DE69914611D1 - Verfahren zur herstellung von polyamidketten von genauer länge und deren konjugate mit proteinen - Google Patents
Verfahren zur herstellung von polyamidketten von genauer länge und deren konjugate mit proteinenInfo
- Publication number
- DE69914611D1 DE69914611D1 DE69914611T DE69914611T DE69914611D1 DE 69914611 D1 DE69914611 D1 DE 69914611D1 DE 69914611 T DE69914611 T DE 69914611T DE 69914611 T DE69914611 T DE 69914611T DE 69914611 D1 DE69914611 D1 DE 69914611D1
- Authority
- DE
- Germany
- Prior art keywords
- chains
- conjugates
- proteins
- exact length
- producing polyamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
- C08G73/06—Polycondensates having nitrogen-containing heterocyclic rings in the main chain of the macromolecule
- C08G73/10—Polyimides; Polyester-imides; Polyamide-imides; Polyamide acids or similar polyimide precursors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
- C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
- C08G69/04—Preparatory processes
- C08G69/06—Solid state polycondensation
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
- C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
- C08G69/08—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino-carboxylic acids
- C08G69/10—Alpha-amino-carboxylic acids
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US9835198P | 1998-08-28 | 1998-08-28 | |
US98351P | 1998-08-28 | ||
US10526198P | 1998-10-22 | 1998-10-22 | |
US105261P | 1998-10-22 | ||
US12426699P | 1999-03-11 | 1999-03-11 | |
US124266P | 1999-03-11 | ||
PCT/US1999/019280 WO2000012587A2 (en) | 1998-08-28 | 1999-08-23 | Polyamide chains of precise length, methods to manufacture them and their conjugates |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69914611D1 true DE69914611D1 (de) | 2004-03-11 |
DE69914611T2 DE69914611T2 (de) | 2004-12-23 |
Family
ID=27378582
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69936322T Expired - Fee Related DE69936322T2 (de) | 1998-08-28 | 1999-08-23 | Polyamideketten von genauer Länge und deren Konjugate mit Proteinen |
DE69914611T Expired - Fee Related DE69914611T2 (de) | 1998-08-28 | 1999-08-23 | Verfahren zur herstellung von polyamidketten von genauer länge und deren konjugate mit proteinen |
DE1107998T Pending DE1107998T1 (de) | 1998-08-28 | 1999-08-24 | Polyamidketten von genauer länge, verfahren zu deren herstellung und deren konjugate mit proteinen |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69936322T Expired - Fee Related DE69936322T2 (de) | 1998-08-28 | 1999-08-23 | Polyamideketten von genauer Länge und deren Konjugate mit Proteinen |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE1107998T Pending DE1107998T1 (de) | 1998-08-28 | 1999-08-24 | Polyamidketten von genauer länge, verfahren zu deren herstellung und deren konjugate mit proteinen |
Country Status (13)
Country | Link |
---|---|
US (2) | US6552167B1 (de) |
EP (1) | EP1107998B1 (de) |
JP (1) | JP2002528562A (de) |
KR (1) | KR20010085742A (de) |
CN (1) | CN1330675A (de) |
AT (2) | ATE258946T1 (de) |
AU (1) | AU764144B2 (de) |
CA (1) | CA2351739A1 (de) |
DE (3) | DE69936322T2 (de) |
DK (1) | DK1400551T3 (de) |
ES (1) | ES2170042T3 (de) |
HK (1) | HK1043801A1 (de) |
WO (1) | WO2000012587A2 (de) |
Families Citing this family (89)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2351739A1 (en) * | 1998-08-28 | 2000-03-09 | Gryphon Sciences | Polyamide chains of precise length, methods to manufacture them and their conjugates with proteins |
DE19924606A1 (de) * | 1999-05-28 | 2000-11-30 | Graffinity Pharm Design Gmbh | Ligand-Anker-Konjugate |
US8183339B1 (en) | 1999-10-12 | 2012-05-22 | Xigen S.A. | Cell-permeable peptide inhibitors of the JNK signal transduction pathway |
US20040082509A1 (en) | 1999-10-12 | 2004-04-29 | Christophe Bonny | Cell-permeable peptide inhibitors of the JNK signal transduction pathway |
JP2004507557A (ja) * | 2000-09-01 | 2004-03-11 | グリフォン セラピューティクス,インコーポレーテッド | 求核物質に対して安定なチオエステル生成化合物、製造および使用の方法 |
SK2772003A3 (en) * | 2000-09-08 | 2003-10-07 | Gryphon Therapeutics Inc | Synthetic erythropoiesis stimulating proteins |
US7118737B2 (en) | 2000-09-08 | 2006-10-10 | Amylin Pharmaceuticals, Inc. | Polymer-modified synthetic proteins |
US7033597B2 (en) * | 2000-10-13 | 2006-04-25 | Université de Lausanne | Intracellular delivery of biological effectors |
US6960648B2 (en) | 2000-10-13 | 2005-11-01 | Universite De Lausanne | Intracellular delivery of biological effectors |
US20040138412A1 (en) * | 2001-09-07 | 2004-07-15 | Paolo Botti | Extended native chemical ligation |
US20040062748A1 (en) | 2002-09-30 | 2004-04-01 | Mountain View Pharmaceuticals, Inc. | Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof |
US8129330B2 (en) | 2002-09-30 | 2012-03-06 | Mountain View Pharmaceuticals, Inc. | Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof |
US20060275768A1 (en) * | 2002-12-30 | 2006-12-07 | Kochendoerfer Gerd G | Multiplex polymer ligation |
US8034900B2 (en) | 2002-12-30 | 2011-10-11 | Amylin Pharmaceuticals, Inc. | Water-soluble thioester and selenoester compounds and methods for making and using the same |
MXPA05012315A (es) * | 2003-05-12 | 2006-04-18 | Affymax Inc | Compuestos poli(etilenglicol) modificados novedosos y usos de los mismos. |
CN1823088B (zh) * | 2003-05-12 | 2011-04-13 | 阿费麦克斯公司 | 结合红细胞生成素受体的新肽 |
EP2204193A3 (de) | 2003-05-12 | 2010-08-18 | Affymax, Inc. | Spacer-Bestandteile für Poly(ethylenglykol)-modifizierte Verbindungen auf Peptidbasis |
DE602004020610D1 (de) | 2003-05-12 | 2009-05-28 | Affymax Inc | Neue, an den erythropoietinrezeptor bindende peptide |
RU2385879C2 (ru) | 2004-01-21 | 2010-04-10 | Ново Нордиск Хелс Кеа Аг | Способ конъюгации пептидов, опосредованной трансглутаминазой |
US8778880B2 (en) * | 2004-02-02 | 2014-07-15 | Ambrx, Inc. | Human growth hormone modified at position 35 |
US7588745B2 (en) * | 2004-04-13 | 2009-09-15 | Si Options, Llc | Silicon-containing products |
CA2568952C (en) * | 2004-06-18 | 2019-05-21 | Ambrx, Inc. | Novel antigen-binding polypeptides and their uses |
WO2006091231A2 (en) * | 2004-07-21 | 2006-08-31 | Ambrx, Inc. | Biosynthetic polypeptides utilizing non-naturally encoded amino acids |
WO2006062685A2 (en) * | 2004-11-11 | 2006-06-15 | Affymax, Inc. | Novel peptides that bind to the erythropoietin receptor |
WO2006060148A2 (en) * | 2004-11-11 | 2006-06-08 | Affymax, Inc. | Novel peptides that bind to the erythropoietin receptor |
SG161210A1 (en) * | 2004-12-22 | 2010-05-27 | Ambrx Inc | Methods for expression and purification of recombinant human growth hormone |
AU2005322019B2 (en) | 2004-12-22 | 2010-08-26 | Ambrx, Inc. | Formulations of human growth hormone comprising a non-naturally encoded amino acid |
ATE541934T1 (de) | 2004-12-22 | 2012-02-15 | Ambrx Inc | Zusammensetzungen von aminoacyl-trna-synthetase und verwendungen davon |
KR20070090023A (ko) | 2004-12-22 | 2007-09-04 | 암브룩스, 인코포레이티드 | 변형 인간 성장 호르몬 |
WO2006082205A1 (en) | 2005-02-02 | 2006-08-10 | Novo Nordisk A/S | Insulin derivatives |
EP1893229B1 (de) | 2005-06-03 | 2011-10-19 | Ambrx, Inc. | Verbesserte humane interferon-moleküle und ihre verwendungen |
US7550433B2 (en) | 2005-06-03 | 2009-06-23 | Affymax, Inc. | Erythropoietin receptor peptide formulations and uses |
US8324159B2 (en) * | 2005-06-03 | 2012-12-04 | Affymax, Inc. | Erythropoietin receptor peptide formulations and uses |
US7919461B2 (en) | 2005-06-03 | 2011-04-05 | Affymax, Inc. | Erythropoietin receptor peptide formulations and uses |
US8080517B2 (en) | 2005-09-12 | 2011-12-20 | Xigen Sa | Cell-permeable peptide inhibitors of the JNK signal transduction pathway |
WO2007031098A1 (en) | 2005-09-12 | 2007-03-22 | Xigen S.A. | Cell-permeable peptide inhibitors of the jnk signal transduction pathway |
WO2007059312A2 (en) | 2005-11-16 | 2007-05-24 | Ambrx, Inc. | Methods and compositions comprising non-natural amino acids |
US20090082254A1 (en) * | 2006-02-14 | 2009-03-26 | Novo Nordisk A/S | Coupling of Polypeptides at the C-Terminus |
US20100029554A1 (en) | 2006-05-26 | 2010-02-04 | Amylin Pharmaceuticals, Inc. | Composition and Methods for Treatment of Congestive Heart Failure |
US8501693B2 (en) * | 2006-08-04 | 2013-08-06 | Amylin Pharmaceuticals, Llc | Use of exendins and exendin agonists and GLP-1 receptor agonists for altering the concentration of fibrinogen |
JP5570809B2 (ja) | 2006-09-01 | 2014-08-13 | ノボ ノルディスク ヘルス ケア アーゲー | 修飾タンパク質 |
KR20090051227A (ko) | 2006-09-08 | 2009-05-21 | 암브룩스, 인코포레이티드 | 척추동물 세포를 위한 하이브리드 서프레서 tRNA |
AU2007292893B2 (en) | 2006-09-08 | 2012-03-01 | Ambrx, Inc. | Suppressor tRNA transcription in vertebrate cells |
JP5840345B2 (ja) * | 2006-09-08 | 2016-01-06 | アンブルックス, インコーポレイテッドAmbrx, Inc. | 修飾ヒト血漿ポリペプチドまたは修飾ヒトFc足場タンパク質ならびにこれらの利用 |
JP2010511637A (ja) * | 2006-12-06 | 2010-04-15 | 南▲開▼大学 | ポリペプチド系重合体およびその合成方法 |
EP2101821B1 (de) | 2006-12-15 | 2014-08-13 | Baxter International Inc. | Faktor-viia-(poly)sialsäurekonjugat mit verlängerter in-vivo-halbwertszeit |
US8012931B2 (en) | 2007-03-30 | 2011-09-06 | Ambrx, Inc. | Modified FGF-21 polypeptides and their uses |
CA2685596A1 (en) | 2007-05-02 | 2008-11-13 | Ambrx, Inc. | Modified interferon beta polypeptides and their uses |
JP5547083B2 (ja) | 2007-11-20 | 2014-07-09 | アンブルックス,インコーポレイテッド | 修飾されたインスリンポリペプチドおよびそれらの使用 |
NZ620606A (en) | 2008-02-08 | 2015-08-28 | Ambrx Inc | Modified leptin polypeptides and their uses |
WO2009143865A1 (en) | 2008-05-30 | 2009-12-03 | Xigen S.A. | Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases |
WO2009143864A1 (en) | 2008-05-30 | 2009-12-03 | Xigen S.A. | Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of chronic or non-chronic inflammatory digestive diseases |
PE20110426A1 (es) | 2008-07-23 | 2011-07-01 | Ambrx Inc | Polipeptidos g-csf bovinos modificados |
KR101647164B1 (ko) | 2008-09-26 | 2016-08-09 | 암브룩스, 인코포레이티드 | 변형된 동물 에리트로포이에틴 폴리펩티드 및 이의 용도 |
MX357314B (es) | 2008-09-26 | 2018-07-04 | Ambrx Inc | Microorganismos y vacunas dependientes de replicacion de aminoacidos no naturales. |
WO2010072228A1 (en) | 2008-12-22 | 2010-07-01 | Xigen S.A. | Novel transporter constructs and transporter cargo conjugate molecules |
SG178051A1 (en) | 2009-07-27 | 2012-03-29 | Lipoxen Technologies Ltd | Glycopolysialylation of non-blood coagulation proteins |
US8809501B2 (en) | 2009-07-27 | 2014-08-19 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
MX2012001207A (es) | 2009-07-27 | 2012-05-08 | Baxter Int | Conjugados proteicos de coagulacion sanguínea. |
ES2856055T3 (es) | 2009-07-27 | 2021-09-27 | Baxalta GmbH | Glicopolisialilación de proteínas diferentes de las proteínas de coagulación de la sangre |
US8642737B2 (en) | 2010-07-26 | 2014-02-04 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
SG181769A1 (en) | 2009-12-21 | 2012-07-30 | Ambrx Inc | Modified porcine somatotropin polypeptides and their uses |
CA2784793A1 (en) | 2009-12-21 | 2011-07-21 | Ambrx, Inc. | Modified bovine somatotropin polypeptides and their uses |
WO2011160653A1 (en) | 2010-06-21 | 2011-12-29 | Xigen S.A. | Novel jnk inhibitor molecules |
US9567386B2 (en) | 2010-08-17 | 2017-02-14 | Ambrx, Inc. | Therapeutic uses of modified relaxin polypeptides |
EP2605789B1 (de) | 2010-08-17 | 2019-06-05 | Ambrx, Inc. | Modifizierte relaxinpolypeptide und ihre verwendungen |
AR083006A1 (es) | 2010-09-23 | 2013-01-23 | Lilly Co Eli | Formulaciones para el factor estimulante de colonias de granulocitos (g-csf) bovino y variantes de las mismas |
US9150618B2 (en) | 2010-10-14 | 2015-10-06 | Xigen Inflammation Ltd. | Use of cell-permeable peptide inhibitors of the JNK signal transduction pathway for the treatment of chronic or non-chronic inflammatory eye diseases |
NZ612320A (en) | 2010-12-22 | 2015-06-26 | Baxter Healthcare Sa | Materials and methods for conjugating a water soluble fatty acid derivative to a protein |
US8440309B2 (en) | 2011-01-31 | 2013-05-14 | Confluent Surgical, Inc. | Crosslinked polymers with the crosslinker as therapeutic for sustained release |
WO2013091670A1 (en) | 2011-12-21 | 2013-06-27 | Xigen S.A. | Novel jnk inhibitor molecules for treatment of various diseases |
PL2859017T3 (pl) | 2012-06-08 | 2019-07-31 | Sutro Biopharma, Inc. | Przeciwciała zawierające swoiste dla miejsca, niewystępujące naturalnie reszty aminokwasowe, sposoby ich wytwarzania i sposoby ich zastosowania |
EP3135690A1 (de) | 2012-06-26 | 2017-03-01 | Sutro Biopharma, Inc. | Modifizierte fc-proteine mit stellenspezifischen nichtnatürlichen aminosäureresten, konjugate daraus, verfahren zu deren herstellung und verfahren zu deren verwendung |
CN104981254B (zh) | 2012-08-31 | 2018-05-22 | 苏特罗生物制药公司 | 含有叠氮基的经修饰的氨基酸 |
WO2014068463A2 (en) * | 2012-11-03 | 2014-05-08 | Mahesh Kandula | Compositions and methods for the treatment of inflammation and metabolic disorders |
CN105307670A (zh) | 2013-06-26 | 2016-02-03 | 埃克西金炎症有限公司 | Jnk信号转导途径的细胞渗透肽抑制剂用于治疗多种疾病的新用途 |
WO2014206427A1 (en) | 2013-06-26 | 2014-12-31 | Xigen Inflammation Ltd. | New use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases |
WO2015197097A1 (en) | 2014-06-26 | 2015-12-30 | Xigen Inflammation Ltd. | New use for jnk inhibitor molecules for treatment of various diseases |
ES2865473T3 (es) | 2013-07-10 | 2021-10-15 | Sutro Biopharma Inc | Anticuerpos que comprenden múltiples residuos de aminoácidos no naturales sitio-específicos, métodos para su preparación y métodos de uso |
EP3055298B1 (de) | 2013-10-11 | 2020-04-29 | Sutro Biopharma, Inc. | Modifizierte aminosäuren mit funktionellen tetrazingruppen, verfahren zur herstellung und verfahren zu deren verwendung |
CN114805532A (zh) | 2014-10-24 | 2022-07-29 | 百时美施贵宝公司 | 修饰的fgf-21多肽及其用途 |
WO2018136779A2 (en) | 2017-01-19 | 2018-07-26 | The University Of Chicago | OXALOBACTER FORMIGENES(Of)-DERIVED FACTORS FOR THE TREATMENT OF TREATMENT/PREVENTION OF EXCESS OXALATE LEVELS |
AU2018219283B2 (en) | 2017-02-08 | 2022-05-19 | Bristol-Myers Squibb Company | Modified relaxin polypeptides comprising a pharmacokinetic enhancer and uses thereof |
FI3849614T3 (fi) | 2018-09-11 | 2024-02-08 | Ambrx Inc | Interleukiini-2-polypeptidikonjugaatteja ja niiden käyttöjä |
US20220009986A1 (en) | 2018-10-19 | 2022-01-13 | Ambrx, Inc. | Interleukin-10 polypeptide conjugates, dimers thereof, and their uses |
KR20210136014A (ko) | 2019-02-12 | 2021-11-16 | 암브룩스, 인코포레이티드 | 항체-tlr 작용제 콘쥬게이트를 함유하는 조성물, 방법 및 이의 용도 |
AU2021233909A1 (en) | 2020-03-11 | 2022-09-29 | Ambrx, Inc. | Interleukin-2 polypeptide conjugates and methods of use thereof |
CA3190606A1 (en) | 2020-08-20 | 2022-02-24 | Ambrx, Inc. | Antibody-tlr agonist conjugates, methods and uses thereof |
KR20240004342A (ko) | 2021-04-03 | 2024-01-11 | 암브룩스, 인코포레이티드 | 항-her2 항체-약물 접합체 및 이의 용도 |
Family Cites Families (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE343210B (de) | 1967-12-20 | 1972-03-06 | Pharmacia Ab | |
US4028315A (en) * | 1970-10-16 | 1977-06-07 | E. R. Squibb & Sons, Inc. | Solid phase synthesis of peptides |
GB1479268A (en) | 1973-07-05 | 1977-07-13 | Beecham Group Ltd | Pharmaceutical compositions |
US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
DE2360794C2 (de) | 1973-12-06 | 1984-12-06 | Hoechst Ag, 6230 Frankfurt | Verfahren zur Herstellung von Peptiden |
US4028313A (en) * | 1975-06-25 | 1977-06-07 | Bayer Aktiengesellschaft | Process for the production of water-dispersible polyhydroxyl compounds |
US4002531A (en) | 1976-01-22 | 1977-01-11 | Pierce Chemical Company | Modifying enzymes with polyethylene glycol and product produced thereby |
GB1578348A (en) | 1976-08-17 | 1980-11-05 | Pharmacia Ab | Products and a method for the therapeutic suppression of reaginic antibodies responsible for common allergic |
US4192798A (en) * | 1978-11-20 | 1980-03-11 | Bioresearch, Inc. | Rapid, large scale, automatable high pressure peptide synthesis |
JPS5792435A (en) | 1980-11-28 | 1982-06-09 | Matsushita Electric Ind Co Ltd | Formation of magnetic tape |
US4415665A (en) | 1980-12-12 | 1983-11-15 | Pharmacia Fine Chemicals Ab | Method of covalently binding biologically active organic substances to polymeric substances |
US4414147A (en) | 1981-04-17 | 1983-11-08 | Massachusetts Institute Of Technology | Methods of decreasing the hydrophobicity of fibroblast and other interferons |
JPS57206622A (en) | 1981-06-10 | 1982-12-18 | Ajinomoto Co Inc | Blood substitute |
DE3380726D1 (en) | 1982-06-24 | 1989-11-23 | Japan Chem Res | Long-acting composition |
IL74177A (en) | 1984-02-03 | 1989-09-10 | Abbott Lab | Stabilized enzyme conjugate composition containing a calcium salt and a polyethylene glycol |
US4732863A (en) | 1984-12-31 | 1988-03-22 | University Of New Mexico | PEG-modified antibody with reduced affinity for cell surface Fc receptors |
US4824659A (en) * | 1985-06-07 | 1989-04-25 | Immunomedics, Inc. | Antibody conjugates |
IT1190389B (it) * | 1985-09-19 | 1988-02-16 | Eniricerche Spa | Esapeptidi ad attivita' ipotensiva |
US4802512A (en) | 1986-02-25 | 1989-02-07 | Kabushiki, Kaisha, Kodera, Denshi, Seisakusho | Automatic wire decorticating and cutting method and apparatus |
US4745180A (en) | 1986-06-27 | 1988-05-17 | Cetus Corporation | Solubilization of proteins for pharmaceutical compositions using heparin fragments |
US5122614A (en) | 1989-04-19 | 1992-06-16 | Enzon, Inc. | Active carbonates of polyalkylene oxides for modification of polypeptides |
US5097070A (en) * | 1989-11-03 | 1992-03-17 | Texaco Chemical Company | High molecular weight trifunctional polyoxyethylene amines |
WO1993020236A1 (en) | 1992-04-03 | 1993-10-14 | Applied Biosystems, Inc. | Probe composition and method |
IL107715A0 (en) | 1992-11-25 | 1994-02-27 | Baxter Int | Water soluble non-immunogenic polyamide cross-linking agents |
FR2698628B1 (fr) * | 1992-12-02 | 1995-02-17 | Fournier Ind & Sante | Analogues de 15-déoxyspergualine, leur procédé de préparation et leur utilisation en thérapeutique. |
NZ250375A (en) | 1992-12-09 | 1995-07-26 | Ortho Pharma Corp | Peg hydrazone and peg oxime linkage forming reagents and protein derivatives |
JP3351476B2 (ja) | 1993-01-22 | 2002-11-25 | 三菱化学株式会社 | リン脂質誘導体及びそれを含有するリポソーム |
US5446090A (en) | 1993-11-12 | 1995-08-29 | Shearwater Polymers, Inc. | Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules |
EP0702553A1 (de) * | 1993-12-27 | 1996-03-27 | BAXTER INTERNATIONAL INC. (a Delaware corporation) | Wasserlösliches, nicht-immunogenes vernetzungsmittel auf polyamidbasis |
US5672662A (en) | 1995-07-07 | 1997-09-30 | Shearwater Polymers, Inc. | Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications |
EP0856026A1 (de) | 1995-10-19 | 1998-08-05 | Receptagen Corporation | Polyethylenglycolen mit diskreter länge |
CA2351739A1 (en) * | 1998-08-28 | 2000-03-09 | Gryphon Sciences | Polyamide chains of precise length, methods to manufacture them and their conjugates with proteins |
-
1999
- 1999-08-23 CA CA002351739A patent/CA2351739A1/en not_active Abandoned
- 1999-08-23 CN CN99812465A patent/CN1330675A/zh active Pending
- 1999-08-23 AT AT99943873T patent/ATE258946T1/de not_active IP Right Cessation
- 1999-08-23 AU AU56883/99A patent/AU764144B2/en not_active Ceased
- 1999-08-23 AT AT03023018T patent/ATE364654T1/de not_active IP Right Cessation
- 1999-08-23 EP EP99943873A patent/EP1107998B1/de not_active Expired - Lifetime
- 1999-08-23 US US09/379,297 patent/US6552167B1/en not_active Expired - Fee Related
- 1999-08-23 JP JP2000567596A patent/JP2002528562A/ja active Pending
- 1999-08-23 WO PCT/US1999/019280 patent/WO2000012587A2/en not_active Application Discontinuation
- 1999-08-23 ES ES99943873T patent/ES2170042T3/es not_active Expired - Lifetime
- 1999-08-23 DK DK03023018T patent/DK1400551T3/da active
- 1999-08-23 DE DE69936322T patent/DE69936322T2/de not_active Expired - Fee Related
- 1999-08-23 DE DE69914611T patent/DE69914611T2/de not_active Expired - Fee Related
- 1999-08-23 KR KR1020017002641A patent/KR20010085742A/ko not_active Application Discontinuation
- 1999-08-24 DE DE1107998T patent/DE1107998T1/de active Pending
-
2002
- 2002-06-25 HK HK02104731.4A patent/HK1043801A1/zh unknown
-
2003
- 2003-03-06 US US10/379,585 patent/US20030228274A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2000012587A8 (en) | 2001-09-20 |
JP2002528562A (ja) | 2002-09-03 |
DE69914611T2 (de) | 2004-12-23 |
KR20010085742A (ko) | 2001-09-07 |
ATE364654T1 (de) | 2007-07-15 |
CA2351739A1 (en) | 2000-03-09 |
EP1107998B1 (de) | 2004-02-04 |
AU764144B2 (en) | 2003-08-14 |
WO2000012587A3 (en) | 2000-06-02 |
US20030228274A1 (en) | 2003-12-11 |
ES2170042T3 (es) | 2004-10-01 |
DE69936322D1 (de) | 2007-07-26 |
CN1330675A (zh) | 2002-01-09 |
DE1107998T1 (de) | 2002-10-17 |
AU5688399A (en) | 2000-03-21 |
ES2170042T1 (es) | 2002-08-01 |
US6552167B1 (en) | 2003-04-22 |
HK1043801A1 (zh) | 2002-09-27 |
EP1107998A2 (de) | 2001-06-20 |
DK1400551T3 (da) | 2007-10-15 |
WO2000012587A2 (en) | 2000-03-09 |
DE69936322T2 (de) | 2008-02-21 |
ATE258946T1 (de) | 2004-02-15 |
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