DE69933763D1 - Biologisch abbaubares alginatgel mit verzögerter freisetzung - Google Patents

Biologisch abbaubares alginatgel mit verzögerter freisetzung

Info

Publication number
DE69933763D1
DE69933763D1 DE69933763T DE69933763T DE69933763D1 DE 69933763 D1 DE69933763 D1 DE 69933763D1 DE 69933763 T DE69933763 T DE 69933763T DE 69933763 T DE69933763 T DE 69933763T DE 69933763 D1 DE69933763 D1 DE 69933763D1
Authority
DE
Germany
Prior art keywords
biodegradable
alginator
delayed release
sustained
particles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69933763T
Other languages
English (en)
Other versions
DE69933763T2 (de
Inventor
Seymour Goldenberg
Hua Gu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amgen Inc
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of DE69933763D1 publication Critical patent/DE69933763D1/de
Application granted granted Critical
Publication of DE69933763T2 publication Critical patent/DE69933763T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
DE69933763T 1998-05-18 1999-05-14 Biologisch abbaubares alginatgel mit verzögerter freisetzung Expired - Fee Related DE69933763T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US80832 1998-05-18
US09/080,832 US6432449B1 (en) 1998-05-18 1998-05-18 Biodegradable sustained-release alginate gels
PCT/US1999/010737 WO1999059549A1 (en) 1998-05-18 1999-05-14 Biodegradable sustained-release alginate gels

Publications (2)

Publication Number Publication Date
DE69933763D1 true DE69933763D1 (de) 2006-12-07
DE69933763T2 DE69933763T2 (de) 2007-10-04

Family

ID=22159900

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69933763T Expired - Fee Related DE69933763T2 (de) 1998-05-18 1999-05-14 Biologisch abbaubares alginatgel mit verzögerter freisetzung

Country Status (25)

Country Link
US (2) US6432449B1 (de)
EP (1) EP1079811B1 (de)
JP (1) JP2002515419A (de)
KR (1) KR20010025023A (de)
CN (1) CN1309556A (de)
AT (1) ATE343378T1 (de)
AU (1) AU3993999A (de)
BG (1) BG65397B1 (de)
BR (1) BR9910553A (de)
CA (1) CA2331446C (de)
CY (1) CY1105944T1 (de)
DE (1) DE69933763T2 (de)
DK (1) DK1079811T3 (de)
EA (1) EA003670B1 (de)
ES (1) ES2275341T3 (de)
HU (1) HUP0101895A3 (de)
IL (1) IL139617A0 (de)
NO (1) NO20005564L (de)
NZ (1) NZ507943A (de)
PL (1) PL199499B1 (de)
PT (1) PT1079811E (de)
RS (1) RS49841B (de)
SK (1) SK16752000A3 (de)
WO (1) WO1999059549A1 (de)
ZA (1) ZA200006299B (de)

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WO2002100425A1 (en) * 2001-06-11 2002-12-19 Ltt Institute Co., Ltd. Aggregate composition for sustained-release preparation, process for producing the same, and sustained-release preparation containing the same
AU2003205106A1 (en) * 2002-01-16 2003-09-02 Agency For Disease Diagnosis And Prevention Pace-a microspheres for delivery of antigens
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KR100507545B1 (ko) * 2002-09-03 2005-08-09 주식회사 엘지생명과학 히알루론산 유도체 및 그의 제조방법
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US20090285785A1 (en) * 2004-09-17 2009-11-19 Cellgentech, Inc. External Agent for Treatment of Skin Ulcer
CA2583373C (en) * 2004-10-12 2013-09-03 Fmc Biopolymer As Self-gelling alginate systems and uses thereof
US8318210B2 (en) * 2005-02-28 2012-11-27 Neos Therapeutics, Lp Compositions and methods of making sustained release liquid formulations
US9119901B2 (en) 2005-04-28 2015-09-01 Warsaw Orthopedic, Inc. Surface treatments for promoting selective tissue attachment to medical impants
US8414907B2 (en) 2005-04-28 2013-04-09 Warsaw Orthopedic, Inc. Coatings on medical implants to guide soft tissue healing
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EP2046288B1 (de) * 2006-07-14 2013-07-03 FMC Biopolymer AS Hydrogele mit niedermolekularen alginaten und daraus hergestellte biostrukturen
DE102007039871A1 (de) * 2007-08-21 2009-02-26 Friedrich-Baur-Gmbh Weichgewebe-Implantat mit antibakterieller Wirkung
KR20100063744A (ko) * 2007-08-28 2010-06-11 에프엠씨 코포레이션 지연된 자가-겔화 알기네이트 시스템 및 이의 용도
ES2327375B1 (es) 2007-11-14 2010-08-05 Universidad Del Pais Vasco Empleo de microparticulas para su uso como vacunas y la liberacion de moleculas biologicamente activas.
US20090183503A1 (en) * 2008-01-18 2009-07-23 Alberto Verdesi Exhaust apparatus
JP5713897B2 (ja) * 2008-07-16 2015-05-07 エボニック コーポレイションＥｖｏｎｉｋ Ｃｏｒｐｏｒａｔｉｏｎ 生理活性ペプチドを含有する微粒子を調製するためのプロセス
US9540630B2 (en) * 2008-09-17 2017-01-10 Beta O2 Technologies Ltd. Optimization of alginate encapsulation of islets for transplantation
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CA2780294C (en) 2009-11-09 2018-01-16 Spotlight Technology Partners Llc Polysaccharide based hydrogels
WO2011153512A2 (en) 2010-06-03 2011-12-08 Indiana University Research And Technology Corporation Use of compounds with thrombopoietic activity to promote bone growth and healing
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CA2804842A1 (en) 2010-07-09 2012-01-12 Board Of Regents Of The University Of Texas System Biodegradable scaffolds
AU2012236962B2 (en) 2011-03-25 2017-05-11 Amgen Inc. Anti-sclerostin antibody crystals and formulations thereof
CN102489027B (zh) * 2011-12-12 2014-06-04 山东凯翔生物化工有限公司 一种葡萄糖酸内酯节能浓缩方法及装置
CN103830266A (zh) * 2013-04-24 2014-06-04 杨亚勤 部分氧化海藻酸钠羧甲基化衍生物的制备方法和应用
RU2548777C2 (ru) * 2013-07-09 2015-04-20 Александр Александрович Кролевец Способ получения частиц инкапсулированных жирорастворимой полимерной оболочкой солей металлов, обладающих супрамолекулярными свойствами
MX2017000527A (es) 2014-07-14 2017-08-10 Amgen Inc Formulaciones de anticuerpos cristalinos.
EP3929218A1 (de) 2014-07-14 2021-12-29 Amgen, Inc Kristalline antikörperformulierungen
AU2016305473B2 (en) * 2015-08-13 2021-08-19 Dana-Farber Cancer Institute, Inc. Biomaterials for combined radiotherapy and immunotherapy of cancer
EP3501553A1 (de) * 2017-12-21 2019-06-26 Association for the Advancement of Tissue Engineering and Cell based Technologies & Therapies (A4TEC) - Associação Hydrogel mit mangan, verfahren und verwendungen davon
CN109293138A (zh) * 2018-10-08 2019-02-01 曹布道 一种养殖污水净化处理方法
EA202290122A1 (ru) 2019-06-21 2022-03-17 Альфасигма С.П.А. Фармацевтические композиции в форме геля, содержащие ксилоглюкан и спирты, для регулируемого высвобождения активных ингредиентов
CN112426981B (zh) * 2020-11-30 2021-12-28 西安交通大学 一种金属离子交联水凝胶及制备方法和应用
CN114685778B (zh) * 2020-12-30 2023-10-17 苏州艾博生物科技有限公司 长循环阳离子脂质体的合成方法
CN112843328B (zh) * 2021-02-25 2022-05-13 山东大学 一种具有抑菌作用的鲍鱼壳粉/ZnO复合材料掺杂的智能水凝胶伤口敷料的制备方法
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Also Published As

Publication number Publication date
US6432449B1 (en) 2002-08-13
EP1079811A1 (de) 2001-03-07
IL139617A0 (en) 2002-02-10
PL344337A1 (en) 2001-11-05
KR20010025023A (ko) 2001-03-26
YU69400A (sh) 2003-02-28
CA2331446A1 (en) 1999-11-25
WO1999059549A1 (en) 1999-11-25
AU3993999A (en) 1999-12-06
CY1105944T1 (el) 2011-04-06
EA200001200A1 (ru) 2001-04-23
HUP0101895A3 (en) 2004-01-28
ZA200006299B (en) 2001-05-30
EA003670B1 (ru) 2003-08-28
PT1079811E (pt) 2007-01-31
PL199499B1 (pl) 2008-09-30
CA2331446C (en) 2004-03-16
ATE343378T1 (de) 2006-11-15
CN1309556A (zh) 2001-08-22
BR9910553A (pt) 2001-01-30
BG104943A (en) 2001-07-31
NO20005564L (no) 2001-01-18
ES2275341T3 (es) 2007-06-01
RS49841B (sr) 2008-08-07
DK1079811T3 (da) 2007-02-26
HUP0101895A2 (hu) 2001-10-28
DE69933763T2 (de) 2007-10-04
NZ507943A (en) 2003-08-29
EP1079811B1 (de) 2006-10-25
BG65397B1 (bg) 2008-06-30
NO20005564D0 (no) 2000-11-03
SK16752000A3 (sk) 2001-09-11
US20020168406A1 (en) 2002-11-14
JP2002515419A (ja) 2002-05-28

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