DE69936377D1 - Verfahren und produkt zur transfektion mit genetischem material - Google Patents
Verfahren und produkt zur transfektion mit genetischem materialInfo
- Publication number
- DE69936377D1 DE69936377D1 DE69936377T DE69936377T DE69936377D1 DE 69936377 D1 DE69936377 D1 DE 69936377D1 DE 69936377 T DE69936377 T DE 69936377T DE 69936377 T DE69936377 T DE 69936377T DE 69936377 D1 DE69936377 D1 DE 69936377D1
- Authority
- DE
- Germany
- Prior art keywords
- genetic material
- gene transfection
- transfection
- product
- conjugated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G83/00—Macromolecular compounds not provided for in groups C08G2/00 - C08G81/00
- C08G83/002—Dendritic macromolecules
- C08G83/003—Dendrimers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/89—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microinjection
- C12N15/895—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microinjection using biolistic methods
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/914—Protein engineering
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/915—Therapeutic or pharmaceutical composition
- Y10S977/916—Gene therapy
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7066698P | 1998-01-07 | 1998-01-07 | |
| PCT/US1999/000133 WO1999034908A1 (en) | 1998-01-07 | 1999-01-06 | Method and articles for transfection of genetic material |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE69936377D1 true DE69936377D1 (de) | 2007-08-09 |
Family
ID=22096666
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69936377T Expired - Lifetime DE69936377D1 (de) | 1998-01-07 | 1999-01-06 | Verfahren und produkt zur transfektion mit genetischem material |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6475994B2 (de) |
| EP (1) | EP1051244B1 (de) |
| JP (1) | JP2002500033A (de) |
| AT (1) | ATE365584T1 (de) |
| CA (1) | CA2317666A1 (de) |
| DE (1) | DE69936377D1 (de) |
| WO (1) | WO1999034908A1 (de) |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040146918A1 (en) * | 2000-02-18 | 2004-07-29 | Weiner Michael L. | Hybrid nucleic acid assembly |
| WO2002000870A2 (en) * | 2000-06-26 | 2002-01-03 | Christian Plank | Method for transfecting cells using a magnetic field |
| JP2005530517A (ja) * | 2002-06-27 | 2005-10-13 | ジョージア テック リサーチ コーポレイション | ナノサイズ光学蛍光ラベルおよびその使用 |
| US20040048260A1 (en) * | 2002-09-10 | 2004-03-11 | Fu-Hsiung Chang | Transfection of nucleic acid |
| US20040138154A1 (en) * | 2003-01-13 | 2004-07-15 | Lei Yu | Solid surface for biomolecule delivery and high-throughput assay |
| US20070269891A9 (en) * | 2003-01-13 | 2007-11-22 | Yasunobu Tanaka | Solid surface with immobilized degradable cationic polymer for transfecting eukaryotic cells |
| PT1444999E (pt) * | 2003-02-03 | 2010-11-11 | Bioware Technology Co Ltd | Canhão de genes acelerado a gás de pressão reduzida |
| US7153905B2 (en) * | 2003-03-21 | 2006-12-26 | The General Hospital Corporation | Hyperbranched dendron and methods of synthesis and use thereof |
| EP1648622A4 (de) * | 2003-07-21 | 2009-11-11 | Dendritic Nanotechnologies Inc | Stabilisierte und chemisch funktionalisierte nanopartikel |
| WO2006078640A2 (en) | 2005-01-19 | 2006-07-27 | International Technology Center | Alterations utilizing nanoparticles |
| US20060211004A1 (en) | 2005-02-15 | 2006-09-21 | Ilsley Diane D | Methods and compositions for determining non-specific cytotoxicity of a transfection agent |
| US7957507B2 (en) | 2005-02-28 | 2011-06-07 | Cadman Patrick F | Method and apparatus for modulating a radiation beam |
| US8232535B2 (en) | 2005-05-10 | 2012-07-31 | Tomotherapy Incorporated | System and method of treating a patient with radiation therapy |
| US8442287B2 (en) | 2005-07-22 | 2013-05-14 | Tomotherapy Incorporated | Method and system for evaluating quality assurance criteria in delivery of a treatment plan |
| CN101268467B (zh) | 2005-07-22 | 2012-07-18 | 断层放疗公司 | 用于评估治疗计划的实施中的质量保证标准的方法和系统 |
| CA2616272A1 (en) | 2005-07-22 | 2007-02-01 | Tomotherapy Incorporated | System and method of detecting a breathing phase of a patient receiving radiation therapy |
| US7839972B2 (en) | 2005-07-22 | 2010-11-23 | Tomotherapy Incorporated | System and method of evaluating dose delivered by a radiation therapy system |
| CN101267857A (zh) | 2005-07-22 | 2008-09-17 | 断层放疗公司 | 对移动的关注区实施放射疗法的系统和方法 |
| EP1907057B1 (de) | 2005-07-23 | 2017-01-25 | TomoTherapy, Inc. | Vorrichtung zur strahlungstherapiebildgebung und abgabe mttels koordinierter bewegung von gantry und liege |
| CA2777682C (en) * | 2009-10-13 | 2015-02-24 | The Regents Of The University Of Michigan | Dendrimer compositions and methods of synthesis |
| NZ598419A (en) * | 2009-10-16 | 2013-11-29 | Dow Agrosciences Llc | Use of dendrimer nanotechnology for delivery of biomolecules into plant cells |
| BR112013000267B8 (pt) * | 2010-07-07 | 2022-06-28 | Dow Agrosciences Llc | Métodos de introdução de uma molécula de cassete de ácido nucleico em uma célula vegetal e de introgressão de um traço em uma planta mediados por nanopartícula de ponto quântico |
| WO2014030147A2 (en) * | 2012-08-23 | 2014-02-27 | Fundación Fraunhofer Chile Research | Synthetic proteins based on dendrimers |
| EP2962309B1 (de) | 2013-02-26 | 2022-02-16 | Accuray, Inc. | Elektromagnetisch betätigter mehrblatt-kollimator |
| TWI632714B (zh) * | 2013-05-02 | 2018-08-11 | 新加坡商泰拉-屏障膜公司 | 封裝障壁堆疊 |
| TWI788307B (zh) | 2016-10-31 | 2023-01-01 | 美商艾歐凡斯生物治療公司 | 用於擴增腫瘤浸潤性淋巴細胞之工程化人造抗原呈現細胞 |
| BR112020009663A2 (pt) | 2017-11-17 | 2020-11-10 | Iovance Biotherapeutics, Inc. | método para a expansão de linfócitos infiltrantes de tumor (tils) em uma população terapêutica de tils, método para o tratamento de um indivíduo com câncer, composição |
| JP2021503885A (ja) | 2017-11-22 | 2021-02-15 | アイオバンス バイオセラピューティクス，インコーポレイテッド | 末梢血からの末梢血リンパ球（ｐｂｌ）の拡大培養 |
| WO2019136456A1 (en) | 2018-01-08 | 2019-07-11 | Iovance Biotherapeutics, Inc. | Processes for generating til products enriched for tumor antigen-specific t-cells |
| WO2019136459A1 (en) | 2018-01-08 | 2019-07-11 | Iovance Biotherapeutics, Inc. | Processes for generating til products enriched for tumor antigen-specific t-cells |
| US11713446B2 (en) | 2018-01-08 | 2023-08-01 | Iovance Biotherapeutics, Inc. | Processes for generating TIL products enriched for tumor antigen-specific T-cells |
| KR20210005138A (ko) | 2018-04-27 | 2021-01-13 | 이오반스 바이오테라퓨틱스, 인크. | 종양 침윤 림프구의 확장 및 유전자 편집을 위한 폐쇄 방법 및 면역요법에서의 그의 용도 |
| WO2020096989A1 (en) | 2018-11-05 | 2020-05-14 | Iovance Biotherapeutics, Inc. | Treatment of nsclc patients refractory for anti-pd-1 antibody |
| MX2021004775A (es) | 2018-11-05 | 2021-06-08 | Iovance Biotherapeutics Inc | Expansion de linfocitos infiltrantes de tumores (tils) usando inhibidores de la via de proteina cinasa b (akt). |
| CN113272421A (zh) | 2018-11-05 | 2021-08-17 | 艾欧凡斯生物治疗公司 | 用于产生肿瘤浸润性淋巴细胞的方法及其在免疫疗法中的用途 |
| EP3877512A2 (de) | 2018-11-05 | 2021-09-15 | Iovance Biotherapeutics, Inc. | Selektion verbesserter tumorreaktiver t-zellen |
| WO2020118110A1 (en) | 2018-12-05 | 2020-06-11 | Fred Hutchinson Cancer Research Center | Reduced and minimal manipulation manufacturing of genetically-modified cells |
| EP3898949A1 (de) | 2018-12-19 | 2021-10-27 | Iovance Biotherapeutics, Inc. | Verfahren zur expansion tumorinfiltrierender lymphozyten unter verwendung von manipulierten cytokin-rezeptorenpaaren und deren verwendungen |
| MX2021010288A (es) | 2019-03-01 | 2021-09-23 | Iovance Biotherapeutics Inc | Expansion de linfocitos infiltrantes de tumores a partir de tumores liquidos y usos terapeuticos de los mismos. |
| US20220249559A1 (en) | 2019-05-13 | 2022-08-11 | Iovance Biotherapeutics, Inc. | Methods and compositions for selecting tumor infiltrating lymphocytes and uses of the same in immunotherapy |
| EP4048295A1 (de) | 2019-10-25 | 2022-08-31 | Iovance Biotherapeutics, Inc. | Genbearbeitung von tumorinfiltrierenden lymphozyten und deren verwendungen in der immuntherapie |
| CA3161104A1 (en) | 2019-12-11 | 2021-06-17 | Cecile Chartier-Courtaud | Processes for the production of tumor infiltrating lymphocytes (tils) and methods of using the same |
| TW202208617A (zh) | 2020-05-04 | 2022-03-01 | 美商艾歐凡斯生物治療公司 | 用於產生腫瘤浸潤性淋巴球的過程及其在免疫療法中的用途 |
| CA3177413A1 (en) | 2020-05-04 | 2021-11-11 | Michelle SIMPSON-ABELSON | Selection of improved tumor reactive t-cells |
| WO2022076606A1 (en) | 2020-10-06 | 2022-04-14 | Iovance Biotherapeutics, Inc. | Treatment of nsclc patients with tumor infiltrating lymphocyte therapies |
| JP2023546359A (ja) | 2020-10-06 | 2023-11-02 | アイオバンス バイオセラピューティクス，インコーポレイテッド | 腫瘍浸潤リンパ球療法によるｎｓｃｌｃ患者の治療 |
| JP2024501452A (ja) | 2020-12-11 | 2024-01-12 | アイオバンス バイオセラピューティクス，インコーポレイテッド | Ｂｒａｆ阻害剤及び／またはｍｅｋ阻害剤と併用した腫瘍浸潤リンパ球治療によるがん患者の治療 |
| WO2022133140A1 (en) | 2020-12-17 | 2022-06-23 | Iovance Biotherapeutics, Inc. | Treatment with tumor infiltrating lymphocyte therapies in combination with ctla-4 and pd-1 inhibitors |
| JP2024500403A (ja) | 2020-12-17 | 2024-01-09 | アイオバンス バイオセラピューティクス，インコーポレイテッド | 腫瘍浸潤リンパ球によるがんの治療 |
| TW202241508A (zh) | 2021-01-29 | 2022-11-01 | 美商艾歐凡斯生物治療公司 | 細胞介素相關之腫瘤浸潤性淋巴球組合物及方法 |
| EP4308691A1 (de) | 2021-03-19 | 2024-01-24 | Iovance Biotherapeutics, Inc. | Verfahren zur expansion von tumorinfiltrierenden lymphozyten (til) im zusammenhang mit der cd39/cd69-auswahl und gen-knockout in tils |
| TW202305118A (zh) | 2021-03-23 | 2023-02-01 | 美商艾歐凡斯生物治療公司 | 腫瘤浸潤淋巴球之ｃｉｓｈ基因編輯及其在免疫療法中之用途 |
| JP2024515189A (ja) | 2021-04-19 | 2024-04-05 | アイオバンス バイオセラピューティクス，インコーポレイテッド | 細胞免疫療法におけるキメラ共刺激受容体、ケモカイン受容体、及びそれらの使用 |
| WO2022245754A1 (en) | 2021-05-17 | 2022-11-24 | Iovance Biotherapeutics, Inc. | Pd-1 gene-edited tumor infiltrating lymphocytes and uses of same in immunotherapy |
| CA3226111A1 (en) | 2021-07-22 | 2023-01-26 | Iovance Biotherapeutics, Inc. | Method for cryopreservation of solid tumor fragments |
| WO2023009716A1 (en) | 2021-07-28 | 2023-02-02 | Iovance Biotherapeutics, Inc. | Treatment of cancer patients with tumor infiltrating lymphocyte therapies in combination with kras inhibitors |
| WO2023039488A1 (en) | 2021-09-09 | 2023-03-16 | Iovance Biotherapeutics, Inc. | Processes for generating til products using pd-1 talen knockdown |
| AR127482A1 (es) | 2021-10-27 | 2024-01-31 | Iovance Biotherapeutics Inc | Sistemas y métodos para coordinar la fabricación de células para inmunoterapia específica de paciente |
| WO2023086803A1 (en) | 2021-11-10 | 2023-05-19 | Iovance Biotherapeutics, Inc. | Methods of expansion treatment utilizing cd8 tumor infiltrating lymphocytes |
| WO2023147488A1 (en) | 2022-01-28 | 2023-08-03 | Iovance Biotherapeutics, Inc. | Cytokine associated tumor infiltrating lymphocytes compositions and methods |
| WO2023147486A1 (en) | 2022-01-28 | 2023-08-03 | Iovance Biotherapeutics, Inc. | Tumor infiltrating lymphocytes engineered to express payloads |
| WO2023196877A1 (en) | 2022-04-06 | 2023-10-12 | Iovance Biotherapeutics, Inc. | Treatment of nsclc patients with tumor infiltrating lymphocyte therapies |
| WO2023201369A1 (en) | 2022-04-15 | 2023-10-19 | Iovance Biotherapeutics, Inc. | Til expansion processes using specific cytokine combinations and/or akti treatment |
| WO2023220608A1 (en) | 2022-05-10 | 2023-11-16 | Iovance Biotherapeutics, Inc. | Treatment of cancer patients with tumor infiltrating lymphocyte therapies in combination with an il-15r agonist |
| WO2024030758A1 (en) | 2022-08-01 | 2024-02-08 | Iovance Biotherapeutics, Inc. | Chimeric costimulatory receptors, chemokine receptors, and the use of same in cellular immunotherapies |
| WO2024055018A1 (en) | 2022-09-09 | 2024-03-14 | Iovance Biotherapeutics, Inc. | Processes for generating til products using pd-1/tigit talen double knockdown |
| WO2024055017A1 (en) | 2022-09-09 | 2024-03-14 | Iovance Biotherapeutics, Inc. | Processes for generating til products using pd-1/tigit talen double knockdown |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4945050A (en) * | 1984-11-13 | 1990-07-31 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
| US5527524A (en) * | 1986-08-18 | 1996-06-18 | The Dow Chemical Company | Dense star polymer conjugates |
| CA2160878A1 (en) * | 1993-04-19 | 1994-10-27 | Sandra Gertrude Mcelligott | Encapsulation of nucleic acids with conjugates that facilitate and target cellular uptake and gene expression |
| GB9317380D0 (en) * | 1993-08-20 | 1993-10-06 | Therexsys Ltd | Transfection process |
| CA2158733C (en) * | 1994-01-21 | 2007-01-16 | Dennis E. Mccabe | Gas driven gene delivery instrument |
| US5962427A (en) * | 1994-02-18 | 1999-10-05 | The Regent Of The University Of Michigan | In vivo gene transfer methods for wound healing |
| DE69533569T2 (de) * | 1994-03-07 | 2006-01-05 | Dendritic Nanotechnologies, Inc., Mt. Pleasant | Bioaktive und/oder gezielte dendrimere-konjugate enthaltend genetisches material |
| NL9401886A (nl) * | 1994-05-27 | 1996-01-02 | Dsm Nv | Samenstelling bestaande uit een dendrimeer en een in het dendrimeer opgesloten actieve stof, een werkwijze voor de bereiding van een dergelijke samenstelling en een werkwijze voor het vrijgeven van de actieve stof. |
| GB9425600D0 (en) * | 1994-12-19 | 1995-02-15 | Medical Res Council | Targeting complexes and use thereof |
| CA2226299A1 (en) * | 1995-08-11 | 1997-02-27 | Dendritech, Inc. | Hyper comb-branched polymer conjugates |
| DE19622628A1 (de) * | 1996-06-05 | 1997-12-11 | Boehringer Mannheim Gmbh | Stabilisierung von Metallkonjugaten |
-
1998
- 1998-12-23 US US09/219,907 patent/US6475994B2/en not_active Expired - Fee Related
-
1999
- 1999-01-06 JP JP2000527344A patent/JP2002500033A/ja active Pending
- 1999-01-06 AT AT99901307T patent/ATE365584T1/de not_active IP Right Cessation
- 1999-01-06 WO PCT/US1999/000133 patent/WO1999034908A1/en active IP Right Grant
- 1999-01-06 DE DE69936377T patent/DE69936377D1/de not_active Expired - Lifetime
- 1999-01-06 CA CA002317666A patent/CA2317666A1/en not_active Abandoned
- 1999-01-06 EP EP99901307A patent/EP1051244B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1051244B1 (de) | 2007-06-27 |
| US6475994B2 (en) | 2002-11-05 |
| EP1051244A4 (de) | 2003-06-11 |
| ATE365584T1 (de) | 2007-07-15 |
| WO1999034908A1 (en) | 1999-07-15 |
| JP2002500033A (ja) | 2002-01-08 |
| CA2317666A1 (en) | 1999-07-15 |
| EP1051244A1 (de) | 2000-11-15 |
| US20020013283A1 (en) | 2002-01-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8332 | No legal effect for de |