DE69920497D1 - Liponsaürederivate und deren verwendung bei der behandlung von krankheiten - Google Patents
Liponsaürederivate und deren verwendung bei der behandlung von krankheitenInfo
- Publication number
- DE69920497D1 DE69920497D1 DE69920497T DE69920497T DE69920497D1 DE 69920497 D1 DE69920497 D1 DE 69920497D1 DE 69920497 T DE69920497 T DE 69920497T DE 69920497 T DE69920497 T DE 69920497T DE 69920497 D1 DE69920497 D1 DE 69920497D1
- Authority
- DE
- Germany
- Prior art keywords
- acid derivatives
- treating diseases
- liponic acid
- diseased cells
- liponic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/48—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups having nitrogen atoms of sulfonamide groups further bound to another hetero atom
- C07C311/49—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups having nitrogen atoms of sulfonamide groups further bound to another hetero atom to nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
- C07D339/02—Five-membered rings
- C07D339/04—Five-membered rings having the hetero atoms in positions 1 and 2, e.g. lipoic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F19/00—Metal compounds according to more than one of main groups C07F1/00 - C07F17/00
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10562898P | 1998-10-26 | 1998-10-26 | |
US105628P | 1998-10-26 | ||
PCT/US1999/025140 WO2000024734A1 (en) | 1998-10-26 | 1999-10-26 | Lipoic acid derivatives and their use in treatment of disease |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69920497D1 true DE69920497D1 (de) | 2004-10-28 |
DE69920497T2 DE69920497T2 (de) | 2006-02-09 |
Family
ID=22306916
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69941800T Expired - Lifetime DE69941800D1 (de) | 1998-10-26 | 1999-10-26 | Salze von Liponsaürederivaten und deren Verwendung bei der Behandlung von Krankheiten |
DE69920497T Expired - Lifetime DE69920497T2 (de) | 1998-10-26 | 1999-10-26 | Liponsaürederivate und deren verwendung bei der behandlung von krankheiten |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69941800T Expired - Lifetime DE69941800D1 (de) | 1998-10-26 | 1999-10-26 | Salze von Liponsaürederivaten und deren Verwendung bei der Behandlung von Krankheiten |
Country Status (12)
Country | Link |
---|---|
US (2) | US6331559B1 (de) |
EP (3) | EP2145883A1 (de) |
JP (2) | JP4728481B2 (de) |
AT (2) | ATE277034T1 (de) |
AU (1) | AU774362B2 (de) |
BR (1) | BR9914789A (de) |
CA (1) | CA2348998C (de) |
DE (2) | DE69941800D1 (de) |
ES (2) | ES2229790T3 (de) |
IL (2) | IL142824A0 (de) |
MX (1) | MXPA01004152A (de) |
WO (1) | WO2000024734A1 (de) |
Families Citing this family (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7381413B1 (en) * | 1998-04-17 | 2008-06-03 | University Of Vermont And State Agricultural College | Methods and products related to metabolic interactions in disease |
AU775388B2 (en) * | 1998-11-25 | 2004-07-29 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Scavenger compounds |
AR042572A1 (es) * | 1999-04-02 | 2005-06-29 | Sod Conseils Rech Applic | Derivados de acido lipoico, procedimiento para su preparacion, medicamentos y composiciones farmaceuticas que los contienen y utilizacion de dichos derivados para la preparacion de los referidos medicamentos |
IT1312060B1 (it) * | 1999-04-09 | 2002-04-04 | Antibioticos Spa | Uso dell'acido alfa lipoico nel trattamento antimetastatico. |
ES2162586B1 (es) * | 1999-11-25 | 2002-07-01 | Moraleda Manuel Gomez | Composicion que comprende aceites ozonizados y/o otros productos naturales y/o sinteticos ozonizados, y su empleo en composiciones farmaceuticas, cosmeticas, dieteticas o de suplementos alimentarios, en los campos humano y veterinario |
US6664287B2 (en) * | 2000-03-15 | 2003-12-16 | Bethesda Pharmaceuticals, Inc. | Antioxidants |
EP1172110A3 (de) * | 2000-07-07 | 2003-09-17 | Basf Aktiengesellschaft | Verwendung von Liponsäure zur Verbesserung der Bioverfügbarkeit von Mineralsalzen |
IT1319196B1 (it) * | 2000-10-10 | 2003-09-26 | Laboratorio Chimico Int Spa | Sintesi dell'acido r(+)alfa-lipoico. |
DE50110077D1 (de) | 2000-11-30 | 2006-07-20 | Basf Ag | Verfahren zur herstellung von liponsäure und dihydroliponsaüre |
WO2002076935A1 (fr) * | 2001-03-19 | 2002-10-03 | Senju Pharmaceutical Co., Ltd. | Nouveau derive de l'acide lipoique et son utilisation |
US6936641B2 (en) * | 2002-06-25 | 2005-08-30 | Johnson & Johnson Vision Care, Inc. | Macromer forming catalysts |
AU2003251955A1 (en) * | 2002-07-16 | 2004-02-02 | Sonus Pharmaceuticals, Inc. | Platinum compound |
WO2004024139A1 (ja) * | 2002-09-13 | 2004-03-25 | Oga Research, Incorporated | メラニン消去剤 |
CN1964630A (zh) | 2003-02-13 | 2007-05-16 | 耶希瓦大学艾伯塔·爱恩斯坦医学院 | 通过控制下丘脑的长链脂肪酰基-辅酶A(LC-CoA)的水平来调控食物摄取和葡萄糖产生 |
US20040248982A1 (en) * | 2003-06-09 | 2004-12-09 | Dyer Gordon Wayne | Use of compounds for the inhibition of proteins and UV protection |
CA2534816A1 (en) * | 2003-06-12 | 2004-12-23 | Evan Newell | Systems and methods for treating human inflammatory and proliferative diseases and wounds, with fatty acid metabolism inhibitors and/or glycolytic inhibitors |
WO2005070126A2 (en) * | 2004-01-08 | 2005-08-04 | The Regents Of The University Of Colorado | Methods and compositions for treating human diseases and wounds with ucp and fas inhibitors |
CA2560059A1 (en) * | 2004-03-15 | 2005-09-29 | Sonus Pharmaceuticals, Inc. | Platinum carboxylate anticancer compounds |
US7582418B2 (en) * | 2004-11-03 | 2009-09-01 | Albion Laboratories, Inc. | Antimicrobial chelates |
CA2611735A1 (en) * | 2005-04-28 | 2006-11-02 | The Regents Of The University Of Colorado | Therapeutic bifunctional compounds |
WO2006118821A2 (en) * | 2005-05-02 | 2006-11-09 | The Regents Of The University Of Colorado | Systems and methods for treating human inflammatory and proliferative diseases, with a combination of compounds, or a bifunctional compound,that provides fatty acid metabolism and glycolysis inhibition |
US20070225354A1 (en) * | 2006-03-21 | 2007-09-27 | Eric Marchewitz | Use of dihydrolipoamide for enhancing physical performance |
JP5412423B2 (ja) * | 2007-04-18 | 2014-02-12 | コーナーストーン ファーマシューティカルズ,インコーポレーテッド | リポ酸誘導体 |
US8263653B2 (en) | 2007-04-18 | 2012-09-11 | Cornerstone Pharmaceuticals, Inc. | Pharmaceutical formulations containing lipoic acid derivatives |
CN101820875B (zh) * | 2007-04-18 | 2014-07-23 | 基石医药公司 | 含有硫辛酸衍生物的药物制剂 |
WO2009105230A2 (en) * | 2008-02-21 | 2009-08-27 | The Regents Of The University Of Colorado | Methods for treating cancer using combination therapy |
JP2011513395A (ja) * | 2008-03-04 | 2011-04-28 | ショール,ロバート | 酵素の構造、活性、及び/又は、発現レベルの調節 |
CN102046178B (zh) * | 2008-04-01 | 2013-05-08 | 安蒂博汀医药公司 | 用于皮肤护理的组合物和方法 |
KR20110025168A (ko) * | 2008-04-04 | 2011-03-09 | 로버트 쇼어 | 약학적 조성물 |
CA2730773A1 (en) | 2008-07-14 | 2010-01-21 | Martha Karen Newell | Methods and products for treating proliferative diseases |
WO2010019225A1 (en) * | 2008-08-15 | 2010-02-18 | Robert Shorr | Pharmaceutical composition |
EP2350274B1 (de) | 2008-10-21 | 2019-01-23 | The General Hospital Corporation | Zelltransplantation |
FR2937867B1 (fr) * | 2008-11-03 | 2011-03-04 | Biorebus | Association pharmaceutique contenant l acide lipoique et l acide hydroxycitrique a titre de principes actifs. |
WO2010062381A1 (en) * | 2008-11-28 | 2010-06-03 | Robert Shorr | Organelle-specific drug delivery |
CN102300571A (zh) * | 2008-12-01 | 2011-12-28 | 英沃兹科医疗有限公司 | 包括肾素—血管紧张素醛固酮系统抑制剂和硫辛酸化合物的组合物,及其用于肾素—血管紧张素醛固酮系统相关病症的治疗 |
CN101787013B (zh) * | 2009-01-22 | 2013-04-24 | 杭州民生药业有限公司 | 硫辛酰胺系列衍生物、制备方法及所述衍生物的制药用途 |
WO2010110887A1 (en) * | 2009-03-24 | 2010-09-30 | Robert Shorr | Fatty acids |
WO2010110771A2 (en) * | 2009-03-25 | 2010-09-30 | Frank Gibson | Substituted thiol-containing alkyl fatty acids and process for synthesizing derivatives thereof |
WO2011046583A1 (en) * | 2009-09-11 | 2011-04-21 | Robert Shorr | Pharmaceutical exploitation of oxidative stress in transformed cells |
WO2011138565A1 (fr) | 2010-05-05 | 2011-11-10 | Biorebus | Association pharmaceutique contenant l'acide lipoïque, l'acide hydroxycitrique et une somatostatine a titre de principes actifs |
FR2959668B1 (fr) * | 2010-05-05 | 2012-07-13 | Biorebus | Association pharmaceutique contenant l'acide lipoique, l'acide hydroxycitrique et une somatostatine a titre de principes actifs |
WO2011143593A1 (en) | 2010-05-14 | 2011-11-17 | Cornerstone Pharmaceuticals, Inc. | Conjugates of a lipoic acid derivative and anti-proliferation agent and medical uses thereof |
WO2011143590A1 (en) | 2010-05-14 | 2011-11-17 | Cornerstone Pharmaceuticals, Inc. | Combination therapy compositions and methods using lipoic acid derivatives and an anti-proliferation agent |
WO2011146635A1 (en) * | 2010-05-21 | 2011-11-24 | North Texas Medical Associates | Malignant neoplasm treatment protocol |
EP2601299B1 (de) | 2010-08-06 | 2019-04-24 | The General Hospital Corporation D/B/A Massachusetts General Hospital | System und vorrichtung zur behandlung von zellen |
JP6395724B2 (ja) * | 2012-12-19 | 2018-09-26 | ロバート・ショア | 医薬化合物 |
US9605012B2 (en) | 2013-01-17 | 2017-03-28 | Garnett Mckeen Laboratory, Inc. | Palladium-ruthenium-zinc-organo complexes and methods for their use in the treatment of inflammatory diseases |
AU2014398232B2 (en) | 2014-06-19 | 2019-11-28 | Rafael Pharmaceuticals, Inc. | Pharmaceutical compounds |
EP3188726B1 (de) | 2014-06-19 | 2019-08-07 | Rafael Pharmaceuticals, Inc. | Pharmazeutische verbindungen |
US10052305B2 (en) | 2015-10-07 | 2018-08-21 | Buck Institute For Research On Aging | Lipoic acid and derivatives thereof for the treatment of cystinuria |
Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE362916C (de) | 1921-08-13 | 1922-11-02 | Eduard Duerr | Abnehmbares Mikrometer fuer Schublehren |
GB758897A (en) * | 1953-10-19 | 1956-10-10 | Merck & Co Inc | Thio-substituted aliphatic carboxylic acids and their preparation |
US2853497A (en) | 1953-12-04 | 1958-09-23 | Merck & Co Inc | 6, 8-bis (hydrocarbon substituted mercapto) 5-hydroxycaprylic acids and delta-lactones thereof |
US2975198A (en) * | 1954-07-08 | 1961-03-14 | Research Corp | Lipoic acid intermediates |
US2872458A (en) * | 1954-12-30 | 1959-02-03 | Merck & Co Inc | Addition product of a metal hydrocarbon mercaptide with an alpha-halogamma-butyrolactone |
JPS57123107A (en) | 1981-01-26 | 1982-07-31 | Pola Chem Ind Inc | Cosmetic |
DE3512911A1 (de) * | 1985-04-11 | 1986-10-16 | Degussa Ag, 6000 Frankfurt | Verfahren zur herstellung von 1,2-dithiolan-3-pentansaeure (thioctsaeure) |
DE3626116A1 (de) | 1986-08-01 | 1988-02-11 | Karl Thiel | Thermostatische regeleinrichtung fuer heizungen bzw. heizaggregate |
DE3629116A1 (de) * | 1986-08-27 | 1988-03-10 | Asta Pharma Ag | Verfahren zur herstellung enantiomerenreiner r-(+)-(alpha)-liponsaeure und s-(-)-(alpha)-liponsaeure (thioctsaeure) sowie nonen- beziehungsweise mesylderivate als zwischenprodukte hierfuer |
DE3900649A1 (de) | 1989-01-11 | 1990-07-12 | Boehringer Mannheim Gmbh | Verfahren zur abloesung eines analyten von seinem bindeprotein |
JPH03193758A (ja) * | 1989-12-25 | 1991-08-23 | Nisshin Oil Mills Ltd:The | 新規γ―アミノ酪酸誘導体 |
DE59209162D1 (de) * | 1991-07-05 | 1998-03-05 | Asta Medica Ag | Verwendung von Schwefel enthaltenden Carbonsäuren zur Bekämpfung von pathophysiologisch bedingten Erregungsstörungen |
DE4137773A1 (de) * | 1991-11-16 | 1993-05-19 | Degussa | Herstellung und verwendung von salzen der reinen enantiomere der (alpha)-liponsaeure |
WO1994006794A1 (en) | 1992-09-24 | 1994-03-31 | National Institutes Of Health | Aralkyl diazabicycloalkane derivatives for cns disorders |
DE4310142A1 (de) * | 1993-03-29 | 1994-10-06 | Boehringer Mannheim Gmbh | Immunologisch aktive Konjugate und ein Verfahren zu ihrer Herstellung |
US5463093A (en) * | 1993-11-26 | 1995-10-31 | Garnett; Merrill | Palladium complexes and methods for using same in the treatment of tumors or Psoriasis |
DE4433764A1 (de) * | 1994-09-22 | 1996-03-28 | Asta Medica Ag | Darreichungsformen enthaltend alpha-Liponsäure, feste Salze von R-Thioctsäure mit verbesserter Freisetzung und Bioverfügbarkeit |
DE4439477C2 (de) * | 1994-11-08 | 1999-10-21 | Asta Medica Ag | Verwendung von R,S-(+/-)-alpha-Liponsäure, R-(+)-alpha-Liponäure, S-(-)-alpha-Liponsäure in reduzierter oder oxidierter Form oder der Metabolite sowie deren Salze, Ester, Amide zur Behandlung der diabetischen Mikroangiopathie |
DE19601787C1 (de) * | 1996-01-19 | 1997-07-24 | Asta Medica Ag | Herstellung und Verwendung von Salzen der 6,8-Bis(amidiniumthio)-octansäure |
WO1998001440A2 (en) * | 1996-07-05 | 1998-01-15 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Anti-viral pharmaceutical compositions containing saturated 1,2-dithiaheterocyclic compounds and uses thereof |
EP0855396A1 (de) * | 1997-01-22 | 1998-07-29 | ASTA Medica Aktiengesellschaft | Metabolite von Thioctsäure und deren Verwendung |
JP4777489B2 (ja) * | 1997-03-31 | 2011-09-21 | ザ チルドレンズ メディカル センター コーポレーション | アポトーシス性酵素を不活性化するためのニトロシル化 |
AU728488B2 (en) * | 1997-04-02 | 2001-01-11 | Sankyo Company Limited | Dithiolan derivatives, their preparation and their therapeutic effect |
JPH11124379A (ja) * | 1997-10-17 | 1999-05-11 | Ss Pharmaceut Co Ltd | ジチオリリデンアセトアミド誘導体 |
FR2777001B1 (fr) * | 1998-04-01 | 2000-06-09 | Cird Galderma | Derives de l'acide 6,8-dimercaptooctanoique substitues en 6-s et/ou en 8-s par le radical (3-methylthiopropanoyl) et compositions pharmaceutiques destinees au traitement des tumeurs cancereuses |
US6204288B1 (en) * | 1999-03-08 | 2001-03-20 | The University Of Mississippi | 1,2-dithiolane derivatives |
US6288106B1 (en) * | 1999-05-25 | 2001-09-11 | Chronorx, Llc | Processes for the synthesis and use of various α-lipoic acid complexes |
US6387945B2 (en) * | 2000-04-11 | 2002-05-14 | The Regents Of The University Of California | Lipoic acid analogs |
AU2017214589B2 (en) | 2016-02-05 | 2020-09-03 | Ea Pharma Co., Ltd. | Sulfonamide derivative and pharmaceutical composition containing same |
-
1999
- 1999-10-26 AU AU13246/00A patent/AU774362B2/en not_active Expired
- 1999-10-26 EP EP09012728A patent/EP2145883A1/de not_active Withdrawn
- 1999-10-26 IL IL14282499A patent/IL142824A0/xx unknown
- 1999-10-26 US US09/427,477 patent/US6331559B1/en not_active Expired - Lifetime
- 1999-10-26 AT AT99956698T patent/ATE277034T1/de not_active IP Right Cessation
- 1999-10-26 AT AT04077618T patent/ATE451362T1/de not_active IP Right Cessation
- 1999-10-26 WO PCT/US1999/025140 patent/WO2000024734A1/en active IP Right Grant
- 1999-10-26 DE DE69941800T patent/DE69941800D1/de not_active Expired - Lifetime
- 1999-10-26 DE DE69920497T patent/DE69920497T2/de not_active Expired - Lifetime
- 1999-10-26 BR BR9914789-0A patent/BR9914789A/pt not_active Application Discontinuation
- 1999-10-26 EP EP04077618A patent/EP1486495B1/de not_active Expired - Lifetime
- 1999-10-26 JP JP2000578304A patent/JP4728481B2/ja not_active Expired - Lifetime
- 1999-10-26 ES ES99956698T patent/ES2229790T3/es not_active Expired - Lifetime
- 1999-10-26 MX MXPA01004152A patent/MXPA01004152A/es active IP Right Grant
- 1999-10-26 CA CA2348998A patent/CA2348998C/en not_active Expired - Lifetime
- 1999-10-26 ES ES04077618T patent/ES2340488T3/es not_active Expired - Lifetime
- 1999-10-26 EP EP99956698A patent/EP1124820B1/de not_active Expired - Lifetime
-
2001
- 2001-04-26 IL IL142824A patent/IL142824A/en not_active IP Right Cessation
- 2001-09-24 US US09/962,372 patent/US6951887B2/en not_active Expired - Lifetime
-
2010
- 2010-06-02 JP JP2010126848A patent/JP5727721B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP1124820A1 (de) | 2001-08-22 |
BR9914789A (pt) | 2001-10-02 |
US6331559B1 (en) | 2001-12-18 |
ES2340488T3 (es) | 2010-06-04 |
ATE451362T1 (de) | 2009-12-15 |
JP5727721B2 (ja) | 2015-06-03 |
WO2000024734A1 (en) | 2000-05-04 |
AU1324600A (en) | 2000-05-15 |
DE69941800D1 (de) | 2010-01-21 |
US6951887B2 (en) | 2005-10-04 |
CA2348998A1 (en) | 2000-05-04 |
AU774362B2 (en) | 2004-06-24 |
DE69920497T2 (de) | 2006-02-09 |
EP1124820B1 (de) | 2004-09-22 |
IL142824A0 (en) | 2002-03-10 |
JP4728481B2 (ja) | 2011-07-20 |
JP2010248203A (ja) | 2010-11-04 |
MXPA01004152A (es) | 2002-06-04 |
JP2002528446A (ja) | 2002-09-03 |
US20020107234A1 (en) | 2002-08-08 |
IL142824A (en) | 2010-11-30 |
EP2145883A1 (de) | 2010-01-20 |
EP1486495A1 (de) | 2004-12-15 |
CA2348998C (en) | 2012-03-06 |
ATE277034T1 (de) | 2004-10-15 |
EP1486495B1 (de) | 2009-12-09 |
ES2229790T3 (es) | 2005-04-16 |
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