DE69922394D1 - Arzneistoffabgabe in den dünndarm und den dickdarm unter verwendung von hpmc-kapseln - Google Patents

Arzneistoffabgabe in den dünndarm und den dickdarm unter verwendung von hpmc-kapseln

Info

Publication number
DE69922394D1
DE69922394D1 DE69922394T DE69922394T DE69922394D1 DE 69922394 D1 DE69922394 D1 DE 69922394D1 DE 69922394 T DE69922394 T DE 69922394T DE 69922394 T DE69922394 T DE 69922394T DE 69922394 D1 DE69922394 D1 DE 69922394D1
Authority
DE
Germany
Prior art keywords
darm
thick
drug dispensing
hpmc capsules
drug
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69922394T
Other languages
English (en)
Other versions
DE69922394T2 (de
Inventor
Thomas Cole
Anthony Scott
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Publication of DE69922394D1 publication Critical patent/DE69922394D1/de
Application granted granted Critical
Publication of DE69922394T2 publication Critical patent/DE69922394T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4891Coated capsules; Multilayered drug free capsule shells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816Wall or shell material
DE69922394T 1998-09-28 1999-09-23 Arzneistoffabgabe in den dünndarm und den dickdarm unter verwendung von hpmc-kapseln Expired - Lifetime DE69922394T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10201798P 1998-09-28 1998-09-28
US102017P 1998-09-28
PCT/US1999/022117 WO2000018377A1 (en) 1998-09-28 1999-09-23 Enteric and colonic delivery using hpmc capsules

Publications (2)

Publication Number Publication Date
DE69922394D1 true DE69922394D1 (de) 2005-01-05
DE69922394T2 DE69922394T2 (de) 2005-12-22

Family

ID=22287676

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69922394T Expired - Lifetime DE69922394T2 (de) 1998-09-28 1999-09-23 Arzneistoffabgabe in den dünndarm und den dickdarm unter verwendung von hpmc-kapseln

Country Status (14)

Country Link
US (1) US7094425B2 (de)
EP (1) EP1117386B1 (de)
JP (1) JP5068401B2 (de)
KR (1) KR100695562B1 (de)
CN (1) CN100358509C (de)
AT (1) ATE283689T1 (de)
AU (1) AU757343B2 (de)
CA (1) CA2344680C (de)
DE (1) DE69922394T2 (de)
ES (1) ES2234306T3 (de)
ID (1) ID28275A (de)
MX (1) MXPA01003197A (de)
PT (1) PT1117386E (de)
WO (1) WO2000018377A1 (de)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0000773D0 (sv) * 2000-03-08 2000-03-08 Astrazeneca Ab New formulation
SE0000774D0 (sv) 2000-03-08 2000-03-08 Astrazeneca Ab New formulation
US7115565B2 (en) 2001-01-18 2006-10-03 Pharmacia & Upjohn Company Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability
US7012068B2 (en) 2001-03-27 2006-03-14 Pro-Pharmaceuticals, Inc. Co-administration of a polysaccharide with a chemotherapeutic agent for the treatment of cancer
US6645946B1 (en) 2001-03-27 2003-11-11 Pro-Pharmaceuticals, Inc. Delivery of a therapeutic agent in a formulation for reduced toxicity
US8206741B2 (en) 2001-06-01 2012-06-26 Pozen Inc. Pharmaceutical compositions for the coordinated delivery of NSAIDs
US6926907B2 (en) * 2001-06-01 2005-08-09 Pozen Inc. Pharmaceutical compositions for the coordinated delivery of NSAIDs
SE0102993D0 (sv) 2001-09-07 2001-09-07 Astrazeneca Ab New self emulsifying drug delivery system
EP1350507A1 (de) * 2002-04-04 2003-10-08 Applied NanoSystems B.V. Verabreichung einer Substanz in einen vorbestimmten Zielort
AU2003250250B2 (en) 2002-06-19 2008-02-14 Intrexon Actobiotics Nv Methods and means to promote gut absorption
US7485322B2 (en) * 2002-12-24 2009-02-03 Lek Pharmaceuticals D.D. Modified release pharmaceutical composition
US7737133B2 (en) 2003-09-03 2010-06-15 Agi Therapeutics Ltd. Formulations and methods of treating inflammatory bowel disease
US7825106B2 (en) 2003-09-03 2010-11-02 Agi Therapeutics Ltd. Modified release formulations and methods of treating inflammatory bowel disease
PT1883396E (pt) 2005-05-18 2013-10-08 Centre Nat Rech Scient Administração colónica de adsorventes
US20070082046A1 (en) * 2005-10-11 2007-04-12 Banner Pharmacaps, Inc. Enteric valproic acid
ES2596855T3 (es) 2005-11-29 2017-01-12 Intrexon Actobiotics Nv Inducción de tolerancia mucosa a antígenos
EP1962873B1 (de) * 2005-12-14 2013-05-29 OxThera, Inc., Pharmazeutische zusammensetzungen enthaltend oxalat reduzierende bakterien
CA2633238A1 (en) 2005-12-16 2007-07-05 Oxthera, Inc. Compositions and methods for oxalate reduction
US20070148248A1 (en) 2005-12-22 2007-06-28 Banner Pharmacaps, Inc. Gastric reflux resistant dosage forms
EP1965774A2 (de) * 2005-12-30 2008-09-10 Cogentus Pharmaceuticals, Inc. Orale pharmazeutische formulierungen mit nichtsteroidalen entzündungshemmern und säurehemmern
SE529040C2 (sv) 2006-01-18 2007-04-17 Bows Pharmaceuticals Ag Förfarande för framställning av en dextranmatris för kontrollerad frisättning av insulin
US8048413B2 (en) 2006-05-17 2011-11-01 Helene Huguet Site-specific intestinal delivery of adsorbents, alone or in combination with degrading molecules
AU2007310534A1 (en) * 2006-10-27 2008-05-02 Capsugel Belgium Nv Hydroxypropyl methyl cellulose hard capsules and process of manufacture
DK3351268T3 (da) 2007-01-25 2020-11-02 Intrexon Actobiotics Nv Behandling af immunsygdom ved mukosal indgivelse af antigener
EP2380564B1 (de) 2007-04-04 2014-10-22 Sigmoid Pharma Limited Orale pharmazeutische Zusammensetzung
IT1393245B1 (it) * 2008-07-24 2012-04-12 Universita' Degli Studi Di Milano Forme farmaceutiche per il rilascio tempo-specifico di farmaci
WO2010027498A2 (en) * 2008-09-03 2010-03-11 New Science Holdings, Llc Compositions and methods for inducing satiety and treating non-insulin dependent diabetes emillitus, pre-diabetic symptoms, insulin resistance and related disease states and conditions
US9757346B2 (en) 2008-09-03 2017-09-12 Volant Holdings Gmbh Compositions and methods for treating insulin resistance and non-insulin dependent diabetes mellitus (type II diabetes)
US9220698B2 (en) 2008-09-09 2015-12-29 Pozen Inc. Method for delivering a pharmaceutical composition to patient in need thereof
KR101053731B1 (ko) * 2008-10-21 2011-08-02 이문성 용해시간 조절형 장세척제 조성물의 제조방법
DE102009001636A1 (de) * 2009-03-18 2010-09-23 Henkel Ag & Co. Kgaa Bleichmittel mit verzögertem Bleichbeginn
EP2445344A4 (de) * 2009-06-25 2013-01-23 Pozen Inc Verfahren zur behandlung eines patienten mit bedarf an einer aspirintherapie
EA201290026A1 (ru) 2009-06-25 2012-07-30 Астразенека Аб Способ лечения пациента, имеющего риск развития язвы, связанной с приемом нестероидных противовоспалительных средств (nsaid)
EP2283830A1 (de) 2009-07-23 2011-02-16 Actogenix N.V. Wässriger magensaftresistenter Kapselüberzug
KR101705204B1 (ko) 2009-09-11 2017-02-09 롯데정밀화학 주식회사 장용성 경질 캡슐용 수성 조성물, 장용성 경질 캡슐의 제조방법 및 장용성 경질 캡슐
TW201118084A (en) 2009-09-18 2011-06-01 Adolor Corp The use of an opioid receptor antagonist for the treatment or prevention of gastrointestinal tract disorders
WO2011103920A2 (en) 2010-02-25 2011-09-01 Evonik Röhm Gmbh Pharmaceutical or neutraceutical formulation
WO2012024767A1 (en) * 2010-08-25 2012-03-01 Grant Rufus Sparling Ii Improved enteric active substance delivery
US9198868B2 (en) 2010-10-26 2015-12-01 Capsugel Belgium Nv Bulk enteric capsule shells
KR101747211B1 (ko) * 2010-11-19 2017-06-14 롯데정밀화학 주식회사 장용성 경질 캡슐용 조성물 및 상기 조성물을 사용하여 제조된 장용성 경질 캡슐
CN103562390B (zh) 2011-06-01 2017-07-18 英特瑞克斯顿阿克图比奥帝克斯有限公司 用于细菌的多顺反子表达系统
WO2013035081A2 (de) 2011-09-07 2013-03-14 JÄNISCH, Melisa Optimale formulierung zur freisetzung eines wirkstoffes im dickdarm
US10653631B2 (en) 2011-09-07 2020-05-19 Roland SAUR-BROSCH Optimal colon targeting technology
JP6219836B2 (ja) 2011-11-09 2017-10-25 キャプシュゲル・ベルジウム・エヌ・ヴィ 耐酸性ツーピースハードカプセル用の耐酸性バンディング溶液
UA115139C2 (uk) 2011-12-28 2017-09-25 Поузен Інк. Спосіб доставки фармацевтичної композиції, яка містить омепразол й ацетилсаліцилову кислоту, пацієнту
AU2013240289B2 (en) 2012-03-29 2018-01-25 Therabiome, Llc Gastrointestinal site-specific oral vaccination formulations active on the ileum and appendix
CN103355656B (zh) * 2012-04-01 2016-01-20 中国科学院大连化学物理研究所 一种益生菌微胶囊产品及其制备与应用
WO2013164121A1 (en) 2012-05-02 2013-11-07 Capsugel France SAS Aqueous dispersions of hydroxypropyl methylcellulose acetate succinate (hpmcas)
US20150150817A1 (en) * 2012-07-23 2015-06-04 Dow Global Technologies Llc Film composition for hard capsule shells
US20140066837A1 (en) 2012-07-26 2014-03-06 Ronald L. Moy Skin care compositions and methods
MX2015002210A (es) * 2012-08-29 2015-05-08 Salix Pharmaceuticals Inc Composiciones laxantes y metodos para tratar estreñimiento y enfermedades y condiciones gastrointestinales relacionadas.
US20140141075A1 (en) * 2012-11-21 2014-05-22 Warner Chilcott Company, Llc 5-aminosalicylic acid capsule formulation
WO2014120804A1 (en) * 2013-01-30 2014-08-07 University Of Miami Enteric coated nanoparticles for oral vaccine and drug delivery and methods of production and use thereof
EP2968187A4 (de) 2013-03-14 2016-08-17 Therabiome Llc Gezielte gastrointestinale freisetzung von probiotischen organismen und/oder therapeutika
US20160256399A1 (en) 2013-11-04 2016-09-08 Capsugel Belgium Nv Methods and systems for improved bioavailability of active pharmaceutical ingredients including esomeprazole
EP2946774B1 (de) * 2014-05-19 2020-04-22 Tillotts Pharma AG Beschichtete Kapseln mit modifizierter Freisetzung
EP3028694B1 (de) 2014-12-02 2017-07-12 Capsugel Belgium NV Dosierformartikel für zeitverzögerte Freisetzung
EP3566699A1 (de) 2015-11-10 2019-11-13 Capsugel Belgium NV Säurebeständige bändelungs- oder dichtungslösung für säurebeständige zweiteilige hartkapseln
AU2017208153B2 (en) 2016-01-14 2021-01-28 Intrexon Actobiotics N.V. Compositions and methods for the treatment of type 1 diabetes
US10513599B2 (en) * 2016-08-23 2019-12-24 Global Dow Technologies LLC Cellulose ether acetate phthalates
AU2017319707B2 (en) 2016-09-02 2023-11-09 Intrexon Actobiotics N.V. Genetically modified bacteria stably expressing IL-10 and insulin
CN109983028B (zh) 2016-09-13 2023-10-20 英特瑞克斯顿阿克图比奥帝克斯有限公司 黏膜黏附性微生物
US10561630B2 (en) 2016-10-25 2020-02-18 Glykon Technologies Group, Llc Hydroxycitric acid compounds and capsule liquid delivery
EP3653203A4 (de) 2017-07-11 2020-06-24 Qualicaps Co., Ltd. Enterale hartkapsel
CN112105347A (zh) * 2018-05-03 2020-12-18 兆瓦恩卡普有限公司 将药物递送至下消化道的剂型
CN112566668A (zh) 2018-06-22 2021-03-26 快力胶囊股份有限公司 肠溶性硬胶囊
EP3610862A1 (de) * 2018-08-14 2020-02-19 Apillet APS Neuartige orale zusammensetzung
CN109528689B (zh) * 2018-12-24 2021-09-21 江苏辰星药业股份有限公司 一种肠溶缓释植物胶囊及其制备方法
US20220340621A1 (en) 2019-09-27 2022-10-27 Intrexon Actobiotics Nv D/B/A Precigen Actobio Treatment of celiac disease
CN113164405B (zh) * 2020-07-22 2022-09-06 绍兴康可胶囊有限公司 羟丙甲纤维素空心胶囊
CN113164404B (zh) * 2020-07-22 2022-09-02 绍兴康可胶囊有限公司 肠溶羟丙甲纤维素空心胶囊
WO2022137265A1 (en) * 2021-10-18 2022-06-30 Nutra Grace Enteric coated hpmc based herbal oil capsule for treatment of irritable bowel syndrome
WO2023212749A2 (en) * 2022-04-29 2023-11-02 Novatek Therapeutics, Llc Black seed oil formulations

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4138013A (en) * 1976-08-27 1979-02-06 Parke, Davis & Company Enteric capsules
JPS61100519A (ja) * 1984-10-23 1986-05-19 Shin Etsu Chem Co Ltd 医薬用硬質カプセル
US5314696A (en) * 1991-06-27 1994-05-24 Paulos Manley A Methods for making and administering a blinded oral dosage form and blinded oral dosage form therefor
JP3116602B2 (ja) * 1992-10-06 2000-12-11 シオノギクオリカプス株式会社 硬質カプセル
US5656290A (en) * 1993-02-26 1997-08-12 The Procter & Gamble Company Bisacodyl dosage form with multiple enteric polymer coatings for colonic delivery
DE4329503A1 (de) * 1993-09-01 1995-03-02 Galenik Labor Freiburg Gmbh Pharmazeutische Präparate zur gezielten Behandlung von Morbus Crohn und Colitis Ulcerosa
GB9412394D0 (en) * 1994-06-21 1994-08-10 Danbiosyst Uk Colonic drug delivery composition
DE9414065U1 (de) * 1994-08-31 1994-11-03 Roehm Gmbh Thermoplastischer Kunststoff für darmsaftlösliche Arznei-Umhüllungen
JP2959423B2 (ja) * 1994-12-01 1999-10-06 シオノギクオリカプス株式会社 カプセル用皮膜組成物
SG80553A1 (en) * 1995-07-20 2001-05-22 Tanabe Seiyaku Co Pharmaceutical preparation in form of coated capsule releasable at lower part of digestive tract
JP3185206B2 (ja) * 1995-07-20 2001-07-09 田辺製薬株式会社 消化管下部放出型被覆カプセル製剤
KR20000029784A (ko) * 1996-08-02 2000-05-25 나까도미 히로다카 경구제제용캡슐과경구캡슐제제
JPH10152431A (ja) * 1996-08-02 1998-06-09 Hisamitsu Pharmaceut Co Inc 経口製剤用カプセルと経口カプセル製剤

Also Published As

Publication number Publication date
MXPA01003197A (es) 2004-04-21
ES2234306T3 (es) 2005-06-16
PT1117386E (pt) 2005-04-29
JP2002525314A (ja) 2002-08-13
CN1321085A (zh) 2001-11-07
WO2000018377A1 (en) 2000-04-06
EP1117386A1 (de) 2001-07-25
JP5068401B2 (ja) 2012-11-07
CA2344680C (en) 2008-11-25
KR100695562B1 (ko) 2007-03-15
AU6261399A (en) 2000-04-17
KR20010075395A (ko) 2001-08-09
CN100358509C (zh) 2008-01-02
CA2344680A1 (en) 2000-04-06
EP1117386B1 (de) 2004-12-01
DE69922394T2 (de) 2005-12-22
ATE283689T1 (de) 2004-12-15
ID28275A (id) 2001-05-10
AU757343B2 (en) 2003-02-20
US20010036473A1 (en) 2001-11-01
US7094425B2 (en) 2006-08-22

Similar Documents

Publication Publication Date Title
DE69922394D1 (de) Arzneistoffabgabe in den dünndarm und den dickdarm unter verwendung von hpmc-kapseln
DK0754452T3 (da) Farmaceutisk præparat i form af en overtrukket kapsel, der frigives i den nedre del af fordøjelsessystemet
DE69505671T2 (de) Ein neues arzneimittelabgabesystem
FI965154A0 (fi) Lääkkeen paksusuoleen kuljettava koostumus
MX9600857A (es) Forma de dosificacion i en tabletas, con unidades multiples.
EA200200126A1 (ru) Гидродинамически сбалансированная пероральная система доставки лекарства
IL123813A0 (en) Drug delivery system for two or more active substances
ATE401892T1 (de) Verwendung von pharmazeutischen zubereitungen enthaltend oxcarbazepin im nüchternzustand
DE69820108D1 (de) Doppelkapsel zur verabreichung von arzneimitteln für vielfache therapien
DE69832298D1 (de) Gerät zur kontrollierten abgabe von pharmazeutischen und medizinischen produkten
HK1031197A1 (en) Osmotic dosage form comprising first and second coats
MX9700152A (es) Nueva formulacion farmaceutica oral, que contiene sal de magnesio de omeprazol.
GR3019171T3 (en) System for delivering drug with enhanced bioacceptability.
ATE295157T1 (de) Mittel zur transdermalen verabreichung von arzneistoffen
DE60025264D1 (de) Dosierbehälter für pulverförmige medikamente
SE9503620D0 (sv) Användning av proteinet S-100b i läkemedel samt läkemedel innehållande proteinet S-100b
TH57760B (th) การลำเลียงยาสู่ลำไส้เล็กและลำไส้ใหญ่โดยใช้แคปซูลชนิด hpmc
ITFI950120V0 (it) "contenitore distributore, specialmente per prodotti medicianali in compresse o capsule e simili".
UA23119A (uk) Психотропhий засіб
JO1881B1 (en) Formula II for multi unit disc calibration
GB9508774D0 (en) Delivery of drugs etc.

Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: WARNER-LAMBERT COMPANY LLC, MORRIS PLAINS, N.J., U

8364 No opposition during term of opposition