerät zur darreichung von therapeutischen mitteln in verbindung mit dem plazieren von radioaktiven körnern

Country Status (7)

Country Link
US (2) US6159143A (de)
EP (1) EP1109583B1 (de)
JP (2) JP4806488B2 (de)
AU (1) AU769312B2 (de)
CA (1) CA2334810C (de)
DE (1) DE69911221T2 (de)
WO (1) WO1999065532A1 (de)

Families Citing this family (91)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0686342B1 (de) 1994-06-10 1998-09-09 Schneider (Europe) GmbH Arzneigerät für die Behandlung eines Teiles von Körpergefäss mittels Ionisierungsbestrahlung
DE69426071T2 (de) 1994-06-24 2001-05-10 Schneider Europ Gmbh Buelach Arzneigerät für die Behandlung eines Teiles eines Körpergefässes mittels Ionisierungsbestrahlung
US6234951B1 (en) 1996-02-29 2001-05-22 Scimed Life Systems, Inc. Intravascular radiation delivery system
US7637948B2 (en) 1997-10-10 2009-12-29 Senorx, Inc. Tissue marking implant
US8668737B2 (en) 1997-10-10 2014-03-11 Senorx, Inc. Tissue marking implant
US6161034A (en) * 1999-02-02 2000-12-12 Senorx, Inc. Methods and chemical preparations for time-limited marking of biopsy sites
US6347241B2 (en) * 1999-02-02 2002-02-12 Senorx, Inc. Ultrasonic and x-ray detectable biopsy site marker and apparatus for applying it
US6159143A (en) * 1998-06-17 2000-12-12 Scimed Life Systems, Inc. Method and device for delivery of therapeutic agents in conjunction with isotope seed placement
DE19850203C1 (de) * 1998-10-23 2000-05-31 Eurotope Entwicklungsgesellsch Radioaktive Jod-125-Seeds basierend auf Keramikträgern und Verfahren zur Herstellung dieser Seeds
US8361082B2 (en) 1999-02-02 2013-01-29 Senorx, Inc. Marker delivery device with releasable plug
US20090030309A1 (en) * 2007-07-26 2009-01-29 Senorx, Inc. Deployment of polysaccharide markers
US7983734B2 (en) * 2003-05-23 2011-07-19 Senorx, Inc. Fibrous marker and intracorporeal delivery thereof
US6725083B1 (en) 1999-02-02 2004-04-20 Senorx, Inc. Tissue site markers for in VIVO imaging
US7651505B2 (en) 2002-06-17 2010-01-26 Senorx, Inc. Plugged tip delivery for marker placement
US20080039819A1 (en) * 2006-08-04 2008-02-14 Senorx, Inc. Marker formed of starch or other suitable polysaccharide
US9820824B2 (en) 1999-02-02 2017-11-21 Senorx, Inc. Deployment of polysaccharide markers for treating a site within a patent
US8498693B2 (en) 1999-02-02 2013-07-30 Senorx, Inc. Intracorporeal marker and marker delivery device
US6862470B2 (en) * 1999-02-02 2005-03-01 Senorx, Inc. Cavity-filling biopsy site markers
US6685913B1 (en) * 1999-03-09 2004-02-03 Thomas Jefferson University Lipid soluble radioactive metal chelates for tumor therapy
ATE380046T1 (de) * 1999-04-28 2007-12-15 Medi Physics Inc Produkte für brachytherapie und herstellungsverfahren dafür
US6575991B1 (en) 1999-06-17 2003-06-10 Inrad, Inc. Apparatus for the percutaneous marking of a lesion
US6264600B1 (en) * 1999-10-21 2001-07-24 Peter D. Grimm Hollow suture member with radioactive seeds positioned therein for treatment of prostate cancer
WO2001036007A2 (en) * 1999-11-12 2001-05-25 Angiotech Pharmaceuticals, Inc. Compositions of a combination of radioactive therapy and cell-cycle inhibitors
US6575888B2 (en) 2000-01-25 2003-06-10 Biosurface Engineering Technologies, Inc. Bioabsorbable brachytherapy device
US6749553B2 (en) * 2000-05-18 2004-06-15 Theragenics Corporation Radiation delivery devices and methods for their manufacture
US6450939B1 (en) * 2000-11-06 2002-09-17 Peter D. Grimm Hinged spacer element for joining radioactive seeds used in treatment of cancer
US6514193B2 (en) 2000-11-16 2003-02-04 Microspherix Llc Method of administering a therapeutically active substance
US7776310B2 (en) 2000-11-16 2010-08-17 Microspherix Llc Flexible and/or elastic brachytherapy seed or strand
ES2409758T3 (es) 2000-11-20 2013-06-27 Senorx, Inc. Marcadores de sitios tisulares para formación de imagen in vivo
US6800055B2 (en) 2001-02-21 2004-10-05 Cordis Corporation Low attenuating radioactive seeds
US6497646B1 (en) 2001-03-14 2002-12-24 Cordis Corporation Intravascular radiotherapy source ribbon having variable radiopacity
US6669621B2 (en) 2001-03-14 2003-12-30 Cordis Corporation Method and assembly for containing radioactive materials
US6761680B2 (en) * 2001-11-02 2004-07-13 Richard A. Terwilliger Delivery system and method for interstitial radiation therapy using seed strands constructed with preformed strand housing
US7094198B2 (en) * 2001-11-02 2006-08-22 Worldwide Medical Technologies, Llc Delivery system and method for interstitial radiation therapy using seed elements with ends having one of projections and indentations
US6786858B2 (en) * 2001-11-02 2004-09-07 Ideamatrix, Inc. Delivery system and method for interstitial radiotherapy using hollow seeds
US7074291B2 (en) 2001-11-02 2006-07-11 Worldwide Medical Technologies, L.L.C. Delivery system and method for interstitial radiation therapy using strands constructed with extruded strand housings
US6820318B2 (en) 2001-11-02 2004-11-23 Ideamatrix, Inc. System for manufacturing interstitial radiation therapy seed strands
US7060020B2 (en) * 2001-11-02 2006-06-13 Ideamatrix, Inc. Delivery system and method for interstitial radiation therapy
CA2497919C (en) 2002-09-10 2015-11-03 Curay Medical, Inc. Brachtherapy apparatus
US20060036158A1 (en) 2003-11-17 2006-02-16 Inrad, Inc. Self-contained, self-piercing, side-expelling marking apparatus
US6918869B2 (en) 2002-12-02 2005-07-19 Scimed Life Systems System for administering a combination of therapies to a body lumen
WO2004064727A2 (en) * 2003-01-16 2004-08-05 Georgetown University Method of cancer treatment using hdac inhibitors
US6932758B1 (en) * 2003-02-12 2005-08-23 Bruno Schmidt Coupled seed train
US7037252B2 (en) * 2003-05-05 2006-05-02 Draxis Specialty Pharmaceuticals, Inc. Brachytherapy seed transport devices and methods for using same
US6997862B2 (en) * 2003-05-13 2006-02-14 Ideamatrix, Inc. Delivery system and method for interstitial radiation therapy using seed strands with custom end spacing
US7877133B2 (en) * 2003-05-23 2011-01-25 Senorx, Inc. Marker or filler forming fluid
US20050119562A1 (en) * 2003-05-23 2005-06-02 Senorx, Inc. Fibrous marker formed of synthetic polymer strands
US7922646B2 (en) * 2003-08-20 2011-04-12 International Brachytherapy, S.A. Plastic brachytherapy sources
US20050080314A1 (en) * 2003-10-09 2005-04-14 Terwilliger Richard A. Shielded transport for multiple brachytheapy implants with integrated measuring and cutting board
US20050273002A1 (en) 2004-06-04 2005-12-08 Goosen Ryan L Multi-mode imaging marker
US7540998B2 (en) * 2003-11-19 2009-06-02 Biocompatibles Uk Limited Delivery system and prescription method for interstitial radiation therapy using enhanced parametric release sterilization techniques
US7351192B2 (en) * 2004-05-25 2008-04-01 Core Oncology, Inc. Selectively loadable/sealable bioresorbable carrier assembly for radioisotope seeds
US10357328B2 (en) 2005-04-20 2019-07-23 Bard Peripheral Vascular, Inc. and Bard Shannon Limited Marking device with retractable cannula
US7736293B2 (en) 2005-07-22 2010-06-15 Biocompatibles Uk Limited Implants for use in brachytherapy and other radiation therapy that resist migration and rotation
US8187159B2 (en) 2005-07-22 2012-05-29 Biocompatibles, UK Therapeutic member including a rail used in brachytherapy and other radiation therapy
CA2562580C (en) 2005-10-07 2014-04-29 Inrad, Inc. Drug-eluting tissue marker
US8349443B2 (en) * 2006-02-23 2013-01-08 Meadwestvaco Corporation Method for treating a substrate
US7988611B2 (en) 2006-05-09 2011-08-02 Biocompatibles Uk Limited After-loader for positioning implants for needle delivery in brachytherapy and other radiation therapy
US20070265487A1 (en) * 2006-05-09 2007-11-15 Worldwide Medical Technologies Llc Applicators for use in positioning implants for use in brachytherapy and other radiation therapy
US20090216063A1 (en) * 2008-01-29 2009-08-27 Biocompatibles Uk Limited Bio-absorbable brachytherapy strands
WO2008024959A2 (en) * 2006-08-25 2008-02-28 C. R. Bard, Inc. Therapeutic and directionally dosed implants
US7878964B1 (en) 2006-09-07 2011-02-01 Biocompatibles Uk Limited Echogenic spacers and strands
US7874976B1 (en) 2006-09-07 2011-01-25 Biocompatibles Uk Limited Echogenic strands and spacers therein
ES2443526T3 (es) 2006-10-23 2014-02-19 C.R. Bard, Inc. Marcador mamario
EP3542748B1 (de) 2006-12-12 2023-08-16 C. R. Bard, Inc. Gewebemarker mit mehreren bildgebungsmodi
US8401622B2 (en) 2006-12-18 2013-03-19 C. R. Bard, Inc. Biopsy marker with in situ-generated imaging properties
US20080269540A1 (en) * 2007-04-27 2008-10-30 Worldwide Medical Technologies Llc Seed cartridge adaptor and methods for use therewith
US7962223B2 (en) * 2007-11-16 2011-06-14 Boston Scientific Scimed, Inc. Ablation probe for drug release in tissue ablation procedures
EP2231254B9 (de) 2007-12-11 2015-04-08 Massachusetts Institute of Technology Implantierbare arzneiabgabevorrichtung
US8311610B2 (en) 2008-01-31 2012-11-13 C. R. Bard, Inc. Biopsy tissue marker
US9327061B2 (en) 2008-09-23 2016-05-03 Senorx, Inc. Porous bioabsorbable implant
CA2742765C (en) 2008-12-30 2016-04-12 C.R. Bard Inc. Marker delivery device for tissue marker placement
TW201034641A (en) * 2009-02-28 2010-10-01 Charles Knezevich Apparatus, system, and method for creating immunologically enhanced spaces in-vivo
EA023921B1 (ru) 2009-06-26 2016-07-29 ТАРИС Биомедикал ЛЛК Твердые таблетки лекарства для имплантируемых устройств для доставки лекарств
US9017312B2 (en) 2009-09-10 2015-04-28 Taris Biomedical Llc Implantable device for controlled drug delivery
WO2011050049A2 (en) * 2009-10-21 2011-04-28 The University Of North Carolina At Chapel Hill Delivery systems for brachytherapy, and associated methods
PL2512581T3 (pl) * 2009-12-17 2021-11-02 Taris Biomedical Llc Wszczepiane urządzenie z tolerancją wewnątrzpęcherzową
WO2012018923A1 (en) 2010-08-05 2012-02-09 Taris Biomedical, Inc. Implantable drug delivery devices for genitourinary sites
CA2882984A1 (en) * 2012-08-24 2014-02-27 Boston Scientific Corporation Device and method for improving brachytherapy
CA2903164A1 (en) 2013-03-15 2014-09-18 Taris Biomedical Llc Drug delivery devices with drug-permeable component and methods
SG10202004675QA (en) 2013-08-19 2020-06-29 Taris Biomedical Llc Multi-unit drug delivery devices and methods
USD716450S1 (en) 2013-09-24 2014-10-28 C. R. Bard, Inc. Tissue marker for intracorporeal site identification
USD715942S1 (en) 2013-09-24 2014-10-21 C. R. Bard, Inc. Tissue marker for intracorporeal site identification
USD715442S1 (en) 2013-09-24 2014-10-14 C. R. Bard, Inc. Tissue marker for intracorporeal site identification
USD716451S1 (en) 2013-09-24 2014-10-28 C. R. Bard, Inc. Tissue marker for intracorporeal site identification
JP7425534B2 (ja) 2015-04-23 2024-01-31 タリス バイオメディカル エルエルシー 薬物透過性構成要素を有する薬物送達デバイス及び方法
WO2017070147A1 (en) 2015-10-23 2017-04-27 Boston Scientific Scimed, Inc. Radioactive stents
US20180289467A1 (en) * 2017-04-05 2018-10-11 Ernesto Andrade Dispensing device, kit, and method for tissue augmentation
WO2019099813A1 (en) * 2017-11-17 2019-05-23 Musara Mubayiwa Cornelious Multilayered biologic mesh and methods of use thereof
US11690807B2 (en) 2018-05-24 2023-07-04 Celanese Eva Performance Polymers Llc Implantable device for sustained release of a macromolecular drug compound
CN111989068A (zh) 2018-05-24 2020-11-24 塞拉尼斯伊娃高性能聚合物公司 用于持续释放大分子药物化合物的可植入器件

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3993073A (en) * 1969-04-01 1976-11-23 Alza Corporation Novel drug delivery device
US4351337A (en) * 1973-05-17 1982-09-28 Arthur D. Little, Inc. Biodegradable, implantable drug delivery device, and process for preparing and using the same
US4167179A (en) * 1977-10-17 1979-09-11 Mark Kirsch Planar radioactive seed implanter
US4427005A (en) * 1982-03-04 1984-01-24 Tener William S Apparatus and method for treating breast tumors
US4697575A (en) * 1984-11-21 1987-10-06 Henry Ford Hospital Delivery system for interstitial radiation therapy including substantially non-deflecting elongated member
US4754745A (en) * 1984-11-21 1988-07-05 Horowitz Bruce S Conformable sheet material for use in brachytherapy
EP0212558B1 (de) * 1985-08-15 1991-12-04 Asahi Denka Kogyo Kabushiki Kaisha Strahlungssensibilisator
US4700692A (en) * 1985-12-23 1987-10-20 Baumgartner George C Surgical implantation method and apparatus
US4706652A (en) * 1985-12-30 1987-11-17 Henry Ford Hospital Temporary radiation therapy
US4763642A (en) * 1986-04-07 1988-08-16 Horowitz Bruce S Intracavitational brachytherapy
US5030195A (en) * 1989-06-05 1991-07-09 Nardi George L Radioactive seed patch for prophylactic therapy
US5059166A (en) * 1989-12-11 1991-10-22 Medical Innovative Technologies R & D Limited Partnership Intra-arterial stent with the capability to inhibit intimal hyperplasia
US5342283A (en) * 1990-08-13 1994-08-30 Good Roger R Endocurietherapy
US5620700A (en) * 1990-10-30 1997-04-15 Alza Corporation Injectable drug delivery system and method
US5429582A (en) * 1991-06-14 1995-07-04 Williams; Jeffery A. Tumor treatment
US5242373A (en) * 1991-09-17 1993-09-07 Scott Walter P Medical seed implantation instrument
US5424288A (en) * 1992-02-28 1995-06-13 Order; Stanley E. Method of treating solid tumor cancers utilizing macro aggregated proteins and colloidal radioactive phosphorous
CA2131032A1 (en) * 1992-02-28 1993-09-02 Stanley E. Order Use of aggregated proteins to prolong retention time of a therapeutic agent adjacent a targeted site such as a tumor
US5486360A (en) * 1993-04-22 1996-01-23 St. Joseph Health Centre Method of treating tumour cells using catalase
US5498227A (en) * 1993-09-15 1996-03-12 Mawad; Michel E. Retrievable, shielded radiotherapy implant
EP0722320B1 (de) * 1993-10-08 2000-07-19 THE UNITED STATES OF AMERICA, as represented by the Secretary of the Department of Health and Human Services Verwendung von stickstoffoxid freisetzenden verbindungen als arzneimittel zur strahlungssensibilisation fur hypoxische zellen
US5460592A (en) * 1994-01-24 1995-10-24 Amersham Holdings, Inc. Apparatus and method for making carrier assembly for radioactive seed carrier
WO1996001638A1 (en) * 1994-07-11 1996-01-25 Hoechst Marion Roussel, Inc. Method of treating a neoplastic disease state by conjunctive therapy with 2'-fluoromethylidene derivatives and radiation or chemotherapy
US5626862A (en) * 1994-08-02 1997-05-06 Massachusetts Institute Of Technology Controlled local delivery of chemotherapeutic agents for treating solid tumors
US5626829A (en) * 1994-11-16 1997-05-06 Pgk, Enterprises, Inc. Method and apparatus for interstitial radiation of the prostate gland
US6589502B1 (en) * 1995-11-27 2003-07-08 International Brachytherapy S.A. Radioisotope dispersed in a matrix for brachytherapy
US5871437A (en) * 1996-12-10 1999-02-16 Inflow Dynamics, Inc. Radioactive stent for treating blood vessels to prevent restenosis
US6159143A (en) * 1998-06-17 2000-12-12 Scimed Life Systems, Inc. Method and device for delivery of therapeutic agents in conjunction with isotope seed placement

Also Published As

Publication number Publication date
DE69911221T2 (de) 2004-03-18
US6537193B1 (en) 2003-03-25
CA2334810A1 (en) 1999-12-23
JP2011156373A (ja) 2011-08-18
JP2002518350A (ja) 2002-06-25
EP1109583B1 (de) 2003-09-10
AU5081199A (en) 2000-01-05
CA2334810C (en) 2009-06-16
EP1109583A1 (de) 2001-06-27
JP4806488B2 (ja) 2011-11-02
JP5106649B2 (ja) 2012-12-26
WO1999065532A1 (en) 1999-12-23
AU769312B2 (en) 2004-01-22
US6159143A (en) 2000-12-12

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