DE69934406D1 - Polymere zur freisetzung von stickstoffmonoxid in vivo - Google Patents
Polymere zur freisetzung von stickstoffmonoxid in vivoInfo
- Publication number
- DE69934406D1 DE69934406D1 DE69934406T DE69934406T DE69934406D1 DE 69934406 D1 DE69934406 D1 DE 69934406D1 DE 69934406 T DE69934406 T DE 69934406T DE 69934406 T DE69934406 T DE 69934406T DE 69934406 D1 DE69934406 D1 DE 69934406D1
- Authority
- DE
- Germany
- Prior art keywords
- vivo
- polymers
- release
- nitrogen monoxide
- monoxide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
- A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
- A61L29/10—Inorganic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
- A61L29/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
- A61L33/06—Use of macromolecular materials
- A61L33/068—Use of macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
- A61L33/06—Use of macromolecular materials
- A61L33/08—Polysaccharides
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
- C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G75/00—Macromolecular compounds obtained by reactions forming a linkage containing sulfur with or without nitrogen, oxygen, or carbon in the main chain of the macromolecule
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
- C08L5/16—Cyclodextrin; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D105/00—Coating compositions based on polysaccharides or on their derivatives, not provided for in groups C09D101/00 or C09D103/00
- C09D105/16—Cyclodextrin; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/114—Nitric oxide, i.e. NO
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/42—Anti-thrombotic agents, anticoagulants, anti-platelet agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/13—Hollow or container type article [e.g., tube, vase, etc.]
- Y10T428/1352—Polymer or resin containing [i.e., natural or synthetic]
- Y10T428/139—Open-ended, self-supporting conduit, cylinder, or tube-type article
- Y10T428/1393—Multilayer [continuous layer]
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US103225 | 1998-06-23 | ||
US09/103,225 US6232434B1 (en) | 1996-08-02 | 1998-06-23 | Polymers for delivering nitric oxide in vivo |
PCT/US1999/013731 WO1999067296A1 (en) | 1998-06-23 | 1999-06-17 | Polymers for delivering nitric oxide in vivo |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69934406D1 true DE69934406D1 (de) | 2007-01-25 |
DE69934406T2 DE69934406T2 (de) | 2007-09-27 |
Family
ID=22294044
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69934406T Expired - Lifetime DE69934406T2 (de) | 1998-06-23 | 1999-06-17 | Polymere zur freisetzung von stickstoffmonoxid in vivo |
Country Status (8)
Country | Link |
---|---|
US (6) | US6232434B1 (de) |
EP (1) | EP1093468B1 (de) |
JP (2) | JP4846099B2 (de) |
AU (1) | AU4692999A (de) |
CA (1) | CA2336138C (de) |
DE (1) | DE69934406T2 (de) |
ES (1) | ES2279621T3 (de) |
WO (1) | WO1999067296A1 (de) |
Families Citing this family (101)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6232434B1 (en) * | 1996-08-02 | 2001-05-15 | Duke University Medical Center | Polymers for delivering nitric oxide in vivo |
US7220747B2 (en) * | 1999-07-20 | 2007-05-22 | Gambro, Inc. | Method for preventing damage to or rejuvenating a cellular blood component using mitochondrial enhancer |
US6797743B2 (en) * | 2000-09-27 | 2004-09-28 | Michigan Biotechnology Institute | Antimicrobial polymer |
US6398806B1 (en) * | 2000-12-26 | 2002-06-04 | Scimed Life Systems, Inc. | Monolayer modification to gold coated stents to reduce adsorption of protein |
CN1235579C (zh) * | 2001-02-27 | 2006-01-11 | 奥索-麦克尼尔药品公司 | 用于预防或治疗神经变性疾病的氨基甲酸酯化合物 |
US20030228564A1 (en) * | 2001-05-30 | 2003-12-11 | Edrich Richard Alan | Nitric oxide in a pathogen inactivation process |
US6676855B2 (en) * | 2001-08-02 | 2004-01-13 | Duke University | Use of a blood-flow decrease preventing agent in conjunction with insufflating gas |
US6841166B1 (en) * | 2001-08-21 | 2005-01-11 | The Regents Of The University Of Michigan | Nitric oxide-releasing polymers incorporating diazeniumdiolated silane derivatives |
DE60234642D1 (de) * | 2001-12-06 | 2010-01-14 | Univ Duke | Verhinderung von hautlappennekrose in der plastischen chirurgie |
US6939554B2 (en) * | 2002-02-05 | 2005-09-06 | Michigan Biotechnology Institute | Antimicrobial polymer |
WO2003080730A1 (en) | 2002-03-20 | 2003-10-02 | Michigan Biotechnology Institute | Conductive polymer-based material |
WO2003092763A1 (en) * | 2002-05-03 | 2003-11-13 | Duke University | Carbon nanotubules for storage of nitric oxide |
US6951902B2 (en) * | 2002-08-16 | 2005-10-04 | Michigan Biotechnology Institute | Two dimensional polymer that generates nitric oxide |
EP2277551B1 (de) | 2002-09-06 | 2013-05-08 | Cerulean Pharma Inc. | Polymere auf basis von cyclodextrin zur verabreichung von an diese kovalent gebundene arzneimittel |
FR2845090B1 (fr) * | 2002-10-01 | 2004-12-24 | Merck Sante Sas | Nouveau polymere de nitrosation en synthese organique |
US7285287B2 (en) * | 2002-11-14 | 2007-10-23 | Synecor, Llc | Carbon dioxide-assisted methods of providing biocompatible intraluminal prostheses |
US20040098106A1 (en) * | 2002-11-14 | 2004-05-20 | Williams Michael S. | Intraluminal prostheses and carbon dioxide-assisted methods of impregnating same with pharmacological agents |
US6932930B2 (en) * | 2003-03-10 | 2005-08-23 | Synecor, Llc | Intraluminal prostheses having polymeric material with selectively modified crystallinity and methods of making same |
AU2004233347A1 (en) * | 2003-04-23 | 2004-11-04 | Darrell H. Reneker | Sequestered reactive materials |
HUE051305T2 (hu) * | 2003-08-08 | 2021-03-01 | Hollister Inc | Hidrofil katéter csomagolásban |
WO2005033198A1 (en) * | 2003-10-07 | 2005-04-14 | Coloplast A/S | A composition useful as an adhesive and use of such a composition |
CA2555591C (en) * | 2004-02-09 | 2011-01-04 | Amulet Pharmaceuticals, Inc. | Nitric oxide-releasing polymers |
US7867531B2 (en) | 2005-04-04 | 2011-01-11 | Curwood, Inc. | Myoglobin blooming agent containing shrink films, packages and methods for packaging |
US8029893B2 (en) | 2004-04-02 | 2011-10-04 | Curwood, Inc. | Myoglobin blooming agent, films, packages and methods for packaging |
US8053047B2 (en) | 2004-04-02 | 2011-11-08 | Curwood, Inc. | Packaging method that causes and maintains the preferred red color of fresh meat |
US8110259B2 (en) | 2004-04-02 | 2012-02-07 | Curwood, Inc. | Packaging articles, films and methods that promote or preserve the desirable color of meat |
US8470417B2 (en) | 2004-04-02 | 2013-06-25 | Curwood, Inc. | Packaging inserts with myoglobin blooming agents, packages and methods for packaging |
US8545950B2 (en) | 2004-04-02 | 2013-10-01 | Curwood, Inc. | Method for distributing a myoglobin-containing food product |
US8741402B2 (en) | 2004-04-02 | 2014-06-03 | Curwood, Inc. | Webs with synergists that promote or preserve the desirable color of meat |
US20080260861A1 (en) * | 2004-04-07 | 2008-10-23 | The General Hospital Corporation | Modulating Lymphatic Function |
JP2007534389A (ja) * | 2004-04-29 | 2007-11-29 | キューブ・メディカル・アクティーゼルスカブ | 血管形成に用いるバルーン |
US20060039950A1 (en) * | 2004-08-23 | 2006-02-23 | Zhengrong Zhou | Multi-functional biocompatible coatings for intravascular devices |
SE0402221D0 (sv) | 2004-09-14 | 2004-09-14 | Aerocrine Ab | Treatment of insufficient perfusion |
JP5274248B2 (ja) | 2005-05-27 | 2013-08-28 | ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル | 酸化窒素治療及び医生物的応用のための酸化窒素放出粒子 |
WO2006128743A1 (en) * | 2005-06-01 | 2006-12-07 | Nolabs Ab | Feedstuff |
EP1728438A1 (de) * | 2005-06-01 | 2006-12-06 | NOLabs AB | Futtermittel |
ATE513568T1 (de) * | 2005-06-30 | 2011-07-15 | Accord Biomaterials Inc | Stickstoffoxidbeschichtungen für medizinische vorrichtungen |
US20080241208A1 (en) * | 2005-06-30 | 2008-10-02 | Charles Shanley | Methods, Compositions and Devices For Promoting Anglogenesis |
US20080262330A1 (en) * | 2005-06-30 | 2008-10-23 | Reynolds Melissa M | Analyte Sensors and Compositions for Use Therein |
JP2009505727A (ja) | 2005-08-25 | 2009-02-12 | メドトロニック ヴァスキュラー インコーポレイテッド | 医療機器及びそのコーティングとして有益な一酸化窒素放出生分解性ポリマー |
CA2632224A1 (en) * | 2005-12-02 | 2007-06-07 | The Regents Of The University Of Michigan | Polymer compositions, coatings and devices, and methods of making and using the same |
JP2009518516A (ja) * | 2005-12-06 | 2009-05-07 | アミュレット ファーマシューティカルズ インコーポレイティッド | 一酸化窒素放出ポリマー |
US20070196428A1 (en) | 2006-02-17 | 2007-08-23 | Thierry Glauser | Nitric oxide generating medical devices |
WO2007126344A1 (en) * | 2006-04-27 | 2007-11-08 | St. Jude Medical Ab | Implantable medical device with releasing compound |
US8241619B2 (en) | 2006-05-15 | 2012-08-14 | Medtronic Vascular, Inc. | Hindered amine nitric oxide donating polymers for coating medical devices |
ES2426272T3 (es) * | 2006-06-08 | 2013-10-22 | Hollister Incorporated | Envase para producto de catéter |
US11229746B2 (en) | 2006-06-22 | 2022-01-25 | Excelsior Medical Corporation | Antiseptic cap |
US9259535B2 (en) | 2006-06-22 | 2016-02-16 | Excelsior Medical Corporation | Antiseptic cap equipped syringe |
JP2010516625A (ja) | 2007-01-24 | 2010-05-20 | インサート セラピューティクス, インコーポレイテッド | 制御された薬物送達のためのテザー基を有するポリマー−薬物コンジュゲート |
US7811600B2 (en) * | 2007-03-08 | 2010-10-12 | Medtronic Vascular, Inc. | Nitric oxide donating medical devices and methods of making same |
US20080287984A1 (en) * | 2007-05-18 | 2008-11-20 | Jan Weber | Medical balloons and methods of making the same |
ITMI20071341A1 (it) * | 2007-07-05 | 2009-01-06 | Fidia Farmaceutici | Derivati di acido ialuronico contenenti gruppi in grado di rilasciare no |
US8273828B2 (en) * | 2007-07-24 | 2012-09-25 | Medtronic Vascular, Inc. | Methods for introducing reactive secondary amines pendant to polymers backbones that are useful for diazeniumdiolation |
ES2604253T3 (es) | 2007-11-19 | 2017-03-06 | Hollister Incorporated | Conjunto de catéter hidratado al vapor y método de fabricación del mismo |
US20090171455A1 (en) * | 2007-12-31 | 2009-07-02 | Boston Scientific Scimed, Inc. | Biodegradable polymers |
US20090222088A1 (en) * | 2008-02-29 | 2009-09-03 | Medtronic Vascular, Inc. | Secondary Amine Containing Nitric Oxide Releasing Polymer Composition |
US20090232868A1 (en) * | 2008-03-17 | 2009-09-17 | Medtronic Vascular, Inc. | Nitric Oxide Releasing Polymer Composition |
US20090232863A1 (en) * | 2008-03-17 | 2009-09-17 | Medtronic Vascular, Inc. | Biodegradable Carbon Diazeniumdiolate Based Nitric Oxide Donating Polymers |
US8580912B2 (en) * | 2008-09-19 | 2013-11-12 | Northwestern University | Biodegradable nitric oxide generating polymers and related biomedical devices |
WO2010044875A2 (en) * | 2008-10-16 | 2010-04-22 | Novan, Inc. | Nitric oxide releasing particles for oral care applications |
US9078992B2 (en) | 2008-10-27 | 2015-07-14 | Pursuit Vascular, Inc. | Medical device for applying antimicrobial to proximal end of catheter |
US8158187B2 (en) * | 2008-12-19 | 2012-04-17 | Medtronic Vascular, Inc. | Dry diazeniumdiolation methods for producing nitric oxide releasing medical devices |
US8709465B2 (en) * | 2009-04-13 | 2014-04-29 | Medtronic Vascular, Inc. | Diazeniumdiolated phosphorylcholine polymers for nitric oxide release |
US20110319987A1 (en) | 2009-05-20 | 2011-12-29 | Arsenal Medical | Medical implant |
US9265633B2 (en) | 2009-05-20 | 2016-02-23 | 480 Biomedical, Inc. | Drug-eluting medical implants |
US9309347B2 (en) | 2009-05-20 | 2016-04-12 | Biomedical, Inc. | Bioresorbable thermoset polyester/urethane elastomers |
EP2432425B1 (de) * | 2009-05-20 | 2018-08-08 | 480 Biomedical, Inc. | Medizinisches implantat |
US8992601B2 (en) | 2009-05-20 | 2015-03-31 | 480 Biomedical, Inc. | Medical implants |
US8888840B2 (en) * | 2009-05-20 | 2014-11-18 | Boston Scientific Scimed, Inc. | Drug eluting medical implant |
CN102695528B (zh) | 2009-08-21 | 2016-07-13 | 诺万公司 | 创伤敷料、其使用方法及其形成方法 |
CA3062005C (en) | 2009-08-21 | 2022-02-15 | Novan, Inc. | Topical gels comprising nitric oxide-releasing polysiloxane macromolecules and uses thereof |
US8372133B2 (en) * | 2009-10-05 | 2013-02-12 | 480 Biomedical, Inc. | Polymeric implant delivery system |
BR112012008508A2 (pt) * | 2009-10-13 | 2017-06-13 | Novan Inc | revestimento de sol-gel, substrato, método para produzir um revestimento de sol-gel |
US8771756B2 (en) | 2009-12-28 | 2014-07-08 | Colorado State University Research Foundation | Biocompatible materials for medical devices |
EP2591009A1 (de) | 2010-07-09 | 2013-05-15 | Fresenius Kabi Deutschland GmbH | Stickoxidfreisetzende hydroxyalkylstärkederivate |
US8591876B2 (en) | 2010-12-15 | 2013-11-26 | Novan, Inc. | Methods of decreasing sebum production in the skin |
EP2678041A4 (de) * | 2011-02-24 | 2015-12-23 | Univ Colorado State Res Found | Materialien zur modulation biologischer reaktionen und herstellungsverfahren dafür |
ES2695173T3 (es) | 2011-02-28 | 2019-01-02 | Novan Inc | Partículas de sílice modificadas con S-nitrosotiol que liberan óxido nítrico y procedimientos de fabricación de las mismas |
CA2841832C (en) | 2011-07-12 | 2019-06-04 | Pursuit Vascular, Inc. | Device for delivery of antimicrobial agent into a trans-dermal catheter |
JP5591860B2 (ja) | 2012-03-28 | 2014-09-17 | 株式会社東芝 | 有機半導体およびそれを用いた太陽電池 |
CN106986952B (zh) | 2012-08-17 | 2020-03-10 | 北卡罗来纳大学查珀尔希尔分校 | 水溶性的释放一氧化氮的聚葡糖胺和其用途 |
US20140094432A1 (en) | 2012-10-02 | 2014-04-03 | Cerulean Pharma Inc. | Methods and systems for polymer precipitation and generation of particles |
EP3673928B1 (de) | 2013-02-07 | 2021-06-30 | The Regents Of The University Of Michigan | Gerinnungsbeständige/bakterizide s-nitroso-n-acetylpenicillamin-dotierte stickoxidfreisetzungspolymere mit verbesserter stabilität |
WO2015048747A1 (en) * | 2013-09-30 | 2015-04-02 | Northwestern University | Targeted therapy for the prevention of restenosis in the cardiovascular system |
EP3294404A4 (de) | 2015-05-08 | 2018-11-14 | ICU Medical, Inc. | Für die aufnahme von emittern von therapeutika konfigurierte medizinische verbinder |
US11186681B2 (en) | 2016-10-07 | 2021-11-30 | The University Of North Carolina At Chapel Hill | S-Nitrosothiol-mediated hyperbranched polyesters |
WO2018071717A1 (en) | 2016-10-14 | 2018-04-19 | Icu Medical, Inc. | Sanitizing caps for medical connectors |
WO2018112405A1 (en) * | 2016-12-16 | 2018-06-21 | University Of Georgia Research Foundation, Inc. | Nitric oxide releasing slippery surfaces for decreased fouling, thrombosis, and infection of medical devices |
CA3048785A1 (en) | 2017-01-03 | 2018-07-12 | The University Of North Carolina At Chapel Hill | Nitric oxide-releasing alginates as biodegradable antibacterial scaffolds and methods pertaining thereto |
CA3055474A1 (en) | 2017-03-28 | 2018-10-04 | The University Of North Carolina At Chapel Hill | Nitric oxide-releasing polyaminoglycosides as biodegradable antibacterial scaffolds and methods pertaining thereto |
US11883807B2 (en) | 2017-04-11 | 2024-01-30 | Colorado State University Research Foundation | Functionalization of metal-organic frameworks |
WO2018204206A2 (en) | 2017-05-01 | 2018-11-08 | Icu Medical, Inc. | Medical fluid connectors and methods for providing additives in medical fluid lines |
AU2019231712A1 (en) | 2018-03-06 | 2020-10-15 | The University Of North Carolina At Chapel Hill | Nitric oxide-releasing cyclodextrins as biodegradable antibacterial scaffolds and methods pertaining thereto |
US11541221B2 (en) | 2018-11-07 | 2023-01-03 | Icu Medical, Inc. | Tubing set with antimicrobial properties |
US11534595B2 (en) | 2018-11-07 | 2022-12-27 | Icu Medical, Inc. | Device for delivering an antimicrobial composition into an infusion device |
US11400195B2 (en) | 2018-11-07 | 2022-08-02 | Icu Medical, Inc. | Peritoneal dialysis transfer set with antimicrobial properties |
US11517732B2 (en) | 2018-11-07 | 2022-12-06 | Icu Medical, Inc. | Syringe with antimicrobial properties |
US11541220B2 (en) | 2018-11-07 | 2023-01-03 | Icu Medical, Inc. | Needleless connector with antimicrobial properties |
EP3883638A1 (de) | 2018-11-21 | 2021-09-29 | ICU Medical, Inc. | Antimikrobielle vorrichtung mit einer kappe mit ring und einsatz |
US11421044B2 (en) | 2018-12-28 | 2022-08-23 | The University Of North Carolina At Chapel Hill | Nitric oxide-releasing antibacterial polymers and scaffolds fabricated therefrom and methods pertaining thereto |
EP4255552A1 (de) | 2020-12-07 | 2023-10-11 | ICU Medical, Inc. | Peritonealdialysekappen, systeme und verfahren |
Family Cites Families (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4138535A (en) | 1970-05-25 | 1979-02-06 | Schweiger Richard Georg | Nitrite esters of polyhydroxy polymers |
US5025001A (en) * | 1988-06-15 | 1991-06-18 | Brigham And Women's Hospital | S-nitroso derivatives of ACE inhibitors and the use thereof |
DE69008454T2 (de) | 1989-08-07 | 1994-08-25 | Takeda Chemical Industries Ltd | Nitrolsothiolderivate, ihre Herstellung und Verwendung. |
GB9007384D0 (en) | 1990-04-02 | 1990-05-30 | Duncan Ruth | Coupling between polymers and other organic molecular entities utilising thiol-specific reactive groups |
IL101406A (en) * | 1991-03-29 | 1998-02-08 | Brigham & Womens Hospital | Pharmaceutical compositions containing s-nitrosothiol derivatives |
US5380758A (en) | 1991-03-29 | 1995-01-10 | Brigham And Women's Hospital | S-nitrosothiols as smooth muscle relaxants and therapeutic uses thereof |
US5385937A (en) * | 1991-04-10 | 1995-01-31 | Brigham & Women's Hospital | Nitrosation of homocysteine as a method for treating homocysteinemia |
US5114506A (en) | 1991-07-08 | 1992-05-19 | The United States Of America As Represented By The Secretary Of The Navy | Energetic composites of cyclodextrin nitrate esters and nitrate ester plasticizers |
WO1993012068A1 (en) | 1991-12-11 | 1993-06-24 | Brigham And Women's Hospital | S-nitrosothiols as smooth muscle relaxants and therapeutic uses thereof |
AU3969793A (en) | 1992-04-13 | 1993-11-18 | United States Of America, Represented By The Secretary, Department Of Health And Human Services, The | Use of nitric oxide/nucleophile complexes for the treatment of cancer |
US5525357A (en) | 1992-08-24 | 1996-06-11 | The United States Of America As Represented By The Department Of Health And Human Services | Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same |
US5405919A (en) | 1992-08-24 | 1995-04-11 | The United States Of America As Represented By The Secretary Of Health And Human Services | Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions and methods of treating biological disorders |
US5632981A (en) | 1992-08-24 | 1997-05-27 | The United States Of America As Represented By The Department Of Health And Human Services | Biopolymer-bound nitric oxide-releasing compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same |
US5650447A (en) | 1992-08-24 | 1997-07-22 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Nitric oxide-releasing polymers to treat restenosis and related disorders |
US5385940A (en) | 1992-11-05 | 1995-01-31 | The General Hospital Corporation | Treatment of stroke with nitric-oxide releasing compounds |
AU6232794A (en) | 1993-01-29 | 1994-08-15 | Brigham And Women's Hospital | The use of nitric oxide-delivering compounds for the treatment or prevention of alcoholic liver injury |
US5427797A (en) | 1993-04-06 | 1995-06-27 | Brigham And Women's Hospital | Systemic effects of nitric oxide inhalation |
WO1994022306A1 (en) | 1993-04-06 | 1994-10-13 | Brigham And Womens Hospital | Nitric oxide combination therapy |
US5595970A (en) | 1993-07-16 | 1997-01-21 | Schering Aktiengesellschaft | Treatment of climacteric disorders with nitric oxide synthase substrates and/or donors |
US5895783A (en) | 1993-07-16 | 1999-04-20 | Schering Aktiengesellschaft | Treatment of preeclampsia and preterm labor with combination of progestational agent and a nitric oxide synthase substrate and/or donor |
WO1995007691A1 (en) | 1993-09-17 | 1995-03-23 | Brigham And Women's Hospital | Use of nitric oxide-adducts to prevent thrombosis on artificial and vascular surfaces |
US6087479A (en) | 1993-09-17 | 2000-07-11 | Nitromed, Inc. | Localized use of nitric oxide-adducts to prevent internal tissue damage |
US6255277B1 (en) | 1993-09-17 | 2001-07-03 | Brigham And Women's Hospital | Localized use of nitric oxide-adducts to prevent internal tissue damage |
US5728705A (en) | 1993-10-04 | 1998-03-17 | The Trustees Of Columbia University In The City Of New York | Method of inducing vasorelaxation to treat pulmonary hypertension |
WO1995009612A1 (en) | 1993-10-07 | 1995-04-13 | Entremed, Inc. | Encapsulated and non-encapsulated nitric oxide generators used as antimicrobial agents |
DE69425331D1 (de) | 1993-10-08 | 2000-08-24 | Us Health | Verwendung von stickstoffoxid freisetzenden verbindungen als arzneimittel zur strahlungssensibilisation fur hypoxische zellen |
PT726768E (pt) | 1993-11-02 | 2000-11-30 | Us Health | Utilizacao de compostos libertadores de acido nitrico para o fabrico de um medicamento para proteccao na lesao por isquemia-reperfusao |
NZ276105A (en) | 1993-11-16 | 2001-04-27 | Schering Ag | Use of nitric oxide synthase substrate and/or nitric oxide donor optionally with other compounds to prevent uterine contraction or a nitric oxide inhibitor to stimulate uterine contraction |
US5482925A (en) | 1994-03-17 | 1996-01-09 | Comedicus Incorporated | Complexes of nitric oxide with cardiovascular amines as dual acting cardiovascular agents |
US5504117A (en) | 1994-05-27 | 1996-04-02 | Neptune Pharmaceutical Corporation | Pharmacologic preparation for the treatment of anal disorders |
DE4420523A1 (de) | 1994-06-13 | 1995-12-14 | Cassella Ag | Verwendung von NO-freisetzenden Verbindungen zur Behandlung und Vorbeugung von systemischen Entzündungssyndromen |
US5583101A (en) | 1994-07-15 | 1996-12-10 | Harvard College | Use of nitrogen oxide species and adducts to inhibit skeletal muscle contraction |
AU2970595A (en) | 1994-07-15 | 1996-02-16 | Brigham And Women's Hospital | Inhibition of virus by nitric oxide |
WO1996003139A1 (en) * | 1994-07-27 | 1996-02-08 | Duke University | Use of nitric oxide or nitric oxide adducts to preserve platelets |
US5519020A (en) | 1994-10-28 | 1996-05-21 | The University Of Akron | Polymeric wound healing accelerators |
US5700830A (en) | 1994-11-22 | 1997-12-23 | The United States Of America As Represented By The Department Of Health And Human Services | Use of nitric oxide-releasing agents for reducing metastasis risk |
GB9423868D0 (en) | 1994-11-25 | 1995-01-11 | Wellcome Found | Compounds for use in medicine |
GB9424694D0 (en) | 1994-12-07 | 1995-02-01 | Wellcome Found | Compounds for use in medicine |
JP4579349B2 (ja) | 1995-03-14 | 2010-11-10 | バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト | 子宮頸の拡大及び拡張度を制御するための酸化窒素供与体及び/又は基質又は酸化窒素インヒビター |
US5770645A (en) | 1996-08-02 | 1998-06-23 | Duke University Medical Center | Polymers for delivering nitric oxide in vivo |
US6232434B1 (en) * | 1996-08-02 | 2001-05-15 | Duke University Medical Center | Polymers for delivering nitric oxide in vivo |
-
1998
- 1998-06-23 US US09/103,225 patent/US6232434B1/en not_active Expired - Fee Related
-
1999
- 1999-06-17 JP JP2000555946A patent/JP4846099B2/ja not_active Expired - Fee Related
- 1999-06-17 DE DE69934406T patent/DE69934406T2/de not_active Expired - Lifetime
- 1999-06-17 ES ES99930378T patent/ES2279621T3/es not_active Expired - Lifetime
- 1999-06-17 AU AU46929/99A patent/AU4692999A/en not_active Abandoned
- 1999-06-17 CA CA2336138A patent/CA2336138C/en not_active Expired - Fee Related
- 1999-06-17 WO PCT/US1999/013731 patent/WO1999067296A1/en active IP Right Grant
- 1999-06-17 EP EP99930378A patent/EP1093468B1/de not_active Expired - Lifetime
-
2000
- 2000-12-29 US US09/752,223 patent/US6403759B2/en not_active Expired - Fee Related
-
2002
- 2002-06-05 US US10/164,366 patent/US6673891B2/en not_active Expired - Fee Related
-
2003
- 2003-09-23 US US10/668,667 patent/US6875840B2/en not_active Expired - Fee Related
-
2005
- 2005-02-08 US US11/053,593 patent/US7087709B2/en not_active Expired - Fee Related
-
2006
- 2006-08-07 US US11/500,180 patent/US7417109B2/en not_active Expired - Fee Related
-
2011
- 2011-01-21 JP JP2011011097A patent/JP2011144376A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
JP2002518557A (ja) | 2002-06-25 |
US20050220756A1 (en) | 2005-10-06 |
EP1093468B1 (de) | 2006-12-13 |
US20010020083A1 (en) | 2001-09-06 |
US6673891B2 (en) | 2004-01-06 |
US6403759B2 (en) | 2002-06-11 |
CA2336138C (en) | 2011-08-23 |
US6232434B1 (en) | 2001-05-15 |
WO1999067296A1 (en) | 1999-12-29 |
US7417109B2 (en) | 2008-08-26 |
ES2279621T3 (es) | 2007-08-16 |
EP1093468A1 (de) | 2001-04-25 |
US20030078365A1 (en) | 2003-04-24 |
AU4692999A (en) | 2000-01-10 |
US7087709B2 (en) | 2006-08-08 |
US20040132904A1 (en) | 2004-07-08 |
CA2336138A1 (en) | 1999-12-29 |
US20070088435A1 (en) | 2007-04-19 |
JP4846099B2 (ja) | 2011-12-28 |
US6875840B2 (en) | 2005-04-05 |
JP2011144376A (ja) | 2011-07-28 |
DE69934406T2 (de) | 2007-09-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69934406D1 (de) | Polymere zur freisetzung von stickstoffmonoxid in vivo | |
DE69840251D1 (de) | Festpolymerelektrolyt und Verfahren zur Herstellung | |
DE69941841D1 (de) | Polymere anordnungen | |
DE69916715T2 (de) | Vernetzte sulfonierte polymere und verfahren zur herstellung davon | |
DE69717223T2 (de) | Fluorocyanat- und Fluorocarbamat-Monomere und davon abgeleitete Polymere | |
DE69838337D1 (de) | Ampholitische polymere zur verwendung in körperpflegeprodukten | |
DE69738299D1 (de) | Phosphor-enthaltende fluoromonomere und polymere davon | |
DE59712326D1 (de) | Vorrichtung zur in-vivo-Bestimmung von Parametern der Hämodialyse | |
NO982894L (no) | Polymere | |
DE69819015D1 (de) | Norbonenpolymer und verfahren zur herstellung | |
ATE231683T1 (de) | Matte zur abgabe von flüchtigen stoffen | |
DE69943023D1 (de) | Absorbierbare polymere und daraus hergestellte chirurgische artikel | |
NO2011010I1 (no) | Naproksen- og esomeprazoltabletter med modifisert frisetting | |
DE19983155T1 (de) | Persönliches Identifikationssystem und Verfahren | |
DE69917815D1 (de) | Polymere zusammensetzung | |
DE69829526D1 (de) | System zur Detektion von Zügen | |
DE69914999D1 (de) | Verfahren zur Authentisierung und Absprache zwischen zwei Teilnehmern | |
ATE419310T1 (de) | Produkte auf der basis von gefälltem kalziumkarbonat mit verbessertem glanz und verfahren zur herstellung derselben | |
DE60002505D1 (de) | Lithium kobaltoxide und verfahren zur herstellung | |
DE60033322D1 (de) | Vorrichtung zur Gefässeanastomose | |
ID29053A (id) | Metode untuk menghasilkan 3-alkanoilindola dan 3-alkilindola | |
ID27255A (id) | Lampu berbentuk lampu pijar dan metoda pembuatannya | |
ATE366764T1 (de) | Egioreguläres copolymer und verfahren zur herstellung | |
DE60026167D1 (de) | Schmiermittelkombination und verfahren zur herstellung desselben | |
DE69704737D1 (de) | Amphotere Polymere zur Lederbehandlung |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |